GPCRdb

Refined structure (7DB6) of G_i1 - MT₁ receptor

Full

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G_i/o

DATE

2024-02-01

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

Structure

GPCR

Gα

Gβ

Gγ
Model

AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 219 from structure (61.9%), 135 from model (38.1%)
Residue sidechains - 219 from structure (61.9%), 135 from model (38.1%)

Showing 1 to 354 of 354 entries

Search:

Segment	Seq.num.	AA	CGN#	Backbone from	Sidechain from
	:

Segment	Seq.num.	AA	CGN#	Backbone from	Sidechain from

G.HN	1	M	G.HN.01	AF2	AF2
G.HN	2	G	G.HN.02	AF2	AF2
G.HN	3	C	G.HN.09	Structure	Structure
G.HN	4	T	G.HN.10	Structure	Structure
G.HN	5	L	G.HN.11	Structure	Structure
G.HN	6	S	G.HN.30	Structure	Structure
G.HN	7	A	G.HN.31	Structure	Structure
G.HN	8	E	G.HN.32	Structure	Structure
G.HN	9	D	G.HN.33	Structure	Structure
G.HN	10	K	G.HN.34	Structure	Structure
G.HN	11	A	G.HN.35	Structure	Structure
G.HN	12	A	G.HN.36	Structure	Structure
G.HN	13	V	G.HN.37	Structure	Structure
G.HN	14	E	G.HN.38	Structure	Structure
G.HN	15	R	G.HN.39	Structure	Structure
G.HN	16	S	G.HN.40	Structure	Structure
G.HN	17	K	G.HN.41	Structure	Structure
G.HN	18	M	G.HN.42	Structure	Structure
G.HN	19	I	G.HN.43	Structure	Structure
G.HN	20	D	G.HN.44	Structure	Structure
G.HN	21	R	G.HN.45	Structure	Structure
G.HN	22	N	G.HN.46	Structure	Structure
G.HN	23	L	G.HN.47	Structure	Structure
G.HN	24	R	G.HN.48	Structure	Structure
G.HN	25	E	G.HN.49	Structure	Structure
G.HN	26	D	G.HN.50	Structure	Structure
G.HN	27	G	G.HN.51	Structure	Structure
G.HN	28	E	G.HN.52	Structure	Structure
G.HN	29	K	G.HN.53	Structure	Structure
G.hns1	30	A	G.hns1.01	Structure	Structure
G.hns1	31	A	G.hns1.02	Structure	Structure
G.hns1	32	R	G.hns1.03	Structure	Structure
G.S1	33	E	G.S1.01	Structure	Structure
G.S1	34	V	G.S1.02	Structure	Structure
G.S1	35	K	G.S1.03	Structure	Structure
G.S1	36	L	G.S1.04	Structure	Structure
G.S1	37	L	G.S1.05	Structure	Structure
G.S1	38	L	G.S1.06	Structure	Structure
G.S1	39	L	G.S1.07	Structure	Structure
G.s1h1	40	G	G.s1h1.01	Structure	Structure
G.s1h1	41	A	G.s1h1.02	Structure	Structure
G.s1h1	42	G	G.s1h1.03	Structure	Structure
G.s1h1	43	E	G.s1h1.04	Structure	Structure
G.s1h1	44	S	G.s1h1.05	Structure	Structure
G.s1h1	45	G	G.s1h1.06	Structure	Structure
G.H1	46	K	G.H1.01	Structure	Structure
G.H1	47	S	G.H1.02	Structure	Structure
G.H1	48	T	G.H1.03	Structure	Structure
G.H1	49	I	G.H1.04	Structure	Structure
G.H1	50	V	G.H1.05	Structure	Structure
G.H1	51	K	G.H1.06	Structure	Structure
G.H1	52	Q	G.H1.07	Structure	Structure
G.H1	53	M	G.H1.08	Structure	Structure
G.H1	54	K	G.H1.09	Structure	Structure
G.H1	55	I	G.H1.10	Structure	Structure
G.H1	56	I	G.H1.11	AF2	AF2
G.H1	57	H	G.H1.12	AF2	AF2
G.h1ha	58	E	G.h1ha.01	AF2	AF2
G.h1ha	59	A	G.h1ha.02	AF2	AF2
G.h1ha	60	G	G.h1ha.03	AF2	AF2
G.h1ha	61	Y	G.h1ha.04	AF2	AF2
G.h1ha	62	S	G.h1ha.05	AF2	AF2
H.HA	63	E	H.HA.01	AF2	AF2
H.HA	64	E	H.HA.02	AF2	AF2
H.HA	65	E	H.HA.03	AF2	AF2
H.HA	66	C	H.HA.04	AF2	AF2
H.HA	67	K	H.HA.05	AF2	AF2
H.HA	68	Q	H.HA.06	AF2	AF2
H.HA	69	Y	H.HA.07	AF2	AF2
H.HA	70	K	H.HA.08	AF2	AF2
H.HA	71	A	H.HA.09	AF2	AF2
H.HA	72	V	H.HA.10	AF2	AF2
H.HA	73	V	H.HA.11	AF2	AF2
H.HA	74	Y	H.HA.12	AF2	AF2
H.HA	75	S	H.HA.13	AF2	AF2
H.HA	76	N	H.HA.14	AF2	AF2
H.HA	77	T	H.HA.15	AF2	AF2
H.HA	78	I	H.HA.16	AF2	AF2
H.HA	79	Q	H.HA.17	AF2	AF2
H.HA	80	S	H.HA.18	AF2	AF2
H.HA	81	I	H.HA.19	AF2	AF2
H.HA	82	I	H.HA.20	AF2	AF2
H.HA	83	A	H.HA.21	AF2	AF2
H.HA	84	I	H.HA.22	AF2	AF2
H.HA	85	I	H.HA.23	AF2	AF2
H.HA	86	R	H.HA.24	AF2	AF2
H.HA	87	A	H.HA.25	AF2	AF2
H.HA	88	M	H.HA.26	AF2	AF2
H.HA	89	G	H.HA.27	AF2	AF2
H.HA	90	R	H.HA.28	AF2	AF2
H.HA	91	L	H.HA.29	AF2	AF2
H.hahb	92	K	H.hahb.01	AF2	AF2
H.hahb	93	I	H.hahb.04	AF2	AF2
H.hahb	94	D	H.hahb.05	AF2	AF2
H.hahb	95	F	H.hahb.06	AF2	AF2
H.hahb	96	G	H.hahb.07	AF2	AF2
H.hahb	97	D	H.hahb.08	AF2	AF2
H.hahb	98	S	H.hahb.09	AF2	AF2
H.HB	99	A	H.HB.01	AF2	AF2
H.HB	100	R	H.HB.02	AF2	AF2
H.HB	101	A	H.HB.03	AF2	AF2
H.HB	102	D	H.HB.04	AF2	AF2
H.HB	103	D	H.HB.05	AF2	AF2
H.HB	104	A	H.HB.06	AF2	AF2
H.HB	105	R	H.HB.07	AF2	AF2
H.HB	106	Q	H.HB.08	AF2	AF2
H.HB	107	L	H.HB.09	AF2	AF2
H.HB	108	F	H.HB.10	AF2	AF2
H.HB	109	V	H.HB.11	AF2	AF2
H.HB	110	L	H.HB.12	AF2	AF2
H.HB	111	A	H.HB.13	AF2	AF2
H.HB	112	G	H.HB.14	AF2	AF2
H.hbhc	113	A	H.hbhc.01	AF2	AF2
H.hbhc	114	A	H.hbhc.02	AF2	AF2
H.hbhc	115	E	H.hbhc.03	AF2	AF2
H.hbhc	116	E	H.hbhc.04	AF2	AF2
H.hbhc	117	G	H.hbhc.12	AF2	AF2
H.hbhc	118	F	H.hbhc.13	AF2	AF2
H.hbhc	119	M	H.hbhc.14	AF2	AF2
H.hbhc	120	T	H.hbhc.15	AF2	AF2
H.HC	121	A	H.HC.01	AF2	AF2
H.HC	122	E	H.HC.02	AF2	AF2
H.HC	123	L	H.HC.03	AF2	AF2
H.HC	124	A	H.HC.04	AF2	AF2
H.HC	125	G	H.HC.05	AF2	AF2
H.HC	126	V	H.HC.06	AF2	AF2
H.HC	127	I	H.HC.07	AF2	AF2
H.HC	128	K	H.HC.08	AF2	AF2
H.HC	129	R	H.HC.09	AF2	AF2
H.HC	130	L	H.HC.10	AF2	AF2
H.HC	131	W	H.HC.11	AF2	AF2
H.HC	132	K	H.HC.12	AF2	AF2
H.hchd	133	D	H.hchd.01	AF2	AF2
H.HD	134	S	H.HD.01	AF2	AF2
H.HD	135	G	H.HD.02	AF2	AF2
H.HD	136	V	H.HD.03	AF2	AF2
H.HD	137	Q	H.HD.04	AF2	AF2
H.HD	138	A	H.HD.05	AF2	AF2
H.HD	139	C	H.HD.06	AF2	AF2
H.HD	140	F	H.HD.07	AF2	AF2
H.HD	141	N	H.HD.08	AF2	AF2
H.HD	142	R	H.HD.09	AF2	AF2
H.HD	143	S	H.HD.10	AF2	AF2
H.HD	144	R	H.HD.11	AF2	AF2
H.HD	145	E	H.HD.12	AF2	AF2
H.hdhe	146	Y	H.hdhe.01	AF2	AF2
H.hdhe	147	Q	H.hdhe.02	AF2	AF2
H.hdhe	148	L	H.hdhe.03	AF2	AF2
H.hdhe	149	N	H.hdhe.04	AF2	AF2
H.hdhe	150	D	H.hdhe.05	AF2	AF2
H.HE	151	S	H.HE.01	AF2	AF2
H.HE	152	A	H.HE.02	AF2	AF2
H.HE	153	A	H.HE.03	AF2	AF2
H.HE	154	Y	H.HE.04	AF2	AF2
H.HE	155	Y	H.HE.05	AF2	AF2
H.HE	156	L	H.HE.06	AF2	AF2
H.HE	157	N	H.HE.07	AF2	AF2
H.HE	158	D	H.HE.08	AF2	AF2
H.HE	159	L	H.HE.09	AF2	AF2
H.HE	160	D	H.HE.10	AF2	AF2
H.HE	161	R	H.HE.11	AF2	AF2
H.HE	162	I	H.HE.12	AF2	AF2
H.HE	163	A	H.HE.13	AF2	AF2
H.hehf	164	Q	H.hehf.01	AF2	AF2
H.hehf	165	P	H.hehf.02	AF2	AF2
H.hehf	166	N	H.hehf.03	AF2	AF2
H.hehf	167	Y	H.hehf.04	AF2	AF2
H.hehf	168	I	H.hehf.05	AF2	AF2
H.hehf	169	P	H.hehf.06	AF2	AF2
H.hehf	170	T	H.hehf.07	AF2	AF2
H.HF	171	Q	H.HF.01	AF2	AF2
H.HF	172	Q	H.HF.02	AF2	AF2
H.HF	173	D	H.HF.03	AF2	AF2
H.HF	174	V	H.HF.04	AF2	AF2
H.HF	175	L	H.HF.05	AF2	AF2
H.HF	176	R	H.HF.06	AF2	AF2
G.hfs2	177	T	G.hfs2.01	AF2	AF2
G.hfs2	178	R	G.hfs2.02	AF2	AF2
G.hfs2	179	V	G.hfs2.03	AF2	AF2
G.hfs2	180	K	G.hfs2.04	AF2	AF2
G.hfs2	181	T	G.hfs2.05	AF2	AF2
G.hfs2	182	T	G.hfs2.06	Structure	Structure
G.hfs2	183	G	G.hfs2.07	Structure	Structure
G.S2	184	I	G.S2.01	Structure	Structure
G.S2	185	V	G.S2.02	Structure	Structure
G.S2	186	E	G.S2.03	Structure	Structure
G.S2	187	T	G.S2.04	Structure	Structure
G.S2	188	H	G.S2.05	Structure	Structure
G.S2	189	F	G.S2.06	Structure	Structure
G.S2	190	T	G.S2.07	Structure	Structure
G.S2	191	F	G.S2.08	Structure	Structure
G.s2s3	192	K	G.s2s3.01	Structure	Structure
G.s2s3	193	D	G.s2s3.02	Structure	Structure
G.S3	194	L	G.S3.01	Structure	Structure
G.S3	195	H	G.S3.02	Structure	Structure
G.S3	196	F	G.S3.03	Structure	Structure
G.S3	197	K	G.S3.04	Structure	Structure
G.S3	198	M	G.S3.05	Structure	Structure
G.S3	199	F	G.S3.06	Structure	Structure
G.S3	200	D	G.S3.07	Structure	Structure
G.S3	201	V	G.S3.08	Structure	Structure
G.s3h2	202	G	G.s3h2.01	Structure	Structure
G.s3h2	203	G	G.s3h2.02	Structure	Structure
G.s3h2	204	Q	G.s3h2.03	Structure	Structure
G.H2	205	R	G.H2.01	Structure	Structure
G.H2	206	S	G.H2.02	Structure	Structure
G.H2	207	E	G.H2.03	Structure	Structure
G.H2	208	R	G.H2.04	Structure	Structure
G.H2	209	K	G.H2.05	Structure	Structure
G.H2	210	K	G.H2.06	Structure	Structure
G.H2	211	W	G.H2.07	Structure	Structure
G.H2	212	I	G.H2.08	Structure	Structure
G.H2	213	H	G.H2.09	Structure	Structure
G.H2	214	C	G.H2.10	Structure	Structure
G.h2s4	215	F	G.h2s4.01	Structure	Structure
G.h2s4	216	E	G.h2s4.02	Structure	Structure
G.h2s4	217	G	G.h2s4.03	Structure	Structure
G.h2s4	218	V	G.h2s4.04	Structure	Structure
G.h2s4	219	T	G.h2s4.05	Structure	Structure
G.S4	220	A	G.S4.01	Structure	Structure
G.S4	221	I	G.S4.02	Structure	Structure
G.S4	222	I	G.S4.03	Structure	Structure
G.S4	223	F	G.S4.04	Structure	Structure
G.S4	224	C	G.S4.05	Structure	Structure
G.S4	225	V	G.S4.06	Structure	Structure
G.S4	226	A	G.S4.07	Structure	Structure
G.s4h3	227	L	G.s4h3.01	Structure	Structure
G.s4h3	228	S	G.s4h3.02	Structure	Structure
G.s4h3	229	D	G.s4h3.03	Structure	Structure
G.s4h3	230	Y	G.s4h3.04	Structure	Structure
G.s4h3	231	D	G.s4h3.05	Structure	Structure
G.s4h3	232	L	G.s4h3.06	Structure	Structure
G.s4h3	233	V	G.s4h3.07	Structure	Structure
G.s4h3	234	L	G.s4h3.08	AF2	AF2
G.s4h3	235	A	G.s4h3.09	AF2	AF2
G.s4h3	236	E	G.s4h3.10	AF2	AF2
G.s4h3	237	D	G.s4h3.11	AF2	AF2
G.s4h3	238	E	G.s4h3.12	AF2	AF2
G.s4h3	239	E	G.s4h3.13	AF2	AF2
G.s4h3	240	M	G.s4h3.14	AF2	AF2
G.s4h3	241	N	G.s4h3.15	Structure	Structure
G.H3	242	R	G.H3.01	Structure	Structure
G.H3	243	M	G.H3.02	Structure	Structure
G.H3	244	H	G.H3.03	Structure	Structure
G.H3	245	E	G.H3.04	Structure	Structure
G.H3	246	S	G.H3.05	Structure	Structure
G.H3	247	M	G.H3.06	Structure	Structure
G.H3	248	K	G.H3.07	Structure	Structure
G.H3	249	L	G.H3.08	Structure	Structure
G.H3	250	F	G.H3.09	Structure	Structure
G.H3	251	D	G.H3.10	Structure	Structure
G.H3	252	S	G.H3.11	Structure	Structure
G.H3	253	I	G.H3.12	Structure	Structure
G.H3	254	C	G.H3.13	Structure	Structure
G.H3	255	N	G.H3.14	Structure	Structure
G.H3	256	N	G.H3.15	Structure	Structure
G.H3	257	K	G.H3.16	Structure	Structure
G.H3	258	W	G.H3.17	Structure	Structure
G.H3	259	F	G.H3.18	Structure	Structure
G.h3s5	260	T	G.h3s5.01	Structure	Structure
G.h3s5	261	D	G.h3s5.02	Structure	Structure
G.h3s5	262	T	G.h3s5.03	Structure	Structure
G.S5	263	S	G.S5.01	Structure	Structure
G.S5	264	I	G.S5.02	Structure	Structure
G.S5	265	I	G.S5.03	Structure	Structure
G.S5	266	L	G.S5.04	Structure	Structure
G.S5	267	F	G.S5.05	Structure	Structure
G.S5	268	L	G.S5.06	Structure	Structure
G.S5	269	N	G.S5.07	Structure	Structure
G.s5hg	270	K	G.s5hg.01	Structure	Structure
G.HG	271	K	G.HG.01	Structure	Structure
G.HG	272	D	G.HG.02	Structure	Structure
G.HG	273	L	G.HG.03	Structure	Structure
G.HG	274	F	G.HG.04	Structure	Structure
G.HG	275	E	G.HG.05	Structure	Structure
G.HG	276	E	G.HG.06	Structure	Structure
G.HG	277	K	G.HG.07	Structure	Structure
G.HG	278	I	G.HG.08	Structure	Structure
G.HG	279	K	G.HG.09	Structure	Structure
G.HG	280	K	G.HG.12	Structure	Structure
G.HG	281	S	G.HG.13	Structure	Structure
G.HG	282	P	G.HG.14	Structure	Structure
G.HG	283	L	G.HG.15	Structure	Structure
G.HG	284	T	G.HG.16	Structure	Structure
G.HG	285	I	G.HG.17	Structure	Structure
G.hgh4	286	C	G.hgh4.01	Structure	Structure
G.hgh4	287	Y	G.hgh4.02	Structure	Structure
G.hgh4	288	P	G.hgh4.03	Structure	Structure
G.hgh4	289	E	G.hgh4.04	Structure	Structure
G.hgh4	290	Y	G.hgh4.05	Structure	Structure
G.hgh4	291	A	G.hgh4.06	Structure	Structure
G.hgh4	292	G	G.hgh4.07	Structure	Structure
G.hgh4	293	S	G.hgh4.08	Structure	Structure
G.H4	294	N	G.H4.01	Structure	Structure
G.H4	295	T	G.H4.02	Structure	Structure
G.H4	296	Y	G.H4.03	Structure	Structure
G.H4	297	E	G.H4.04	Structure	Structure
G.H4	298	E	G.H4.05	Structure	Structure
G.H4	299	A	G.H4.06	Structure	Structure
G.H4	300	A	G.H4.07	Structure	Structure
G.H4	301	A	G.H4.08	Structure	Structure
G.H4	302	Y	G.H4.10	Structure	Structure
G.H4	303	I	G.H4.11	Structure	Structure
G.H4	304	Q	G.H4.12	Structure	Structure
G.H4	305	C	G.H4.13	Structure	Structure
G.H4	306	Q	G.H4.14	Structure	Structure
G.H4	307	F	G.H4.15	Structure	Structure
G.H4	308	E	G.H4.16	Structure	Structure
G.H4	309	D	G.H4.17	Structure	Structure
G.h4s6	310	L	G.h4s6.01	Structure	Structure
G.h4s6	311	N	G.h4s6.02	Structure	Structure
G.h4s6	312	K	G.h4s6.03	Structure	Structure
G.h4s6	313	R	G.h4s6.04	Structure	Structure
G.h4s6	314	K	G.h4s6.08	Structure	Structure
G.h4s6	315	D	G.h4s6.09	Structure	Structure
G.h4s6	316	T	G.h4s6.10	Structure	Structure
G.h4s6	317	K	G.h4s6.11	Structure	Structure
G.h4s6	318	E	G.h4s6.12	Structure	Structure
G.S6	319	I	G.S6.01	Structure	Structure
G.S6	320	Y	G.S6.02	Structure	Structure
G.S6	321	T	G.S6.03	Structure	Structure
G.S6	322	H	G.S6.04	Structure	Structure
G.S6	323	F	G.S6.05	Structure	Structure
G.s6h5	324	T	G.s6h5.01	Structure	Structure
G.s6h5	325	C	G.s6h5.02	Structure	Structure
G.s6h5	326	A	G.s6h5.03	Structure	Structure
G.s6h5	327	T	G.s6h5.04	Structure	Structure
G.s6h5	328	D	G.s6h5.05	Structure	Structure
G.H5	329	T	G.H5.01	Structure	Structure
G.H5	330	K	G.H5.02	Structure	Structure
G.H5	331	N	G.H5.03	Structure	Structure
G.H5	332	V	G.H5.04	Structure	Structure
G.H5	333	Q	G.H5.05	Structure	Structure
G.H5	334	F	G.H5.06	Structure	Structure
G.H5	335	V	G.H5.07	Structure	Structure
G.H5	336	F	G.H5.08	Structure	Structure
G.H5	337	D	G.H5.09	Structure	Structure
G.H5	338	A	G.H5.10	Structure	Structure
G.H5	339	V	G.H5.11	Structure	Structure
G.H5	340	T	G.H5.12	Structure	Structure
G.H5	341	D	G.H5.13	Structure	Structure
G.H5	342	V	G.H5.14	Structure	Structure
G.H5	343	I	G.H5.15	Structure	Structure
G.H5	344	I	G.H5.16	Structure	Structure
G.H5	345	K	G.H5.17	Structure	Structure
G.H5	346	N	G.H5.18	Structure	Structure
G.H5	347	N	G.H5.19	Structure	Structure
G.H5	348	L	G.H5.20	Structure	Structure
G.H5	349	K	G.H5.21	Structure	Structure
G.H5	350	D	G.H5.22	Structure	Structure
G.H5	351	C	G.H5.23	Structure	Structure
G.H5	352	G	G.H5.24	Structure	Structure
G.H5	353	L	G.H5.25	Structure	Structure
G.H5	354	F	G.H5.26	Structure	Structure

REFINED GPCR RESIDUES

Residue backbones - 275 from structure (84.6%), 50 from model (15.4%)
Residue sidechains - 275 from structure (84.6%), 50 from model (15.4%)

Showing 1 to 325 of 325 entries

Search:

Segment	Seq.num.	AA	GPCRdb#	Backbone from	Sidechain from

N-term	1	M	-	AF2	AF2
N-term	2	Q	-	AF2	AF2
N-term	3	G	-	AF2	AF2
N-term	4	N	-	AF2	AF2
N-term	5	G	-	AF2	AF2
N-term	6	S	-	AF2	AF2
N-term	7	A	-	AF2	AF2
N-term	8	L	-	AF2	AF2
N-term	9	P	-	AF2	AF2
N-term	10	N	-	AF2	AF2
N-term	11	A	-	AF2	AF2
N-term	12	S	-	AF2	AF2
N-term	13	Q	-	AF2	AF2
N-term	14	P	-	AF2	AF2
N-term	15	V	-	AF2	AF2
N-term	16	L	-	AF2	AF2
N-term	17	R	-	AF2	AF2
N-term	18	G	-	AF2	AF2
N-term	19	D	-	AF2	AF2
N-term	20	G	-	AF2	AF2
N-term	21	A	-	AF2	AF2
N-term	22	R	-	AF2	AF2
TM1	23	P	1.28x28	Structure	Structure
TM1	24	S	1.29x29	Structure	Structure
TM1	25	W	1.30x30	Structure	Structure
TM1	26	L	1.31x31	Structure	Structure
TM1	27	A	1.32x32	Structure	Structure
TM1	28	S	1.33x33	Structure	Structure
TM1	29	A	1.34x34	Structure	Structure
TM1	30	L	1.35x35	Structure	Structure
TM1	31	A	1.36x36	Structure	Structure
TM1	32	C	1.37x37	Structure	Structure
TM1	33	V	1.38x38	Structure	Structure
TM1	34	L	1.39x39	Structure	Structure
TM1	35	I	1.40x40	Structure	Structure
TM1	36	F	1.41x41	Structure	Structure
TM1	37	T	1.42x42	Structure	Structure
TM1	38	I	1.43x43	Structure	Structure
TM1	39	V	1.44x44	Structure	Structure
TM1	40	V	1.45x45	Structure	Structure
TM1	41	D	1.46x46	Structure	Structure
TM1	42	I	1.47x47	Structure	Structure
TM1	43	L	1.48x48	Structure	Structure
TM1	44	G	1.49x49	Structure	Structure
TM1	45	N	1.50x50	Structure	Structure
TM1	46	L	1.51x51	Structure	Structure
TM1	47	L	1.52x52	Structure	Structure
TM1	48	V	1.53x53	Structure	Structure
TM1	49	I	1.54x54	Structure	Structure
TM1	50	L	1.55x55	Structure	Structure
TM1	51	S	1.56x56	Structure	Structure
TM1	52	V	1.57x57	Structure	Structure
TM1	53	Y	1.58x58	Structure	Structure
TM1	54	R	1.59x59	Structure	Structure
TM1	55	N	1.60x60	Structure	Structure
ICL1	56	K	12.48x48	Structure	Structure
ICL1	57	K	12.49x49	Structure	Structure
ICL1	58	L	12.50x50	Structure	Structure
ICL1	59	R	12.51x51	Structure	Structure
TM2	60	N	2.37x37	Structure	Structure
TM2	61	A	2.38x38	Structure	Structure
TM2	62	G	2.39x39	Structure	Structure
TM2	63	N	2.40x40	Structure	Structure
TM2	64	I	2.41x41	Structure	Structure
TM2	65	F	2.42x42	Structure	Structure
TM2	66	V	2.43x43	Structure	Structure
TM2	67	V	2.44x44	Structure	Structure
TM2	68	S	2.45x45	Structure	Structure
TM2	69	L	2.46x46	Structure	Structure
TM2	70	A	2.47x47	Structure	Structure
TM2	71	V	2.48x48	Structure	Structure
TM2	72	A	2.49x49	Structure	Structure
TM2	73	D	2.50x50	Structure	Structure
TM2	74	L	2.51x51	Structure	Structure
TM2	75	V	2.52x52	Structure	Structure
TM2	76	V	2.53x53	Structure	Structure
TM2	77	A	2.54x54	Structure	Structure
TM2	78	I	2.55x55	Structure	Structure
TM2	79	Y	2.56x551	Structure	Structure
TM2	80	P	2.57x56	Structure	Structure
TM2	81	Y	2.58x57	Structure	Structure
TM2	82	P	2.59x58	Structure	Structure
TM2	83	L	2.60x59	Structure	Structure
TM2	84	V	2.61x60	Structure	Structure
TM2	85	L	2.62x61	Structure	Structure
TM2	86	M	2.63x62	Structure	Structure
TM2	87	S	2.64x63	Structure	Structure
TM2	88	I	2.65x64	Structure	Structure
TM2	89	F	2.66x65	Structure	Structure
TM2	90	N	2.67x66	Structure	Structure
TM2	91	N	2.68x67	Structure	Structure
ECL1	92	G	23.49x49	Structure	Structure
ECL1	93	W	23.50x50	Structure	Structure
ECL1	94	N	23.51x51	Structure	Structure
ECL1	95	L	23.52x52	Structure	Structure
TM3	96	G	3.21x21	Structure	Structure
TM3	97	Y	3.22x22	Structure	Structure
TM3	98	L	3.23x23	Structure	Structure
TM3	99	H	3.24x24	Structure	Structure
TM3	100	C	3.25x25	Structure	Structure
TM3	101	Q	3.26x26	Structure	Structure
TM3	102	V	3.27x27	Structure	Structure
TM3	103	S	3.28x28	Structure	Structure
TM3	104	G	3.29x29	Structure	Structure
TM3	105	F	3.30x30	Structure	Structure
TM3	106	L	3.31x31	Structure	Structure
TM3	107	M	3.32x32	Structure	Structure
TM3	108	G	3.33x33	Structure	Structure
TM3	109	L	3.34x34	Structure	Structure
TM3	110	S	3.35x35	Structure	Structure
TM3	111	V	3.36x36	Structure	Structure
TM3	112	I	3.37x37	Structure	Structure
TM3	113	G	3.38x38	Structure	Structure
TM3	114	S	3.39x39	Structure	Structure
TM3	115	I	3.40x40	Structure	Structure
TM3	116	F	3.41x41	Structure	Structure
TM3	117	N	3.42x42	Structure	Structure
TM3	118	I	3.43x43	Structure	Structure
TM3	119	T	3.44x44	Structure	Structure
TM3	120	G	3.45x45	Structure	Structure
TM3	121	I	3.46x46	Structure	Structure
TM3	122	A	3.47x47	Structure	Structure
TM3	123	I	3.48x48	Structure	Structure
TM3	124	N	3.49x49	Structure	Structure
TM3	125	R	3.50x50	Structure	Structure
TM3	126	Y	3.51x51	Structure	Structure
TM3	127	C	3.52x52	Structure	Structure
TM3	128	Y	3.53x53	Structure	Structure
TM3	129	I	3.54x54	Structure	Structure
TM3	130	C	3.55x55	Structure	Structure
TM3	131	H	3.56x56	Structure	Structure
ICL2	132	S	34.50x50	Structure	Structure
ICL2	133	L	34.51x51	Structure	Structure
ICL2	134	K	34.52x52	Structure	Structure
ICL2	135	Y	34.53x53	Structure	Structure
ICL2	136	D	34.54x54	Structure	Structure
ICL2	137	K	34.55x55	Structure	Structure
ICL2	138	L	34.56x56	Structure	Structure
ICL2	139	Y	34.57x57	Structure	Structure
TM4	140	S	4.38x38	Structure	Structure
TM4	141	S	4.39x39	Structure	Structure
TM4	142	K	4.40x40	Structure	Structure
TM4	143	N	4.41x41	Structure	Structure
TM4	144	S	4.42x42	Structure	Structure
TM4	145	L	4.43x43	Structure	Structure
TM4	146	C	4.44x44	Structure	Structure
TM4	147	Y	4.45x45	Structure	Structure
TM4	148	V	4.46x46	Structure	Structure
TM4	149	L	4.47x47	Structure	Structure
TM4	150	L	4.48x48	Structure	Structure
TM4	151	I	4.49x49	Structure	Structure
TM4	152	W	4.50x50	Structure	Structure
TM4	153	L	4.51x51	Structure	Structure
TM4	154	L	4.52x52	Structure	Structure
TM4	155	T	4.53x53	Structure	Structure
TM4	156	L	4.54x54	Structure	Structure
TM4	157	A	4.55x55	Structure	Structure
TM4	158	A	4.56x56	Structure	Structure
TM4	159	V	4.57x57	Structure	Structure
TM4	160	L	4.58x59	Structure	Structure
TM4	161	P	4.59x60	Structure	Structure
TM4	162	N	4.60x61	Structure	Structure
TM4	163	L	4.61x62	Structure	Structure
TM4	164	R	4.62x63	Structure	Structure
TM4	165	A	4.63x64	Structure	Structure
TM4	166	G	4.64x65	Structure	Structure
ECL2	167	T	-	Structure	Structure
ECL2	168	L	-	Structure	Structure
ECL2	169	Q	-	Structure	Structure
ECL2	170	Y	-	Structure	Structure
ECL2	171	D	-	Structure	Structure
ECL2	172	P	-	Structure	Structure
ECL2	173	R	-	Structure	Structure
ECL2	174	I	-	Structure	Structure
ECL2	175	Y	-	Structure	Structure
ECL2	176	S	-	Structure	Structure
ECL2	177	C	45.50x50	Structure	Structure
ECL2	178	T	45.51x51	Structure	Structure
ECL2	179	F	45.52x52	Structure	Structure
ECL2	180	A	-	Structure	Structure
ECL2	181	Q	-	Structure	Structure
ECL2	182	S	-	Structure	Structure
ECL2	183	V	-	Structure	Structure
TM5	184	S	5.35x36	Structure	Structure
TM5	185	S	5.36x37	Structure	Structure
TM5	186	A	5.37x38	Structure	Structure
TM5	187	Y	5.38x39	Structure	Structure
TM5	188	T	5.39x40	Structure	Structure
TM5	189	I	5.40x41	Structure	Structure
TM5	190	A	5.41x42	Structure	Structure
TM5	191	V	5.42x43	Structure	Structure
TM5	192	V	5.43x44	Structure	Structure
TM5	193	V	5.44x45	Structure	Structure
TM5	194	F	5.45x46	Structure	Structure
TM5	195	H	5.46x461	Structure	Structure
TM5	196	F	5.47x47	Structure	Structure
TM5	197	L	5.48x48	Structure	Structure
TM5	198	V	5.49x49	Structure	Structure
TM5	199	P	5.50x50	Structure	Structure
TM5	200	M	5.51x51	Structure	Structure
TM5	201	I	5.52x52	Structure	Structure
TM5	202	I	5.53x53	Structure	Structure
TM5	203	V	5.54x54	Structure	Structure
TM5	204	I	5.55x55	Structure	Structure
TM5	205	F	5.56x56	Structure	Structure
TM5	206	C	5.57x57	Structure	Structure
TM5	207	Y	5.58x58	Structure	Structure
TM5	208	L	5.59x59	Structure	Structure
TM5	209	R	5.60x60	Structure	Structure
TM5	210	I	5.61x61	Structure	Structure
TM5	211	W	5.62x62	Structure	Structure
TM5	212	I	5.63x63	Structure	Structure
TM5	213	L	5.64x64	Structure	Structure
TM5	214	V	5.65x65	Structure	Structure
TM5	215	L	5.66x66	Structure	Structure
TM5	216	Q	5.67x67	Structure	Structure
TM5	217	V	5.68x68	Structure	Structure
TM5	218	R	5.69x69	Structure	Structure
TM5	219	Q	5.70x70	Structure	Structure
TM5	220	R	5.71x71	Structure	Structure
TM5	221	V	5.72x72	Structure	Structure
ICL3	222	K	-	AF2	AF2
ICL3	223	P	-	AF2	AF2
ICL3	224	D	-	AF2	AF2
ICL3	225	R	-	AF2	AF2
ICL3	226	K	-	AF2	AF2
TM6	227	P	6.24x24	AF2	AF2
TM6	228	K	6.25x25	AF2	AF2
TM6	229	L	6.26x26	AF2	AF2
TM6	230	K	6.27x27	AF2	AF2
TM6	231	P	6.28x28	Structure	Structure
TM6	232	Q	6.29x29	Structure	Structure
TM6	233	D	6.30x30	Structure	Structure
TM6	234	F	6.31x31	Structure	Structure
TM6	235	R	6.32x32	Structure	Structure
TM6	236	N	6.33x33	Structure	Structure
TM6	237	F	6.34x34	Structure	Structure
TM6	238	V	6.35x35	Structure	Structure
TM6	239	T	6.36x36	Structure	Structure
TM6	240	M	6.37x37	Structure	Structure
TM6	241	F	6.38x38	Structure	Structure
TM6	242	V	6.39x39	Structure	Structure
TM6	243	V	6.40x40	Structure	Structure
TM6	244	F	6.41x41	Structure	Structure
TM6	245	V	6.42x42	Structure	Structure
TM6	246	L	6.43x43	Structure	Structure
TM6	247	F	6.44x44	Structure	Structure
TM6	248	A	6.45x45	Structure	Structure
TM6	249	I	6.46x46	Structure	Structure
TM6	250	C	6.47x47	Structure	Structure
TM6	251	W	6.48x48	Structure	Structure
TM6	252	A	6.49x49	Structure	Structure
TM6	253	P	6.50x50	Structure	Structure
TM6	254	L	6.51x51	Structure	Structure
TM6	255	N	6.52x52	Structure	Structure
TM6	256	F	6.53x53	Structure	Structure
TM6	257	I	6.54x54	Structure	Structure
TM6	258	G	6.55x55	Structure	Structure
TM6	259	L	6.56x56	Structure	Structure
TM6	260	A	6.57x57	Structure	Structure
TM6	261	V	6.58x58	Structure	Structure
TM6	262	A	6.59x59	Structure	Structure
TM6	263	S	6.60x60	Structure	Structure
TM6	264	D	6.61x61	Structure	Structure
ECL3	265	P	-	Structure	Structure
ECL3	266	A	-	Structure	Structure
ECL3	267	S	-	Structure	Structure
ECL3	268	M	-	Structure	Structure
ECL3	269	V	-	Structure	Structure
ECL3	270	P	-	Structure	Structure
ECL3	271	R	-	Structure	Structure
ECL3	272	I	-	Structure	Structure
TM7	273	P	7.31x30	Structure	Structure
TM7	274	E	7.32x31	Structure	Structure
TM7	275	W	7.33x32	Structure	Structure
TM7	276	L	7.34x33	Structure	Structure
TM7	277	F	7.35x34	Structure	Structure
TM7	278	V	7.36x35	Structure	Structure
TM7	279	A	7.37x36	Structure	Structure
TM7	280	S	7.38x37	Structure	Structure
TM7	281	Y	7.39x38	Structure	Structure
TM7	282	Y	7.40x39	Structure	Structure
TM7	283	M	7.41x40	Structure	Structure
TM7	284	A	7.42x41	Structure	Structure
TM7	285	Y	7.43x42	Structure	Structure
TM7	286	F	7.44x43	Structure	Structure
TM7	287	N	7.45x45	Structure	Structure
TM7	288	S	7.46x46	Structure	Structure
TM7	289	C	7.47x47	Structure	Structure
TM7	290	L	7.48x48	Structure	Structure
TM7	291	N	7.49x49	Structure	Structure
TM7	292	A	7.50x50	Structure	Structure
TM7	293	I	7.51x51	Structure	Structure
TM7	294	I	7.52x52	Structure	Structure
TM7	295	Y	7.53x53	Structure	Structure
TM7	296	G	7.54x54	Structure	Structure
TM7	297	L	7.55x55	Structure	Structure
TM7	298	L	7.56x56	Structure	Structure
H8	299	N	8.47x47	Structure	Structure
H8	300	Q	8.48x48	Structure	Structure
H8	301	N	8.49x49	Structure	Structure
H8	302	F	8.50x50	Structure	Structure
H8	303	R	8.51x51	Structure	Structure
H8	304	K	8.52x52	Structure	Structure
H8	305	E	8.53x53	Structure	Structure
H8	306	Y	8.54x54	Structure	Structure
H8	307	R	8.55x55	AF2	AF2
H8	308	R	8.56x56	AF2	AF2
H8	309	I	8.57x57	AF2	AF2
H8	310	I	8.58x58	AF2	AF2
H8	311	V	8.59x59	AF2	AF2
H8	312	S	8.60x60	AF2	AF2
H8	313	L	8.61x61	AF2	AF2
H8	314	C	8.62x62	AF2	AF2
H8	315	T	8.63x63	AF2	AF2
C-term	316	A	-	AF2	AF2
C-term	317	R	-	AF2	AF2
C-term	318	V	-	AF2	AF2
C-term	319	F	-	AF2	AF2
C-term	320	F	-	AF2	AF2
C-term	321	V	-	AF2	AF2
C-term	322	D	-	AF2	AF2
C-term	323	S	-	AF2	AF2
C-term	324	S	-	AF2	AF2
C-term	325	N	-	AF2	AF2

GPCR - G protein interface interactions

The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.

Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):

bb-bb

bb-sc

sc-sc

sc-bb

Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Search:

Interaction type	GPCR Segment	AA	Number	Generic number	Gα segment	AA	Number	Generic number

Interaction type	GPCR Segment	AA	Number	Generic number	Gα segment	AA	Number	Generic number

Hydrophobic	TM5	I	210	5x61	G.H5	L	353	G.H5.25
Hydrophobic	TM5	R	220	5x71	G.H5	D	337	G.H5.09
Hydrophobic	TM6	N	236	6x33	G.H5	F	354	G.H5.26
Hydrophobic	H8	N	299	8x47	G.H5	G	352	G.H5.24
Hydrophobic	TM5	V	221	5x72	G.H5	D	341	G.H5.13
Hydrophobic	TM3	Y	128	3x53	G.H5	D	350	G.H5.22
Hydrophobic	TM3	I	129	3x54	G.H5	I	344	G.H5.16
Hydrophobic	TM5	I	210	5x61	G.H5	L	348	G.H5.20
Hydrophobic	TM3	I	129	3x54	G.H5	L	348	G.H5.20
Hydrophobic	TM5	L	213	5x64	G.H5	I	344	G.H5.16
Hydrophobic	TM5	V	214	5x65	G.H5	F	354	G.H5.26
Hydrophobic	H8	Q	300	8x48	G.H5	G	352	G.H5.24
Hydrophobic	TM3	I	129	3x54	G.H5	C	351	G.H5.23
Hydrophobic	TM5	V	214	5x65	G.H5	I	344	G.H5.16
Hydrophobic	TM3	R	125	3x50	G.H5	C	351	G.H5.23
Hydrophobic	TM5	V	221	5x72	G.H5	A	338	G.H5.10
Hydrophobic	TM5	V	214	5x65	G.H5	L	348	G.H5.20
Hydrophobic	TM5	V	221	5x72	G.S6	Y	320	G.S6.02
Hydrophobic	TM5	V	217	5x68	G.H5	I	344	G.H5.16
Hydrophobic	TM6	T	239	6x36	G.H5	F	354	G.H5.26
Hydrophobic	TM3	R	125	3x50	G.H5	L	353	G.H5.25
Hydrophobic	ICL2	S	132	34x50	G.hns1	R	32	G.hns1.03
Hydrophobic	TM5	I	210	5x61	G.H5	F	354	G.H5.26
Hydrophobic	TM3	I	129	3x54	G.H5	N	347	G.H5.19
Hydrophobic	TM5	V	221	5x72	G.H5	D	337	G.H5.09
Hydrophobic	TM5	Y	207	5x58	G.H5	L	353	G.H5.25
Hydrophobic	ICL2	D	136	34x54	G.hns1	R	32	G.hns1.03
Hydrophobic	ICL2	D	136	34x54	G.HN	E	28	G.HN.52
Hydrophobic	TM3	Y	128	3x53	G.H5	C	351	G.H5.23
Hydrophobic	TM5	W	211	5x62	G.H5	F	354	G.H5.26
Ionic	TM5	R	220	5x71	G.H5	D	337	G.H5.09
Ionic	ICL2	D	136	34x54	G.hns1	R	32	G.hns1.03
Polar	ICL2	S	132	34x50	G.H5	N	347	G.H5.19
Polar	TM3	Y	128	3x53	G.H5	D	350	G.H5.22
Polar	H8	Q	300	8x48	G.H5	K	349	G.H5.21
Polar	TM6	R	235	6x32	G.H5	L	353	G.H5.25
Polar	TM3	Y	128	3x53	G.H5	N	347	G.H5.19
Polar	TM3	R	125	3x50	G.H5	C	351	G.H5.23
Polar	TM6	T	239	6x36	G.H5	L	353	G.H5.25
Polar	TM6	T	239	6x36	G.H5	F	354	G.H5.26
Polar	ICL2	S	132	34x50	G.hns1	R	32	G.hns1.03
Polar	ICL2	D	136	34x54	G.hns1	R	32	G.hns1.03
Van-der-waals	TM6	N	236	6x33	G.H5	F	354	G.H5.26
Van-der-waals	H8	N	299	8x47	G.H5	G	352	G.H5.24
Van-der-waals	H8	Q	300	8x48	G.H5	K	349	G.H5.21
Van-der-waals	TM3	I	129	3x54	G.H5	L	348	G.H5.20
Van-der-waals	ICL2	Y	135	34x53	G.hns1	R	32	G.hns1.03
Van-der-waals	H8	Q	300	8x48	G.H5	G	352	G.H5.24
Van-der-waals	TM5	V	214	5x65	G.H5	L	348	G.H5.20
Van-der-waals	TM6	T	239	6x36	G.H5	L	353	G.H5.25
Van-der-waals	TM5	V	221	5x72	G.S6	Y	320	G.S6.02
Van-der-waals	TM6	T	239	6x36	G.H5	F	354	G.H5.26
Van-der-waals	ICL2	S	132	34x50	G.hns1	R	32	G.hns1.03
Van-der-waals	TM3	I	129	3x54	G.H5	N	347	G.H5.19
Van-der-waals	TM6	R	235	6x32	G.H5	F	354	G.H5.26
Van-der-waals	TM5	Y	207	5x58	G.H5	L	353	G.H5.25
Van-der-waals	TM3	Y	128	3x53	G.H5	C	351	G.H5.23
Van-der-waals	TM5	W	211	5x62	G.H5	F	354	G.H5.26

Showing 1 to 58 of 58 entries

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Main reference

Refined structure (7DB6) of Gi1 - MT1 receptor Download Full

GPCR CLASS (FAMILY)

SPECIES

G PROTEIN FAMILY

DATE

3D VIEW

REFINED G PROTEIN RESIDUES

REFINED GPCR RESIDUES

GPCR - G protein interface interactions

Structures

Refined structure (7DB6) of G_i1 - MT₁ receptor

Full