SST2 receptor - Go

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

E

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.3 Å

REFERENCE

PUBLICATION DATE

Oct. 19, 2022

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

Octreotide - Agonist pubchem

PHYSIOLOGICAL LIGANDS

CST-17, SRIF-28, cortistatin-14, SRIF-14



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic ICL3 I 240 - G.H5 A 338 G.H5.10
Hydrophobic TM5 K 234 5x64 G.H5 I 344 G.H5.16
Hydrophobic TM3 V 144 3x54 G.H5 I 344 G.H5.16
Polar H8 N 318 8x49 G.H5 R 349 G.H5.21
Polar TM2 T 78 2x39 G.H5 G 350 G.H5.22
Van-der-waals TM2 T 78 2x39 G.H5 G 350 G.H5.22
Hydrophobic TM3 A 143 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 143 3x53 G.H5 N 347 G.H5.19
Hydrophobic ICL3 I 240 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 I 240 - G.H5 D 341 G.H5.13
Hydrophobic ICL2 P 147 34x50 G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 147 34x50 G.H5 I 343 G.H5.15
Polar TM6 K 253 6x32 G.H5 Y 354 G.H5.26
Hydrophobic TM6 K 253 6x32 G.H5 Y 354 G.H5.26
Van-der-waals TM6 K 253 6x32 G.H5 Y 354 G.H5.26
Hydrophobic TM3 A 143 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM6 K 253 6x32 G.H5 L 353 G.H5.25
Hydrophobic ICL3 I 240 - G.H5 D 337 G.H5.09
Hydrophobic TM6 V 254 6x33 G.H5 Y 354 G.H5.26
Hydrophobic H8 S 316 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 S 316 8x47 G.H5 G 352 G.H5.24
Hydrophobic TM6 V 254 6x33 G.H5 L 353 G.H5.25
Van-der-waals ICL4 L 315 - G.H5 G 352 G.H5.24
Polar TM6 S 250 6x29 G.H5 Y 354 G.H5.26
Hydrophobic TM6 S 250 6x29 G.H5 Y 354 G.H5.26
Van-der-waals TM6 S 250 6x29 G.H5 Y 354 G.H5.26
Hydrophobic ICL3 V 242 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 V 242 - G.h4s6 E 318 G.h4s6.12
Polar TM3 R 140 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 140 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 140 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 V 144 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM3 R 140 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 140 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM6 V 254 6x33 G.H5 L 348 G.H5.20
Hydrophobic TM6 M 257 6x36 G.H5 L 353 G.H5.25
Hydrophobic H8 D 317 8x48 G.H5 Y 354 G.H5.26
Van-der-waals H8 D 317 8x48 G.H5 Y 354 G.H5.26