Refined structure (6LFM) of Gi1 - CXCR2

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2024-02-01

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 230 from structure (65.0%), 124 from model (35.0%)
Residue sidechains - 218 from structure (61.6%), 136 from model (38.4%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 Structure Structure
G.HN 4 T G.HN.10 Structure Structure
G.HN 5 L G.HN.11 Structure Structure
G.HN 6 S G.HN.30 Structure Structure
G.HN 7 A G.HN.31 Structure Structure
G.HN 8 E G.HN.32 Structure Structure
G.HN 9 D G.HN.33 Structure Structure
G.HN 10 K G.HN.34 Structure Structure
G.HN 11 A G.HN.35 Structure Structure
G.HN 12 A G.HN.36 Structure Structure
G.HN 13 V G.HN.37 Structure Structure
G.HN 14 E G.HN.38 Structure Structure
G.HN 15 R G.HN.39 Structure Structure
G.HN 16 S G.HN.40 Structure Structure
G.HN 17 K G.HN.41 Structure Structure
G.HN 18 M G.HN.42 Structure Structure
G.HN 19 I G.HN.43 Structure Structure
G.HN 20 D G.HN.44 Structure Structure
G.HN 21 R G.HN.45 Structure Structure
G.HN 22 N G.HN.46 Structure Structure
G.HN 23 L G.HN.47 Structure Structure
G.HN 24 R G.HN.48 Structure Structure
G.HN 25 E G.HN.49 Structure AF2
G.HN 26 D G.HN.50 Structure Structure
G.HN 27 G G.HN.51 Structure Structure
G.HN 28 E G.HN.52 Structure Structure
G.HN 29 K G.HN.53 Structure Structure
G.hns1 30 A G.hns1.01 Structure Structure
G.hns1 31 A G.hns1.02 Structure Structure
G.hns1 32 R G.hns1.03 Structure Structure
G.S1 33 E G.S1.01 Structure Structure
G.S1 34 V G.S1.02 Structure Structure
G.S1 35 K G.S1.03 Structure Structure
G.S1 36 L G.S1.04 Structure Structure
G.S1 37 L G.S1.05 Structure Structure
G.S1 38 L G.S1.06 Structure Structure
G.S1 39 L G.S1.07 Structure Structure
G.s1h1 40 G G.s1h1.01 Structure Structure
G.s1h1 41 A G.s1h1.02 Structure Structure
G.s1h1 42 G G.s1h1.03 Structure Structure
G.s1h1 43 E G.s1h1.04 Structure Structure
G.s1h1 44 S G.s1h1.05 Structure Structure
G.s1h1 45 G G.s1h1.06 Structure Structure
G.H1 46 K G.H1.01 Structure Structure
G.H1 47 S G.H1.02 Structure Structure
G.H1 48 T G.H1.03 Structure Structure
G.H1 49 I G.H1.04 Structure Structure
G.H1 50 V G.H1.05 Structure Structure
G.H1 51 K G.H1.06 Structure AF2
G.H1 52 Q G.H1.07 Structure Structure
G.H1 53 M G.H1.08 Structure Structure
G.H1 54 K G.H1.09 Structure AF2
G.H1 55 I G.H1.10 Structure Structure
G.H1 56 I G.H1.11 Structure Structure
G.H1 57 H G.H1.12 AF2 AF2
G.h1ha 58 E G.h1ha.01 AF2 AF2
G.h1ha 59 A G.h1ha.02 AF2 AF2
G.h1ha 60 G G.h1ha.03 AF2 AF2
G.h1ha 61 Y G.h1ha.04 AF2 AF2
G.h1ha 62 S G.h1ha.05 AF2 AF2
H.HA 63 E H.HA.01 AF2 AF2
H.HA 64 E H.HA.02 AF2 AF2
H.HA 65 E H.HA.03 AF2 AF2
H.HA 66 C H.HA.04 AF2 AF2
H.HA 67 K H.HA.05 AF2 AF2
H.HA 68 Q H.HA.06 AF2 AF2
H.HA 69 Y H.HA.07 AF2 AF2
H.HA 70 K H.HA.08 AF2 AF2
H.HA 71 A H.HA.09 AF2 AF2
H.HA 72 V H.HA.10 AF2 AF2
H.HA 73 V H.HA.11 AF2 AF2
H.HA 74 Y H.HA.12 AF2 AF2
H.HA 75 S H.HA.13 AF2 AF2
H.HA 76 N H.HA.14 AF2 AF2
H.HA 77 T H.HA.15 AF2 AF2
H.HA 78 I H.HA.16 AF2 AF2
H.HA 79 Q H.HA.17 AF2 AF2
H.HA 80 S H.HA.18 AF2 AF2
H.HA 81 I H.HA.19 AF2 AF2
H.HA 82 I H.HA.20 AF2 AF2
H.HA 83 A H.HA.21 AF2 AF2
H.HA 84 I H.HA.22 AF2 AF2
H.HA 85 I H.HA.23 AF2 AF2
H.HA 86 R H.HA.24 AF2 AF2
H.HA 87 A H.HA.25 AF2 AF2
H.HA 88 M H.HA.26 AF2 AF2
H.HA 89 G H.HA.27 AF2 AF2
H.HA 90 R H.HA.28 AF2 AF2
H.HA 91 L H.HA.29 AF2 AF2
H.hahb 92 K H.hahb.01 AF2 AF2
H.hahb 93 I H.hahb.04 AF2 AF2
H.hahb 94 D H.hahb.05 AF2 AF2
H.hahb 95 F H.hahb.06 AF2 AF2
H.hahb 96 G H.hahb.07 AF2 AF2
H.hahb 97 D H.hahb.08 AF2 AF2
H.hahb 98 S H.hahb.09 AF2 AF2
H.HB 99 A H.HB.01 AF2 AF2
H.HB 100 R H.HB.02 AF2 AF2
H.HB 101 A H.HB.03 AF2 AF2
H.HB 102 D H.HB.04 AF2 AF2
H.HB 103 D H.HB.05 AF2 AF2
H.HB 104 A H.HB.06 AF2 AF2
H.HB 105 R H.HB.07 AF2 AF2
H.HB 106 Q H.HB.08 AF2 AF2
H.HB 107 L H.HB.09 AF2 AF2
H.HB 108 F H.HB.10 AF2 AF2
H.HB 109 V H.HB.11 AF2 AF2
H.HB 110 L H.HB.12 AF2 AF2
H.HB 111 A H.HB.13 AF2 AF2
H.HB 112 G H.HB.14 AF2 AF2
H.hbhc 113 A H.hbhc.01 AF2 AF2
H.hbhc 114 A H.hbhc.02 AF2 AF2
H.hbhc 115 E H.hbhc.03 AF2 AF2
H.hbhc 116 E H.hbhc.04 AF2 AF2
H.hbhc 117 G H.hbhc.12 AF2 AF2
H.hbhc 118 F H.hbhc.13 AF2 AF2
H.hbhc 119 M H.hbhc.14 AF2 AF2
H.hbhc 120 T H.hbhc.15 AF2 AF2
H.HC 121 A H.HC.01 AF2 AF2
H.HC 122 E H.HC.02 AF2 AF2
H.HC 123 L H.HC.03 AF2 AF2
H.HC 124 A H.HC.04 AF2 AF2
H.HC 125 G H.HC.05 AF2 AF2
H.HC 126 V H.HC.06 AF2 AF2
H.HC 127 I H.HC.07 AF2 AF2
H.HC 128 K H.HC.08 AF2 AF2
H.HC 129 R H.HC.09 AF2 AF2
H.HC 130 L H.HC.10 AF2 AF2
H.HC 131 W H.HC.11 AF2 AF2
H.HC 132 K H.HC.12 AF2 AF2
H.hchd 133 D H.hchd.01 AF2 AF2
H.HD 134 S H.HD.01 AF2 AF2
H.HD 135 G H.HD.02 AF2 AF2
H.HD 136 V H.HD.03 AF2 AF2
H.HD 137 Q H.HD.04 AF2 AF2
H.HD 138 A H.HD.05 AF2 AF2
H.HD 139 C H.HD.06 AF2 AF2
H.HD 140 F H.HD.07 AF2 AF2
H.HD 141 N H.HD.08 AF2 AF2
H.HD 142 R H.HD.09 AF2 AF2
H.HD 143 S H.HD.10 AF2 AF2
H.HD 144 R H.HD.11 AF2 AF2
H.HD 145 E H.HD.12 AF2 AF2
H.hdhe 146 Y H.hdhe.01 AF2 AF2
H.hdhe 147 Q H.hdhe.02 AF2 AF2
H.hdhe 148 L H.hdhe.03 AF2 AF2
H.hdhe 149 N H.hdhe.04 AF2 AF2
H.hdhe 150 D H.hdhe.05 AF2 AF2
H.HE 151 S H.HE.01 AF2 AF2
H.HE 152 A H.HE.02 AF2 AF2
H.HE 153 A H.HE.03 AF2 AF2
H.HE 154 Y H.HE.04 AF2 AF2
H.HE 155 Y H.HE.05 AF2 AF2
H.HE 156 L H.HE.06 AF2 AF2
H.HE 157 N H.HE.07 AF2 AF2
H.HE 158 D H.HE.08 AF2 AF2
H.HE 159 L H.HE.09 AF2 AF2
H.HE 160 D H.HE.10 AF2 AF2
H.HE 161 R H.HE.11 AF2 AF2
H.HE 162 I H.HE.12 AF2 AF2
H.HE 163 A H.HE.13 AF2 AF2
H.hehf 164 Q H.hehf.01 AF2 AF2
H.hehf 165 P H.hehf.02 AF2 AF2
H.hehf 166 N H.hehf.03 AF2 AF2
H.hehf 167 Y H.hehf.04 AF2 AF2
H.hehf 168 I H.hehf.05 AF2 AF2
H.hehf 169 P H.hehf.06 AF2 AF2
H.hehf 170 T H.hehf.07 AF2 AF2
H.HF 171 Q H.HF.01 AF2 AF2
H.HF 172 Q H.HF.02 AF2 AF2
H.HF 173 D H.HF.03 AF2 AF2
H.HF 174 V H.HF.04 AF2 AF2
H.HF 175 L H.HF.05 AF2 AF2
H.HF 176 R H.HF.06 AF2 AF2
G.hfs2 177 T G.hfs2.01 AF2 AF2
G.hfs2 178 R G.hfs2.02 AF2 AF2
G.hfs2 179 V G.hfs2.03 Structure Structure
G.hfs2 180 K G.hfs2.04 Structure Structure
G.hfs2 181 T G.hfs2.05 Structure Structure
G.hfs2 182 T G.hfs2.06 Structure Structure
G.hfs2 183 G G.hfs2.07 Structure Structure
G.S2 184 I G.S2.01 Structure Structure
G.S2 185 V G.S2.02 Structure Structure
G.S2 186 E G.S2.03 Structure Structure
G.S2 187 T G.S2.04 Structure Structure
G.S2 188 H G.S2.05 Structure Structure
G.S2 189 F G.S2.06 Structure Structure
G.S2 190 T G.S2.07 Structure Structure
G.S2 191 F G.S2.08 Structure Structure
G.s2s3 192 K G.s2s3.01 Structure Structure
G.s2s3 193 D G.s2s3.02 Structure AF2
G.S3 194 L G.S3.01 Structure Structure
G.S3 195 H G.S3.02 Structure Structure
G.S3 196 F G.S3.03 Structure Structure
G.S3 197 K G.S3.04 Structure Structure
G.S3 198 M G.S3.05 Structure Structure
G.S3 199 F G.S3.06 Structure Structure
G.S3 200 D G.S3.07 Structure Structure
G.S3 201 V G.S3.08 Structure Structure
G.s3h2 202 G G.s3h2.01 Structure Structure
G.s3h2 203 G G.s3h2.02 Structure Structure
G.s3h2 204 Q G.s3h2.03 Structure Structure
G.H2 205 R G.H2.01 Structure AF2
G.H2 206 S G.H2.02 Structure Structure
G.H2 207 E G.H2.03 Structure Structure
G.H2 208 R G.H2.04 Structure Structure
G.H2 209 K G.H2.05 Structure Structure
G.H2 210 K G.H2.06 Structure Structure
G.H2 211 W G.H2.07 Structure Structure
G.H2 212 I G.H2.08 Structure Structure
G.H2 213 H G.H2.09 Structure Structure
G.H2 214 C G.H2.10 Structure Structure
G.h2s4 215 F G.h2s4.01 Structure Structure
G.h2s4 216 E G.h2s4.02 Structure Structure
G.h2s4 217 G G.h2s4.03 Structure Structure
G.h2s4 218 V G.h2s4.04 Structure Structure
G.h2s4 219 T G.h2s4.05 Structure Structure
G.S4 220 A G.S4.01 Structure Structure
G.S4 221 I G.S4.02 Structure Structure
G.S4 222 I G.S4.03 Structure Structure
G.S4 223 F G.S4.04 Structure Structure
G.S4 224 C G.S4.05 Structure Structure
G.S4 225 V G.S4.06 Structure Structure
G.S4 226 A G.S4.07 Structure Structure
G.s4h3 227 L G.s4h3.01 Structure Structure
G.s4h3 228 S G.s4h3.02 Structure Structure
G.s4h3 229 D G.s4h3.03 Structure Structure
G.s4h3 230 Y G.s4h3.04 Structure Structure
G.s4h3 231 D G.s4h3.05 Structure Structure
G.s4h3 232 L G.s4h3.06 Structure Structure
G.s4h3 233 V G.s4h3.07 Structure Structure
G.s4h3 234 L G.s4h3.08 Structure Structure
G.s4h3 235 A G.s4h3.09 Structure Structure
G.s4h3 236 E G.s4h3.10 Structure Structure
G.s4h3 237 D G.s4h3.11 Structure Structure
G.s4h3 238 E G.s4h3.12 Structure Structure
G.s4h3 239 E G.s4h3.13 Structure Structure
G.s4h3 240 M G.s4h3.14 Structure Structure
G.s4h3 241 N G.s4h3.15 Structure Structure
G.H3 242 R G.H3.01 Structure Structure
G.H3 243 M G.H3.02 Structure Structure
G.H3 244 H G.H3.03 Structure Structure
G.H3 245 E G.H3.04 Structure Structure
G.H3 246 S G.H3.05 Structure Structure
G.H3 247 M G.H3.06 Structure Structure
G.H3 248 K G.H3.07 Structure Structure
G.H3 249 L G.H3.08 Structure Structure
G.H3 250 F G.H3.09 Structure Structure
G.H3 251 D G.H3.10 Structure Structure
G.H3 252 S G.H3.11 Structure Structure
G.H3 253 I G.H3.12 Structure Structure
G.H3 254 C G.H3.13 Structure Structure
G.H3 255 N G.H3.14 Structure Structure
G.H3 256 N G.H3.15 Structure Structure
G.H3 257 K G.H3.16 Structure Structure
G.H3 258 W G.H3.17 Structure Structure
G.H3 259 F G.H3.18 Structure Structure
G.h3s5 260 T G.h3s5.01 Structure Structure
G.h3s5 261 D G.h3s5.02 Structure AF2
G.h3s5 262 T G.h3s5.03 Structure Structure
G.S5 263 S G.S5.01 Structure Structure
G.S5 264 I G.S5.02 Structure Structure
G.S5 265 I G.S5.03 Structure Structure
G.S5 266 L G.S5.04 Structure Structure
G.S5 267 F G.S5.05 Structure Structure
G.S5 268 L G.S5.06 Structure Structure
G.S5 269 N G.S5.07 Structure Structure
G.s5hg 270 K G.s5hg.01 Structure Structure
G.HG 271 K G.HG.01 Structure Structure
G.HG 272 D G.HG.02 Structure AF2
G.HG 273 L G.HG.03 Structure Structure
G.HG 274 F G.HG.04 Structure Structure
G.HG 275 E G.HG.05 Structure Structure
G.HG 276 E G.HG.06 Structure Structure
G.HG 277 K G.HG.07 Structure Structure
G.HG 278 I G.HG.08 Structure Structure
G.HG 279 K G.HG.09 Structure AF2
G.HG 280 K G.HG.12 Structure AF2
G.HG 281 S G.HG.13 Structure Structure
G.HG 282 P G.HG.14 Structure Structure
G.HG 283 L G.HG.15 Structure Structure
G.HG 284 T G.HG.16 Structure Structure
G.HG 285 I G.HG.17 Structure Structure
G.hgh4 286 C G.hgh4.01 Structure Structure
G.hgh4 287 Y G.hgh4.02 Structure Structure
G.hgh4 288 P G.hgh4.03 Structure Structure
G.hgh4 289 E G.hgh4.04 Structure AF2
G.hgh4 290 Y G.hgh4.05 Structure Structure
G.hgh4 291 A G.hgh4.06 Structure Structure
G.hgh4 292 G G.hgh4.07 Structure Structure
G.hgh4 293 S G.hgh4.08 Structure Structure
G.H4 294 N G.H4.01 Structure Structure
G.H4 295 T G.H4.02 Structure AF2
G.H4 296 Y G.H4.03 Structure Structure
G.H4 297 E G.H4.04 Structure AF2
G.H4 298 E G.H4.05 Structure Structure
G.H4 299 A G.H4.06 Structure Structure
G.H4 300 A G.H4.07 Structure Structure
G.H4 301 A G.H4.08 Structure Structure
G.H4 302 Y G.H4.10 Structure Structure
G.H4 303 I G.H4.11 Structure Structure
G.H4 304 Q G.H4.12 Structure Structure
G.H4 305 C G.H4.13 Structure Structure
G.H4 306 Q G.H4.14 Structure Structure
G.H4 307 F G.H4.15 Structure Structure
G.H4 308 E G.H4.16 Structure Structure
G.H4 309 D G.H4.17 Structure Structure
G.h4s6 310 L G.h4s6.01 Structure Structure
G.h4s6 311 N G.h4s6.02 Structure Structure
G.h4s6 312 K G.h4s6.03 Structure Structure
G.h4s6 313 R G.h4s6.04 Structure Structure
G.h4s6 314 K G.h4s6.08 Structure Structure
G.h4s6 315 D G.h4s6.09 Structure Structure
G.h4s6 316 T G.h4s6.10 Structure Structure
G.h4s6 317 K G.h4s6.11 Structure Structure
G.h4s6 318 E G.h4s6.12 Structure Structure
G.S6 319 I G.S6.01 Structure Structure
G.S6 320 Y G.S6.02 Structure Structure
G.S6 321 T G.S6.03 Structure Structure
G.S6 322 H G.S6.04 Structure Structure
G.S6 323 F G.S6.05 Structure Structure
G.s6h5 324 T G.s6h5.01 Structure Structure
G.s6h5 325 C G.s6h5.02 Structure Structure
G.s6h5 326 A G.s6h5.03 Structure Structure
G.s6h5 327 T G.s6h5.04 Structure Structure
G.s6h5 328 D G.s6h5.05 Structure Structure
G.H5 329 T G.H5.01 Structure Structure
G.H5 330 K G.H5.02 Structure Structure
G.H5 331 N G.H5.03 Structure Structure
G.H5 332 V G.H5.04 Structure Structure
G.H5 333 Q G.H5.05 Structure Structure
G.H5 334 F G.H5.06 Structure Structure
G.H5 335 V G.H5.07 Structure Structure
G.H5 336 F G.H5.08 Structure Structure
G.H5 337 D G.H5.09 Structure Structure
G.H5 338 A G.H5.10 Structure Structure
G.H5 339 V G.H5.11 Structure Structure
G.H5 340 T G.H5.12 Structure Structure
G.H5 341 D G.H5.13 Structure Structure
G.H5 342 V G.H5.14 Structure Structure
G.H5 343 I G.H5.15 Structure Structure
G.H5 344 I G.H5.16 Structure Structure
G.H5 345 K G.H5.17 Structure Structure
G.H5 346 N G.H5.18 Structure Structure
G.H5 347 N G.H5.19 Structure Structure
G.H5 348 L G.H5.20 Structure Structure
G.H5 349 K G.H5.21 Structure Structure
G.H5 350 D G.H5.22 Structure Structure
G.H5 351 C G.H5.23 Structure Structure
G.H5 352 G G.H5.24 Structure Structure
G.H5 353 L G.H5.25 Structure Structure
G.H5 354 F G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 307 from structure (89.8%), 35 from model (10.2%)
Residue sidechains - 306 from structure (89.5%), 36 from model (10.5%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 E - AF2 AF2
N-term 3 D - AF2 AF2
N-term 4 F - AF2 AF2
N-term 5 N - AF2 AF2
N-term 6 M - AF2 AF2
N-term 7 E - AF2 AF2
N-term 8 S - AF2 AF2
N-term 9 D - AF2 AF2
N-term 10 S - AF2 AF2
N-term 11 F - AF2 AF2
N-term 12 E - AF2 AF2
N-term 13 D - AF2 AF2
N-term 14 F - AF2 AF2
N-term 15 W - AF2 AF2
N-term 16 K - AF2 AF2
N-term 17 G - AF2 AF2
N-term 18 E - AF2 AF2
N-term 19 D - AF2 AF2
N-term 20 L - AF2 AF2
N-term 21 S - AF2 AF2
N-term 22 N - AF2 AF2
N-term 23 Y - AF2 AF2
N-term 24 S - AF2 AF2
N-term 25 Y - AF2 AF2
N-term 26 S - Structure Structure
N-term 27 S - Structure Structure
N-term 28 T - Structure Structure
N-term 29 L - Structure Structure
N-term 30 P - Structure Structure
N-term 31 P - Structure Structure
N-term 32 F - Structure Structure
N-term 33 L - Structure Structure
N-term 34 L - Structure Structure
N-term 35 D - Structure Structure
N-term 36 A - Structure Structure
N-term 37 A - Structure Structure
N-term 38 P - Structure Structure
N-term 39 C - Structure Structure
N-term 40 E - Structure Structure
N-term 41 P - Structure Structure
N-term 42 E - Structure Structure
N-term 43 S - Structure Structure
N-term 44 L - Structure Structure
TM1 45 E 1.29x29 Structure Structure
TM1 46 I 1.30x30 Structure Structure
TM1 47 N 1.31x31 Structure Structure
TM1 48 K 1.32x32 Structure Structure
TM1 49 Y 1.33x33 Structure Structure
TM1 50 F 1.34x34 Structure Structure
TM1 51 V 1.35x35 Structure Structure
TM1 52 V 1.36x36 Structure Structure
TM1 53 I 1.37x37 Structure Structure
TM1 54 I 1.38x38 Structure Structure
TM1 55 Y 1.39x39 Structure Structure
TM1 56 A 1.40x40 Structure Structure
TM1 57 L 1.41x41 Structure Structure
TM1 58 V 1.42x42 Structure Structure
TM1 59 F 1.43x43 Structure Structure
TM1 60 L 1.44x44 Structure Structure
TM1 61 L 1.45x45 Structure Structure
TM1 62 S 1.46x46 Structure Structure
TM1 63 L 1.47x47 Structure Structure
TM1 64 L 1.48x48 Structure Structure
TM1 65 G 1.49x49 Structure Structure
TM1 66 N 1.50x50 Structure Structure
TM1 67 S 1.51x51 Structure Structure
TM1 68 L 1.52x52 Structure Structure
TM1 69 V 1.53x53 Structure Structure
TM1 70 M 1.54x54 Structure Structure
TM1 71 L 1.55x55 Structure Structure
TM1 72 V 1.56x56 Structure Structure
TM1 73 I 1.57x57 Structure Structure
TM1 74 L 1.58x58 Structure Structure
TM1 75 Y 1.59x59 Structure Structure
TM1 76 S 1.60x60 Structure Structure
ICL1 77 R 12.48x48 Structure Structure
ICL1 78 V 12.49x49 Structure Structure
ICL1 79 G 12.50x50 Structure Structure
ICL1 80 R 12.51x51 Structure Structure
TM2 81 S 2.37x37 Structure Structure
TM2 82 V 2.38x38 Structure Structure
TM2 83 T 2.39x39 Structure Structure
TM2 84 D 2.40x40 Structure Structure
TM2 85 V 2.41x41 Structure Structure
TM2 86 Y 2.42x42 Structure Structure
TM2 87 L 2.43x43 Structure Structure
TM2 88 L 2.44x44 Structure Structure
TM2 89 N 2.45x45 Structure Structure
TM2 90 L 2.46x46 Structure Structure
TM2 91 A 2.47x47 Structure Structure
TM2 92 L 2.48x48 Structure Structure
TM2 93 A 2.49x49 Structure Structure
TM2 94 D 2.50x50 Structure Structure
TM2 95 L 2.51x51 Structure Structure
TM2 96 L 2.52x52 Structure Structure
TM2 97 F 2.53x53 Structure Structure
TM2 98 A 2.54x54 Structure Structure
TM2 99 L 2.55x55 Structure Structure
TM2 100 T 2.56x56 Structure Structure
TM2 101 L 2.57x57 Structure Structure
TM2 102 P 2.58x58 Structure Structure
TM2 103 I 2.59x59 Structure Structure
TM2 104 W 2.60x60 Structure Structure
TM2 105 A 2.61x61 Structure Structure
TM2 106 A 2.62x62 Structure Structure
TM2 107 S 2.63x63 Structure Structure
TM2 108 K 2.64x64 Structure Structure
TM2 109 V 2.65x65 Structure Structure
TM2 110 N 2.66x66 Structure Structure
ECL1 111 G 23.49x49 Structure Structure
ECL1 112 W 23.50x50 Structure Structure
ECL1 113 I 23.51x51 Structure Structure
ECL1 114 F 23.52x52 Structure Structure
TM3 115 G 3.21x21 Structure Structure
TM3 116 T 3.22x22 Structure Structure
TM3 117 F 3.23x23 Structure Structure
TM3 118 L 3.24x24 Structure Structure
TM3 119 C 3.25x25 Structure Structure
TM3 120 K 3.26x26 Structure AF2
TM3 121 V 3.27x27 Structure Structure
TM3 122 V 3.28x28 Structure Structure
TM3 123 S 3.29x29 Structure Structure
TM3 124 L 3.30x30 Structure Structure
TM3 125 L 3.31x31 Structure Structure
TM3 126 K 3.32x32 Structure Structure
TM3 127 E 3.33x33 Structure Structure
TM3 128 V 3.34x34 Structure Structure
TM3 129 N 3.35x35 Structure Structure
TM3 130 F 3.36x36 Structure Structure
TM3 131 Y 3.37x37 Structure Structure
TM3 132 S 3.38x38 Structure Structure
TM3 133 G 3.39x39 Structure Structure
TM3 134 I 3.40x40 Structure Structure
TM3 135 L 3.41x41 Structure Structure
TM3 136 L 3.42x42 Structure Structure
TM3 137 L 3.43x43 Structure Structure
TM3 138 A 3.44x44 Structure Structure
TM3 139 C 3.45x45 Structure Structure
TM3 140 I 3.46x46 Structure Structure
TM3 141 S 3.47x47 Structure Structure
TM3 142 V 3.48x48 Structure Structure
TM3 143 D 3.49x49 Structure Structure
TM3 144 R 3.50x50 Structure Structure
TM3 145 Y 3.51x51 Structure Structure
TM3 146 L 3.52x52 Structure Structure
TM3 147 A 3.53x53 Structure Structure
TM3 148 I 3.54x54 Structure Structure
TM3 149 V 3.55x55 Structure Structure
TM3 150 H 3.56x56 Structure Structure
ICL2 151 A 34.50x50 Structure Structure
ICL2 152 T 34.51x51 Structure Structure
ICL2 153 R 34.52x52 Structure Structure
ICL2 154 T 34.53x53 Structure Structure
ICL2 155 L 34.54x54 Structure Structure
ICL2 156 T 34.55x55 Structure Structure
ICL2 157 Q 34.56x56 Structure Structure
ICL2 158 K 34.57x57 Structure Structure
ICL2 159 R 34.58x58 Structure Structure
ICL2 160 Y 34.59x59 Structure Structure
TM4 161 L 4.41x41 Structure Structure
TM4 162 V 4.42x42 Structure Structure
TM4 163 K 4.43x43 Structure Structure
TM4 164 F 4.44x44 Structure Structure
TM4 165 I 4.45x45 Structure Structure
TM4 166 C 4.46x46 Structure Structure
TM4 167 L 4.47x47 Structure Structure
TM4 168 S 4.48x48 Structure Structure
TM4 169 I 4.49x49 Structure Structure
TM4 170 W 4.50x50 Structure Structure
TM4 171 G 4.51x51 Structure Structure
TM4 172 L 4.52x52 Structure Structure
TM4 173 S 4.53x53 Structure Structure
TM4 174 L 4.54x54 Structure Structure
TM4 175 L 4.55x55 Structure Structure
TM4 176 L 4.56x56 Structure Structure
TM4 177 A 4.57x57 Structure Structure
TM4 178 L 4.58x59 Structure Structure
TM4 179 P 4.59x60 Structure Structure
TM4 180 V 4.60x61 Structure Structure
TM4 181 L 4.61x62 Structure Structure
TM4 182 L 4.62x63 Structure Structure
TM4 183 F 4.63x64 Structure Structure
TM4 184 R 4.64x65 Structure Structure
ECL2 185 R - Structure Structure
ECL2 186 T - Structure Structure
ECL2 187 V - Structure Structure
ECL2 188 Y - Structure Structure
ECL2 189 S - Structure Structure
ECL2 190 S - Structure Structure
ECL2 191 N - Structure Structure
ECL2 192 V - Structure Structure
ECL2 193 S - Structure Structure
ECL2 194 P - Structure Structure
ECL2 195 A - Structure Structure
ECL2 196 C 45.50x50 Structure Structure
ECL2 197 Y 45.51x51 Structure Structure
ECL2 198 E 45.52x52 Structure Structure
ECL2 199 D - Structure Structure
ECL2 200 M - Structure Structure
ECL2 201 G - Structure Structure
ECL2 202 N - Structure Structure
TM5 203 N 5.30x31 Structure Structure
TM5 204 T 5.31x32 Structure Structure
TM5 205 A 5.32x33 Structure Structure
TM5 206 N 5.33x34 Structure Structure
TM5 207 W 5.34x35 Structure Structure
TM5 208 R 5.35x36 Structure Structure
TM5 209 M 5.36x37 Structure Structure
TM5 210 L 5.37x38 Structure Structure
TM5 211 L 5.38x39 Structure Structure
TM5 212 R 5.39x40 Structure Structure
TM5 213 I 5.40x41 Structure Structure
TM5 214 L 5.41x42 Structure Structure
TM5 215 P 5.42x43 Structure Structure
TM5 216 Q 5.43x44 Structure Structure
TM5 217 S 5.44x45 Structure Structure
TM5 218 F 5.45x46 Structure Structure
TM5 219 G 5.46x461 Structure Structure
TM5 220 F 5.47x47 Structure Structure
TM5 221 I 5.48x48 Structure Structure
TM5 222 V 5.49x49 Structure Structure
TM5 223 P 5.50x50 Structure Structure
TM5 224 L 5.51x51 Structure Structure
TM5 225 L 5.52x52 Structure Structure
TM5 226 I 5.53x53 Structure Structure
TM5 227 M 5.54x54 Structure Structure
TM5 228 L 5.55x55 Structure Structure
TM5 229 F 5.56x56 Structure Structure
TM5 230 C 5.57x57 Structure Structure
TM5 231 Y 5.58x58 Structure Structure
TM5 232 G 5.59x59 Structure Structure
TM5 233 F 5.60x60 Structure Structure
TM5 234 T 5.61x61 Structure Structure
TM5 235 L 5.62x62 Structure Structure
TM5 236 R 5.63x63 Structure Structure
TM5 237 T 5.64x64 Structure Structure
TM5 238 L 5.65x65 Structure Structure
TM5 239 F 5.66x66 Structure Structure
TM5 240 K 5.67x67 Structure Structure
TM5 241 A 5.68x68 Structure Structure
ICL3 242 H - Structure Structure
ICL3 243 M - Structure Structure
ICL3 244 G - Structure Structure
TM6 245 Q 6.29x29 Structure Structure
TM6 246 K 6.30x30 Structure Structure
TM6 247 H 6.31x31 Structure Structure
TM6 248 R 6.32x32 Structure Structure
TM6 249 A 6.33x33 Structure Structure
TM6 250 M 6.34x34 Structure Structure
TM6 251 R 6.35x35 Structure Structure
TM6 252 V 6.36x36 Structure Structure
TM6 253 I 6.37x37 Structure Structure
TM6 254 F 6.38x38 Structure Structure
TM6 255 A 6.39x39 Structure Structure
TM6 256 V 6.40x40 Structure Structure
TM6 257 V 6.41x41 Structure Structure
TM6 258 L 6.42x42 Structure Structure
TM6 259 I 6.43x43 Structure Structure
TM6 260 F 6.44x44 Structure Structure
TM6 261 L 6.45x45 Structure Structure
TM6 262 L 6.46x46 Structure Structure
TM6 263 C 6.47x47 Structure Structure
TM6 264 W 6.48x48 Structure Structure
TM6 265 L 6.49x49 Structure Structure
TM6 266 P 6.50x50 Structure Structure
TM6 267 Y 6.51x51 Structure Structure
TM6 268 N 6.52x52 Structure Structure
TM6 269 L 6.53x53 Structure Structure
TM6 270 V 6.54x54 Structure Structure
TM6 271 L 6.55x55 Structure Structure
TM6 272 L 6.56x56 Structure Structure
TM6 273 A 6.57x57 Structure Structure
TM6 274 D 6.58x58 Structure Structure
TM6 275 T 6.59x59 Structure Structure
TM6 276 L 6.60x60 Structure Structure
TM6 277 M 6.61x61 Structure Structure
TM6 278 R 6.62x62 Structure Structure
TM6 279 T 6.63x63 Structure Structure
TM6 280 Q 6.64x64 Structure Structure
ECL3 281 V - Structure Structure
ECL3 282 I - Structure Structure
ECL3 283 Q - Structure Structure
ECL3 284 E - Structure Structure
TM7 285 T 7.24x23 Structure Structure
TM7 286 C 7.25x24 Structure Structure
TM7 287 E 7.26x25 Structure Structure
TM7 288 R 7.27x26 Structure Structure
TM7 289 R 7.28x27 Structure Structure
TM7 290 N 7.29x28 Structure Structure
TM7 291 H 7.30x29 Structure Structure
TM7 292 I 7.31x30 Structure Structure
TM7 293 D 7.32x31 Structure Structure
TM7 294 R 7.33x32 Structure Structure
TM7 295 A 7.34x33 Structure Structure
TM7 296 L 7.35x34 Structure Structure
TM7 297 D 7.36x35 Structure Structure
TM7 298 A 7.37x36 Structure Structure
TM7 299 T 7.38x37 Structure Structure
TM7 300 E 7.39x38 Structure Structure
TM7 301 I 7.40x39 Structure Structure
TM7 302 L 7.41x40 Structure Structure
TM7 303 G 7.42x41 Structure Structure
TM7 304 I 7.43x42 Structure Structure
TM7 305 L 7.44x43 Structure Structure
TM7 306 H 7.45x45 Structure Structure
TM7 307 S 7.46x46 Structure Structure
TM7 308 C 7.47x47 Structure Structure
TM7 309 L 7.48x48 Structure Structure
TM7 310 N 7.49x49 Structure Structure
TM7 311 P 7.50x50 Structure Structure
TM7 312 L 7.51x51 Structure Structure
TM7 313 I 7.52x52 Structure Structure
TM7 314 Y 7.53x53 Structure Structure
TM7 315 A 7.54x54 Structure Structure
TM7 316 F 7.55x55 Structure Structure
TM7 317 I 7.56x56 Structure Structure
H8 318 G 8.47x47 Structure Structure
H8 319 Q 8.48x48 Structure Structure
H8 320 K 8.49x49 Structure Structure
H8 321 F 8.50x50 Structure Structure
H8 322 R 8.51x51 Structure Structure
H8 323 H 8.52x52 Structure Structure
H8 324 G 8.53x53 Structure Structure
H8 325 L 8.54x54 Structure Structure
H8 326 L 8.55x55 Structure Structure
H8 327 K 8.56x56 Structure Structure
H8 328 I 8.57x57 Structure Structure
H8 329 L 8.58x58 Structure Structure
H8 330 A 8.59x59 Structure Structure
H8 331 I 8.60x60 Structure Structure
H8 332 H 8.61x61 Structure Structure
C-term 333 G - AF2 AF2
C-term 334 L - AF2 AF2
C-term 335 I - AF2 AF2
C-term 336 S - AF2 AF2
C-term 337 K - AF2 AF2
C-term 338 D - AF2 AF2
C-term 339 S - AF2 AF2
C-term 340 L - AF2 AF2
C-term 341 P - AF2 AF2
C-term 342 K - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 R 144 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 144 3x50 G.H5 L 353 G.H5.25
Polar ICL2 L 155 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic ICL3 M 243 - G.H5 L 348 G.H5.20
Hydrophobic TM3 A 147 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 A 147 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM5 T 237 5x64 G.H5 I 344 G.H5.16
Polar H8 G 318 8x47 G.H5 G 352 G.H5.24
Hydrophobic H8 G 318 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 G 318 8x47 G.H5 G 352 G.H5.24
Polar TM3 A 147 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 147 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 147 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM5 L 238 5x65 G.H5 L 348 G.H5.20
Hydrophobic H8 Q 319 8x48 G.H5 K 349 G.H5.21
Van-der-waals H8 Q 319 8x48 G.H5 K 349 G.H5.21
Polar TM2 S 81 2x37 G.H5 D 350 G.H5.22
Hydrophobic TM2 S 81 2x37 G.H5 D 350 G.H5.22
Van-der-waals TM2 S 81 2x37 G.H5 D 350 G.H5.22
Polar TM6 R 248 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 248 6x32 G.H5 F 354 G.H5.26
Polar ICL3 M 243 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 M 243 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 M 243 - G.H5 D 341 G.H5.13
Ionic ICL3 H 242 - G.H5 D 341 G.H5.13
Polar ICL3 H 242 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 H 242 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 H 242 - G.H5 D 341 G.H5.13
Polar H8 Q 319 8x48 G.H5 F 354 G.H5.26
Hydrophobic TM7 I 317 7x56 G.H5 G 352 G.H5.24
Van-der-waals TM7 I 317 7x56 G.H5 G 352 G.H5.24
Polar ICL2 T 156 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 T 156 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 T 156 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 A 151 34x50 G.H5 I 343 G.H5.15
Hydrophobic ICL2 T 152 34x51 G.H5 F 336 G.H5.08
Hydrophobic H8 K 320 8x49 G.H5 D 350 G.H5.22
Polar TM6 R 248 6x32 G.H5 L 353 G.H5.25
Van-der-waals TM6 R 248 6x32 G.H5 L 353 G.H5.25
Hydrophobic TM6 I 253 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM3 I 148 3x54 G.H5 L 353 G.H5.25
Hydrophobic TM3 I 148 3x54 G.H5 I 344 G.H5.16
Hydrophobic ICL2 R 159 34x58 G.HN E 28 G.HN.52
Van-der-waals ICL2 R 159 34x58 G.HN E 28 G.HN.52
Polar TM3 R 144 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 144 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM2 T 83 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM6 Q 245 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 Q 245 6x29 G.H5 F 354 G.H5.26
Van-der-waals ICL2 R 159 34x58 G.hns1 R 32 G.hns1.03
Hydrophobic TM5 L 238 5x65 G.H5 I 344 G.H5.16
Hydrophobic ICL3 M 243 - G.H5 I 344 G.H5.16
Van-der-waals ICL3 M 243 - G.H5 I 344 G.H5.16
Hydrophobic ICL2 T 152 34x51 G.S3 L 194 G.S3.01
Hydrophobic ICL3 M 243 - G.H5 K 345 G.H5.17
Van-der-waals ICL3 M 243 - G.H5 K 345 G.H5.17
Hydrophobic ICL2 A 151 34x50 G.H5 I 344 G.H5.16
Hydrophobic TM6 V 252 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM6 A 249 6x33 G.H5 L 348 G.H5.20
Hydrophobic TM3 I 148 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 148 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM6 A 249 6x33 G.H5 L 353 G.H5.25