SST2 receptor - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

E

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.5 Å

REFERENCE

PUBLICATION DATE

Oct. 19, 2022

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

SOMATOSTATIN - Agonist chembl_ligand pubchem

PHYSIOLOGICAL LIGANDS

CST-17, SRIF-28, cortistatin-14, SRIF-14



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Polar ICL2 R 154 - G.H5 Y 243 G.H5.23
Hydrophobic TM3 V 144 3x54 G.H5 Y 243 G.H5.23
Hydrophobic ICL2 I 148 - G.H5 I 235 G.H5.15
Van-der-waals ICL2 I 148 - G.H5 I 235 G.H5.15
Hydrophobic ICL2 P 147 - G.H5 I 235 G.H5.15
Hydrophobic TM3 V 144 3x54 G.H5 L 240 G.H5.20
Van-der-waals TM2 T 76 2x37 G.H5 E 242 G.H5.22
Hydrophobic TM3 A 143 3x53 G.H5 Y 243 G.H5.23
Van-der-waals TM3 A 143 3x53 G.H5 Y 243 G.H5.23
Hydrophobic TM5 I 231 5x61 G.H5 L 245 G.H5.25
Hydrophobic ICL2 I 148 - G.H5 F 228 G.H5.08
Van-der-waals ICL2 I 148 - G.H5 F 228 G.H5.08
Polar TM5 S 238 5x68 G.H5 D 233 G.H5.13
Hydrophobic TM5 V 235 5x65 G.H5 L 240 G.H5.20