FPR2/ALX - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.2 Å

REFERENCE

PUBLICATION DATE

Feb. 26, 2020

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

CHEMBL552527 - Agonist chembl_ligand pubchem

ENDOGENOUS LIGANDS

aspirin-triggered resolvin D1, LL-37, resolvin D1, 15-deoxy-LXA4, LXA4, LTD4, LTC4, aspirin triggered lipoxin A4, fMet-Leu-Phe, serum amyloid A, PrP106-126, annexin I, humanin



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Polar ICL2 Q 134 34x54 G.hns1 R 32 G.hns1.03
Polar TM6 R 238 6x32 G.H5 L 353 G.H5.25
Van-der-waals TM6 R 238 6x32 G.H5 L 353 G.H5.25
Hydrophobic ICL2 Q 134 34x54 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 Q 134 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 P 130 34x50 G.H5 T 340 G.H5.12
Van-der-waals ICL2 P 130 34x50 G.H5 T 340 G.H5.12
Ionic TM5 K 231 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM5 I 228 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 I 228 5x65 G.H5 L 348 G.H5.20
Polar ICL2 Q 134 34x54 G.hns1 A 31 G.hns1.02
Polar TM5 K 231 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM6 R 238 6x32 G.H5 F 354 G.H5.26
Hydrophobic ICL2 V 131 34x51 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 V 131 34x51 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL3 I 234 - G.H5 F 354 G.H5.26
Polar TM6 P 239 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 P 239 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 P 239 6x33 G.H5 L 353 G.H5.25
Hydrophobic ICL2 Q 134 34x54 G.S1 V 34 G.S1.02
Polar ICL2 N 135 34x55 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 N 135 34x55 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL3 M 233 - G.H5 I 344 G.H5.16
Polar TM3 C 126 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 C 126 3x53 G.H5 N 347 G.H5.19
Hydrophobic ICL2 P 130 34x50 G.H5 I 343 G.H5.15
Hydrophobic TM7 V 305 7x56 G.H5 G 352 G.H5.24
Polar TM4 S 140 4x40 G.HN E 28 G.HN.52
Hydrophobic TM4 S 140 4x40 G.HN E 28 G.HN.52
Van-der-waals TM4 S 140 4x40 G.HN E 28 G.HN.52
Hydrophobic ICL2 V 131 34x51 G.S3 L 194 G.S3.01
Hydrophobic TM3 V 127 3x54 G.H5 I 344 G.H5.16
Van-der-waals TM3 V 127 3x54 G.H5 I 344 G.H5.16
Polar ICL2 N 135 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 N 135 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 N 135 34x55 G.hns1 R 32 G.hns1.03
Polar TM4 V 139 4x39 G.HN E 28 G.HN.52
Ionic H8 D 308 8x49 G.H5 K 349 G.H5.21
Polar H8 D 308 8x49 G.H5 K 349 G.H5.21
Hydrophobic ICL2 Q 134 34x54 G.H5 I 343 G.H5.15
Van-der-waals ICL2 Q 134 34x54 G.H5 I 343 G.H5.15
Ionic ICL3 K 235 - G.h4s6 E 318 G.h4s6.12
Polar ICL3 K 235 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 K 235 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 K 235 - G.h4s6 E 318 G.h4s6.12
Hydrophobic H8 G 306 8x47 G.H5 G 352 G.H5.24
Hydrophobic ICL2 V 131 34x51 G.H5 F 336 G.H5.08
Van-der-waals ICL2 V 131 34x51 G.H5 F 336 G.H5.08
Hydrophobic ICL2 Q 134 34x54 G.S3 L 194 G.S3.01
Van-der-waals ICL2 Q 134 34x54 G.S3 L 194 G.S3.01
Polar TM2 Y 64 2x43 G.H5 C 351 G.H5.23
Van-der-waals TM2 Y 64 2x43 G.H5 C 351 G.H5.23
Hydrophobic TM6 V 242 6x36 G.H5 L 353 G.H5.25
Hydrophobic ICL3 M 233 - G.H5 K 345 G.H5.17
Van-der-waals ICL3 M 233 - G.H5 K 345 G.H5.17
Hydrophobic ICL2 P 130 34x50 G.H5 I 344 G.H5.16
Polar TM3 R 123 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 123 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 123 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 V 127 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 127 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM2 T 60 2x39 G.H5 C 351 G.H5.23
Polar TM4 T 138 4x38 G.HN E 28 G.HN.52
Hydrophobic TM4 T 138 4x38 G.HN E 28 G.HN.52
Hydrophobic ICL3 M 233 - G.H5 F 354 G.H5.26
Van-der-waals ICL3 M 233 - G.H5 F 354 G.H5.26
Polar TM2 T 60 2x39 G.H5 D 350 G.H5.22
Hydrophobic TM2 T 60 2x39 G.H5 D 350 G.H5.22
Hydrophobic TM6 L 243 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM6 P 239 6x33 G.H5 F 354 G.H5.26
Van-der-waals TM6 P 239 6x33 G.H5 F 354 G.H5.26
Hydrophobic TM5 I 224 5x61 G.H5 L 353 G.H5.25