FZD7 - Gs

GPCR CLASS (FAMILY)

Class F (Frizzled)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.2 Å

REFERENCE

PUBLICATION DATE

April 24, 2024

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

Apo (no ligand) - Apo (no ligand)

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic ICL3 T 459 - G.H5 L 388 G.H5.20
Hydrophobic TM5 M 454 5x76 G.H5 L 388 G.H5.20
Van-der-waals TM5 M 454 5x76 G.H5 L 388 G.H5.20
Hydrophobic TM6 K 463 6x25 G.H5 L 393 G.H5.25
Van-der-waals TM6 K 463 6x25 G.H5 L 393 G.H5.25
Aromatic ICL2 H 371 - G.H5 Y 391 G.H5.23
Hydrophobic ICL2 H 371 - G.H5 Y 391 G.H5.23
Van-der-waals ICL2 H 371 - G.H5 Y 391 G.H5.23
Hydrophobic ICL3 T 459 - G.H5 L 394 G.H5.26
Polar ICL2 W 369 - G.H5 Y 391 G.H5.23
Van-der-waals ICL2 W 369 - G.H5 Y 391 G.H5.23
Hydrophobic ICL2 G 370 - G.H5 Q 390 G.H5.22
Hydrophobic TM3 A 364 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 A 364 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM5 I 450 5x72 G.H5 L 388 G.H5.20
Polar ICL2 H 371 - G.H5 Q 390 G.H5.22
Hydrophobic ICL2 H 371 - G.H5 Q 390 G.H5.22
Van-der-waals ICL2 H 371 - G.H5 Q 390 G.H5.22
Hydrophobic TM6 L 464 6x26 G.H5 L 393 G.H5.25
Hydrophobic TM5 I 453 5x75 G.H5 Q 384 G.H5.16
Van-der-waals TM5 I 453 5x75 G.H5 Q 384 G.H5.16
Hydrophobic ICL1 P 285 - G.H5 Y 391 G.H5.23
Hydrophobic TM6 L 467 6x29 G.H5 L 393 G.H5.25
Van-der-waals TM6 L 467 6x29 G.H5 L 393 G.H5.25
Hydrophobic ICL2 K 368 - G.H5 H 387 G.H5.19
Van-der-waals ICL2 K 368 - G.H5 H 387 G.H5.19
Polar TM6 K 463 6x25 G.H5 L 394 G.H5.26
Hydrophobic TM6 K 463 6x25 G.H5 L 394 G.H5.26
Van-der-waals TM6 K 463 6x25 G.H5 L 394 G.H5.26
Polar ICL3 T 459 - G.H5 R 385 G.H5.17
Hydrophobic TM5 M 454 5x76 G.H5 Q 384 G.H5.16