Refined structure (7EXD) of Gi1 - 5-HT1F receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2024-02-01

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 219 from structure (61.9%), 135 from model (38.1%)
Residue sidechains - 215 from structure (60.7%), 139 from model (39.3%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 AF2 AF2
G.HN 4 T G.HN.10 Structure Structure
G.HN 5 L G.HN.11 Structure Structure
G.HN 6 S G.HN.30 Structure Structure
G.HN 7 A G.HN.31 Structure Structure
G.HN 8 E G.HN.32 Structure Structure
G.HN 9 D G.HN.33 Structure Structure
G.HN 10 K G.HN.34 Structure Structure
G.HN 11 A G.HN.35 Structure Structure
G.HN 12 A G.HN.36 Structure Structure
G.HN 13 V G.HN.37 Structure Structure
G.HN 14 E G.HN.38 Structure Structure
G.HN 15 R G.HN.39 Structure Structure
G.HN 16 S G.HN.40 Structure Structure
G.HN 17 K G.HN.41 Structure Structure
G.HN 18 M G.HN.42 Structure Structure
G.HN 19 I G.HN.43 Structure Structure
G.HN 20 D G.HN.44 Structure Structure
G.HN 21 R G.HN.45 Structure Structure
G.HN 22 N G.HN.46 Structure Structure
G.HN 23 L G.HN.47 Structure Structure
G.HN 24 R G.HN.48 Structure Structure
G.HN 25 E G.HN.49 Structure Structure
G.HN 26 D G.HN.50 Structure Structure
G.HN 27 G G.HN.51 Structure Structure
G.HN 28 E G.HN.52 Structure Structure
G.HN 29 K G.HN.53 Structure Structure
G.hns1 30 A G.hns1.01 Structure Structure
G.hns1 31 A G.hns1.02 Structure Structure
G.hns1 32 R G.hns1.03 Structure Structure
G.S1 33 E G.S1.01 Structure Structure
G.S1 34 V G.S1.02 Structure Structure
G.S1 35 K G.S1.03 Structure Structure
G.S1 36 L G.S1.04 Structure Structure
G.S1 37 L G.S1.05 Structure Structure
G.S1 38 L G.S1.06 Structure Structure
G.S1 39 L G.S1.07 Structure Structure
G.s1h1 40 G G.s1h1.01 Structure Structure
G.s1h1 41 A G.s1h1.02 Structure Structure
G.s1h1 42 G G.s1h1.03 Structure Structure
G.s1h1 43 E G.s1h1.04 Structure Structure
G.s1h1 44 S G.s1h1.05 Structure Structure
G.s1h1 45 G G.s1h1.06 Structure Structure
G.H1 46 K G.H1.01 Structure Structure
G.H1 47 S G.H1.02 Structure AF2
G.H1 48 T G.H1.03 Structure Structure
G.H1 49 I G.H1.04 Structure Structure
G.H1 50 V G.H1.05 Structure Structure
G.H1 51 K G.H1.06 Structure Structure
G.H1 52 Q G.H1.07 Structure Structure
G.H1 53 M G.H1.08 Structure Structure
G.H1 54 K G.H1.09 Structure Structure
G.H1 55 I G.H1.10 Structure Structure
G.H1 56 I G.H1.11 AF2 AF2
G.H1 57 H G.H1.12 AF2 AF2
G.h1ha 58 E G.h1ha.01 AF2 AF2
G.h1ha 59 A G.h1ha.02 AF2 AF2
G.h1ha 60 G G.h1ha.03 AF2 AF2
G.h1ha 61 Y G.h1ha.04 AF2 AF2
G.h1ha 62 S G.h1ha.05 AF2 AF2
H.HA 63 E H.HA.01 AF2 AF2
H.HA 64 E H.HA.02 AF2 AF2
H.HA 65 E H.HA.03 AF2 AF2
H.HA 66 C H.HA.04 AF2 AF2
H.HA 67 K H.HA.05 AF2 AF2
H.HA 68 Q H.HA.06 AF2 AF2
H.HA 69 Y H.HA.07 AF2 AF2
H.HA 70 K H.HA.08 AF2 AF2
H.HA 71 A H.HA.09 AF2 AF2
H.HA 72 V H.HA.10 AF2 AF2
H.HA 73 V H.HA.11 AF2 AF2
H.HA 74 Y H.HA.12 AF2 AF2
H.HA 75 S H.HA.13 AF2 AF2
H.HA 76 N H.HA.14 AF2 AF2
H.HA 77 T H.HA.15 AF2 AF2
H.HA 78 I H.HA.16 AF2 AF2
H.HA 79 Q H.HA.17 AF2 AF2
H.HA 80 S H.HA.18 AF2 AF2
H.HA 81 I H.HA.19 AF2 AF2
H.HA 82 I H.HA.20 AF2 AF2
H.HA 83 A H.HA.21 AF2 AF2
H.HA 84 I H.HA.22 AF2 AF2
H.HA 85 I H.HA.23 AF2 AF2
H.HA 86 R H.HA.24 AF2 AF2
H.HA 87 A H.HA.25 AF2 AF2
H.HA 88 M H.HA.26 AF2 AF2
H.HA 89 G H.HA.27 AF2 AF2
H.HA 90 R H.HA.28 AF2 AF2
H.HA 91 L H.HA.29 AF2 AF2
H.hahb 92 K H.hahb.01 AF2 AF2
H.hahb 93 I H.hahb.04 AF2 AF2
H.hahb 94 D H.hahb.05 AF2 AF2
H.hahb 95 F H.hahb.06 AF2 AF2
H.hahb 96 G H.hahb.07 AF2 AF2
H.hahb 97 D H.hahb.08 AF2 AF2
H.hahb 98 S H.hahb.09 AF2 AF2
H.HB 99 A H.HB.01 AF2 AF2
H.HB 100 R H.HB.02 AF2 AF2
H.HB 101 A H.HB.03 AF2 AF2
H.HB 102 D H.HB.04 AF2 AF2
H.HB 103 D H.HB.05 AF2 AF2
H.HB 104 A H.HB.06 AF2 AF2
H.HB 105 R H.HB.07 AF2 AF2
H.HB 106 Q H.HB.08 AF2 AF2
H.HB 107 L H.HB.09 AF2 AF2
H.HB 108 F H.HB.10 AF2 AF2
H.HB 109 V H.HB.11 AF2 AF2
H.HB 110 L H.HB.12 AF2 AF2
H.HB 111 A H.HB.13 AF2 AF2
H.HB 112 G H.HB.14 AF2 AF2
H.hbhc 113 A H.hbhc.01 AF2 AF2
H.hbhc 114 A H.hbhc.02 AF2 AF2
H.hbhc 115 E H.hbhc.03 AF2 AF2
H.hbhc 116 E H.hbhc.04 AF2 AF2
H.hbhc 117 G H.hbhc.12 AF2 AF2
H.hbhc 118 F H.hbhc.13 AF2 AF2
H.hbhc 119 M H.hbhc.14 AF2 AF2
H.hbhc 120 T H.hbhc.15 AF2 AF2
H.HC 121 A H.HC.01 AF2 AF2
H.HC 122 E H.HC.02 AF2 AF2
H.HC 123 L H.HC.03 AF2 AF2
H.HC 124 A H.HC.04 AF2 AF2
H.HC 125 G H.HC.05 AF2 AF2
H.HC 126 V H.HC.06 AF2 AF2
H.HC 127 I H.HC.07 AF2 AF2
H.HC 128 K H.HC.08 AF2 AF2
H.HC 129 R H.HC.09 AF2 AF2
H.HC 130 L H.HC.10 AF2 AF2
H.HC 131 W H.HC.11 AF2 AF2
H.HC 132 K H.HC.12 AF2 AF2
H.hchd 133 D H.hchd.01 AF2 AF2
H.HD 134 S H.HD.01 AF2 AF2
H.HD 135 G H.HD.02 AF2 AF2
H.HD 136 V H.HD.03 AF2 AF2
H.HD 137 Q H.HD.04 AF2 AF2
H.HD 138 A H.HD.05 AF2 AF2
H.HD 139 C H.HD.06 AF2 AF2
H.HD 140 F H.HD.07 AF2 AF2
H.HD 141 N H.HD.08 AF2 AF2
H.HD 142 R H.HD.09 AF2 AF2
H.HD 143 S H.HD.10 AF2 AF2
H.HD 144 R H.HD.11 AF2 AF2
H.HD 145 E H.HD.12 AF2 AF2
H.hdhe 146 Y H.hdhe.01 AF2 AF2
H.hdhe 147 Q H.hdhe.02 AF2 AF2
H.hdhe 148 L H.hdhe.03 AF2 AF2
H.hdhe 149 N H.hdhe.04 AF2 AF2
H.hdhe 150 D H.hdhe.05 AF2 AF2
H.HE 151 S H.HE.01 AF2 AF2
H.HE 152 A H.HE.02 AF2 AF2
H.HE 153 A H.HE.03 AF2 AF2
H.HE 154 Y H.HE.04 AF2 AF2
H.HE 155 Y H.HE.05 AF2 AF2
H.HE 156 L H.HE.06 AF2 AF2
H.HE 157 N H.HE.07 AF2 AF2
H.HE 158 D H.HE.08 AF2 AF2
H.HE 159 L H.HE.09 AF2 AF2
H.HE 160 D H.HE.10 AF2 AF2
H.HE 161 R H.HE.11 AF2 AF2
H.HE 162 I H.HE.12 AF2 AF2
H.HE 163 A H.HE.13 AF2 AF2
H.hehf 164 Q H.hehf.01 AF2 AF2
H.hehf 165 P H.hehf.02 AF2 AF2
H.hehf 166 N H.hehf.03 AF2 AF2
H.hehf 167 Y H.hehf.04 AF2 AF2
H.hehf 168 I H.hehf.05 AF2 AF2
H.hehf 169 P H.hehf.06 AF2 AF2
H.hehf 170 T H.hehf.07 AF2 AF2
H.HF 171 Q H.HF.01 AF2 AF2
H.HF 172 Q H.HF.02 AF2 AF2
H.HF 173 D H.HF.03 AF2 AF2
H.HF 174 V H.HF.04 AF2 AF2
H.HF 175 L H.HF.05 AF2 AF2
H.HF 176 R H.HF.06 AF2 AF2
G.hfs2 177 T G.hfs2.01 AF2 AF2
G.hfs2 178 R G.hfs2.02 AF2 AF2
G.hfs2 179 V G.hfs2.03 AF2 AF2
G.hfs2 180 K G.hfs2.04 AF2 AF2
G.hfs2 181 T G.hfs2.05 AF2 AF2
G.hfs2 182 T G.hfs2.06 Structure Structure
G.hfs2 183 G G.hfs2.07 Structure Structure
G.S2 184 I G.S2.01 Structure Structure
G.S2 185 V G.S2.02 Structure Structure
G.S2 186 E G.S2.03 Structure Structure
G.S2 187 T G.S2.04 Structure Structure
G.S2 188 H G.S2.05 Structure Structure
G.S2 189 F G.S2.06 Structure Structure
G.S2 190 T G.S2.07 Structure Structure
G.S2 191 F G.S2.08 Structure Structure
G.s2s3 192 K G.s2s3.01 Structure Structure
G.s2s3 193 D G.s2s3.02 Structure Structure
G.S3 194 L G.S3.01 Structure Structure
G.S3 195 H G.S3.02 Structure Structure
G.S3 196 F G.S3.03 Structure Structure
G.S3 197 K G.S3.04 Structure Structure
G.S3 198 M G.S3.05 Structure Structure
G.S3 199 F G.S3.06 Structure Structure
G.S3 200 D G.S3.07 Structure Structure
G.S3 201 V G.S3.08 Structure Structure
G.s3h2 202 G G.s3h2.01 Structure Structure
G.s3h2 203 G G.s3h2.02 Structure AF2
G.s3h2 204 Q G.s3h2.03 Structure Structure
G.H2 205 R G.H2.01 Structure Structure
G.H2 206 S G.H2.02 Structure Structure
G.H2 207 E G.H2.03 Structure Structure
G.H2 208 R G.H2.04 Structure Structure
G.H2 209 K G.H2.05 Structure Structure
G.H2 210 K G.H2.06 Structure Structure
G.H2 211 W G.H2.07 Structure Structure
G.H2 212 I G.H2.08 Structure Structure
G.H2 213 H G.H2.09 Structure Structure
G.H2 214 C G.H2.10 Structure Structure
G.h2s4 215 F G.h2s4.01 Structure Structure
G.h2s4 216 E G.h2s4.02 Structure Structure
G.h2s4 217 G G.h2s4.03 Structure Structure
G.h2s4 218 V G.h2s4.04 Structure Structure
G.h2s4 219 T G.h2s4.05 Structure Structure
G.S4 220 A G.S4.01 Structure Structure
G.S4 221 I G.S4.02 Structure Structure
G.S4 222 I G.S4.03 Structure Structure
G.S4 223 F G.S4.04 Structure Structure
G.S4 224 C G.S4.05 Structure Structure
G.S4 225 V G.S4.06 Structure Structure
G.S4 226 A G.S4.07 Structure Structure
G.s4h3 227 L G.s4h3.01 Structure Structure
G.s4h3 228 S G.s4h3.02 Structure Structure
G.s4h3 229 D G.s4h3.03 Structure Structure
G.s4h3 230 Y G.s4h3.04 Structure Structure
G.s4h3 231 D G.s4h3.05 Structure Structure
G.s4h3 232 L G.s4h3.06 Structure Structure
G.s4h3 233 V G.s4h3.07 Structure Structure
G.s4h3 234 L G.s4h3.08 Structure Structure
G.s4h3 235 A G.s4h3.09 AF2 AF2
G.s4h3 236 E G.s4h3.10 AF2 AF2
G.s4h3 237 D G.s4h3.11 AF2 AF2
G.s4h3 238 E G.s4h3.12 AF2 AF2
G.s4h3 239 E G.s4h3.13 AF2 AF2
G.s4h3 240 M G.s4h3.14 AF2 AF2
G.s4h3 241 N G.s4h3.15 Structure Structure
G.H3 242 R G.H3.01 Structure Structure
G.H3 243 M G.H3.02 Structure Structure
G.H3 244 H G.H3.03 Structure Structure
G.H3 245 E G.H3.04 Structure AF2
G.H3 246 S G.H3.05 Structure Structure
G.H3 247 M G.H3.06 Structure Structure
G.H3 248 K G.H3.07 Structure Structure
G.H3 249 L G.H3.08 Structure Structure
G.H3 250 F G.H3.09 Structure Structure
G.H3 251 D G.H3.10 Structure Structure
G.H3 252 S G.H3.11 Structure Structure
G.H3 253 I G.H3.12 Structure Structure
G.H3 254 C G.H3.13 Structure Structure
G.H3 255 N G.H3.14 Structure Structure
G.H3 256 N G.H3.15 Structure Structure
G.H3 257 K G.H3.16 Structure Structure
G.H3 258 W G.H3.17 Structure Structure
G.H3 259 F G.H3.18 Structure Structure
G.h3s5 260 T G.h3s5.01 Structure Structure
G.h3s5 261 D G.h3s5.02 Structure Structure
G.h3s5 262 T G.h3s5.03 Structure Structure
G.S5 263 S G.S5.01 Structure Structure
G.S5 264 I G.S5.02 Structure Structure
G.S5 265 I G.S5.03 Structure Structure
G.S5 266 L G.S5.04 Structure Structure
G.S5 267 F G.S5.05 Structure Structure
G.S5 268 L G.S5.06 Structure Structure
G.S5 269 N G.S5.07 Structure Structure
G.s5hg 270 K G.s5hg.01 Structure Structure
G.HG 271 K G.HG.01 Structure Structure
G.HG 272 D G.HG.02 Structure Structure
G.HG 273 L G.HG.03 Structure Structure
G.HG 274 F G.HG.04 Structure Structure
G.HG 275 E G.HG.05 Structure Structure
G.HG 276 E G.HG.06 Structure Structure
G.HG 277 K G.HG.07 Structure Structure
G.HG 278 I G.HG.08 Structure Structure
G.HG 279 K G.HG.09 Structure Structure
G.HG 280 K G.HG.12 Structure Structure
G.HG 281 S G.HG.13 Structure Structure
G.HG 282 P G.HG.14 Structure Structure
G.HG 283 L G.HG.15 Structure Structure
G.HG 284 T G.HG.16 Structure Structure
G.HG 285 I G.HG.17 Structure Structure
G.hgh4 286 C G.hgh4.01 Structure Structure
G.hgh4 287 Y G.hgh4.02 Structure Structure
G.hgh4 288 P G.hgh4.03 Structure Structure
G.hgh4 289 E G.hgh4.04 Structure Structure
G.hgh4 290 Y G.hgh4.05 Structure Structure
G.hgh4 291 A G.hgh4.06 Structure Structure
G.hgh4 292 G G.hgh4.07 Structure Structure
G.hgh4 293 S G.hgh4.08 Structure Structure
G.H4 294 N G.H4.01 Structure Structure
G.H4 295 T G.H4.02 Structure Structure
G.H4 296 Y G.H4.03 Structure Structure
G.H4 297 E G.H4.04 Structure Structure
G.H4 298 E G.H4.05 Structure Structure
G.H4 299 A G.H4.06 Structure Structure
G.H4 300 A G.H4.07 Structure Structure
G.H4 301 A G.H4.08 Structure Structure
G.H4 302 Y G.H4.10 Structure Structure
G.H4 303 I G.H4.11 Structure Structure
G.H4 304 Q G.H4.12 Structure Structure
G.H4 305 C G.H4.13 Structure Structure
G.H4 306 Q G.H4.14 Structure Structure
G.H4 307 F G.H4.15 Structure Structure
G.H4 308 E G.H4.16 Structure Structure
G.H4 309 D G.H4.17 Structure Structure
G.h4s6 310 L G.h4s6.01 Structure Structure
G.h4s6 311 N G.h4s6.02 Structure Structure
G.h4s6 312 K G.h4s6.03 Structure Structure
G.h4s6 313 R G.h4s6.04 Structure Structure
G.h4s6 314 K G.h4s6.08 Structure Structure
G.h4s6 315 D G.h4s6.09 Structure Structure
G.h4s6 316 T G.h4s6.10 Structure Structure
G.h4s6 317 K G.h4s6.11 Structure Structure
G.h4s6 318 E G.h4s6.12 Structure Structure
G.S6 319 I G.S6.01 Structure Structure
G.S6 320 Y G.S6.02 Structure Structure
G.S6 321 T G.S6.03 Structure Structure
G.S6 322 H G.S6.04 Structure Structure
G.S6 323 F G.S6.05 Structure Structure
G.s6h5 324 T G.s6h5.01 Structure Structure
G.s6h5 325 C G.s6h5.02 Structure Structure
G.s6h5 326 A G.s6h5.03 Structure AF2
G.s6h5 327 T G.s6h5.04 Structure Structure
G.s6h5 328 D G.s6h5.05 Structure Structure
G.H5 329 T G.H5.01 Structure Structure
G.H5 330 K G.H5.02 Structure Structure
G.H5 331 N G.H5.03 Structure Structure
G.H5 332 V G.H5.04 Structure Structure
G.H5 333 Q G.H5.05 Structure Structure
G.H5 334 F G.H5.06 Structure Structure
G.H5 335 V G.H5.07 Structure Structure
G.H5 336 F G.H5.08 Structure Structure
G.H5 337 D G.H5.09 Structure Structure
G.H5 338 A G.H5.10 Structure Structure
G.H5 339 V G.H5.11 Structure Structure
G.H5 340 T G.H5.12 Structure Structure
G.H5 341 D G.H5.13 Structure Structure
G.H5 342 V G.H5.14 Structure Structure
G.H5 343 I G.H5.15 Structure Structure
G.H5 344 I G.H5.16 Structure Structure
G.H5 345 K G.H5.17 Structure Structure
G.H5 346 N G.H5.18 Structure Structure
G.H5 347 N G.H5.19 Structure Structure
G.H5 348 L G.H5.20 Structure Structure
G.H5 349 K G.H5.21 Structure Structure
G.H5 350 D G.H5.22 Structure Structure
G.H5 351 C G.H5.23 Structure Structure
G.H5 352 G G.H5.24 Structure Structure
G.H5 353 L G.H5.25 Structure Structure
G.H5 354 F G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 271 from structure (85.2%), 47 from model (14.8%)
Residue sidechains - 270 from structure (84.9%), 48 from model (15.1%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 D - AF2 AF2
N-term 3 F - AF2 AF2
N-term 4 L - AF2 AF2
N-term 5 N - AF2 AF2
N-term 6 S - AF2 AF2
N-term 7 S - AF2 AF2
N-term 8 D - AF2 AF2
N-term 9 Q - AF2 AF2
N-term 10 N - AF2 AF2
N-term 11 L - AF2 AF2
N-term 12 T - AF2 AF2
N-term 13 S - AF2 AF2
N-term 14 E - AF2 AF2
N-term 15 E - AF2 AF2
N-term 16 L - AF2 AF2
N-term 17 L - AF2 AF2
N-term 18 N - AF2 AF2
N-term 19 R - AF2 AF2
TM1 20 M 1.29x29 Structure Structure
TM1 21 P 1.30x30 Structure Structure
TM1 22 S 1.31x31 Structure Structure
TM1 23 K 1.32x32 Structure Structure
TM1 24 I 1.33x33 Structure Structure
TM1 25 L 1.34x34 Structure Structure
TM1 26 V 1.35x35 Structure Structure
TM1 27 S 1.36x36 Structure Structure
TM1 28 L 1.37x37 Structure Structure
TM1 29 T 1.38x38 Structure Structure
TM1 30 L 1.39x39 Structure Structure
TM1 31 S 1.40x40 Structure Structure
TM1 32 G 1.41x41 Structure Structure
TM1 33 L 1.42x42 Structure Structure
TM1 34 A 1.43x43 Structure Structure
TM1 35 L 1.44x44 Structure Structure
TM1 36 M 1.45x45 Structure Structure
TM1 37 T 1.46x46 Structure Structure
TM1 38 T 1.47x47 Structure Structure
TM1 39 T 1.48x48 Structure Structure
TM1 40 I 1.49x49 Structure Structure
TM1 41 N 1.50x50 Structure Structure
TM1 42 S 1.51x51 Structure Structure
TM1 43 L 1.52x52 Structure Structure
TM1 44 V 1.53x53 Structure Structure
TM1 45 I 1.54x54 Structure Structure
TM1 46 A 1.55x55 Structure Structure
TM1 47 A 1.56x56 Structure Structure
TM1 48 I 1.57x57 Structure Structure
TM1 49 I 1.58x58 Structure Structure
TM1 50 V 1.59x59 Structure Structure
TM1 51 T 1.60x60 Structure Structure
ICL1 52 R 12.48x48 Structure Structure
ICL1 53 K 12.49x49 Structure Structure
ICL1 54 L 12.50x50 Structure Structure
ICL1 55 H 12.51x51 Structure Structure
TM2 56 H 2.37x37 Structure Structure
TM2 57 P 2.38x38 Structure Structure
TM2 58 A 2.39x39 Structure Structure
TM2 59 N 2.40x40 Structure Structure
TM2 60 Y 2.41x41 Structure Structure
TM2 61 L 2.42x42 Structure Structure
TM2 62 I 2.43x43 Structure Structure
TM2 63 C 2.44x44 Structure Structure
TM2 64 S 2.45x45 Structure Structure
TM2 65 L 2.46x46 Structure Structure
TM2 66 A 2.47x47 Structure Structure
TM2 67 V 2.48x48 Structure Structure
TM2 68 T 2.49x49 Structure Structure
TM2 69 D 2.50x50 Structure Structure
TM2 70 F 2.51x51 Structure Structure
TM2 71 L 2.52x52 Structure Structure
TM2 72 V 2.53x53 Structure Structure
TM2 73 A 2.54x54 Structure Structure
TM2 74 V 2.55x55 Structure Structure
TM2 75 L 2.56x551 Structure Structure
TM2 76 V 2.57x56 Structure Structure
TM2 77 M 2.58x57 Structure Structure
TM2 78 P 2.59x58 Structure Structure
TM2 79 F 2.60x59 Structure Structure
TM2 80 S 2.61x60 Structure Structure
TM2 81 I 2.62x61 Structure Structure
TM2 82 V 2.63x62 Structure Structure
TM2 83 Y 2.64x63 Structure Structure
TM2 84 I 2.65x64 Structure Structure
TM2 85 V 2.66x65 Structure Structure
TM2 86 R 2.67x66 Structure Structure
TM2 87 E 2.68x67 Structure Structure
ECL1 88 S 23.49x49 Structure Structure
ECL1 89 W 23.50x50 Structure Structure
ECL1 90 I 23.51x51 Structure Structure
ECL1 91 M 23.52x52 Structure Structure
TM3 92 G 3.21x21 Structure Structure
TM3 93 Q 3.22x22 Structure Structure
TM3 94 V 3.23x23 Structure Structure
TM3 95 V 3.24x24 Structure Structure
TM3 96 C 3.25x25 Structure Structure
TM3 97 D 3.26x26 Structure Structure
TM3 98 I 3.27x27 Structure Structure
TM3 99 W 3.28x28 Structure Structure
TM3 100 L 3.29x29 Structure Structure
TM3 101 S 3.30x30 Structure Structure
TM3 102 V 3.31x31 Structure Structure
TM3 103 D 3.32x32 Structure Structure
TM3 104 I 3.33x33 Structure Structure
TM3 105 T 3.34x34 Structure Structure
TM3 106 C 3.35x35 Structure Structure
TM3 107 C 3.36x36 Structure Structure
TM3 108 T 3.37x37 Structure Structure
TM3 109 C 3.38x38 Structure Structure
TM3 110 S 3.39x39 Structure Structure
TM3 111 I 3.40x40 Structure Structure
TM3 112 L 3.41x41 Structure Structure
TM3 113 H 3.42x42 Structure Structure
TM3 114 L 3.43x43 Structure Structure
TM3 115 S 3.44x44 Structure Structure
TM3 116 A 3.45x45 Structure Structure
TM3 117 I 3.46x46 Structure Structure
TM3 118 A 3.47x47 Structure Structure
TM3 119 L 3.48x48 Structure Structure
TM3 120 D 3.49x49 Structure Structure
TM3 121 R 3.50x50 Structure Structure
TM3 122 Y 3.51x51 Structure Structure
TM3 123 R 3.52x52 Structure Structure
TM3 124 A 3.53x53 Structure Structure
TM3 125 I 3.54x54 Structure Structure
TM3 126 T 3.55x55 Structure Structure
TM3 127 D 3.56x56 Structure Structure
ICL2 128 A 34.50x50 Structure Structure
ICL2 129 V 34.51x51 Structure Structure
ICL2 130 E 34.52x52 Structure Structure
ICL2 131 Y 34.53x53 Structure Structure
ICL2 132 A 34.54x54 Structure Structure
ICL2 133 R 34.55x55 Structure Structure
ICL2 134 K 34.56x56 Structure Structure
ICL2 135 R 34.57x57 Structure Structure
TM4 136 T 4.38x38 Structure Structure
TM4 137 P 4.39x39 Structure Structure
TM4 138 K 4.40x40 Structure Structure
TM4 139 H 4.41x41 Structure Structure
TM4 140 A 4.42x42 Structure Structure
TM4 141 G 4.43x43 Structure Structure
TM4 142 I 4.44x44 Structure Structure
TM4 143 M 4.45x45 Structure Structure
TM4 144 I 4.46x46 Structure Structure
TM4 145 T 4.47x47 Structure Structure
TM4 146 I 4.48x48 Structure Structure
TM4 147 V 4.49x49 Structure Structure
TM4 148 W 4.50x50 Structure Structure
TM4 149 I 4.51x51 Structure Structure
TM4 150 I 4.52x52 Structure Structure
TM4 151 S 4.53x53 Structure Structure
TM4 152 V 4.54x54 Structure Structure
TM4 153 F 4.55x55 Structure Structure
TM4 154 I 4.56x56 Structure Structure
TM4 155 S 4.57x57 Structure Structure
TM4 156 M 4.58x58 Structure Structure
TM4 157 P 4.59x59 Structure Structure
TM4 158 P 4.60x60 Structure Structure
TM4 159 L 4.61x61 Structure Structure
TM4 160 F 4.62x62 Structure Structure
TM4 161 W 4.63x63 Structure Structure
TM4 162 R 4.64x64 Structure Structure
TM4 163 H 4.65x65 Structure Structure
ECL2 164 Q - Structure Structure
ECL2 165 G - Structure Structure
ECL2 166 T - Structure Structure
ECL2 167 S - Structure Structure
ECL2 168 R - Structure Structure
ECL2 169 D - Structure Structure
ECL2 170 D - Structure Structure
ECL2 171 E - Structure Structure
ECL2 172 C 45.50x50 Structure Structure
ECL2 173 I 45.51x51 Structure Structure
ECL2 174 I 45.52x52 Structure Structure
ECL2 175 K - Structure Structure
ECL2 176 H - Structure Structure
ECL2 177 D - Structure Structure
TM5 178 H 5.35x36 Structure Structure
TM5 179 I 5.36x37 Structure Structure
TM5 180 V 5.37x38 Structure Structure
TM5 181 S 5.38x39 Structure Structure
TM5 182 T 5.39x40 Structure Structure
TM5 183 I 5.40x41 Structure Structure
TM5 184 Y 5.41x42 Structure Structure
TM5 185 S 5.42x43 Structure Structure
TM5 186 T 5.43x44 Structure Structure
TM5 187 F 5.44x45 Structure Structure
TM5 188 G 5.45x46 Structure Structure
TM5 189 A 5.46x461 Structure Structure
TM5 190 F 5.47x47 Structure Structure
TM5 191 Y 5.48x48 Structure Structure
TM5 192 I 5.49x49 Structure Structure
TM5 193 P 5.50x50 Structure Structure
TM5 194 L 5.51x51 Structure Structure
TM5 195 A 5.52x52 Structure Structure
TM5 196 L 5.53x53 Structure Structure
TM5 197 I 5.54x54 Structure Structure
TM5 198 L 5.55x55 Structure Structure
TM5 199 I 5.56x56 Structure Structure
TM5 200 L 5.57x57 Structure Structure
TM5 201 Y 5.58x58 Structure Structure
TM5 202 Y 5.59x59 Structure Structure
TM5 203 K 5.60x60 Structure Structure
TM5 204 I 5.61x61 Structure Structure
TM5 205 Y 5.62x62 Structure Structure
TM5 206 R 5.63x63 Structure Structure
TM5 207 A 5.64x64 Structure Structure
TM5 208 A 5.65x65 Structure Structure
TM5 209 K 5.66x66 Structure Structure
TM5 210 T 5.67x67 Structure Structure
TM5 211 L 5.68x68 Structure Structure
TM5 212 Y 5.69x69 Structure Structure
TM5 213 H 5.70x70 Structure Structure
TM5 214 K 5.71x71 AF2 AF2
TM5 215 R 5.72x72 AF2 AF2
TM5 216 Q 5.73x73 AF2 AF2
TM5 217 A 5.74x74 AF2 AF2
TM5 218 S 5.75x75 AF2 AF2
TM5 219 R 5.76x76 AF2 AF2
ICL3 220 I - AF2 AF2
ICL3 221 A - AF2 AF2
ICL3 222 K - AF2 AF2
ICL3 223 E - AF2 AF2
ICL3 224 E - AF2 AF2
ICL3 225 V - AF2 AF2
ICL3 226 N - AF2 AF2
ICL3 275 E - AF2 AF2
ICL3 276 K - AF2 AF2
ICL3 277 S - AF2 AF2
ICL3 278 W - AF2 AF2
ICL3 279 R - AF2 AF2
ICL3 280 R - AF2 AF2
ICL3 281 Q - AF2 AF2
TM6 282 K 6.24x24 AF2 AF2
TM6 283 I 6.25x25 AF2 AF2
TM6 284 S 6.26x26 AF2 AF2
TM6 285 G 6.27x27 Structure Structure
TM6 286 T 6.28x28 Structure Structure
TM6 287 R 6.29x29 Structure Structure
TM6 288 E 6.30x30 Structure Structure
TM6 289 R 6.31x31 Structure Structure
TM6 290 K 6.32x32 Structure Structure
TM6 291 A 6.33x33 Structure Structure
TM6 292 A 6.34x34 Structure Structure
TM6 293 T 6.35x35 Structure Structure
TM6 294 T 6.36x36 Structure Structure
TM6 295 L 6.37x37 Structure Structure
TM6 296 G 6.38x38 Structure Structure
TM6 297 L 6.39x39 Structure Structure
TM6 298 I 6.40x40 Structure Structure
TM6 299 L 6.41x41 Structure Structure
TM6 300 G 6.42x42 Structure Structure
TM6 301 A 6.43x43 Structure Structure
TM6 302 F 6.44x44 Structure Structure
TM6 303 V 6.45x45 Structure Structure
TM6 304 I 6.46x46 Structure Structure
TM6 305 C 6.47x47 Structure Structure
TM6 306 W 6.48x48 Structure Structure
TM6 307 L 6.49x49 Structure Structure
TM6 308 P 6.50x50 Structure Structure
TM6 309 F 6.51x51 Structure Structure
TM6 310 F 6.52x52 Structure Structure
TM6 311 V 6.53x53 Structure Structure
TM6 312 K 6.54x54 Structure Structure
TM6 313 E 6.55x55 Structure Structure
TM6 314 L 6.56x56 Structure Structure
TM6 315 V 6.57x57 Structure Structure
TM6 316 V 6.58x58 Structure Structure
TM6 317 N 6.59x59 Structure Structure
TM6 318 V 6.60x60 Structure Structure
TM6 319 C 6.61x61 Structure Structure
ECL3 320 D - Structure Structure
ECL3 321 K - Structure Structure
ECL3 322 C - Structure Structure
ECL3 323 K - Structure AF2
ECL3 324 I - Structure Structure
TM7 325 S 7.31x30 Structure Structure
TM7 326 E 7.32x31 Structure Structure
TM7 327 E 7.33x32 Structure Structure
TM7 328 M 7.34x33 Structure Structure
TM7 329 S 7.35x34 Structure Structure
TM7 330 N 7.36x35 Structure Structure
TM7 331 F 7.37x36 Structure Structure
TM7 332 L 7.38x37 Structure Structure
TM7 333 A 7.39x38 Structure Structure
TM7 334 W 7.40x39 Structure Structure
TM7 335 L 7.41x40 Structure Structure
TM7 336 G 7.42x41 Structure Structure
TM7 337 Y 7.43x42 Structure Structure
TM7 338 L 7.44x43 Structure Structure
TM7 339 N 7.45x45 Structure Structure
TM7 340 S 7.46x46 Structure Structure
TM7 341 L 7.47x47 Structure Structure
TM7 342 I 7.48x48 Structure Structure
TM7 343 N 7.49x49 Structure Structure
TM7 344 P 7.50x50 Structure Structure
TM7 345 L 7.51x51 Structure Structure
TM7 346 I 7.52x52 Structure Structure
TM7 347 Y 7.53x53 Structure Structure
TM7 348 T 7.54x54 Structure Structure
TM7 349 I 7.55x55 Structure Structure
TM7 350 F 7.56x56 Structure Structure
H8 351 N 8.47x47 Structure Structure
H8 352 E 8.48x48 Structure Structure
H8 353 D 8.49x49 Structure Structure
H8 354 F 8.50x50 Structure Structure
H8 355 K 8.51x51 Structure Structure
H8 356 K 8.52x52 Structure Structure
H8 357 A 8.53x53 Structure Structure
H8 358 F 8.54x54 Structure Structure
H8 359 Q 8.55x55 Structure Structure
H8 360 K 8.56x56 Structure Structure
H8 361 L 8.57x57 Structure Structure
C-term 362 V - AF2 AF2
C-term 363 R - AF2 AF2
C-term 364 C - AF2 AF2
C-term 365 R - AF2 AF2
C-term 366 C - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 R 215 5x72 G.H5 K 345 G.H5.17
Van-der-waals TM5 R 215 5x72 G.H5 K 345 G.H5.17
Ionic ICL3 K 222 - G.H4 E 308 G.H4.16
Polar ICL3 K 222 - G.H4 E 308 G.H4.16
Hydrophobic ICL3 K 222 - G.H4 E 308 G.H4.16
Van-der-waals ICL3 K 222 - G.H4 E 308 G.H4.16
Polar TM3 R 121 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 121 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 121 3x50 G.H5 C 351 G.H5.23
Hydrophobic ICL2 V 129 34x51 G.H5 F 336 G.H5.08
Polar H8 N 351 8x47 G.H5 D 350 G.H5.22
Hydrophobic H8 N 351 8x47 G.H5 D 350 G.H5.22
Hydrophobic TM3 I 125 3x54 G.H5 I 344 G.H5.16
Van-der-waals TM3 I 125 3x54 G.H5 I 344 G.H5.16
Hydrophobic TM5 L 211 5x68 G.H5 D 341 G.H5.13
Polar TM6 K 290 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM6 K 290 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 290 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM3 I 125 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 125 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM5 I 204 5x61 G.H5 L 348 G.H5.20
Polar TM5 R 219 5x76 G.h4s6 K 314 G.h4s6.08
Aromatic TM6 R 287 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM6 R 287 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 287 6x29 G.H5 F 354 G.H5.26
Polar ICL3 K 222 - G.S6 T 321 G.S6.03
Van-der-waals ICL3 K 222 - G.S6 T 321 G.S6.03
Polar TM3 A 124 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 124 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 124 3x53 G.H5 N 347 G.H5.19
Hydrophobic ICL2 V 129 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 V 129 34x51 G.S3 L 194 G.S3.01
Polar TM6 R 287 6x29 G.h4s6 D 315 G.h4s6.09
Hydrophobic ICL2 A 128 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 A 128 34x50 G.H5 I 344 G.H5.16
Hydrophobic TM5 A 208 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM5 I 204 5x61 G.H5 L 353 G.H5.25
Hydrophobic TM5 L 211 5x68 G.H5 K 345 G.H5.17
Polar ICL3 K 222 - G.H4 Q 304 G.H4.12
Hydrophobic ICL3 K 222 - G.H4 Q 304 G.H4.12
Van-der-waals ICL3 K 222 - G.H4 Q 304 G.H4.12
Hydrophobic TM6 A 291 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 A 291 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM5 L 211 5x68 G.H5 I 344 G.H5.16
Polar TM6 K 290 6x32 G.H5 G 352 G.H5.24
Van-der-waals TM6 K 290 6x32 G.H5 G 352 G.H5.24
Hydrophobic ICL2 A 128 34x50 G.H5 I 343 G.H5.15
Hydrophobic TM6 I 283 6x25 G.h4s6 D 315 G.h4s6.09
Ionic ICL3 K 276 - G.H4 D 309 G.H4.17
Polar ICL3 K 276 - G.H4 D 309 G.H4.17
Van-der-waals ICL3 K 276 - G.H4 D 309 G.H4.17
Hydrophobic TM5 L 211 5x68 G.H5 L 348 G.H5.20
Van-der-waals TM5 L 211 5x68 G.H5 L 348 G.H5.20
Polar TM7 F 350 7x56 G.H5 G 352 G.H5.24
Hydrophobic TM7 F 350 7x56 G.H5 G 352 G.H5.24
Van-der-waals TM7 F 350 7x56 G.H5 G 352 G.H5.24
Ionic H8 E 352 8x48 G.H5 K 349 G.H5.21
Polar H8 E 352 8x48 G.H5 K 349 G.H5.21
Ionic TM5 R 215 5x72 G.H5 D 341 G.H5.13
Polar TM5 R 215 5x72 G.H5 D 341 G.H5.13
Van-der-waals TM5 R 215 5x72 G.H5 D 341 G.H5.13
Hydrophobic TM5 A 208 5x65 G.H5 L 353 G.H5.25
Hydrophobic TM3 I 125 3x54 G.H5 N 347 G.H5.19
Van-der-waals TM3 I 125 3x54 G.H5 N 347 G.H5.19
Hydrophobic TM6 I 283 6x25 G.h4s6 K 314 G.h4s6.08
Polar ICL2 R 133 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 R 133 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 R 133 34x55 G.hns1 R 32 G.hns1.03
Polar TM6 T 294 6x36 G.H5 G 352 G.H5.24
Hydrophobic TM6 T 294 6x36 G.H5 G 352 G.H5.24
Van-der-waals TM6 T 294 6x36 G.H5 G 352 G.H5.24
Hydrophobic ICL3 K 222 - G.H4 C 305 G.H4.13