GPCRdb

Refined structure (7EXD) of G_i1 - 5-HT_1F receptor

Full

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G_i/o

DATE

2024-02-01

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

Structure

GPCR

Gα

Gβ

Gγ
Model

AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 219 from structure (61.9%), 135 from model (38.1%)
Residue sidechains - 215 from structure (60.7%), 139 from model (39.3%)

Showing 1 to 354 of 354 entries

Search:

Segment	Seq.num.	AA	CGN#	Backbone from	Sidechain from
	:

Segment	Seq.num.	AA	CGN#	Backbone from	Sidechain from

G.HN	1	M	G.HN.01	AF2	AF2
G.HN	2	G	G.HN.02	AF2	AF2
G.HN	3	C	G.HN.09	AF2	AF2
G.HN	4	T	G.HN.10	Structure	Structure
G.HN	5	L	G.HN.11	Structure	Structure
G.HN	6	S	G.HN.30	Structure	Structure
G.HN	7	A	G.HN.31	Structure	Structure
G.HN	8	E	G.HN.32	Structure	Structure
G.HN	9	D	G.HN.33	Structure	Structure
G.HN	10	K	G.HN.34	Structure	Structure
G.HN	11	A	G.HN.35	Structure	Structure
G.HN	12	A	G.HN.36	Structure	Structure
G.HN	13	V	G.HN.37	Structure	Structure
G.HN	14	E	G.HN.38	Structure	Structure
G.HN	15	R	G.HN.39	Structure	Structure
G.HN	16	S	G.HN.40	Structure	Structure
G.HN	17	K	G.HN.41	Structure	Structure
G.HN	18	M	G.HN.42	Structure	Structure
G.HN	19	I	G.HN.43	Structure	Structure
G.HN	20	D	G.HN.44	Structure	Structure
G.HN	21	R	G.HN.45	Structure	Structure
G.HN	22	N	G.HN.46	Structure	Structure
G.HN	23	L	G.HN.47	Structure	Structure
G.HN	24	R	G.HN.48	Structure	Structure
G.HN	25	E	G.HN.49	Structure	Structure
G.HN	26	D	G.HN.50	Structure	Structure
G.HN	27	G	G.HN.51	Structure	Structure
G.HN	28	E	G.HN.52	Structure	Structure
G.HN	29	K	G.HN.53	Structure	Structure
G.hns1	30	A	G.hns1.01	Structure	Structure
G.hns1	31	A	G.hns1.02	Structure	Structure
G.hns1	32	R	G.hns1.03	Structure	Structure
G.S1	33	E	G.S1.01	Structure	Structure
G.S1	34	V	G.S1.02	Structure	Structure
G.S1	35	K	G.S1.03	Structure	Structure
G.S1	36	L	G.S1.04	Structure	Structure
G.S1	37	L	G.S1.05	Structure	Structure
G.S1	38	L	G.S1.06	Structure	Structure
G.S1	39	L	G.S1.07	Structure	Structure
G.s1h1	40	G	G.s1h1.01	Structure	Structure
G.s1h1	41	A	G.s1h1.02	Structure	Structure
G.s1h1	42	G	G.s1h1.03	Structure	Structure
G.s1h1	43	E	G.s1h1.04	Structure	Structure
G.s1h1	44	S	G.s1h1.05	Structure	Structure
G.s1h1	45	G	G.s1h1.06	Structure	Structure
G.H1	46	K	G.H1.01	Structure	Structure
G.H1	47	S	G.H1.02	Structure	AF2
G.H1	48	T	G.H1.03	Structure	Structure
G.H1	49	I	G.H1.04	Structure	Structure
G.H1	50	V	G.H1.05	Structure	Structure
G.H1	51	K	G.H1.06	Structure	Structure
G.H1	52	Q	G.H1.07	Structure	Structure
G.H1	53	M	G.H1.08	Structure	Structure
G.H1	54	K	G.H1.09	Structure	Structure
G.H1	55	I	G.H1.10	Structure	Structure
G.H1	56	I	G.H1.11	AF2	AF2
G.H1	57	H	G.H1.12	AF2	AF2
G.h1ha	58	E	G.h1ha.01	AF2	AF2
G.h1ha	59	A	G.h1ha.02	AF2	AF2
G.h1ha	60	G	G.h1ha.03	AF2	AF2
G.h1ha	61	Y	G.h1ha.04	AF2	AF2
G.h1ha	62	S	G.h1ha.05	AF2	AF2
H.HA	63	E	H.HA.01	AF2	AF2
H.HA	64	E	H.HA.02	AF2	AF2
H.HA	65	E	H.HA.03	AF2	AF2
H.HA	66	C	H.HA.04	AF2	AF2
H.HA	67	K	H.HA.05	AF2	AF2
H.HA	68	Q	H.HA.06	AF2	AF2
H.HA	69	Y	H.HA.07	AF2	AF2
H.HA	70	K	H.HA.08	AF2	AF2
H.HA	71	A	H.HA.09	AF2	AF2
H.HA	72	V	H.HA.10	AF2	AF2
H.HA	73	V	H.HA.11	AF2	AF2
H.HA	74	Y	H.HA.12	AF2	AF2
H.HA	75	S	H.HA.13	AF2	AF2
H.HA	76	N	H.HA.14	AF2	AF2
H.HA	77	T	H.HA.15	AF2	AF2
H.HA	78	I	H.HA.16	AF2	AF2
H.HA	79	Q	H.HA.17	AF2	AF2
H.HA	80	S	H.HA.18	AF2	AF2
H.HA	81	I	H.HA.19	AF2	AF2
H.HA	82	I	H.HA.20	AF2	AF2
H.HA	83	A	H.HA.21	AF2	AF2
H.HA	84	I	H.HA.22	AF2	AF2
H.HA	85	I	H.HA.23	AF2	AF2
H.HA	86	R	H.HA.24	AF2	AF2
H.HA	87	A	H.HA.25	AF2	AF2
H.HA	88	M	H.HA.26	AF2	AF2
H.HA	89	G	H.HA.27	AF2	AF2
H.HA	90	R	H.HA.28	AF2	AF2
H.HA	91	L	H.HA.29	AF2	AF2
H.hahb	92	K	H.hahb.01	AF2	AF2
H.hahb	93	I	H.hahb.04	AF2	AF2
H.hahb	94	D	H.hahb.05	AF2	AF2
H.hahb	95	F	H.hahb.06	AF2	AF2
H.hahb	96	G	H.hahb.07	AF2	AF2
H.hahb	97	D	H.hahb.08	AF2	AF2
H.hahb	98	S	H.hahb.09	AF2	AF2
H.HB	99	A	H.HB.01	AF2	AF2
H.HB	100	R	H.HB.02	AF2	AF2
H.HB	101	A	H.HB.03	AF2	AF2
H.HB	102	D	H.HB.04	AF2	AF2
H.HB	103	D	H.HB.05	AF2	AF2
H.HB	104	A	H.HB.06	AF2	AF2
H.HB	105	R	H.HB.07	AF2	AF2
H.HB	106	Q	H.HB.08	AF2	AF2
H.HB	107	L	H.HB.09	AF2	AF2
H.HB	108	F	H.HB.10	AF2	AF2
H.HB	109	V	H.HB.11	AF2	AF2
H.HB	110	L	H.HB.12	AF2	AF2
H.HB	111	A	H.HB.13	AF2	AF2
H.HB	112	G	H.HB.14	AF2	AF2
H.hbhc	113	A	H.hbhc.01	AF2	AF2
H.hbhc	114	A	H.hbhc.02	AF2	AF2
H.hbhc	115	E	H.hbhc.03	AF2	AF2
H.hbhc	116	E	H.hbhc.04	AF2	AF2
H.hbhc	117	G	H.hbhc.12	AF2	AF2
H.hbhc	118	F	H.hbhc.13	AF2	AF2
H.hbhc	119	M	H.hbhc.14	AF2	AF2
H.hbhc	120	T	H.hbhc.15	AF2	AF2
H.HC	121	A	H.HC.01	AF2	AF2
H.HC	122	E	H.HC.02	AF2	AF2
H.HC	123	L	H.HC.03	AF2	AF2
H.HC	124	A	H.HC.04	AF2	AF2
H.HC	125	G	H.HC.05	AF2	AF2
H.HC	126	V	H.HC.06	AF2	AF2
H.HC	127	I	H.HC.07	AF2	AF2
H.HC	128	K	H.HC.08	AF2	AF2
H.HC	129	R	H.HC.09	AF2	AF2
H.HC	130	L	H.HC.10	AF2	AF2
H.HC	131	W	H.HC.11	AF2	AF2
H.HC	132	K	H.HC.12	AF2	AF2
H.hchd	133	D	H.hchd.01	AF2	AF2
H.HD	134	S	H.HD.01	AF2	AF2
H.HD	135	G	H.HD.02	AF2	AF2
H.HD	136	V	H.HD.03	AF2	AF2
H.HD	137	Q	H.HD.04	AF2	AF2
H.HD	138	A	H.HD.05	AF2	AF2
H.HD	139	C	H.HD.06	AF2	AF2
H.HD	140	F	H.HD.07	AF2	AF2
H.HD	141	N	H.HD.08	AF2	AF2
H.HD	142	R	H.HD.09	AF2	AF2
H.HD	143	S	H.HD.10	AF2	AF2
H.HD	144	R	H.HD.11	AF2	AF2
H.HD	145	E	H.HD.12	AF2	AF2
H.hdhe	146	Y	H.hdhe.01	AF2	AF2
H.hdhe	147	Q	H.hdhe.02	AF2	AF2
H.hdhe	148	L	H.hdhe.03	AF2	AF2
H.hdhe	149	N	H.hdhe.04	AF2	AF2
H.hdhe	150	D	H.hdhe.05	AF2	AF2
H.HE	151	S	H.HE.01	AF2	AF2
H.HE	152	A	H.HE.02	AF2	AF2
H.HE	153	A	H.HE.03	AF2	AF2
H.HE	154	Y	H.HE.04	AF2	AF2
H.HE	155	Y	H.HE.05	AF2	AF2
H.HE	156	L	H.HE.06	AF2	AF2
H.HE	157	N	H.HE.07	AF2	AF2
H.HE	158	D	H.HE.08	AF2	AF2
H.HE	159	L	H.HE.09	AF2	AF2
H.HE	160	D	H.HE.10	AF2	AF2
H.HE	161	R	H.HE.11	AF2	AF2
H.HE	162	I	H.HE.12	AF2	AF2
H.HE	163	A	H.HE.13	AF2	AF2
H.hehf	164	Q	H.hehf.01	AF2	AF2
H.hehf	165	P	H.hehf.02	AF2	AF2
H.hehf	166	N	H.hehf.03	AF2	AF2
H.hehf	167	Y	H.hehf.04	AF2	AF2
H.hehf	168	I	H.hehf.05	AF2	AF2
H.hehf	169	P	H.hehf.06	AF2	AF2
H.hehf	170	T	H.hehf.07	AF2	AF2
H.HF	171	Q	H.HF.01	AF2	AF2
H.HF	172	Q	H.HF.02	AF2	AF2
H.HF	173	D	H.HF.03	AF2	AF2
H.HF	174	V	H.HF.04	AF2	AF2
H.HF	175	L	H.HF.05	AF2	AF2
H.HF	176	R	H.HF.06	AF2	AF2
G.hfs2	177	T	G.hfs2.01	AF2	AF2
G.hfs2	178	R	G.hfs2.02	AF2	AF2
G.hfs2	179	V	G.hfs2.03	AF2	AF2
G.hfs2	180	K	G.hfs2.04	AF2	AF2
G.hfs2	181	T	G.hfs2.05	AF2	AF2
G.hfs2	182	T	G.hfs2.06	Structure	Structure
G.hfs2	183	G	G.hfs2.07	Structure	Structure
G.S2	184	I	G.S2.01	Structure	Structure
G.S2	185	V	G.S2.02	Structure	Structure
G.S2	186	E	G.S2.03	Structure	Structure
G.S2	187	T	G.S2.04	Structure	Structure
G.S2	188	H	G.S2.05	Structure	Structure
G.S2	189	F	G.S2.06	Structure	Structure
G.S2	190	T	G.S2.07	Structure	Structure
G.S2	191	F	G.S2.08	Structure	Structure
G.s2s3	192	K	G.s2s3.01	Structure	Structure
G.s2s3	193	D	G.s2s3.02	Structure	Structure
G.S3	194	L	G.S3.01	Structure	Structure
G.S3	195	H	G.S3.02	Structure	Structure
G.S3	196	F	G.S3.03	Structure	Structure
G.S3	197	K	G.S3.04	Structure	Structure
G.S3	198	M	G.S3.05	Structure	Structure
G.S3	199	F	G.S3.06	Structure	Structure
G.S3	200	D	G.S3.07	Structure	Structure
G.S3	201	V	G.S3.08	Structure	Structure
G.s3h2	202	G	G.s3h2.01	Structure	Structure
G.s3h2	203	G	G.s3h2.02	Structure	AF2
G.s3h2	204	Q	G.s3h2.03	Structure	Structure
G.H2	205	R	G.H2.01	Structure	Structure
G.H2	206	S	G.H2.02	Structure	Structure
G.H2	207	E	G.H2.03	Structure	Structure
G.H2	208	R	G.H2.04	Structure	Structure
G.H2	209	K	G.H2.05	Structure	Structure
G.H2	210	K	G.H2.06	Structure	Structure
G.H2	211	W	G.H2.07	Structure	Structure
G.H2	212	I	G.H2.08	Structure	Structure
G.H2	213	H	G.H2.09	Structure	Structure
G.H2	214	C	G.H2.10	Structure	Structure
G.h2s4	215	F	G.h2s4.01	Structure	Structure
G.h2s4	216	E	G.h2s4.02	Structure	Structure
G.h2s4	217	G	G.h2s4.03	Structure	Structure
G.h2s4	218	V	G.h2s4.04	Structure	Structure
G.h2s4	219	T	G.h2s4.05	Structure	Structure
G.S4	220	A	G.S4.01	Structure	Structure
G.S4	221	I	G.S4.02	Structure	Structure
G.S4	222	I	G.S4.03	Structure	Structure
G.S4	223	F	G.S4.04	Structure	Structure
G.S4	224	C	G.S4.05	Structure	Structure
G.S4	225	V	G.S4.06	Structure	Structure
G.S4	226	A	G.S4.07	Structure	Structure
G.s4h3	227	L	G.s4h3.01	Structure	Structure
G.s4h3	228	S	G.s4h3.02	Structure	Structure
G.s4h3	229	D	G.s4h3.03	Structure	Structure
G.s4h3	230	Y	G.s4h3.04	Structure	Structure
G.s4h3	231	D	G.s4h3.05	Structure	Structure
G.s4h3	232	L	G.s4h3.06	Structure	Structure
G.s4h3	233	V	G.s4h3.07	Structure	Structure
G.s4h3	234	L	G.s4h3.08	Structure	Structure
G.s4h3	235	A	G.s4h3.09	AF2	AF2
G.s4h3	236	E	G.s4h3.10	AF2	AF2
G.s4h3	237	D	G.s4h3.11	AF2	AF2
G.s4h3	238	E	G.s4h3.12	AF2	AF2
G.s4h3	239	E	G.s4h3.13	AF2	AF2
G.s4h3	240	M	G.s4h3.14	AF2	AF2
G.s4h3	241	N	G.s4h3.15	Structure	Structure
G.H3	242	R	G.H3.01	Structure	Structure
G.H3	243	M	G.H3.02	Structure	Structure
G.H3	244	H	G.H3.03	Structure	Structure
G.H3	245	E	G.H3.04	Structure	AF2
G.H3	246	S	G.H3.05	Structure	Structure
G.H3	247	M	G.H3.06	Structure	Structure
G.H3	248	K	G.H3.07	Structure	Structure
G.H3	249	L	G.H3.08	Structure	Structure
G.H3	250	F	G.H3.09	Structure	Structure
G.H3	251	D	G.H3.10	Structure	Structure
G.H3	252	S	G.H3.11	Structure	Structure
G.H3	253	I	G.H3.12	Structure	Structure
G.H3	254	C	G.H3.13	Structure	Structure
G.H3	255	N	G.H3.14	Structure	Structure
G.H3	256	N	G.H3.15	Structure	Structure
G.H3	257	K	G.H3.16	Structure	Structure
G.H3	258	W	G.H3.17	Structure	Structure
G.H3	259	F	G.H3.18	Structure	Structure
G.h3s5	260	T	G.h3s5.01	Structure	Structure
G.h3s5	261	D	G.h3s5.02	Structure	Structure
G.h3s5	262	T	G.h3s5.03	Structure	Structure
G.S5	263	S	G.S5.01	Structure	Structure
G.S5	264	I	G.S5.02	Structure	Structure
G.S5	265	I	G.S5.03	Structure	Structure
G.S5	266	L	G.S5.04	Structure	Structure
G.S5	267	F	G.S5.05	Structure	Structure
G.S5	268	L	G.S5.06	Structure	Structure
G.S5	269	N	G.S5.07	Structure	Structure
G.s5hg	270	K	G.s5hg.01	Structure	Structure
G.HG	271	K	G.HG.01	Structure	Structure
G.HG	272	D	G.HG.02	Structure	Structure
G.HG	273	L	G.HG.03	Structure	Structure
G.HG	274	F	G.HG.04	Structure	Structure
G.HG	275	E	G.HG.05	Structure	Structure
G.HG	276	E	G.HG.06	Structure	Structure
G.HG	277	K	G.HG.07	Structure	Structure
G.HG	278	I	G.HG.08	Structure	Structure
G.HG	279	K	G.HG.09	Structure	Structure
G.HG	280	K	G.HG.12	Structure	Structure
G.HG	281	S	G.HG.13	Structure	Structure
G.HG	282	P	G.HG.14	Structure	Structure
G.HG	283	L	G.HG.15	Structure	Structure
G.HG	284	T	G.HG.16	Structure	Structure
G.HG	285	I	G.HG.17	Structure	Structure
G.hgh4	286	C	G.hgh4.01	Structure	Structure
G.hgh4	287	Y	G.hgh4.02	Structure	Structure
G.hgh4	288	P	G.hgh4.03	Structure	Structure
G.hgh4	289	E	G.hgh4.04	Structure	Structure
G.hgh4	290	Y	G.hgh4.05	Structure	Structure
G.hgh4	291	A	G.hgh4.06	Structure	Structure
G.hgh4	292	G	G.hgh4.07	Structure	Structure
G.hgh4	293	S	G.hgh4.08	Structure	Structure
G.H4	294	N	G.H4.01	Structure	Structure
G.H4	295	T	G.H4.02	Structure	Structure
G.H4	296	Y	G.H4.03	Structure	Structure
G.H4	297	E	G.H4.04	Structure	Structure
G.H4	298	E	G.H4.05	Structure	Structure
G.H4	299	A	G.H4.06	Structure	Structure
G.H4	300	A	G.H4.07	Structure	Structure
G.H4	301	A	G.H4.08	Structure	Structure
G.H4	302	Y	G.H4.10	Structure	Structure
G.H4	303	I	G.H4.11	Structure	Structure
G.H4	304	Q	G.H4.12	Structure	Structure
G.H4	305	C	G.H4.13	Structure	Structure
G.H4	306	Q	G.H4.14	Structure	Structure
G.H4	307	F	G.H4.15	Structure	Structure
G.H4	308	E	G.H4.16	Structure	Structure
G.H4	309	D	G.H4.17	Structure	Structure
G.h4s6	310	L	G.h4s6.01	Structure	Structure
G.h4s6	311	N	G.h4s6.02	Structure	Structure
G.h4s6	312	K	G.h4s6.03	Structure	Structure
G.h4s6	313	R	G.h4s6.04	Structure	Structure
G.h4s6	314	K	G.h4s6.08	Structure	Structure
G.h4s6	315	D	G.h4s6.09	Structure	Structure
G.h4s6	316	T	G.h4s6.10	Structure	Structure
G.h4s6	317	K	G.h4s6.11	Structure	Structure
G.h4s6	318	E	G.h4s6.12	Structure	Structure
G.S6	319	I	G.S6.01	Structure	Structure
G.S6	320	Y	G.S6.02	Structure	Structure
G.S6	321	T	G.S6.03	Structure	Structure
G.S6	322	H	G.S6.04	Structure	Structure
G.S6	323	F	G.S6.05	Structure	Structure
G.s6h5	324	T	G.s6h5.01	Structure	Structure
G.s6h5	325	C	G.s6h5.02	Structure	Structure
G.s6h5	326	A	G.s6h5.03	Structure	AF2
G.s6h5	327	T	G.s6h5.04	Structure	Structure
G.s6h5	328	D	G.s6h5.05	Structure	Structure
G.H5	329	T	G.H5.01	Structure	Structure
G.H5	330	K	G.H5.02	Structure	Structure
G.H5	331	N	G.H5.03	Structure	Structure
G.H5	332	V	G.H5.04	Structure	Structure
G.H5	333	Q	G.H5.05	Structure	Structure
G.H5	334	F	G.H5.06	Structure	Structure
G.H5	335	V	G.H5.07	Structure	Structure
G.H5	336	F	G.H5.08	Structure	Structure
G.H5	337	D	G.H5.09	Structure	Structure
G.H5	338	A	G.H5.10	Structure	Structure
G.H5	339	V	G.H5.11	Structure	Structure
G.H5	340	T	G.H5.12	Structure	Structure
G.H5	341	D	G.H5.13	Structure	Structure
G.H5	342	V	G.H5.14	Structure	Structure
G.H5	343	I	G.H5.15	Structure	Structure
G.H5	344	I	G.H5.16	Structure	Structure
G.H5	345	K	G.H5.17	Structure	Structure
G.H5	346	N	G.H5.18	Structure	Structure
G.H5	347	N	G.H5.19	Structure	Structure
G.H5	348	L	G.H5.20	Structure	Structure
G.H5	349	K	G.H5.21	Structure	Structure
G.H5	350	D	G.H5.22	Structure	Structure
G.H5	351	C	G.H5.23	Structure	Structure
G.H5	352	G	G.H5.24	Structure	Structure
G.H5	353	L	G.H5.25	Structure	Structure
G.H5	354	F	G.H5.26	Structure	Structure

REFINED GPCR RESIDUES

Residue backbones - 271 from structure (85.2%), 47 from model (14.8%)
Residue sidechains - 270 from structure (84.9%), 48 from model (15.1%)

Showing 1 to 318 of 318 entries

Search:

Segment	Seq.num.	AA	GPCRdb#	Backbone from	Sidechain from

N-term	1	M	-	AF2	AF2
N-term	2	D	-	AF2	AF2
N-term	3	F	-	AF2	AF2
N-term	4	L	-	AF2	AF2
N-term	5	N	-	AF2	AF2
N-term	6	S	-	AF2	AF2
N-term	7	S	-	AF2	AF2
N-term	8	D	-	AF2	AF2
N-term	9	Q	-	AF2	AF2
N-term	10	N	-	AF2	AF2
N-term	11	L	-	AF2	AF2
N-term	12	T	-	AF2	AF2
N-term	13	S	-	AF2	AF2
N-term	14	E	-	AF2	AF2
N-term	15	E	-	AF2	AF2
N-term	16	L	-	AF2	AF2
N-term	17	L	-	AF2	AF2
N-term	18	N	-	AF2	AF2
N-term	19	R	-	AF2	AF2
TM1	20	M	1.29x29	Structure	Structure
TM1	21	P	1.30x30	Structure	Structure
TM1	22	S	1.31x31	Structure	Structure
TM1	23	K	1.32x32	Structure	Structure
TM1	24	I	1.33x33	Structure	Structure
TM1	25	L	1.34x34	Structure	Structure
TM1	26	V	1.35x35	Structure	Structure
TM1	27	S	1.36x36	Structure	Structure
TM1	28	L	1.37x37	Structure	Structure
TM1	29	T	1.38x38	Structure	Structure
TM1	30	L	1.39x39	Structure	Structure
TM1	31	S	1.40x40	Structure	Structure
TM1	32	G	1.41x41	Structure	Structure
TM1	33	L	1.42x42	Structure	Structure
TM1	34	A	1.43x43	Structure	Structure
TM1	35	L	1.44x44	Structure	Structure
TM1	36	M	1.45x45	Structure	Structure
TM1	37	T	1.46x46	Structure	Structure
TM1	38	T	1.47x47	Structure	Structure
TM1	39	T	1.48x48	Structure	Structure
TM1	40	I	1.49x49	Structure	Structure
TM1	41	N	1.50x50	Structure	Structure
TM1	42	S	1.51x51	Structure	Structure
TM1	43	L	1.52x52	Structure	Structure
TM1	44	V	1.53x53	Structure	Structure
TM1	45	I	1.54x54	Structure	Structure
TM1	46	A	1.55x55	Structure	Structure
TM1	47	A	1.56x56	Structure	Structure
TM1	48	I	1.57x57	Structure	Structure
TM1	49	I	1.58x58	Structure	Structure
TM1	50	V	1.59x59	Structure	Structure
TM1	51	T	1.60x60	Structure	Structure
ICL1	52	R	12.48x48	Structure	Structure
ICL1	53	K	12.49x49	Structure	Structure
ICL1	54	L	12.50x50	Structure	Structure
ICL1	55	H	12.51x51	Structure	Structure
TM2	56	H	2.37x37	Structure	Structure
TM2	57	P	2.38x38	Structure	Structure
TM2	58	A	2.39x39	Structure	Structure
TM2	59	N	2.40x40	Structure	Structure
TM2	60	Y	2.41x41	Structure	Structure
TM2	61	L	2.42x42	Structure	Structure
TM2	62	I	2.43x43	Structure	Structure
TM2	63	C	2.44x44	Structure	Structure
TM2	64	S	2.45x45	Structure	Structure
TM2	65	L	2.46x46	Structure	Structure
TM2	66	A	2.47x47	Structure	Structure
TM2	67	V	2.48x48	Structure	Structure
TM2	68	T	2.49x49	Structure	Structure
TM2	69	D	2.50x50	Structure	Structure
TM2	70	F	2.51x51	Structure	Structure
TM2	71	L	2.52x52	Structure	Structure
TM2	72	V	2.53x53	Structure	Structure
TM2	73	A	2.54x54	Structure	Structure
TM2	74	V	2.55x55	Structure	Structure
TM2	75	L	2.56x551	Structure	Structure
TM2	76	V	2.57x56	Structure	Structure
TM2	77	M	2.58x57	Structure	Structure
TM2	78	P	2.59x58	Structure	Structure
TM2	79	F	2.60x59	Structure	Structure
TM2	80	S	2.61x60	Structure	Structure
TM2	81	I	2.62x61	Structure	Structure
TM2	82	V	2.63x62	Structure	Structure
TM2	83	Y	2.64x63	Structure	Structure
TM2	84	I	2.65x64	Structure	Structure
TM2	85	V	2.66x65	Structure	Structure
TM2	86	R	2.67x66	Structure	Structure
TM2	87	E	2.68x67	Structure	Structure
ECL1	88	S	23.49x49	Structure	Structure
ECL1	89	W	23.50x50	Structure	Structure
ECL1	90	I	23.51x51	Structure	Structure
ECL1	91	M	23.52x52	Structure	Structure
TM3	92	G	3.21x21	Structure	Structure
TM3	93	Q	3.22x22	Structure	Structure
TM3	94	V	3.23x23	Structure	Structure
TM3	95	V	3.24x24	Structure	Structure
TM3	96	C	3.25x25	Structure	Structure
TM3	97	D	3.26x26	Structure	Structure
TM3	98	I	3.27x27	Structure	Structure
TM3	99	W	3.28x28	Structure	Structure
TM3	100	L	3.29x29	Structure	Structure
TM3	101	S	3.30x30	Structure	Structure
TM3	102	V	3.31x31	Structure	Structure
TM3	103	D	3.32x32	Structure	Structure
TM3	104	I	3.33x33	Structure	Structure
TM3	105	T	3.34x34	Structure	Structure
TM3	106	C	3.35x35	Structure	Structure
TM3	107	C	3.36x36	Structure	Structure
TM3	108	T	3.37x37	Structure	Structure
TM3	109	C	3.38x38	Structure	Structure
TM3	110	S	3.39x39	Structure	Structure
TM3	111	I	3.40x40	Structure	Structure
TM3	112	L	3.41x41	Structure	Structure
TM3	113	H	3.42x42	Structure	Structure
TM3	114	L	3.43x43	Structure	Structure
TM3	115	S	3.44x44	Structure	Structure
TM3	116	A	3.45x45	Structure	Structure
TM3	117	I	3.46x46	Structure	Structure
TM3	118	A	3.47x47	Structure	Structure
TM3	119	L	3.48x48	Structure	Structure
TM3	120	D	3.49x49	Structure	Structure
TM3	121	R	3.50x50	Structure	Structure
TM3	122	Y	3.51x51	Structure	Structure
TM3	123	R	3.52x52	Structure	Structure
TM3	124	A	3.53x53	Structure	Structure
TM3	125	I	3.54x54	Structure	Structure
TM3	126	T	3.55x55	Structure	Structure
TM3	127	D	3.56x56	Structure	Structure
ICL2	128	A	34.50x50	Structure	Structure
ICL2	129	V	34.51x51	Structure	Structure
ICL2	130	E	34.52x52	Structure	Structure
ICL2	131	Y	34.53x53	Structure	Structure
ICL2	132	A	34.54x54	Structure	Structure
ICL2	133	R	34.55x55	Structure	Structure
ICL2	134	K	34.56x56	Structure	Structure
ICL2	135	R	34.57x57	Structure	Structure
TM4	136	T	4.38x38	Structure	Structure
TM4	137	P	4.39x39	Structure	Structure
TM4	138	K	4.40x40	Structure	Structure
TM4	139	H	4.41x41	Structure	Structure
TM4	140	A	4.42x42	Structure	Structure
TM4	141	G	4.43x43	Structure	Structure
TM4	142	I	4.44x44	Structure	Structure
TM4	143	M	4.45x45	Structure	Structure
TM4	144	I	4.46x46	Structure	Structure
TM4	145	T	4.47x47	Structure	Structure
TM4	146	I	4.48x48	Structure	Structure
TM4	147	V	4.49x49	Structure	Structure
TM4	148	W	4.50x50	Structure	Structure
TM4	149	I	4.51x51	Structure	Structure
TM4	150	I	4.52x52	Structure	Structure
TM4	151	S	4.53x53	Structure	Structure
TM4	152	V	4.54x54	Structure	Structure
TM4	153	F	4.55x55	Structure	Structure
TM4	154	I	4.56x56	Structure	Structure
TM4	155	S	4.57x57	Structure	Structure
TM4	156	M	4.58x58	Structure	Structure
TM4	157	P	4.59x59	Structure	Structure
TM4	158	P	4.60x60	Structure	Structure
TM4	159	L	4.61x61	Structure	Structure
TM4	160	F	4.62x62	Structure	Structure
TM4	161	W	4.63x63	Structure	Structure
TM4	162	R	4.64x64	Structure	Structure
TM4	163	H	4.65x65	Structure	Structure
ECL2	164	Q	-	Structure	Structure
ECL2	165	G	-	Structure	Structure
ECL2	166	T	-	Structure	Structure
ECL2	167	S	-	Structure	Structure
ECL2	168	R	-	Structure	Structure
ECL2	169	D	-	Structure	Structure
ECL2	170	D	-	Structure	Structure
ECL2	171	E	-	Structure	Structure
ECL2	172	C	45.50x50	Structure	Structure
ECL2	173	I	45.51x51	Structure	Structure
ECL2	174	I	45.52x52	Structure	Structure
ECL2	175	K	-	Structure	Structure
ECL2	176	H	-	Structure	Structure
ECL2	177	D	-	Structure	Structure
TM5	178	H	5.35x36	Structure	Structure
TM5	179	I	5.36x37	Structure	Structure
TM5	180	V	5.37x38	Structure	Structure
TM5	181	S	5.38x39	Structure	Structure
TM5	182	T	5.39x40	Structure	Structure
TM5	183	I	5.40x41	Structure	Structure
TM5	184	Y	5.41x42	Structure	Structure
TM5	185	S	5.42x43	Structure	Structure
TM5	186	T	5.43x44	Structure	Structure
TM5	187	F	5.44x45	Structure	Structure
TM5	188	G	5.45x46	Structure	Structure
TM5	189	A	5.46x461	Structure	Structure
TM5	190	F	5.47x47	Structure	Structure
TM5	191	Y	5.48x48	Structure	Structure
TM5	192	I	5.49x49	Structure	Structure
TM5	193	P	5.50x50	Structure	Structure
TM5	194	L	5.51x51	Structure	Structure
TM5	195	A	5.52x52	Structure	Structure
TM5	196	L	5.53x53	Structure	Structure
TM5	197	I	5.54x54	Structure	Structure
TM5	198	L	5.55x55	Structure	Structure
TM5	199	I	5.56x56	Structure	Structure
TM5	200	L	5.57x57	Structure	Structure
TM5	201	Y	5.58x58	Structure	Structure
TM5	202	Y	5.59x59	Structure	Structure
TM5	203	K	5.60x60	Structure	Structure
TM5	204	I	5.61x61	Structure	Structure
TM5	205	Y	5.62x62	Structure	Structure
TM5	206	R	5.63x63	Structure	Structure
TM5	207	A	5.64x64	Structure	Structure
TM5	208	A	5.65x65	Structure	Structure
TM5	209	K	5.66x66	Structure	Structure
TM5	210	T	5.67x67	Structure	Structure
TM5	211	L	5.68x68	Structure	Structure
TM5	212	Y	5.69x69	Structure	Structure
TM5	213	H	5.70x70	Structure	Structure
TM5	214	K	5.71x71	AF2	AF2
TM5	215	R	5.72x72	AF2	AF2
TM5	216	Q	5.73x73	AF2	AF2
TM5	217	A	5.74x74	AF2	AF2
TM5	218	S	5.75x75	AF2	AF2
TM5	219	R	5.76x76	AF2	AF2
ICL3	220	I	-	AF2	AF2
ICL3	221	A	-	AF2	AF2
ICL3	222	K	-	AF2	AF2
ICL3	223	E	-	AF2	AF2
ICL3	224	E	-	AF2	AF2
ICL3	225	V	-	AF2	AF2
ICL3	226	N	-	AF2	AF2
ICL3	275	E	-	AF2	AF2
ICL3	276	K	-	AF2	AF2
ICL3	277	S	-	AF2	AF2
ICL3	278	W	-	AF2	AF2
ICL3	279	R	-	AF2	AF2
ICL3	280	R	-	AF2	AF2
ICL3	281	Q	-	AF2	AF2
TM6	282	K	6.24x24	AF2	AF2
TM6	283	I	6.25x25	AF2	AF2
TM6	284	S	6.26x26	AF2	AF2
TM6	285	G	6.27x27	Structure	Structure
TM6	286	T	6.28x28	Structure	Structure
TM6	287	R	6.29x29	Structure	Structure
TM6	288	E	6.30x30	Structure	Structure
TM6	289	R	6.31x31	Structure	Structure
TM6	290	K	6.32x32	Structure	Structure
TM6	291	A	6.33x33	Structure	Structure
TM6	292	A	6.34x34	Structure	Structure
TM6	293	T	6.35x35	Structure	Structure
TM6	294	T	6.36x36	Structure	Structure
TM6	295	L	6.37x37	Structure	Structure
TM6	296	G	6.38x38	Structure	Structure
TM6	297	L	6.39x39	Structure	Structure
TM6	298	I	6.40x40	Structure	Structure
TM6	299	L	6.41x41	Structure	Structure
TM6	300	G	6.42x42	Structure	Structure
TM6	301	A	6.43x43	Structure	Structure
TM6	302	F	6.44x44	Structure	Structure
TM6	303	V	6.45x45	Structure	Structure
TM6	304	I	6.46x46	Structure	Structure
TM6	305	C	6.47x47	Structure	Structure
TM6	306	W	6.48x48	Structure	Structure
TM6	307	L	6.49x49	Structure	Structure
TM6	308	P	6.50x50	Structure	Structure
TM6	309	F	6.51x51	Structure	Structure
TM6	310	F	6.52x52	Structure	Structure
TM6	311	V	6.53x53	Structure	Structure
TM6	312	K	6.54x54	Structure	Structure
TM6	313	E	6.55x55	Structure	Structure
TM6	314	L	6.56x56	Structure	Structure
TM6	315	V	6.57x57	Structure	Structure
TM6	316	V	6.58x58	Structure	Structure
TM6	317	N	6.59x59	Structure	Structure
TM6	318	V	6.60x60	Structure	Structure
TM6	319	C	6.61x61	Structure	Structure
ECL3	320	D	-	Structure	Structure
ECL3	321	K	-	Structure	Structure
ECL3	322	C	-	Structure	Structure
ECL3	323	K	-	Structure	AF2
ECL3	324	I	-	Structure	Structure
TM7	325	S	7.31x30	Structure	Structure
TM7	326	E	7.32x31	Structure	Structure
TM7	327	E	7.33x32	Structure	Structure
TM7	328	M	7.34x33	Structure	Structure
TM7	329	S	7.35x34	Structure	Structure
TM7	330	N	7.36x35	Structure	Structure
TM7	331	F	7.37x36	Structure	Structure
TM7	332	L	7.38x37	Structure	Structure
TM7	333	A	7.39x38	Structure	Structure
TM7	334	W	7.40x39	Structure	Structure
TM7	335	L	7.41x40	Structure	Structure
TM7	336	G	7.42x41	Structure	Structure
TM7	337	Y	7.43x42	Structure	Structure
TM7	338	L	7.44x43	Structure	Structure
TM7	339	N	7.45x45	Structure	Structure
TM7	340	S	7.46x46	Structure	Structure
TM7	341	L	7.47x47	Structure	Structure
TM7	342	I	7.48x48	Structure	Structure
TM7	343	N	7.49x49	Structure	Structure
TM7	344	P	7.50x50	Structure	Structure
TM7	345	L	7.51x51	Structure	Structure
TM7	346	I	7.52x52	Structure	Structure
TM7	347	Y	7.53x53	Structure	Structure
TM7	348	T	7.54x54	Structure	Structure
TM7	349	I	7.55x55	Structure	Structure
TM7	350	F	7.56x56	Structure	Structure
H8	351	N	8.47x47	Structure	Structure
H8	352	E	8.48x48	Structure	Structure
H8	353	D	8.49x49	Structure	Structure
H8	354	F	8.50x50	Structure	Structure
H8	355	K	8.51x51	Structure	Structure
H8	356	K	8.52x52	Structure	Structure
H8	357	A	8.53x53	Structure	Structure
H8	358	F	8.54x54	Structure	Structure
H8	359	Q	8.55x55	Structure	Structure
H8	360	K	8.56x56	Structure	Structure
H8	361	L	8.57x57	Structure	Structure
C-term	362	V	-	AF2	AF2
C-term	363	R	-	AF2	AF2
C-term	364	C	-	AF2	AF2
C-term	365	R	-	AF2	AF2
C-term	366	C	-	AF2	AF2

GPCR - G protein interface interactions

The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.

Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):

bb-bb

bb-sc

sc-sc

sc-bb

Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Search:

Interaction type	GPCR Segment	AA	Number	Generic number	Gα segment	AA	Number	Generic number

Interaction type	GPCR Segment	AA	Number	Generic number	Gα segment	AA	Number	Generic number

Aromatic	TM6	R	287	6x29	G.H5	F	354	G.H5.26
Hydrophobic	TM5	I	204	5x61	G.H5	L	353	G.H5.25
Hydrophobic	ICL2	R	133	34x55	G.hns1	R	32	G.hns1.03
Hydrophobic	TM3	R	121	3x50	G.H5	C	351	G.H5.23
Hydrophobic	TM6	I	283	6x25	G.h4s6	K	314	G.h4s6.08
Hydrophobic	TM7	F	350	7x56	G.H5	G	352	G.H5.24
Hydrophobic	TM6	A	291	6x33	G.H5	L	353	G.H5.25
Hydrophobic	TM6	T	294	6x36	G.H5	G	352	G.H5.24
Hydrophobic	ICL2	V	129	34x51	G.H5	F	336	G.H5.08
Hydrophobic	TM5	I	204	5x61	G.H5	L	348	G.H5.20
Hydrophobic	ICL3	K	222	-	G.H4	Q	304	G.H4.12
Hydrophobic	TM5	L	211	5x68	G.H5	D	341	G.H5.13
Hydrophobic	TM3	A	124	3x53	G.H5	N	347	G.H5.19
Hydrophobic	TM5	L	211	5x68	G.H5	K	345	G.H5.17
Hydrophobic	TM5	A	208	5x65	G.H5	L	353	G.H5.25
Hydrophobic	TM5	L	211	5x68	G.H5	L	348	G.H5.20
Hydrophobic	TM3	I	125	3x54	G.H5	L	348	G.H5.20
Hydrophobic	TM5	R	215	5x72	G.H5	K	345	G.H5.17
Hydrophobic	TM5	L	211	5x68	G.H5	I	344	G.H5.16
Hydrophobic	TM3	I	125	3x54	G.H5	I	344	G.H5.16
Hydrophobic	TM5	A	208	5x65	G.H5	L	348	G.H5.20
Hydrophobic	TM3	I	125	3x54	G.H5	N	347	G.H5.19
Hydrophobic	TM6	R	287	6x29	G.H5	F	354	G.H5.26
Hydrophobic	ICL2	A	128	34x50	G.H5	I	344	G.H5.16
Hydrophobic	ICL3	K	222	-	G.H4	C	305	G.H4.13
Hydrophobic	H8	N	351	8x47	G.H5	D	350	G.H5.22
Hydrophobic	TM6	I	283	6x25	G.h4s6	D	315	G.h4s6.09
Hydrophobic	ICL3	K	222	-	G.H4	E	308	G.H4.16
Hydrophobic	ICL2	A	128	34x50	G.H5	I	343	G.H5.15
Hydrophobic	ICL2	V	129	34x51	G.S3	L	194	G.S3.01
Hydrophobic	TM6	K	290	6x32	G.H5	F	354	G.H5.26
Ionic	H8	E	352	8x48	G.H5	K	349	G.H5.21
Ionic	ICL3	K	222	-	G.H4	E	308	G.H4.16
Ionic	TM5	R	215	5x72	G.H5	D	341	G.H5.13
Ionic	ICL3	K	276	-	G.H4	D	309	G.H4.17
Polar	ICL2	R	133	34x55	G.hns1	R	32	G.hns1.03
Polar	TM3	R	121	3x50	G.H5	C	351	G.H5.23
Polar	TM7	F	350	7x56	G.H5	G	352	G.H5.24
Polar	TM6	R	287	6x29	G.h4s6	D	315	G.h4s6.09
Polar	TM6	T	294	6x36	G.H5	G	352	G.H5.24
Polar	ICL3	K	222	-	G.H4	Q	304	G.H4.12
Polar	H8	E	352	8x48	G.H5	K	349	G.H5.21
Polar	TM3	A	124	3x53	G.H5	N	347	G.H5.19
Polar	TM5	R	219	5x76	G.h4s6	K	314	G.h4s6.08
Polar	H8	N	351	8x47	G.H5	D	350	G.H5.22
Polar	ICL3	K	222	-	G.H4	E	308	G.H4.16
Polar	TM5	R	215	5x72	G.H5	D	341	G.H5.13
Polar	TM6	K	290	6x32	G.H5	G	352	G.H5.24
Polar	ICL3	K	222	-	G.S6	T	321	G.S6.03
Polar	ICL3	K	276	-	G.H4	D	309	G.H4.17
Polar	TM6	K	290	6x32	G.H5	F	354	G.H5.26
Van-der-waals	ICL2	R	133	34x55	G.hns1	R	32	G.hns1.03
Van-der-waals	TM3	R	121	3x50	G.H5	C	351	G.H5.23
Van-der-waals	TM7	F	350	7x56	G.H5	G	352	G.H5.24
Van-der-waals	TM6	A	291	6x33	G.H5	L	353	G.H5.25
Van-der-waals	TM6	T	294	6x36	G.H5	G	352	G.H5.24
Van-der-waals	ICL3	K	222	-	G.H4	Q	304	G.H4.12
Van-der-waals	TM3	A	124	3x53	G.H5	N	347	G.H5.19
Van-der-waals	TM5	L	211	5x68	G.H5	L	348	G.H5.20
Van-der-waals	TM3	I	125	3x54	G.H5	L	348	G.H5.20
Van-der-waals	TM5	R	215	5x72	G.H5	K	345	G.H5.17
Van-der-waals	TM3	I	125	3x54	G.H5	I	344	G.H5.16
Van-der-waals	TM3	I	125	3x54	G.H5	N	347	G.H5.19
Van-der-waals	TM6	R	287	6x29	G.H5	F	354	G.H5.26
Van-der-waals	ICL2	A	128	34x50	G.H5	I	344	G.H5.16
Van-der-waals	ICL3	K	222	-	G.H4	E	308	G.H4.16
Van-der-waals	TM5	R	215	5x72	G.H5	D	341	G.H5.13
Van-der-waals	TM6	K	290	6x32	G.H5	G	352	G.H5.24
Van-der-waals	ICL3	K	222	-	G.S6	T	321	G.S6.03
Van-der-waals	ICL2	V	129	34x51	G.S3	L	194	G.S3.01
Van-der-waals	ICL3	K	276	-	G.H4	D	309	G.H4.17
Van-der-waals	TM6	K	290	6x32	G.H5	F	354	G.H5.26

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Main reference

Refined structure (7EXD) of Gi1 - 5-HT1F receptor Download Full

GPCR CLASS (FAMILY)

SPECIES

G PROTEIN FAMILY

DATE

3D VIEW

REFINED G PROTEIN RESIDUES

REFINED GPCR RESIDUES

GPCR - G protein interface interactions

Structures

Refined structure (7EXD) of G_i1 - 5-HT_1F receptor

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