PTH1 receptor - Gs

GPCR CLASS (FAMILY)

Class B1 (Secretin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Bos taurus

PDB CODE

RESOLUTION

2.6 Å

REFERENCE

PUBLICATION DATE

Dec. 21, 2022

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

PHYSIOLOGICAL LIGANDS

TIP39, PTHrP-(1-36), PTH, PTHrP



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic TM3 L 306 3x54 G.H5 Y 391 G.H5.23
Hydrophobic TM3 L 309 3x57 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 F 315 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 F 315 - G.H5 R 380 G.H5.12
Hydrophobic ICL2 F 315 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 F 315 - G.H5 I 383 G.H5.15
Van-der-waals TM5 E 391 5x67 G.H5 D 381 G.H5.13
Hydrophobic TM6 K 405 6x37 G.H5 L 394 G.H5.26
Van-der-waals TM6 K 405 6x37 G.H5 L 394 G.H5.26
Hydrophobic TM5 L 385 5x61 G.H5 L 393 G.H5.25
Hydrophobic TM3 L 309 3x57 G.H5 H 387 G.H5.19
Hydrophobic TM5 K 388 5x64 G.H5 L 388 G.H5.20
Van-der-waals TM5 K 388 5x64 G.H5 L 388 G.H5.20
Aromatic ICL2 F 315 - G.H5 F 376 G.H5.08
Hydrophobic ICL2 F 315 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 F 315 - G.H5 F 376 G.H5.08
Hydrophobic ICL2 F 315 - G.S3 F 219 G.S3.03
Polar TM5 K 388 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM5 K 388 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 K 388 5x64 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 F 314 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 F 314 - G.H5 R 380 G.H5.12
Polar TM6 S 409 6x41 G.H5 L 393 G.H5.25
Van-der-waals TM6 S 409 6x41 G.H5 L 393 G.H5.25
Hydrophobic ICL2 F 314 - G.H5 H 387 G.H5.19
Hydrophobic TM5 T 392 5x68 G.H5 R 385 G.H5.17
Van-der-waals TM5 T 392 5x68 G.H5 R 385 G.H5.17
Aromatic TM2 R 219 2x46 G.H5 Y 391 G.H5.23
Hydrophobic TM2 R 219 2x46 G.H5 Y 391 G.H5.23
Hydrophobic TM5 L 385 5x61 G.H5 L 388 G.H5.20
Van-der-waals TM5 L 385 5x61 G.H5 L 388 G.H5.20
Hydrophobic ICL2 F 315 - G.S3 V 217 G.S3.01
Polar H8 G 464 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 G 464 8x48 G.H5 E 392 G.H5.24
Hydrophobic TM6 L 413 6x45 G.H5 L 393 G.H5.25
Hydrophobic H8 N 463 8x47 G.H5 E 392 G.H5.24
Van-der-waals H8 N 463 8x47 G.H5 E 392 G.H5.24
Aromatic ICL2 F 315 - G.S1 H 34 G.S1.02
Hydrophobic ICL2 F 315 - G.S1 H 34 G.S1.02
Van-der-waals ICL2 F 315 - G.S1 H 34 G.S1.02
Ionic TM5 K 388 5x64 G.H5 D 381 G.H5.13
Polar TM5 K 388 5x64 G.H5 D 381 G.H5.13
Polar TM3 I 310 3x58 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 310 3x58 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 310 3x58 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 F 315 - G.H5 C 379 G.H5.11
Van-der-waals ICL2 F 315 - G.H5 C 379 G.H5.11
Polar TM2 R 219 2x46 G.H5 Q 390 G.H5.22
Hydrophobic TM3 I 310 3x58 G.H5 L 388 G.H5.20
Van-der-waals TM3 I 310 3x58 G.H5 L 388 G.H5.20
Hydrophobic TM6 K 405 6x37 G.H5 L 393 G.H5.25
Hydrophobic ICL2 F 314 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 F 314 - G.H5 I 383 G.H5.15
Polar TM5 K 388 5x64 G.H5 R 385 G.H5.17
Hydrophobic TM5 K 388 5x64 G.H5 R 385 G.H5.17
Hydrophobic TM5 L 389 5x65 G.H5 L 394 G.H5.26
Van-der-waals TM3 Y 305 3x53 G.H5 Y 391 G.H5.23
Ionic TM5 E 391 5x67 G.H5 R 385 G.H5.17
Polar TM5 E 391 5x67 G.H5 R 385 G.H5.17
Van-der-waals TM5 E 391 5x67 G.H5 R 385 G.H5.17
Hydrophobic ICL2 F 314 - G.H5 C 379 G.H5.11
Van-der-waals TM7 C 462 7x60 G.H5 E 392 G.H5.24
Hydrophobic ICL2 F 314 - G.H5 Q 384 G.H5.16
Hydrophobic TM2 H 223 2x50 G.H5 Y 391 G.H5.23