PrRP receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.0 Å

REFERENCE

PUBLICATION DATE

Sept. 25, 2024

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

Prolactin-releasing peptide PrRP20 - Agonist

PHYSIOLOGICAL LIGANDS

PrRP-20, neuropeptide Y, PrRP-31, PTHrP



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Polar TM3 V 162 3x53 G.H5 N 354 G.H5.19
Hydrophobic TM3 V 162 3x53 G.H5 N 354 G.H5.19
Van-der-waals TM3 V 162 3x53 G.H5 N 354 G.H5.19
Hydrophobic ICL2 L 167 - G.H5 F 343 G.H5.08
Hydrophobic TM6 W 268 6x25 G.H5 F 361 G.H5.26
Van-der-waals TM6 W 268 6x25 G.H5 F 361 G.H5.26
Hydrophobic ICL2 L 167 - G.H5 I 350 G.H5.15
Polar TM6 T 276 6x33 G.H5 F 361 G.H5.26
Van-der-waals TM6 T 276 6x33 G.H5 F 361 G.H5.26
Polar H8 H 339 8x47 G.H5 G 359 G.H5.24
Hydrophobic H8 H 339 8x47 G.H5 G 359 G.H5.24
Van-der-waals H8 H 339 8x47 G.H5 G 359 G.H5.24
Aromatic TM6 R 272 6x29 G.H5 F 361 G.H5.26
Hydrophobic TM6 R 272 6x29 G.H5 F 361 G.H5.26
Van-der-waals TM6 R 272 6x29 G.H5 F 361 G.H5.26
Hydrophobic TM3 L 163 3x54 G.H5 L 355 G.H5.20
Van-der-waals TM3 L 163 3x54 G.H5 L 355 G.H5.20
Polar H8 H 339 8x47 G.H5 F 361 G.H5.26
Hydrophobic H8 H 339 8x47 G.H5 F 361 G.H5.26
Van-der-waals H8 H 339 8x47 G.H5 F 361 G.H5.26
Hydrophobic TM5 L 252 5x65 G.H5 L 355 G.H5.20
Ionic TM5 R 255 5x68 G.H5 D 348 G.H5.13
Polar TM5 R 255 5x68 G.H5 D 348 G.H5.13
Hydrophobic TM5 R 255 5x68 G.H5 D 348 G.H5.13
Van-der-waals TM5 R 255 5x68 G.H5 D 348 G.H5.13
Hydrophobic TM3 L 163 3x54 G.H5 N 354 G.H5.19
Polar TM3 R 159 3x50 G.H5 C 358 G.H5.23
Hydrophobic TM3 R 159 3x50 G.H5 C 358 G.H5.23
Van-der-waals TM3 R 159 3x50 G.H5 C 358 G.H5.23
Hydrophobic TM3 L 163 3x54 G.H5 L 360 G.H5.25
Van-der-waals TM3 L 163 3x54 G.H5 L 360 G.H5.25
Hydrophobic ICL2 P 166 - G.H5 I 350 G.H5.15
Hydrophobic TM3 R 159 3x50 G.H5 L 360 G.H5.25
Van-der-waals TM3 R 159 3x50 G.H5 L 360 G.H5.25
Hydrophobic ICL2 R 169 - G.hns1 A 32 G.hns1.03
Hydrophobic TM5 R 255 5x68 G.H5 K 352 G.H5.17
Van-der-waals TM5 R 255 5x68 G.H5 K 352 G.H5.17
Hydrophobic TM6 L 279 6x36 G.H5 L 360 G.H5.25
Polar TM6 T 276 6x33 G.H5 L 360 G.H5.25
Hydrophobic TM6 T 276 6x33 G.H5 L 360 G.H5.25
Van-der-waals TM6 T 276 6x33 G.H5 L 360 G.H5.25
Van-der-waals ICL2 P 166 - G.H5 T 347 G.H5.12
Hydrophobic ICL2 L 167 - G.S1 H 34 G.S1.02
Van-der-waals ICL2 L 167 - G.S1 H 34 G.S1.02
Hydrophobic TM6 W 268 6x25 G.H5 R 356 G.H5.21
Van-der-waals TM6 W 268 6x25 G.H5 R 356 G.H5.21
Hydrophobic TM6 R 275 6x32 G.H5 F 361 G.H5.26
Hydrophobic ICL2 P 166 - G.H5 I 351 G.H5.16
Van-der-waals ICL2 P 166 - G.H5 I 351 G.H5.16
Hydrophobic TM3 L 163 3x54 G.H5 I 351 G.H5.16
Hydrophobic TM3 V 162 3x53 G.H5 C 358 G.H5.23
Van-der-waals TM3 V 162 3x53 G.H5 C 358 G.H5.23
Hydrophobic TM2 T 95 2x39 G.H5 C 358 G.H5.23