FPR2/ALX - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7T6S

RESOLUTION

3.0 Å

REFERENCE

10.1038/S41467-022-28586-0

PUBLICATION DATE

March 30, 2022

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

31 interactions (Click to see)

LIGANDS

N-(4-chlorophenyl)-N'-[1-methyl-3-oxo-2-phenyl-5-(propan-2-yl)-2,3-dihydro-1H-pyrazol-4-yl]urea - Agonist pubchem

PHYSIOLOGICAL LIGANDS

humanin, annexin I, LL-37, aspirin triggered lipoxin A4, serum amyloid A, aspirin-triggered resolvin D1, PrP106-126, LXA4, resolvin D1



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 P 130 34x50 G.H5 T 340 G.H5.12
Van-der-waals ICL2 P 130 34x50 G.H5 T 340 G.H5.12
Polar ICL3 K 235 - G.h4s6 K 314 G.h4s6.08
Polar TM6 P 239 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 P 239 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 P 239 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM4 T 138 4x38 G.HN E 28 G.HN.52
Van-der-waals TM5 K 231 5x68 G.H5 I 344 G.H5.16
Hydrophobic TM7 V 305 7x56 G.H5 G 352 G.H5.24
Van-der-waals TM7 V 305 7x56 G.H5 G 352 G.H5.24
Polar ICL2 N 135 34x55 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 N 135 34x55 G.s2s3 D 193 G.s2s3.02
Ionic TM5 K 231 5x68 G.H5 D 341 G.H5.13
Polar TM5 K 231 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM5 K 231 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 K 231 5x68 G.H5 D 341 G.H5.13
Hydrophobic ICL3 M 233 - G.H5 K 345 G.H5.17
Hydrophobic ICL2 P 130 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 130 34x50 G.H5 I 344 G.H5.16
Hydrophobic TM5 I 228 5x65 G.H5 L 348 G.H5.20
Hydrophobic ICL2 Q 134 34x54 G.H5 I 343 G.H5.15
Polar TM6 R 238 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM6 R 238 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 238 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM6 V 242 6x36 G.H5 G 352 G.H5.24
Hydrophobic TM3 V 127 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 127 3x54 G.H5 L 348 G.H5.20
Hydrophobic ICL2 V 131 34x51 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 V 131 34x51 G.S3 L 194 G.S3.01
Hydrophobic ICL2 V 131 34x51 G.H5 F 336 G.H5.08
Van-der-waals ICL2 V 131 34x51 G.H5 F 336 G.H5.08
Hydrophobic TM3 R 123 3x50 G.H5 L 353 G.H5.25
Polar ICL2 N 135 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 N 135 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 N 135 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic TM2 T 60 2x39 G.H5 D 350 G.H5.22
Hydrophobic ICL3 M 233 - G.H5 L 348 G.H5.20
Hydrophobic TM6 L 243 6x37 G.H5 L 353 G.H5.25
Polar TM3 C 126 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 C 126 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 C 126 3x53 G.H5 N 347 G.H5.19
Hydrophobic ICL2 Q 134 34x54 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 Q 134 34x54 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 Q 134 34x54 G.S1 V 34 G.S1.02
Hydrophobic ICL3 M 233 - G.H5 I 344 G.H5.16
Van-der-waals ICL3 M 233 - G.H5 I 344 G.H5.16
Hydrophobic TM3 V 127 3x54 G.H5 I 344 G.H5.16
Van-der-waals TM3 V 127 3x54 G.H5 I 344 G.H5.16
Hydrophobic ICL2 P 130 34x50 G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 130 34x50 G.H5 I 343 G.H5.15
Polar TM4 S 140 4x40 G.HN E 28 G.HN.52
Van-der-waals TM4 S 140 4x40 G.HN E 28 G.HN.52
Polar TM3 R 123 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 123 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 123 3x50 G.H5 C 351 G.H5.23
Van-der-waals ICL2 V 131 34x51 G.s2s3 K 192 G.s2s3.01
Polar ICL3 K 235 - G.h4s6 D 315 G.h4s6.09
Hydrophobic ICL3 K 235 - G.h4s6 D 315 G.h4s6.09
Van-der-waals ICL3 K 235 - G.h4s6 D 315 G.h4s6.09
Hydrophobic H8 G 306 8x47 G.H5 G 352 G.H5.24
Hydrophobic TM5 I 224 5x61 G.H5 L 353 G.H5.25
Van-der-waals TM5 I 224 5x61 G.H5 L 353 G.H5.25
Hydrophobic ICL2 Q 134 34x54 G.S3 L 194 G.S3.01
Polar TM6 R 238 6x32 G.H5 G 352 G.H5.24