Structure information

SST2 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7Y24

SPECIES

Homo sapiens

RESOLUTION

3.250

PREFERRED CHAIN

E

REFERENCE

10.1038/S41589-022-01130-3

PUBLICATION DATE

Oct. 19, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Octreotide D122 3.32x32 TM3 polar (charge-assisted hydrogen bond)
Octreotide Q126 3.36x36 TM3 polar (hydrogen bond)
Octreotide N186 ECL2 Van der Waals
Octreotide Q187 ECL2 polar (hydrogen bond with backbone)
Octreotide Q187 ECL2 Van der Waals
Octreotide I195 45.52x52 ECL2 hydrophobic
Octreotide I195 45.52x52 ECL2 Van der Waals
Octreotide Y205 5.35x36 TM5 hydrophobic
Octreotide Y205 5.35x36 TM5 Van der Waals
Octreotide I209 5.39x40 TM5 hydrophobic
Octreotide I209 5.39x40 TM5 Van der Waals
Octreotide F272 6.51x51 TM6 hydrophobic
Octreotide N276 6.55x55 TM6 polar (hydrogen bond)
Octreotide S279 6.58x58 TM6 Van der Waals
Octreotide S279 6.58x58 TM6 polar (hydrogen bond)
Octreotide F294 7.35x34 TM7 hydrophobic
Octreotide F294 7.35x34 TM7 Van der Waals
Octreotide V298 7.39x38 TM7 Van der Waals

Ligands

Octreotide

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Residue Diagrams

T N G C L G I I C V V F Y I F T L V A N 1 L N L A I A D E L F M L G L P F L A M Q 2 V T L C F I S T F Q N I G D V T M V V R 3 A K M I T M A V W G V S L L V I L P I 4 Y C L C I I T L P V L F G L I F T Y I I F 5 S I V V A V F I F C W L P F Y I F N V S 6 I P N A C S N A Y T L V V V F D F M G 7
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ICL1 A K M K ICL1ECL1 V H W P F ECL1ICL2 P I K S A K W R ICL2ECL2 G L R S N Q W G R S S C T I N W P G E ECL2ICL3 G I R V G ICL3ECL3 A I S P ECL3N-term M D M A D E P L N G S H T W L S I P F D L N G S V V S T N T S N Q T E P Y Y D N-termC-term L V K V S G T D D G E R S D S K Q D K S R L N E T T E T Q R T L L N G D L Q T S I C-term L T S N A V L T F I Y F V V C I I G L C G N T L V I Y V I L R Y T I T N I Y I L N L A I A D E L F M L G L P F L A M Q V A L G K A I C R V V M T V D G I N Q F T S I F C L T V M S I D R Y L A V V H R P R T A K M I T M A V W G V S L L V I L P I M I Y A S G A W Y T G F I I Y T F I L G F L V P L T I I C L C Y L F I I I K V K S S S S K R K K S E K K V T R M V S I V V A V F I F C W L P F Y I F N V S S V S M T P A L K G M F D F V V V L T Y A N S C A N P I L Y A F L S D N F Q N F K K S V L C
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Residue Table


GPCRdb(A)
GPCRdb(A)
SST2 receptor
TM3
3x32 3.32x32 D122
3x36 3.36x36 Q126
ECL2
45x52 45.52x52 I195
TM5
5x36 5.35x36 Y205
5x40 5.39x40 I209
TM6
6x51 6.51x51 F272
6x55 6.55x55 N276
6x58 6.58x58 S279
TM7
7x34 7.35x34 F294
7x38 7.39x38 V298