Refined structure (7Y3G) of Gs - GPR12

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2024-02-01

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 220 from structure (55.8%), 174 from model (44.2%)
Residue sidechains - 212 from structure (53.8%), 182 from model (46.2%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 AF2 AF2
G.HN 4 L G.HN.10 AF2 AF2
G.HN 5 G G.HN.11 AF2 AF2
G.HN 6 N G.HN.22 AF2 AF2
G.HN 7 S G.HN.23 AF2 AF2
G.HN 8 K G.HN.24 AF2 AF2
G.HN 9 T G.HN.26 AF2 AF2
G.HN 10 E G.HN.27 AF2 AF2
G.HN 11 D G.HN.28 Structure Structure
G.HN 12 Q G.HN.29 Structure Structure
G.HN 13 R G.HN.30 Structure Structure
G.HN 14 N G.HN.31 Structure Structure
G.HN 15 E G.HN.32 Structure Structure
G.HN 16 E G.HN.33 Structure Structure
G.HN 17 K G.HN.34 Structure Structure
G.HN 18 A G.HN.35 Structure Structure
G.HN 19 Q G.HN.36 Structure Structure
G.HN 20 R G.HN.37 Structure Structure
G.HN 21 E G.HN.38 Structure Structure
G.HN 22 A G.HN.39 Structure Structure
G.HN 23 N G.HN.40 Structure Structure
G.HN 24 K G.HN.41 Structure Structure
G.HN 25 K G.HN.42 Structure Structure
G.HN 26 I G.HN.43 Structure Structure
G.HN 27 E G.HN.44 Structure Structure
G.HN 28 K G.HN.45 Structure Structure
G.HN 29 Q G.HN.46 Structure Structure
G.HN 30 L G.HN.47 Structure Structure
G.HN 31 Q G.HN.48 Structure Structure
G.HN 32 K G.HN.49 Structure Structure
G.HN 33 D G.HN.50 Structure Structure
G.HN 34 K G.HN.51 Structure Structure
G.HN 35 Q G.HN.52 Structure Structure
G.HN 36 V G.HN.53 Structure Structure
G.hns1 37 Y G.hns1.01 Structure Structure
G.hns1 38 R G.hns1.02 Structure Structure
G.hns1 39 A G.hns1.03 Structure Structure
G.S1 40 T G.S1.01 Structure Structure
G.S1 41 H G.S1.02 Structure Structure
G.S1 42 R G.S1.03 Structure Structure
G.S1 43 L G.S1.04 Structure Structure
G.S1 44 L G.S1.05 Structure Structure
G.S1 45 L G.S1.06 Structure Structure
G.S1 46 L G.S1.07 Structure Structure
G.s1h1 47 G G.s1h1.01 Structure Structure
G.s1h1 48 A G.s1h1.02 AF2 AF2
G.s1h1 49 G G.s1h1.03 AF2 AF2
G.s1h1 50 E G.s1h1.04 AF2 AF2
G.s1h1 51 S G.s1h1.05 AF2 AF2
G.s1h1 52 G G.s1h1.06 Structure Structure
G.H1 53 K G.H1.01 Structure Structure
G.H1 54 S G.H1.02 Structure AF2
G.H1 55 T G.H1.03 Structure Structure
G.H1 56 I G.H1.04 Structure Structure
G.H1 57 V G.H1.05 Structure Structure
G.H1 58 K G.H1.06 Structure Structure
G.H1 59 Q G.H1.07 Structure Structure
G.H1 60 M G.H1.08 AF2 AF2
G.H1 61 R G.H1.09 AF2 AF2
G.H1 62 I G.H1.10 AF2 AF2
G.H1 63 L G.H1.11 AF2 AF2
G.H1 64 H G.H1.12 AF2 AF2
G.h1ha 65 V G.h1ha.01 AF2 AF2
G.h1ha 66 N G.h1ha.02 AF2 AF2
G.h1ha 67 G G.h1ha.03 AF2 AF2
G.h1ha 68 F G.h1ha.04 AF2 AF2
G.h1ha 69 N G.h1ha.05 AF2 AF2
G.h1ha 70 G G.h1ha.06 AF2 AF2
G.h1ha 71 E G.h1ha.07 AF2 AF2
G.h1ha 72 G G.h1ha.08 AF2 AF2
G.h1ha 73 G G.h1ha.09 AF2 AF2
G.h1ha 74 E G.h1ha.10 AF2 AF2
G.h1ha 75 E G.h1ha.11 AF2 AF2
G.h1ha 76 D G.h1ha.12 AF2 AF2
G.h1ha 77 P G.h1ha.13 AF2 AF2
G.h1ha 78 Q G.h1ha.14 AF2 AF2
G.h1ha 79 A G.h1ha.15 AF2 AF2
G.h1ha 80 A G.h1ha.16 AF2 AF2
G.h1ha 81 R G.h1ha.17 AF2 AF2
G.h1ha 82 S G.h1ha.18 AF2 AF2
G.h1ha 83 N G.h1ha.19 AF2 AF2
G.h1ha 84 S G.h1ha.20 AF2 AF2
H.HA 85 D H.HA.01 AF2 AF2
H.HA 86 G H.HA.02 AF2 AF2
H.HA 87 E H.HA.03 AF2 AF2
H.HA 88 K H.HA.04 AF2 AF2
H.HA 89 A H.HA.05 AF2 AF2
H.HA 90 T H.HA.06 AF2 AF2
H.HA 91 K H.HA.07 AF2 AF2
H.HA 92 V H.HA.08 AF2 AF2
H.HA 93 Q H.HA.09 AF2 AF2
H.HA 94 D H.HA.10 AF2 AF2
H.HA 95 I H.HA.11 AF2 AF2
H.HA 96 K H.HA.12 AF2 AF2
H.HA 97 N H.HA.13 AF2 AF2
H.HA 98 N H.HA.14 AF2 AF2
H.HA 99 L H.HA.15 AF2 AF2
H.HA 100 K H.HA.16 AF2 AF2
H.HA 101 E H.HA.17 AF2 AF2
H.HA 102 A H.HA.18 AF2 AF2
H.HA 103 I H.HA.19 AF2 AF2
H.HA 104 E H.HA.20 AF2 AF2
H.HA 105 T H.HA.21 AF2 AF2
H.HA 106 I H.HA.22 AF2 AF2
H.HA 107 V H.HA.23 AF2 AF2
H.HA 108 A H.HA.24 AF2 AF2
H.HA 109 A H.HA.25 AF2 AF2
H.HA 110 M H.HA.26 AF2 AF2
H.HA 111 S H.HA.27 AF2 AF2
H.HA 112 N H.HA.28 AF2 AF2
H.HA 113 L H.HA.29 AF2 AF2
H.hahb 114 V H.hahb.01 AF2 AF2
H.hahb 115 P H.hahb.02 AF2 AF2
H.hahb 116 P H.hahb.03 AF2 AF2
H.hahb 117 V H.hahb.04 AF2 AF2
H.hahb 118 E H.hahb.05 AF2 AF2
H.hahb 119 L H.hahb.06 AF2 AF2
H.hahb 120 A H.hahb.07 AF2 AF2
H.hahb 121 N H.hahb.08 AF2 AF2
H.hahb 122 P H.hahb.09 AF2 AF2
H.HB 123 E H.HB.01 AF2 AF2
H.HB 124 N H.HB.02 AF2 AF2
H.HB 125 Q H.HB.03 AF2 AF2
H.HB 126 F H.HB.04 AF2 AF2
H.HB 127 R H.HB.05 AF2 AF2
H.HB 128 V H.HB.06 AF2 AF2
H.HB 129 D H.HB.07 AF2 AF2
H.HB 130 Y H.HB.08 AF2 AF2
H.HB 131 I H.HB.09 AF2 AF2
H.HB 132 L H.HB.10 AF2 AF2
H.HB 133 S H.HB.11 AF2 AF2
H.HB 134 V H.HB.12 AF2 AF2
H.HB 135 M H.HB.13 AF2 AF2
H.HB 136 N H.HB.14 AF2 AF2
H.hbhc 137 V H.hbhc.01 AF2 AF2
H.hbhc 138 P H.hbhc.02 AF2 AF2
H.hbhc 139 D H.hbhc.03 AF2 AF2
H.hbhc 140 F H.hbhc.04 AF2 AF2
H.hbhc 141 D H.hbhc.13 AF2 AF2
H.hbhc 142 F H.hbhc.14 AF2 AF2
H.hbhc 143 P H.hbhc.15 AF2 AF2
H.HC 144 P H.HC.01 AF2 AF2
H.HC 145 E H.HC.02 AF2 AF2
H.HC 146 F H.HC.03 AF2 AF2
H.HC 147 Y H.HC.04 AF2 AF2
H.HC 148 E H.HC.05 AF2 AF2
H.HC 149 H H.HC.06 AF2 AF2
H.HC 150 A H.HC.07 AF2 AF2
H.HC 151 K H.HC.08 AF2 AF2
H.HC 152 A H.HC.09 AF2 AF2
H.HC 153 L H.HC.10 AF2 AF2
H.HC 154 W H.HC.11 AF2 AF2
H.HC 155 E H.HC.12 AF2 AF2
H.hchd 156 D H.hchd.01 AF2 AF2
H.HD 157 E H.HD.01 AF2 AF2
H.HD 158 G H.HD.02 AF2 AF2
H.HD 159 V H.HD.03 AF2 AF2
H.HD 160 R H.HD.04 AF2 AF2
H.HD 161 A H.HD.05 AF2 AF2
H.HD 162 C H.HD.06 AF2 AF2
H.HD 163 Y H.HD.07 AF2 AF2
H.HD 164 E H.HD.08 AF2 AF2
H.HD 165 R H.HD.09 AF2 AF2
H.HD 166 S H.HD.10 AF2 AF2
H.HD 167 N H.HD.11 AF2 AF2
H.HD 168 E H.HD.12 AF2 AF2
H.hdhe 169 Y H.hdhe.01 AF2 AF2
H.hdhe 170 Q H.hdhe.02 AF2 AF2
H.hdhe 171 L H.hdhe.03 AF2 AF2
H.hdhe 172 I H.hdhe.04 AF2 AF2
H.hdhe 173 D H.hdhe.05 AF2 AF2
H.HE 174 C H.HE.01 AF2 AF2
H.HE 175 A H.HE.02 AF2 AF2
H.HE 176 Q H.HE.03 AF2 AF2
H.HE 177 Y H.HE.04 AF2 AF2
H.HE 178 F H.HE.05 AF2 AF2
H.HE 179 L H.HE.06 AF2 AF2
H.HE 180 D H.HE.07 AF2 AF2
H.HE 181 K H.HE.08 AF2 AF2
H.HE 182 I H.HE.09 AF2 AF2
H.HE 183 D H.HE.10 AF2 AF2
H.HE 184 V H.HE.11 AF2 AF2
H.HE 185 I H.HE.12 AF2 AF2
H.HE 186 K H.HE.13 AF2 AF2
H.hehf 187 Q H.hehf.01 AF2 AF2
H.hehf 188 A H.hehf.02 AF2 AF2
H.hehf 189 D H.hehf.03 AF2 AF2
H.hehf 190 Y H.hehf.04 AF2 AF2
H.hehf 191 V H.hehf.05 AF2 AF2
H.hehf 192 P H.hehf.06 AF2 AF2
H.hehf 193 S H.hehf.07 AF2 AF2
H.HF 194 D H.HF.01 AF2 AF2
H.HF 195 Q H.HF.02 AF2 AF2
H.HF 196 D H.HF.03 AF2 AF2
H.HF 197 L H.HF.04 AF2 AF2
H.HF 198 L H.HF.05 AF2 AF2
H.HF 199 R H.HF.06 AF2 AF2
G.hfs2 200 C G.hfs2.01 AF2 AF2
G.hfs2 201 R G.hfs2.02 AF2 AF2
G.hfs2 202 V G.hfs2.03 AF2 AF2
G.hfs2 203 L G.hfs2.04 AF2 AF2
G.hfs2 204 T G.hfs2.05 AF2 AF2
G.hfs2 205 S G.hfs2.06 Structure Structure
G.hfs2 206 G G.hfs2.07 Structure Structure
G.S2 207 I G.S2.01 Structure Structure
G.S2 208 F G.S2.02 Structure Structure
G.S2 209 E G.S2.03 Structure Structure
G.S2 210 T G.S2.04 Structure Structure
G.S2 211 K G.S2.05 Structure Structure
G.S2 212 F G.S2.06 Structure Structure
G.S2 213 Q G.S2.07 Structure Structure
G.S2 214 V G.S2.08 Structure Structure
G.s2s3 215 D G.s2s3.01 Structure Structure
G.s2s3 216 K G.s2s3.02 Structure Structure
G.S3 217 V G.S3.01 Structure Structure
G.S3 218 N G.S3.02 Structure Structure
G.S3 219 F G.S3.03 Structure Structure
G.S3 220 H G.S3.04 Structure Structure
G.S3 221 M G.S3.05 Structure Structure
G.S3 222 F G.S3.06 Structure Structure
G.S3 223 D G.S3.07 Structure Structure
G.S3 224 V G.S3.08 Structure Structure
G.s3h2 225 G G.s3h2.01 Structure Structure
G.s3h2 226 G G.s3h2.02 Structure AF2
G.s3h2 227 Q G.s3h2.03 Structure Structure
G.H2 228 R G.H2.01 Structure Structure
G.H2 229 D G.H2.02 Structure Structure
G.H2 230 E G.H2.03 Structure Structure
G.H2 231 R G.H2.04 Structure Structure
G.H2 232 R G.H2.05 Structure Structure
G.H2 233 K G.H2.06 Structure Structure
G.H2 234 W G.H2.07 Structure Structure
G.H2 235 I G.H2.08 Structure Structure
G.H2 236 Q G.H2.09 Structure Structure
G.H2 237 C G.H2.10 Structure Structure
G.h2s4 238 F G.h2s4.01 Structure Structure
G.h2s4 239 N G.h2s4.02 Structure Structure
G.h2s4 240 D G.h2s4.03 Structure Structure
G.h2s4 241 V G.h2s4.04 Structure Structure
G.h2s4 242 T G.h2s4.05 Structure Structure
G.S4 243 A G.S4.01 Structure Structure
G.S4 244 I G.S4.02 Structure Structure
G.S4 245 I G.S4.03 Structure Structure
G.S4 246 F G.S4.04 Structure Structure
G.S4 247 V G.S4.05 Structure Structure
G.S4 248 V G.S4.06 Structure Structure
G.S4 249 A G.S4.07 Structure Structure
G.s4h3 250 S G.s4h3.01 Structure Structure
G.s4h3 251 S G.s4h3.02 Structure Structure
G.s4h3 252 S G.s4h3.03 AF2 AF2
G.s4h3 253 Y G.s4h3.04 AF2 AF2
G.s4h3 254 N G.s4h3.05 AF2 AF2
G.s4h3 255 M G.s4h3.06 AF2 AF2
G.s4h3 256 V G.s4h3.07 AF2 AF2
G.s4h3 257 I G.s4h3.08 AF2 AF2
G.s4h3 258 R G.s4h3.09 AF2 AF2
G.s4h3 259 E G.s4h3.10 AF2 AF2
G.s4h3 260 D G.s4h3.11 AF2 AF2
G.s4h3 261 N G.s4h3.12 AF2 AF2
G.s4h3 262 Q G.s4h3.13 AF2 AF2
G.s4h3 263 T G.s4h3.14 AF2 AF2
G.s4h3 264 N G.s4h3.15 Structure Structure
G.H3 265 R G.H3.01 Structure Structure
G.H3 266 L G.H3.02 Structure Structure
G.H3 267 Q G.H3.03 Structure Structure
G.H3 268 E G.H3.04 Structure AF2
G.H3 269 A G.H3.05 Structure Structure
G.H3 270 L G.H3.06 Structure Structure
G.H3 271 N G.H3.07 Structure AF2
G.H3 272 L G.H3.08 Structure Structure
G.H3 273 F G.H3.09 Structure Structure
G.H3 274 K G.H3.10 Structure AF2
G.H3 275 S G.H3.11 Structure Structure
G.H3 276 I G.H3.12 Structure Structure
G.H3 277 W G.H3.13 Structure Structure
G.H3 278 N G.H3.14 Structure Structure
G.H3 279 N G.H3.15 Structure Structure
G.H3 280 R G.H3.16 Structure AF2
G.H3 281 W G.H3.17 Structure Structure
G.H3 282 L G.H3.18 Structure Structure
G.h3s5 283 R G.h3s5.01 Structure Structure
G.h3s5 284 T G.h3s5.02 Structure AF2
G.h3s5 285 I G.h3s5.03 Structure AF2
G.S5 286 S G.S5.01 Structure Structure
G.S5 287 V G.S5.02 Structure Structure
G.S5 288 I G.S5.03 Structure Structure
G.S5 289 L G.S5.04 Structure Structure
G.S5 290 F G.S5.05 Structure Structure
G.S5 291 L G.S5.06 Structure Structure
G.S5 292 N G.S5.07 Structure Structure
G.s5hg 293 K G.s5hg.01 Structure Structure
G.HG 294 Q G.HG.01 Structure Structure
G.HG 295 D G.HG.02 Structure Structure
G.HG 296 L G.HG.03 Structure Structure
G.HG 297 L G.HG.04 Structure Structure
G.HG 298 A G.HG.05 Structure Structure
G.HG 299 E G.HG.06 Structure Structure
G.HG 300 K G.HG.07 Structure Structure
G.HG 301 V G.HG.08 Structure Structure
G.HG 302 L G.HG.09 Structure Structure
G.HG 303 A G.HG.10 Structure Structure
G.HG 304 G G.HG.11 Structure Structure
G.HG 305 K G.HG.12 AF2 AF2
G.HG 306 S G.HG.13 AF2 AF2
G.HG 307 K G.HG.14 Structure Structure
G.HG 308 I G.HG.15 Structure Structure
G.HG 309 E G.HG.16 Structure Structure
G.HG 310 D G.HG.17 Structure Structure
G.hgh4 311 Y G.hgh4.01 Structure Structure
G.hgh4 312 F G.hgh4.02 Structure Structure
G.hgh4 313 P G.hgh4.03 Structure Structure
G.hgh4 314 E G.hgh4.04 Structure Structure
G.hgh4 315 F G.hgh4.05 Structure Structure
G.hgh4 316 A G.hgh4.06 Structure Structure
G.hgh4 317 R G.hgh4.07 Structure Structure
G.hgh4 318 Y G.hgh4.08 Structure Structure
G.hgh4 319 T G.hgh4.09 Structure Structure
G.hgh4 320 T G.hgh4.10 Structure Structure
G.hgh4 321 P G.hgh4.11 Structure Structure
G.hgh4 322 E G.hgh4.12 Structure Structure
G.hgh4 323 D G.hgh4.13 Structure Structure
G.hgh4 324 A G.hgh4.14 Structure Structure
G.hgh4 325 T G.hgh4.15 Structure Structure
G.hgh4 326 P G.hgh4.16 Structure Structure
G.hgh4 327 E G.hgh4.17 Structure Structure
G.hgh4 328 P G.hgh4.18 Structure Structure
G.hgh4 329 G G.hgh4.19 Structure Structure
G.hgh4 330 E G.hgh4.20 AF2 AF2
G.hgh4 331 D G.hgh4.21 Structure Structure
G.H4 332 P G.H4.01 Structure Structure
G.H4 333 R G.H4.02 Structure Structure
G.H4 334 V G.H4.03 Structure Structure
G.H4 335 T G.H4.04 Structure Structure
G.H4 336 R G.H4.05 Structure Structure
G.H4 337 A G.H4.06 Structure Structure
G.H4 338 K G.H4.07 Structure Structure
G.H4 339 Y G.H4.08 Structure Structure
G.H4 340 F G.H4.10 Structure Structure
G.H4 341 I G.H4.11 Structure Structure
G.H4 342 R G.H4.12 Structure Structure
G.H4 343 D G.H4.13 Structure Structure
G.H4 344 E G.H4.14 Structure Structure
G.H4 345 F G.H4.15 Structure Structure
G.H4 346 L G.H4.16 Structure Structure
G.H4 347 R G.H4.17 Structure Structure
G.h4s6 348 I G.h4s6.01 Structure Structure
G.h4s6 349 S G.h4s6.02 Structure Structure
G.h4s6 350 T G.h4s6.03 Structure Structure
G.h4s6 351 A G.h4s6.04 Structure Structure
G.h4s6 352 S G.h4s6.08 Structure Structure
G.h4s6 353 G G.h4s6.09 Structure Structure
G.h4s6 354 D G.h4s6.10 Structure Structure
G.h4s6 355 G G.h4s6.11 Structure Structure
G.h4s6 356 R G.h4s6.12 Structure Structure
G.h4s6 357 H G.h4s6.13 Structure Structure
G.h4s6 358 Y G.h4s6.20 Structure Structure
G.S6 359 C G.S6.01 Structure Structure
G.S6 360 Y G.S6.02 Structure Structure
G.S6 361 P G.S6.03 Structure Structure
G.S6 362 H G.S6.04 Structure Structure
G.S6 363 F G.S6.05 Structure Structure
G.s6h5 364 T G.s6h5.01 Structure Structure
G.s6h5 365 C G.s6h5.02 Structure Structure
G.s6h5 366 A G.s6h5.03 Structure Structure
G.s6h5 367 V G.s6h5.04 Structure Structure
G.s6h5 368 D G.s6h5.05 Structure Structure
G.H5 369 T G.H5.01 Structure Structure
G.H5 370 E G.H5.02 Structure Structure
G.H5 371 N G.H5.03 Structure Structure
G.H5 372 I G.H5.04 Structure Structure
G.H5 373 R G.H5.05 Structure Structure
G.H5 374 R G.H5.06 Structure Structure
G.H5 375 V G.H5.07 Structure Structure
G.H5 376 F G.H5.08 Structure Structure
G.H5 377 N G.H5.09 Structure Structure
G.H5 378 D G.H5.10 Structure Structure
G.H5 379 C G.H5.11 Structure Structure
G.H5 380 R G.H5.12 Structure Structure
G.H5 381 D G.H5.13 Structure Structure
G.H5 382 I G.H5.14 Structure Structure
G.H5 383 I G.H5.15 Structure Structure
G.H5 384 Q G.H5.16 Structure Structure
G.H5 385 R G.H5.17 Structure Structure
G.H5 386 M G.H5.18 Structure Structure
G.H5 387 H G.H5.19 Structure Structure
G.H5 388 L G.H5.20 Structure Structure
G.H5 389 R G.H5.21 Structure Structure
G.H5 390 Q G.H5.22 Structure Structure
G.H5 391 Y G.H5.23 Structure Structure
G.H5 392 E G.H5.24 Structure Structure
G.H5 393 L G.H5.25 Structure Structure
G.H5 394 L G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 258 from structure (78.9%), 69 from model (21.1%)
Residue sidechains - 258 from structure (78.9%), 69 from model (21.1%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 N - AF2 AF2
N-term 3 E - AF2 AF2
N-term 4 D - AF2 AF2
N-term 5 L - AF2 AF2
N-term 6 K - AF2 AF2
N-term 7 V - AF2 AF2
N-term 8 N - AF2 AF2
N-term 9 L - AF2 AF2
N-term 10 S - AF2 AF2
N-term 11 G - AF2 AF2
N-term 12 L - AF2 AF2
N-term 13 P - AF2 AF2
N-term 14 R - AF2 AF2
N-term 15 D - AF2 AF2
N-term 16 Y - AF2 AF2
N-term 17 L - AF2 AF2
N-term 18 D - AF2 AF2
N-term 19 A - AF2 AF2
N-term 20 A - AF2 AF2
N-term 21 A - AF2 AF2
N-term 22 A - AF2 AF2
N-term 23 E - AF2 AF2
N-term 24 N - AF2 AF2
N-term 25 I - AF2 AF2
N-term 26 S - AF2 AF2
N-term 27 A - AF2 AF2
N-term 28 A - AF2 AF2
N-term 29 V - AF2 AF2
N-term 30 S - AF2 AF2
N-term 31 S - AF2 AF2
N-term 32 R - AF2 AF2
N-term 33 V - AF2 AF2
N-term 34 P - AF2 AF2
N-term 35 A - AF2 AF2
N-term 36 V - AF2 AF2
N-term 37 E - AF2 AF2
N-term 38 P - AF2 AF2
N-term 39 E - AF2 AF2
N-term 40 P - AF2 AF2
N-term 41 E - AF2 AF2
TM1 42 L 1.30x30 AF2 AF2
TM1 43 V 1.31x31 AF2 AF2
TM1 44 V 1.32x32 AF2 AF2
TM1 45 N 1.33x33 AF2 AF2
TM1 46 P 1.34x34 Structure Structure
TM1 47 W 1.35x35 Structure Structure
TM1 48 D 1.36x36 Structure Structure
TM1 49 I 1.37x37 Structure Structure
TM1 50 V 1.38x38 Structure Structure
TM1 51 L 1.39x39 Structure Structure
TM1 52 C 1.40x40 Structure Structure
TM1 53 T 1.41x41 Structure Structure
TM1 54 S 1.42x42 Structure Structure
TM1 55 G 1.43x43 Structure Structure
TM1 56 T 1.44x44 Structure Structure
TM1 57 L 1.45x45 Structure Structure
TM1 58 I 1.46x46 Structure Structure
TM1 59 S 1.47x47 Structure Structure
TM1 60 C 1.48x48 Structure Structure
TM1 61 E 1.49x49 Structure Structure
TM1 62 N 1.50x50 Structure Structure
TM1 63 A 1.51x51 Structure Structure
TM1 64 I 1.52x52 Structure Structure
TM1 65 V 1.53x53 Structure Structure
TM1 66 V 1.54x54 Structure Structure
TM1 67 L 1.55x55 Structure Structure
TM1 68 I 1.56x56 Structure Structure
TM1 69 I 1.57x57 Structure Structure
TM1 70 F 1.58x58 Structure Structure
TM1 71 H 1.59x59 Structure Structure
TM1 72 N 1.60x60 Structure Structure
ICL1 73 P 12.48x48 Structure Structure
ICL1 74 S 12.49x49 Structure Structure
ICL1 75 L 12.50x50 Structure Structure
ICL1 76 R 12.51x51 Structure Structure
TM2 77 A 2.37x37 Structure Structure
TM2 78 P 2.38x38 Structure Structure
TM2 79 M 2.39x39 Structure Structure
TM2 80 F 2.40x40 Structure Structure
TM2 81 L 2.41x41 Structure Structure
TM2 82 L 2.42x42 Structure Structure
TM2 83 I 2.43x43 Structure Structure
TM2 84 G 2.44x44 Structure Structure
TM2 85 S 2.45x45 Structure Structure
TM2 86 L 2.46x46 Structure Structure
TM2 87 A 2.47x47 Structure Structure
TM2 88 L 2.48x48 Structure Structure
TM2 89 A 2.49x49 Structure Structure
TM2 90 D 2.50x50 Structure Structure
TM2 91 L 2.51x51 Structure Structure
TM2 92 L 2.52x52 Structure Structure
TM2 93 A 2.53x53 Structure Structure
TM2 94 G 2.54x54 Structure Structure
TM2 95 I 2.55x55 Structure Structure
TM2 96 G 2.56x56 Structure Structure
TM2 97 L 2.57x57 Structure Structure
TM2 98 I 2.58x58 Structure Structure
TM2 99 T 2.59x59 Structure Structure
TM2 100 N 2.60x60 Structure Structure
TM2 101 F 2.61x61 Structure Structure
TM2 102 V 2.62x62 Structure Structure
TM2 103 F 2.63x63 Structure Structure
TM2 104 A 2.64x64 Structure Structure
TM2 105 Y 2.65x65 Structure Structure
TM2 106 L 2.66x66 Structure Structure
TM2 107 L 2.67x67 Structure Structure
ECL1 108 Q - Structure Structure
ECL1 109 S - Structure Structure
ECL1 110 E - Structure Structure
ECL1 111 A - Structure Structure
TM3 112 T 3.24x24 Structure Structure
TM3 113 K 3.25x25 Structure Structure
TM3 114 L 3.26x26 Structure Structure
TM3 115 V 3.27x27 Structure Structure
TM3 116 T 3.28x28 Structure Structure
TM3 117 I 3.29x29 Structure Structure
TM3 118 G 3.30x30 Structure Structure
TM3 119 L 3.31x31 Structure Structure
TM3 120 I 3.32x32 Structure Structure
TM3 121 V 3.33x33 Structure Structure
TM3 122 A 3.34x34 Structure Structure
TM3 123 S 3.35x35 Structure Structure
TM3 124 F 3.36x36 Structure Structure
TM3 125 S 3.37x37 Structure Structure
TM3 126 A 3.38x38 Structure Structure
TM3 127 S 3.39x39 Structure Structure
TM3 128 V 3.40x40 Structure Structure
TM3 129 C 3.41x41 Structure Structure
TM3 130 S 3.42x42 Structure Structure
TM3 131 L 3.43x43 Structure Structure
TM3 132 L 3.44x44 Structure Structure
TM3 133 A 3.45x45 Structure Structure
TM3 134 I 3.46x46 Structure Structure
TM3 135 T 3.47x47 Structure Structure
TM3 136 V 3.48x48 Structure Structure
TM3 137 D 3.49x49 Structure Structure
TM3 138 R 3.50x50 Structure Structure
TM3 139 Y 3.51x51 Structure Structure
TM3 140 L 3.52x52 Structure Structure
TM3 141 S 3.53x53 Structure Structure
TM3 142 L 3.54x54 Structure Structure
TM3 143 Y 3.55x55 Structure Structure
TM3 144 Y 3.56x56 Structure Structure
ICL2 145 A 34.50x50 Structure Structure
ICL2 146 L 34.51x51 Structure Structure
ICL2 147 T 34.52x52 Structure Structure
ICL2 148 Y 34.53x53 Structure Structure
ICL2 149 H - Structure Structure
ICL2 150 S - Structure Structure
ICL2 151 E - Structure Structure
ICL2 152 R - Structure Structure
TM4 153 T 4.38x38 Structure Structure
TM4 154 V 4.39x39 Structure Structure
TM4 155 T 4.40x40 Structure Structure
TM4 156 F 4.41x41 Structure Structure
TM4 157 T 4.42x42 Structure Structure
TM4 158 Y 4.43x43 Structure Structure
TM4 159 V 4.44x44 Structure Structure
TM4 160 M 4.45x45 Structure Structure
TM4 161 L 4.46x46 Structure Structure
TM4 162 V 4.47x47 Structure Structure
TM4 163 M 4.48x48 Structure Structure
TM4 164 L 4.49x49 Structure Structure
TM4 165 W 4.50x50 Structure Structure
TM4 166 G 4.51x51 Structure Structure
TM4 167 T 4.52x52 Structure Structure
TM4 168 S 4.53x53 Structure Structure
TM4 169 I 4.54x54 Structure Structure
TM4 170 C 4.55x55 Structure Structure
TM4 171 L 4.56x56 Structure Structure
TM4 172 G 4.57x57 Structure Structure
TM4 173 L 4.58x58 Structure Structure
TM4 174 L 4.59x59 Structure Structure
TM4 175 P 4.60x60 Structure Structure
TM4 176 V 4.61x61 Structure Structure
TM4 177 M 4.62x62 Structure Structure
TM4 178 G 4.63x63 Structure Structure
ECL2 179 W - Structure Structure
ECL2 180 N - Structure Structure
ECL2 181 C - Structure Structure
ECL2 182 L - Structure Structure
ECL2 183 R - Structure Structure
ECL2 184 D - Structure Structure
ECL2 185 E - Structure Structure
ECL2 186 S - Structure Structure
ECL2 187 T - Structure Structure
ECL2 188 C - Structure Structure
ECL2 189 S - Structure Structure
ECL2 190 V - Structure Structure
ECL2 191 V - Structure Structure
ECL2 192 R - Structure Structure
ECL2 193 P - Structure Structure
TM5 194 L 5.35x35 Structure Structure
TM5 195 T 5.36x36 Structure Structure
TM5 196 K 5.37x37 Structure Structure
TM5 197 N 5.38x38 Structure Structure
TM5 198 N 5.39x39 Structure Structure
TM5 199 A 5.40x40 Structure Structure
TM5 200 A 5.41x41 Structure Structure
TM5 201 I 5.42x42 Structure Structure
TM5 202 L 5.43x43 Structure Structure
TM5 203 S 5.44x44 Structure Structure
TM5 204 V 5.45x45 Structure Structure
TM5 205 S 5.46x46 Structure Structure
TM5 206 F 5.47x47 Structure Structure
TM5 207 L 5.48x48 Structure Structure
TM5 208 F 5.49x49 Structure Structure
TM5 209 M 5.50x50 Structure Structure
TM5 210 F 5.51x51 Structure Structure
TM5 211 A 5.52x52 Structure Structure
TM5 212 L 5.53x53 Structure Structure
TM5 213 M 5.54x54 Structure Structure
TM5 214 L 5.55x55 Structure Structure
TM5 215 Q 5.56x56 Structure Structure
TM5 216 L 5.57x57 Structure Structure
TM5 217 Y 5.58x58 Structure Structure
TM5 218 I 5.59x59 Structure Structure
TM5 219 Q 5.60x60 Structure Structure
TM5 220 I 5.61x61 Structure Structure
TM5 221 C 5.62x62 Structure Structure
TM5 222 K 5.63x63 Structure Structure
TM5 223 I 5.64x64 Structure Structure
TM5 224 V 5.65x65 Structure Structure
TM5 225 M 5.66x66 Structure Structure
TM5 226 R 5.67x67 Structure Structure
TM5 227 H 5.68x68 Structure Structure
TM5 228 A 5.69x69 Structure Structure
TM5 229 H 5.70x70 Structure Structure
TM5 230 Q 5.71x71 Structure Structure
TM5 231 I 5.72x72 Structure Structure
TM5 232 A 5.73x73 Structure Structure
TM5 233 L 5.74x74 Structure Structure
TM5 234 Q 5.75x75 Structure Structure
TM5 235 H 5.76x76 Structure Structure
TM5 236 H 5.77x77 Structure Structure
ICL3 237 F - Structure Structure
ICL3 238 L - AF2 AF2
ICL3 239 A - AF2 AF2
TM6 240 T 6.24x24 AF2 AF2
TM6 241 S 6.25x25 AF2 AF2
TM6 242 H 6.26x26 AF2 AF2
TM6 243 Y 6.27x27 AF2 AF2
TM6 244 V 6.28x28 AF2 AF2
TM6 245 T 6.29x29 AF2 AF2
TM6 246 T 6.30x30 Structure Structure
TM6 247 R 6.31x31 Structure Structure
TM6 248 K 6.32x32 Structure Structure
TM6 249 G 6.33x33 Structure Structure
TM6 250 V 6.34x34 Structure Structure
TM6 251 S 6.35x35 Structure Structure
TM6 252 T 6.36x36 Structure Structure
TM6 253 L 6.37x37 Structure Structure
TM6 254 A 6.38x38 Structure Structure
TM6 255 I 6.39x39 Structure Structure
TM6 256 I 6.40x40 Structure Structure
TM6 257 L 6.41x41 Structure Structure
TM6 258 G 6.42x42 Structure Structure
TM6 259 T 6.43x43 Structure Structure
TM6 260 F 6.44x44 Structure Structure
TM6 261 A 6.45x45 Structure Structure
TM6 262 A 6.46x46 Structure Structure
TM6 263 C 6.47x47 Structure Structure
TM6 264 W 6.48x48 Structure Structure
TM6 265 M 6.49x49 Structure Structure
TM6 266 P 6.50x50 Structure Structure
TM6 267 F 6.51x51 Structure Structure
TM6 268 T 6.52x52 Structure Structure
TM6 269 L 6.53x53 Structure Structure
TM6 270 Y 6.54x54 Structure Structure
TM6 271 S 6.55x55 Structure Structure
TM6 272 L 6.56x56 Structure Structure
TM6 273 I 6.57x57 Structure Structure
TM6 274 A 6.58x58 Structure Structure
ECL3 275 D - Structure Structure
ECL3 276 Y - Structure Structure
ECL3 277 T - Structure Structure
ECL3 278 Y - Structure Structure
ECL3 279 P - Structure Structure
TM7 280 S 7.32x31 Structure Structure
TM7 281 I 7.33x32 Structure Structure
TM7 282 Y 7.34x33 Structure Structure
TM7 283 T 7.35x34 Structure Structure
TM7 284 Y 7.36x35 Structure Structure
TM7 285 A 7.37x36 Structure Structure
TM7 286 T 7.38x37 Structure Structure
TM7 287 L 7.39x38 Structure Structure
TM7 288 L 7.40x39 Structure Structure
TM7 289 P 7.41x40 Structure Structure
TM7 290 A 7.42x41 Structure Structure
TM7 291 T 7.43x42 Structure Structure
TM7 292 Y 7.44x43 Structure Structure
TM7 293 N 7.45x45 Structure Structure
TM7 294 S 7.46x46 Structure Structure
TM7 295 I 7.47x47 Structure Structure
TM7 296 I 7.48x48 Structure Structure
TM7 297 N 7.49x49 Structure Structure
TM7 298 P 7.50x50 Structure Structure
TM7 299 V 7.51x51 Structure Structure
TM7 300 I 7.52x52 Structure Structure
TM7 301 Y 7.53x53 Structure Structure
TM7 302 A 7.54x54 Structure Structure
TM7 303 F 7.55x55 Structure Structure
TM7 304 R 7.56x56 Structure Structure
H8 305 N 8.47x47 Structure Structure
H8 306 Q 8.48x48 Structure Structure
H8 307 E 8.49x49 Structure Structure
H8 308 I 8.50x50 Structure Structure
H8 309 Q 8.51x51 Structure Structure
H8 310 K 8.52x52 Structure Structure
H8 311 A 8.53x53 Structure Structure
H8 312 L 8.54x54 AF2 AF2
H8 313 C 8.55x55 AF2 AF2
H8 314 L 8.56x56 AF2 AF2
H8 315 I 8.57x57 AF2 AF2
H8 316 C 8.58x58 AF2 AF2
H8 317 C 8.59x59 AF2 AF2
C-term 318 G - AF2 AF2
C-term 319 C - AF2 AF2
C-term 320 I - AF2 AF2
C-term 321 P - AF2 AF2
C-term 322 S - AF2 AF2
C-term 323 S - AF2 AF2
C-term 324 L - AF2 AF2
C-term 325 A - AF2 AF2
C-term 326 Q - AF2 AF2
C-term 327 R - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Aromatic TM3 R 138 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 138 3x50 G.H5 Y 391 G.H5.23
Polar TM5 Q 234 5x75 G.S6 C 359 G.S6.01
Van-der-waals TM5 Q 234 5x75 G.S6 C 359 G.S6.01
Ionic TM5 H 227 5x68 G.H5 D 381 G.H5.13
Hydrophobic TM5 H 227 5x68 G.H5 D 381 G.H5.13
Van-der-waals TM5 H 227 5x68 G.H5 D 381 G.H5.13
Hydrophobic TM5 H 227 5x68 G.H5 L 388 G.H5.20
Hydrophobic TM5 Q 234 5x75 G.H4 L 346 G.H4.16
Polar TM6 G 249 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM6 G 249 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 G 249 6x33 G.H5 L 393 G.H5.25
Polar ICL2 S 150 - G.HN Q 35 G.HN.52
Van-der-waals ICL2 S 150 - G.HN Q 35 G.HN.52
Hydrophobic ICL2 L 146 34x51 G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 146 34x51 G.S1 H 41 G.S1.02
Hydrophobic TM2 M 79 2x39 G.H5 Y 391 G.H5.23
Hydrophobic ICL3 F 237 - G.H4 D 343 G.H4.13
Van-der-waals ICL3 F 237 - G.H4 D 343 G.H4.13
Hydrophobic ICL2 L 146 34x51 G.H5 C 379 G.H5.11
Hydrophobic TM5 I 220 5x61 G.H5 L 393 G.H5.25
Hydrophobic ICL2 A 145 34x50 G.H5 R 380 G.H5.12
Polar TM3 S 141 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 S 141 3x53 G.H5 Y 391 G.H5.23
Ionic TM5 R 226 5x67 G.H5 D 381 G.H5.13
Polar TM3 S 141 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 S 141 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 S 141 3x53 G.H5 H 387 G.H5.19
Hydrophobic ICL3 L 238 - G.h4s6 T 350 G.h4s6.03
Van-der-waals ICL3 L 238 - G.h4s6 T 350 G.h4s6.03
Polar TM6 K 248 6x32 G.H5 L 394 G.H5.26
Hydrophobic TM6 K 248 6x32 G.H5 L 394 G.H5.26
Polar TM5 H 227 5x68 G.H5 R 385 G.H5.17
Hydrophobic TM5 H 227 5x68 G.H5 R 385 G.H5.17
Van-der-waals TM5 H 227 5x68 G.H5 R 385 G.H5.17
Polar TM5 R 226 5x67 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 A 145 34x50 G.H5 Q 384 G.H5.16
Hydrophobic TM5 I 231 5x72 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM5 I 231 5x72 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM5 V 224 5x65 G.H5 L 388 G.H5.20
Van-der-waals TM5 V 224 5x65 G.H5 L 388 G.H5.20
Hydrophobic TM6 T 245 6x29 G.H5 L 394 G.H5.26
Van-der-waals TM6 T 245 6x29 G.H5 L 394 G.H5.26
Hydrophobic TM6 T 252 6x36 G.H5 L 393 G.H5.25
Hydrophobic TM5 H 227 5x68 G.H5 L 394 G.H5.26
Aromatic ICL2 H 149 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 H 149 - G.hns1 R 38 G.hns1.02
Ionic TM7 R 304 7x56 G.H5 E 392 G.H5.24
Hydrophobic TM7 R 304 7x56 G.H5 E 392 G.H5.24
Van-der-waals TM7 R 304 7x56 G.H5 E 392 G.H5.24
Hydrophobic ICL2 L 146 34x51 G.S3 V 217 G.S3.01
Polar TM5 H 227 5x68 G.H5 Q 384 G.H5.16
Van-der-waals TM5 H 227 5x68 G.H5 Q 384 G.H5.16
Polar TM5 Q 230 5x71 G.H5 R 385 G.H5.17
Hydrophobic TM6 K 248 6x32 G.H5 E 392 G.H5.24
Hydrophobic TM3 L 142 3x54 G.H5 L 388 G.H5.20
Polar TM6 T 252 6x36 G.H5 E 392 G.H5.24
Hydrophobic ICL2 L 146 34x51 G.H5 R 380 G.H5.12
Hydrophobic TM3 L 142 3x54 G.H5 H 387 G.H5.19
Hydrophobic TM5 V 224 5x65 G.H5 L 393 G.H5.25
Hydrophobic ICL2 L 146 34x51 G.H5 F 376 G.H5.08
Van-der-waals ICL2 L 146 34x51 G.H5 F 376 G.H5.08
Hydrophobic TM5 I 231 5x72 G.H5 L 394 G.H5.26
Hydrophobic ICL3 F 237 - G.hgh4 P 321 G.hgh4.11
Hydrophobic ICL2 E 151 - G.hns1 A 39 G.hns1.03
Hydrophobic ICL2 L 146 34x51 G.H5 I 383 G.H5.15
Van-der-waals ICL2 L 146 34x51 G.H5 I 383 G.H5.15
Hydrophobic TM5 A 228 5x69 G.H5 L 394 G.H5.26
Hydrophobic TM6 L 253 6x37 G.H5 L 393 G.H5.25
Van-der-waals TM6 L 253 6x37 G.H5 L 393 G.H5.25
Hydrophobic ICL3 L 238 - G.H4 R 347 G.H4.17
Hydrophobic ICL2 S 150 - G.hns1 R 38 G.hns1.02
Hydrophobic TM5 I 231 5x72 G.H5 R 385 G.H5.17
Polar TM3 L 142 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 L 142 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 L 142 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM5 I 223 5x64 G.H5 L 388 G.H5.20
Hydrophobic ICL2 A 145 34x50 G.H5 I 383 G.H5.15