Refined structure (7VIF) of Gi1 - S1P1 receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2024-02-01

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 225 from structure (63.6%), 129 from model (36.4%)
Residue sidechains - 222 from structure (62.7%), 132 from model (37.3%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 Structure Structure
G.HN 4 T G.HN.10 Structure Structure
G.HN 5 L G.HN.11 Structure Structure
G.HN 6 S G.HN.30 Structure Structure
G.HN 7 A G.HN.31 Structure Structure
G.HN 8 E G.HN.32 Structure Structure
G.HN 9 D G.HN.33 Structure Structure
G.HN 10 K G.HN.34 Structure Structure
G.HN 11 A G.HN.35 Structure Structure
G.HN 12 A G.HN.36 Structure Structure
G.HN 13 V G.HN.37 Structure Structure
G.HN 14 E G.HN.38 Structure Structure
G.HN 15 R G.HN.39 Structure Structure
G.HN 16 S G.HN.40 Structure Structure
G.HN 17 K G.HN.41 Structure Structure
G.HN 18 M G.HN.42 Structure Structure
G.HN 19 I G.HN.43 Structure Structure
G.HN 20 D G.HN.44 Structure Structure
G.HN 21 R G.HN.45 Structure Structure
G.HN 22 N G.HN.46 Structure Structure
G.HN 23 L G.HN.47 Structure Structure
G.HN 24 R G.HN.48 Structure Structure
G.HN 25 E G.HN.49 Structure Structure
G.HN 26 D G.HN.50 Structure Structure
G.HN 27 G G.HN.51 Structure Structure
G.HN 28 E G.HN.52 Structure Structure
G.HN 29 K G.HN.53 Structure Structure
G.hns1 30 A G.hns1.01 Structure Structure
G.hns1 31 A G.hns1.02 Structure Structure
G.hns1 32 R G.hns1.03 Structure Structure
G.S1 33 E G.S1.01 Structure Structure
G.S1 34 V G.S1.02 Structure Structure
G.S1 35 K G.S1.03 Structure Structure
G.S1 36 L G.S1.04 Structure Structure
G.S1 37 L G.S1.05 Structure Structure
G.S1 38 L G.S1.06 Structure Structure
G.S1 39 L G.S1.07 Structure Structure
G.s1h1 40 G G.s1h1.01 Structure Structure
G.s1h1 41 A G.s1h1.02 Structure Structure
G.s1h1 42 G G.s1h1.03 Structure Structure
G.s1h1 43 E G.s1h1.04 Structure Structure
G.s1h1 44 S G.s1h1.05 Structure Structure
G.s1h1 45 G G.s1h1.06 Structure Structure
G.H1 46 K G.H1.01 Structure Structure
G.H1 47 S G.H1.02 Structure Structure
G.H1 48 T G.H1.03 Structure Structure
G.H1 49 I G.H1.04 Structure Structure
G.H1 50 V G.H1.05 Structure Structure
G.H1 51 K G.H1.06 Structure Structure
G.H1 52 Q G.H1.07 Structure Structure
G.H1 53 M G.H1.08 Structure Structure
G.H1 54 K G.H1.09 Structure Structure
G.H1 55 I G.H1.10 Structure Structure
G.H1 56 I G.H1.11 Structure Structure
G.H1 57 H G.H1.12 AF2 AF2
G.h1ha 58 E G.h1ha.01 AF2 AF2
G.h1ha 59 A G.h1ha.02 AF2 AF2
G.h1ha 60 G G.h1ha.03 AF2 AF2
G.h1ha 61 Y G.h1ha.04 AF2 AF2
G.h1ha 62 S G.h1ha.05 AF2 AF2
H.HA 63 E H.HA.01 AF2 AF2
H.HA 64 E H.HA.02 AF2 AF2
H.HA 65 E H.HA.03 AF2 AF2
H.HA 66 C H.HA.04 AF2 AF2
H.HA 67 K H.HA.05 AF2 AF2
H.HA 68 Q H.HA.06 AF2 AF2
H.HA 69 Y H.HA.07 AF2 AF2
H.HA 70 K H.HA.08 AF2 AF2
H.HA 71 A H.HA.09 AF2 AF2
H.HA 72 V H.HA.10 AF2 AF2
H.HA 73 V H.HA.11 AF2 AF2
H.HA 74 Y H.HA.12 AF2 AF2
H.HA 75 S H.HA.13 AF2 AF2
H.HA 76 N H.HA.14 AF2 AF2
H.HA 77 T H.HA.15 AF2 AF2
H.HA 78 I H.HA.16 AF2 AF2
H.HA 79 Q H.HA.17 AF2 AF2
H.HA 80 S H.HA.18 AF2 AF2
H.HA 81 I H.HA.19 AF2 AF2
H.HA 82 I H.HA.20 AF2 AF2
H.HA 83 A H.HA.21 AF2 AF2
H.HA 84 I H.HA.22 AF2 AF2
H.HA 85 I H.HA.23 AF2 AF2
H.HA 86 R H.HA.24 AF2 AF2
H.HA 87 A H.HA.25 AF2 AF2
H.HA 88 M H.HA.26 AF2 AF2
H.HA 89 G H.HA.27 AF2 AF2
H.HA 90 R H.HA.28 AF2 AF2
H.HA 91 L H.HA.29 AF2 AF2
H.hahb 92 K H.hahb.01 AF2 AF2
H.hahb 93 I H.hahb.04 AF2 AF2
H.hahb 94 D H.hahb.05 AF2 AF2
H.hahb 95 F H.hahb.06 AF2 AF2
H.hahb 96 G H.hahb.07 AF2 AF2
H.hahb 97 D H.hahb.08 AF2 AF2
H.hahb 98 S H.hahb.09 AF2 AF2
H.HB 99 A H.HB.01 AF2 AF2
H.HB 100 R H.HB.02 AF2 AF2
H.HB 101 A H.HB.03 AF2 AF2
H.HB 102 D H.HB.04 AF2 AF2
H.HB 103 D H.HB.05 AF2 AF2
H.HB 104 A H.HB.06 AF2 AF2
H.HB 105 R H.HB.07 AF2 AF2
H.HB 106 Q H.HB.08 AF2 AF2
H.HB 107 L H.HB.09 AF2 AF2
H.HB 108 F H.HB.10 AF2 AF2
H.HB 109 V H.HB.11 AF2 AF2
H.HB 110 L H.HB.12 AF2 AF2
H.HB 111 A H.HB.13 AF2 AF2
H.HB 112 G H.HB.14 AF2 AF2
H.hbhc 113 A H.hbhc.01 AF2 AF2
H.hbhc 114 A H.hbhc.02 AF2 AF2
H.hbhc 115 E H.hbhc.03 AF2 AF2
H.hbhc 116 E H.hbhc.04 AF2 AF2
H.hbhc 117 G H.hbhc.12 AF2 AF2
H.hbhc 118 F H.hbhc.13 AF2 AF2
H.hbhc 119 M H.hbhc.14 AF2 AF2
H.hbhc 120 T H.hbhc.15 AF2 AF2
H.HC 121 A H.HC.01 AF2 AF2
H.HC 122 E H.HC.02 AF2 AF2
H.HC 123 L H.HC.03 AF2 AF2
H.HC 124 A H.HC.04 AF2 AF2
H.HC 125 G H.HC.05 AF2 AF2
H.HC 126 V H.HC.06 AF2 AF2
H.HC 127 I H.HC.07 AF2 AF2
H.HC 128 K H.HC.08 AF2 AF2
H.HC 129 R H.HC.09 AF2 AF2
H.HC 130 L H.HC.10 AF2 AF2
H.HC 131 W H.HC.11 AF2 AF2
H.HC 132 K H.HC.12 AF2 AF2
H.hchd 133 D H.hchd.01 AF2 AF2
H.HD 134 S H.HD.01 AF2 AF2
H.HD 135 G H.HD.02 AF2 AF2
H.HD 136 V H.HD.03 AF2 AF2
H.HD 137 Q H.HD.04 AF2 AF2
H.HD 138 A H.HD.05 AF2 AF2
H.HD 139 C H.HD.06 AF2 AF2
H.HD 140 F H.HD.07 AF2 AF2
H.HD 141 N H.HD.08 AF2 AF2
H.HD 142 R H.HD.09 AF2 AF2
H.HD 143 S H.HD.10 AF2 AF2
H.HD 144 R H.HD.11 AF2 AF2
H.HD 145 E H.HD.12 AF2 AF2
H.hdhe 146 Y H.hdhe.01 AF2 AF2
H.hdhe 147 Q H.hdhe.02 AF2 AF2
H.hdhe 148 L H.hdhe.03 AF2 AF2
H.hdhe 149 N H.hdhe.04 AF2 AF2
H.hdhe 150 D H.hdhe.05 AF2 AF2
H.HE 151 S H.HE.01 AF2 AF2
H.HE 152 A H.HE.02 AF2 AF2
H.HE 153 A H.HE.03 AF2 AF2
H.HE 154 Y H.HE.04 AF2 AF2
H.HE 155 Y H.HE.05 AF2 AF2
H.HE 156 L H.HE.06 AF2 AF2
H.HE 157 N H.HE.07 AF2 AF2
H.HE 158 D H.HE.08 AF2 AF2
H.HE 159 L H.HE.09 AF2 AF2
H.HE 160 D H.HE.10 AF2 AF2
H.HE 161 R H.HE.11 AF2 AF2
H.HE 162 I H.HE.12 AF2 AF2
H.HE 163 A H.HE.13 AF2 AF2
H.hehf 164 Q H.hehf.01 AF2 AF2
H.hehf 165 P H.hehf.02 AF2 AF2
H.hehf 166 N H.hehf.03 AF2 AF2
H.hehf 167 Y H.hehf.04 AF2 AF2
H.hehf 168 I H.hehf.05 AF2 AF2
H.hehf 169 P H.hehf.06 AF2 AF2
H.hehf 170 T H.hehf.07 AF2 AF2
H.HF 171 Q H.HF.01 AF2 AF2
H.HF 172 Q H.HF.02 AF2 AF2
H.HF 173 D H.HF.03 AF2 AF2
H.HF 174 V H.HF.04 AF2 AF2
H.HF 175 L H.HF.05 AF2 AF2
H.HF 176 R H.HF.06 AF2 AF2
G.hfs2 177 T G.hfs2.01 AF2 AF2
G.hfs2 178 R G.hfs2.02 AF2 AF2
G.hfs2 179 V G.hfs2.03 AF2 AF2
G.hfs2 180 K G.hfs2.04 AF2 AF2
G.hfs2 181 T G.hfs2.05 AF2 AF2
G.hfs2 182 T G.hfs2.06 AF2 AF2
G.hfs2 183 G G.hfs2.07 Structure Structure
G.S2 184 I G.S2.01 Structure Structure
G.S2 185 V G.S2.02 Structure Structure
G.S2 186 E G.S2.03 Structure Structure
G.S2 187 T G.S2.04 Structure Structure
G.S2 188 H G.S2.05 Structure Structure
G.S2 189 F G.S2.06 Structure Structure
G.S2 190 T G.S2.07 Structure Structure
G.S2 191 F G.S2.08 Structure Structure
G.s2s3 192 K G.s2s3.01 Structure Structure
G.s2s3 193 D G.s2s3.02 Structure Structure
G.S3 194 L G.S3.01 Structure Structure
G.S3 195 H G.S3.02 Structure Structure
G.S3 196 F G.S3.03 Structure Structure
G.S3 197 K G.S3.04 Structure Structure
G.S3 198 M G.S3.05 Structure Structure
G.S3 199 F G.S3.06 Structure Structure
G.S3 200 D G.S3.07 Structure Structure
G.S3 201 V G.S3.08 Structure Structure
G.s3h2 202 G G.s3h2.01 Structure Structure
G.s3h2 203 G G.s3h2.02 Structure Structure
G.s3h2 204 Q G.s3h2.03 Structure Structure
G.H2 205 R G.H2.01 Structure Structure
G.H2 206 S G.H2.02 Structure Structure
G.H2 207 E G.H2.03 Structure Structure
G.H2 208 R G.H2.04 Structure Structure
G.H2 209 K G.H2.05 Structure Structure
G.H2 210 K G.H2.06 Structure Structure
G.H2 211 W G.H2.07 Structure Structure
G.H2 212 I G.H2.08 Structure Structure
G.H2 213 H G.H2.09 Structure Structure
G.H2 214 C G.H2.10 Structure Structure
G.h2s4 215 F G.h2s4.01 Structure Structure
G.h2s4 216 E G.h2s4.02 Structure Structure
G.h2s4 217 G G.h2s4.03 Structure Structure
G.h2s4 218 V G.h2s4.04 Structure Structure
G.h2s4 219 T G.h2s4.05 Structure Structure
G.S4 220 A G.S4.01 Structure Structure
G.S4 221 I G.S4.02 Structure Structure
G.S4 222 I G.S4.03 Structure Structure
G.S4 223 F G.S4.04 Structure Structure
G.S4 224 C G.S4.05 Structure Structure
G.S4 225 V G.S4.06 Structure Structure
G.S4 226 A G.S4.07 Structure Structure
G.s4h3 227 L G.s4h3.01 Structure Structure
G.s4h3 228 S G.s4h3.02 Structure Structure
G.s4h3 229 D G.s4h3.03 Structure Structure
G.s4h3 230 Y G.s4h3.04 Structure Structure
G.s4h3 231 D G.s4h3.05 Structure Structure
G.s4h3 232 L G.s4h3.06 Structure Structure
G.s4h3 233 V G.s4h3.07 Structure Structure
G.s4h3 234 L G.s4h3.08 Structure Structure
G.s4h3 235 A G.s4h3.09 Structure Structure
G.s4h3 236 E G.s4h3.10 Structure AF2
G.s4h3 237 D G.s4h3.11 AF2 AF2
G.s4h3 238 E G.s4h3.12 Structure AF2
G.s4h3 239 E G.s4h3.13 Structure Structure
G.s4h3 240 M G.s4h3.14 Structure Structure
G.s4h3 241 N G.s4h3.15 Structure Structure
G.H3 242 R G.H3.01 Structure Structure
G.H3 243 M G.H3.02 Structure Structure
G.H3 244 H G.H3.03 Structure Structure
G.H3 245 E G.H3.04 Structure Structure
G.H3 246 S G.H3.05 Structure Structure
G.H3 247 M G.H3.06 Structure Structure
G.H3 248 K G.H3.07 Structure Structure
G.H3 249 L G.H3.08 Structure Structure
G.H3 250 F G.H3.09 Structure Structure
G.H3 251 D G.H3.10 Structure Structure
G.H3 252 S G.H3.11 Structure Structure
G.H3 253 I G.H3.12 Structure Structure
G.H3 254 C G.H3.13 Structure Structure
G.H3 255 N G.H3.14 Structure Structure
G.H3 256 N G.H3.15 Structure Structure
G.H3 257 K G.H3.16 Structure Structure
G.H3 258 W G.H3.17 Structure Structure
G.H3 259 F G.H3.18 Structure Structure
G.h3s5 260 T G.h3s5.01 Structure Structure
G.h3s5 261 D G.h3s5.02 Structure Structure
G.h3s5 262 T G.h3s5.03 Structure Structure
G.S5 263 S G.S5.01 Structure Structure
G.S5 264 I G.S5.02 Structure Structure
G.S5 265 I G.S5.03 Structure Structure
G.S5 266 L G.S5.04 Structure Structure
G.S5 267 F G.S5.05 Structure Structure
G.S5 268 L G.S5.06 Structure Structure
G.S5 269 N G.S5.07 Structure Structure
G.s5hg 270 K G.s5hg.01 Structure Structure
G.HG 271 K G.HG.01 Structure Structure
G.HG 272 D G.HG.02 Structure Structure
G.HG 273 L G.HG.03 Structure Structure
G.HG 274 F G.HG.04 Structure Structure
G.HG 275 E G.HG.05 Structure Structure
G.HG 276 E G.HG.06 Structure Structure
G.HG 277 K G.HG.07 Structure Structure
G.HG 278 I G.HG.08 Structure Structure
G.HG 279 K G.HG.09 Structure Structure
G.HG 280 K G.HG.12 Structure AF2
G.HG 281 S G.HG.13 Structure Structure
G.HG 282 P G.HG.14 Structure Structure
G.HG 283 L G.HG.15 Structure Structure
G.HG 284 T G.HG.16 Structure Structure
G.HG 285 I G.HG.17 Structure Structure
G.hgh4 286 C G.hgh4.01 Structure Structure
G.hgh4 287 Y G.hgh4.02 Structure Structure
G.hgh4 288 P G.hgh4.03 Structure Structure
G.hgh4 289 E G.hgh4.04 Structure Structure
G.hgh4 290 Y G.hgh4.05 Structure Structure
G.hgh4 291 A G.hgh4.06 Structure Structure
G.hgh4 292 G G.hgh4.07 Structure Structure
G.hgh4 293 S G.hgh4.08 Structure Structure
G.H4 294 N G.H4.01 Structure Structure
G.H4 295 T G.H4.02 Structure Structure
G.H4 296 Y G.H4.03 Structure Structure
G.H4 297 E G.H4.04 Structure Structure
G.H4 298 E G.H4.05 Structure Structure
G.H4 299 A G.H4.06 Structure Structure
G.H4 300 A G.H4.07 Structure Structure
G.H4 301 A G.H4.08 Structure Structure
G.H4 302 Y G.H4.10 Structure Structure
G.H4 303 I G.H4.11 Structure Structure
G.H4 304 Q G.H4.12 Structure Structure
G.H4 305 C G.H4.13 Structure Structure
G.H4 306 Q G.H4.14 Structure Structure
G.H4 307 F G.H4.15 Structure Structure
G.H4 308 E G.H4.16 Structure Structure
G.H4 309 D G.H4.17 Structure Structure
G.h4s6 310 L G.h4s6.01 Structure Structure
G.h4s6 311 N G.h4s6.02 Structure Structure
G.h4s6 312 K G.h4s6.03 Structure Structure
G.h4s6 313 R G.h4s6.04 Structure Structure
G.h4s6 314 K G.h4s6.08 Structure Structure
G.h4s6 315 D G.h4s6.09 Structure Structure
G.h4s6 316 T G.h4s6.10 Structure Structure
G.h4s6 317 K G.h4s6.11 Structure Structure
G.h4s6 318 E G.h4s6.12 Structure Structure
G.S6 319 I G.S6.01 Structure Structure
G.S6 320 Y G.S6.02 Structure Structure
G.S6 321 T G.S6.03 Structure Structure
G.S6 322 H G.S6.04 Structure Structure
G.S6 323 F G.S6.05 Structure Structure
G.s6h5 324 T G.s6h5.01 Structure Structure
G.s6h5 325 C G.s6h5.02 Structure Structure
G.s6h5 326 A G.s6h5.03 Structure Structure
G.s6h5 327 T G.s6h5.04 Structure Structure
G.s6h5 328 D G.s6h5.05 Structure Structure
G.H5 329 T G.H5.01 Structure Structure
G.H5 330 K G.H5.02 Structure Structure
G.H5 331 N G.H5.03 Structure Structure
G.H5 332 V G.H5.04 Structure Structure
G.H5 333 Q G.H5.05 Structure Structure
G.H5 334 F G.H5.06 Structure Structure
G.H5 335 V G.H5.07 Structure Structure
G.H5 336 F G.H5.08 Structure Structure
G.H5 337 D G.H5.09 Structure Structure
G.H5 338 A G.H5.10 Structure Structure
G.H5 339 V G.H5.11 Structure Structure
G.H5 340 T G.H5.12 Structure Structure
G.H5 341 D G.H5.13 Structure Structure
G.H5 342 V G.H5.14 Structure Structure
G.H5 343 I G.H5.15 Structure Structure
G.H5 344 I G.H5.16 Structure Structure
G.H5 345 K G.H5.17 Structure Structure
G.H5 346 N G.H5.18 Structure Structure
G.H5 347 N G.H5.19 Structure Structure
G.H5 348 L G.H5.20 Structure Structure
G.H5 349 K G.H5.21 Structure Structure
G.H5 350 D G.H5.22 Structure Structure
G.H5 351 C G.H5.23 Structure Structure
G.H5 352 G G.H5.24 Structure Structure
G.H5 353 L G.H5.25 Structure Structure
G.H5 354 F G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 280 from structure (83.1%), 57 from model (16.9%)
Residue sidechains - 280 from structure (83.1%), 57 from model (16.9%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 G - AF2 AF2
N-term 3 P - AF2 AF2
N-term 4 T - AF2 AF2
N-term 5 S - AF2 AF2
N-term 6 V - AF2 AF2
N-term 7 P - AF2 AF2
N-term 8 L - AF2 AF2
N-term 9 V - AF2 AF2
N-term 10 K - AF2 AF2
N-term 11 A - AF2 AF2
N-term 12 H - AF2 AF2
N-term 13 R - AF2 AF2
N-term 14 S - AF2 AF2
N-term 15 S - AF2 AF2
N-term 16 V - AF2 AF2
N-term 17 S - AF2 AF2
N-term 18 D - AF2 AF2
N-term 19 Y - AF2 AF2
N-term 20 V - AF2 AF2
N-term 21 N - AF2 AF2
N-term 22 Y - AF2 AF2
N-term 23 D - Structure Structure
N-term 24 I - Structure Structure
N-term 25 I - Structure Structure
N-term 26 V - Structure Structure
N-term 27 R - Structure Structure
N-term 28 H - Structure Structure
N-term 29 Y - Structure Structure
N-term 30 N - Structure Structure
N-term 31 Y - Structure Structure
N-term 32 T - Structure Structure
N-term 33 G - Structure Structure
N-term 34 K - Structure Structure
N-term 35 L - Structure Structure
N-term 36 N - Structure Structure
N-term 37 I - AF2 AF2
N-term 38 S - AF2 AF2
N-term 39 A - AF2 AF2
N-term 40 D - AF2 AF2
N-term 41 K - AF2 AF2
TM1 42 E 1.29x29 AF2 AF2
TM1 43 N 1.30x30 AF2 AF2
TM1 44 S 1.31x31 AF2 AF2
TM1 45 I 1.32x32 AF2 AF2
TM1 46 K 1.33x33 AF2 AF2
TM1 47 L 1.34x34 AF2 AF2
TM1 48 T 1.35x35 Structure Structure
TM1 49 S 1.36x36 Structure Structure
TM1 50 V 1.37x37 Structure Structure
TM1 51 V 1.38x38 Structure Structure
TM1 52 F 1.39x39 Structure Structure
TM1 53 I 1.40x40 Structure Structure
TM1 54 L 1.41x41 Structure Structure
TM1 55 I 1.42x42 Structure Structure
TM1 56 C 1.43x43 Structure Structure
TM1 57 C 1.44x44 Structure Structure
TM1 58 F 1.45x45 Structure Structure
TM1 59 I 1.46x46 Structure Structure
TM1 60 I 1.47x47 Structure Structure
TM1 61 L 1.48x48 Structure Structure
TM1 62 E 1.49x49 Structure Structure
TM1 63 N 1.50x50 Structure Structure
TM1 64 I 1.51x51 Structure Structure
TM1 65 F 1.52x52 Structure Structure
TM1 66 V 1.53x53 Structure Structure
TM1 67 L 1.54x54 Structure Structure
TM1 68 L 1.55x55 Structure Structure
TM1 69 T 1.56x56 Structure Structure
TM1 70 I 1.57x57 Structure Structure
TM1 71 W 1.58x58 Structure Structure
TM1 72 K 1.59x59 Structure Structure
TM1 73 T 1.60x60 Structure Structure
ICL1 74 K 12.48x48 Structure Structure
ICL1 75 K 12.49x49 Structure Structure
ICL1 76 F 12.50x50 Structure Structure
ICL1 77 H 12.51x51 Structure Structure
TM2 78 R 2.37x37 Structure Structure
TM2 79 P 2.38x38 Structure Structure
TM2 80 M 2.39x39 Structure Structure
TM2 81 Y 2.40x40 Structure Structure
TM2 82 Y 2.41x41 Structure Structure
TM2 83 F 2.42x42 Structure Structure
TM2 84 I 2.43x43 Structure Structure
TM2 85 G 2.44x44 Structure Structure
TM2 86 N 2.45x45 Structure Structure
TM2 87 L 2.46x46 Structure Structure
TM2 88 A 2.47x47 Structure Structure
TM2 89 L 2.48x48 Structure Structure
TM2 90 S 2.49x49 Structure Structure
TM2 91 D 2.50x50 Structure Structure
TM2 92 L 2.51x51 Structure Structure
TM2 93 L 2.52x52 Structure Structure
TM2 94 A 2.53x53 Structure Structure
TM2 95 G 2.54x54 Structure Structure
TM2 96 V 2.55x55 Structure Structure
TM2 97 A 2.56x56 Structure Structure
TM2 98 Y 2.57x57 Structure Structure
TM2 99 T 2.58x58 Structure Structure
TM2 100 A 2.59x59 Structure Structure
TM2 101 N 2.60x60 Structure Structure
TM2 102 L 2.61x61 Structure Structure
TM2 103 L 2.62x62 Structure Structure
TM2 104 L 2.63x63 Structure Structure
TM2 105 S 2.64x64 Structure Structure
ECL1 106 G 23.47x47 Structure Structure
ECL1 107 A 23.48x48 Structure Structure
ECL1 108 T 23.49x49 Structure Structure
ECL1 109 T 23.50x50 Structure Structure
ECL1 110 Y 23.51x501 Structure Structure
ECL1 111 K 23.52x51 Structure Structure
ECL1 112 L 23.53x52 Structure Structure
TM3 113 T 3.21x21 Structure Structure
TM3 114 P 3.22x22 Structure Structure
TM3 115 A 3.23x23 Structure Structure
TM3 116 Q 3.24x24 Structure Structure
TM3 117 W 3.25x25 Structure Structure
TM3 118 F 3.26x26 Structure Structure
TM3 119 L 3.27x27 Structure Structure
TM3 120 R 3.28x28 Structure Structure
TM3 121 E 3.29x29 Structure Structure
TM3 122 G 3.30x30 Structure Structure
TM3 123 S 3.31x31 Structure Structure
TM3 124 M 3.32x32 Structure Structure
TM3 125 F 3.33x33 Structure Structure
TM3 126 V 3.34x34 Structure Structure
TM3 127 A 3.35x35 Structure Structure
TM3 128 L 3.36x36 Structure Structure
TM3 129 S 3.37x37 Structure Structure
TM3 130 A 3.38x38 Structure Structure
TM3 131 S 3.39x39 Structure Structure
TM3 132 V 3.40x40 Structure Structure
TM3 133 F 3.41x41 Structure Structure
TM3 134 S 3.42x42 Structure Structure
TM3 135 L 3.43x43 Structure Structure
TM3 136 L 3.44x44 Structure Structure
TM3 137 A 3.45x45 Structure Structure
TM3 138 I 3.46x46 Structure Structure
TM3 139 A 3.47x47 Structure Structure
TM3 140 I 3.48x48 Structure Structure
TM3 141 E 3.49x49 Structure Structure
TM3 142 R 3.50x50 Structure Structure
TM3 143 Y 3.51x51 Structure Structure
TM3 144 I 3.52x52 Structure Structure
TM3 145 T 3.53x53 Structure Structure
TM3 146 M 3.54x54 Structure Structure
TM3 147 L 3.55x55 Structure Structure
TM3 148 K 3.56x56 Structure Structure
ICL2 149 M 34.50x50 Structure Structure
ICL2 150 K 34.51x51 Structure Structure
ICL2 151 L 34.52x52 Structure Structure
ICL2 152 H 34.53x53 Structure Structure
ICL2 153 N 34.54x54 Structure Structure
ICL2 154 G 34.55x55 Structure Structure
ICL2 155 S 34.56x56 Structure Structure
TM4 156 N 4.38x38 Structure Structure
TM4 157 N 4.39x39 Structure Structure
TM4 158 F 4.40x40 Structure Structure
TM4 159 R 4.41x41 Structure Structure
TM4 160 L 4.42x42 Structure Structure
TM4 161 F 4.43x43 Structure Structure
TM4 162 L 4.44x44 Structure Structure
TM4 163 L 4.45x45 Structure Structure
TM4 164 I 4.46x46 Structure Structure
TM4 165 S 4.47x47 Structure Structure
TM4 166 A 4.48x48 Structure Structure
TM4 167 C 4.49x49 Structure Structure
TM4 168 W 4.50x50 Structure Structure
TM4 169 V 4.51x51 Structure Structure
TM4 170 I 4.52x52 Structure Structure
TM4 171 S 4.53x53 Structure Structure
TM4 172 L 4.54x54 Structure Structure
TM4 173 I 4.55x55 Structure Structure
TM4 174 L 4.56x56 Structure Structure
TM4 175 G 4.57x57 Structure Structure
TM4 176 G 4.58x58 Structure Structure
TM4 177 L 4.59x59 Structure Structure
TM4 178 P 4.60x60 Structure Structure
TM4 179 I 4.61x61 Structure Structure
TM4 180 M 4.62x62 Structure Structure
TM4 181 G 4.63x63 Structure Structure
ECL2 182 W - Structure Structure
ECL2 183 N - Structure Structure
ECL2 184 C - Structure Structure
ECL2 185 I - Structure Structure
ECL2 186 S - Structure Structure
ECL2 187 A - Structure Structure
ECL2 188 L - Structure Structure
ECL2 189 S - Structure Structure
ECL2 190 S - Structure Structure
ECL2 191 C - Structure Structure
ECL2 192 S - Structure Structure
ECL2 193 T - Structure Structure
ECL2 194 V - Structure Structure
ECL2 195 L - Structure Structure
ECL2 196 P - Structure Structure
ECL2 197 L - Structure Structure
ECL2 198 Y - Structure Structure
TM5 199 H 5.36x36 Structure Structure
TM5 200 K 5.37x37 Structure Structure
TM5 201 H 5.38x38 Structure Structure
TM5 202 Y 5.39x39 Structure Structure
TM5 203 I 5.40x40 Structure Structure
TM5 204 L 5.41x41 Structure Structure
TM5 205 F 5.42x42 Structure Structure
TM5 206 C 5.43x43 Structure Structure
TM5 207 T 5.44x44 Structure Structure
TM5 208 T 5.45x45 Structure Structure
TM5 209 V 5.46x46 Structure Structure
TM5 210 F 5.47x47 Structure Structure
TM5 211 T 5.48x48 Structure Structure
TM5 212 L 5.49x49 Structure Structure
TM5 213 L 5.50x50 Structure Structure
TM5 214 L 5.51x51 Structure Structure
TM5 215 L 5.52x52 Structure Structure
TM5 216 S 5.53x53 Structure Structure
TM5 217 I 5.54x54 Structure Structure
TM5 218 V 5.55x55 Structure Structure
TM5 219 I 5.56x56 Structure Structure
TM5 220 L 5.57x57 Structure Structure
TM5 221 Y 5.58x58 Structure Structure
TM5 222 C 5.59x59 Structure Structure
TM5 223 R 5.60x60 Structure Structure
TM5 224 I 5.61x61 Structure Structure
TM5 225 Y 5.62x62 Structure Structure
TM5 226 S 5.63x63 Structure Structure
TM5 227 L 5.64x64 Structure Structure
TM5 228 V 5.65x65 Structure Structure
TM5 229 R 5.66x66 Structure Structure
TM5 230 T 5.67x67 Structure Structure
TM5 231 R 5.68x68 Structure Structure
TM5 232 S 5.69x69 Structure Structure
TM5 233 R 5.70x70 Structure Structure
TM5 234 R 5.71x71 Structure Structure
TM5 235 L 5.72x72 Structure Structure
TM5 236 T 5.73x73 Structure Structure
ICL3 237 F - Structure Structure
ICL3 238 R - AF2 AF2
ICL3 239 K - AF2 AF2
ICL3 240 N - AF2 AF2
ICL3 241 I - AF2 AF2
ICL3 242 S - AF2 AF2
ICL3 243 K - AF2 AF2
ICL3 244 A - AF2 AF2
TM6 245 S 6.24x24 AF2 AF2
TM6 246 R 6.25x25 AF2 AF2
TM6 247 S 6.26x26 AF2 AF2
TM6 248 S 6.27x27 AF2 AF2
TM6 249 E 6.28x28 Structure Structure
TM6 250 K 6.29x29 Structure Structure
TM6 251 S 6.30x30 Structure Structure
TM6 252 L 6.31x31 Structure Structure
TM6 253 A 6.32x32 Structure Structure
TM6 254 L 6.33x33 Structure Structure
TM6 255 L 6.34x34 Structure Structure
TM6 256 K 6.35x35 Structure Structure
TM6 257 T 6.36x36 Structure Structure
TM6 258 V 6.37x37 Structure Structure
TM6 259 I 6.38x38 Structure Structure
TM6 260 I 6.39x39 Structure Structure
TM6 261 V 6.40x40 Structure Structure
TM6 262 L 6.41x41 Structure Structure
TM6 263 S 6.42x42 Structure Structure
TM6 264 V 6.43x43 Structure Structure
TM6 265 F 6.44x44 Structure Structure
TM6 266 I 6.45x45 Structure Structure
TM6 267 A 6.46x46 Structure Structure
TM6 268 C 6.47x47 Structure Structure
TM6 269 W 6.48x48 Structure Structure
TM6 270 A 6.49x49 Structure Structure
TM6 271 P 6.50x50 Structure Structure
TM6 272 L 6.51x51 Structure Structure
TM6 273 F 6.52x52 Structure Structure
TM6 274 I 6.53x53 Structure Structure
TM6 275 L 6.54x54 Structure Structure
TM6 276 L 6.55x55 Structure Structure
TM6 277 L 6.56x56 Structure Structure
TM6 278 L 6.57x57 Structure Structure
TM6 279 D 6.58x58 Structure Structure
TM6 280 V 6.59x59 Structure Structure
TM6 281 G 6.60x60 Structure Structure
TM6 282 C 6.61x61 Structure Structure
ECL3 283 K - Structure Structure
ECL3 284 V - Structure Structure
ECL3 285 K - Structure Structure
ECL3 286 T - Structure Structure
ECL3 287 C - Structure Structure
TM7 288 D 7.30x29 Structure Structure
TM7 289 I 7.31x30 Structure Structure
TM7 290 L 7.32x31 Structure Structure
TM7 291 F 7.33x32 Structure Structure
TM7 292 R 7.34x33 Structure Structure
TM7 293 A 7.35x34 Structure Structure
TM7 294 E 7.36x35 Structure Structure
TM7 295 Y 7.37x36 Structure Structure
TM7 296 F 7.38x37 Structure Structure
TM7 297 L 7.39x38 Structure Structure
TM7 298 V 7.40x39 Structure Structure
TM7 299 L 7.41x40 Structure Structure
TM7 300 A 7.42x41 Structure Structure
TM7 301 V 7.43x42 Structure Structure
TM7 302 L 7.44x43 Structure Structure
TM7 303 N 7.45x45 Structure Structure
TM7 304 S 7.46x46 Structure Structure
TM7 305 G 7.47x47 Structure Structure
TM7 306 T 7.48x48 Structure Structure
TM7 307 N 7.49x49 Structure Structure
TM7 308 P 7.50x50 Structure Structure
TM7 309 I 7.51x51 Structure Structure
TM7 310 I 7.52x52 Structure Structure
TM7 311 Y 7.53x53 Structure Structure
TM7 312 T 7.54x54 Structure Structure
TM7 313 L 7.55x55 Structure Structure
TM7 314 T 7.56x56 Structure Structure
H8 315 N 8.47x47 Structure Structure
H8 316 K 8.48x48 Structure Structure
H8 317 E 8.49x49 Structure Structure
H8 318 M 8.50x50 Structure Structure
H8 319 R 8.51x51 Structure Structure
H8 320 R 8.52x52 Structure Structure
H8 321 A 8.53x53 Structure Structure
H8 322 F 8.54x54 Structure Structure
H8 323 I 8.55x55 Structure Structure
H8 324 R 8.56x56 Structure Structure
H8 325 I 8.57x57 AF2 AF2
H8 326 M 8.58x58 AF2 AF2
H8 327 S 8.59x59 AF2 AF2
C-term 328 C - AF2 AF2
C-term 329 C - AF2 AF2
C-term 330 K - AF2 AF2
C-term 331 C - AF2 AF2
C-term 332 P - AF2 AF2
C-term 333 S - AF2 AF2
C-term 334 G - AF2 AF2
C-term 335 D - AF2 AF2
C-term 336 S - AF2 AF2
C-term 337 A - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 K 150 34x51 G.H5 I 343 G.H5.15
Van-der-waals ICL2 K 150 34x51 G.H5 I 343 G.H5.15
Ionic TM2 R 78 2x37 G.H5 D 350 G.H5.22
Polar TM2 R 78 2x37 G.H5 D 350 G.H5.22
Hydrophobic TM2 R 78 2x37 G.H5 D 350 G.H5.22
Van-der-waals TM2 R 78 2x37 G.H5 D 350 G.H5.22
Hydrophobic TM5 L 235 5x72 G.H5 D 337 G.H5.09
Van-der-waals TM5 L 235 5x72 G.H5 D 337 G.H5.09
Hydrophobic TM6 L 254 6x33 G.H5 L 348 G.H5.20
Hydrophobic TM2 M 80 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 M 80 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM2 M 80 2x39 G.H5 D 350 G.H5.22
Van-der-waals TM2 M 80 2x39 G.H5 D 350 G.H5.22
Hydrophobic ICL2 M 149 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 M 149 34x50 G.H5 I 344 G.H5.16
Ionic ICL3 R 238 - G.H5 D 337 G.H5.09
Hydrophobic ICL3 R 238 - G.H5 D 337 G.H5.09
Van-der-waals ICL3 R 238 - G.H5 D 337 G.H5.09
Ionic TM6 R 246 6x25 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 R 246 6x25 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 R 246 6x25 G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL2 L 151 34x52 G.H5 I 343 G.H5.15
Polar ICL2 N 153 34x54 G.H5 N 347 G.H5.19
Polar ICL2 N 153 34x54 G.H5 D 350 G.H5.22
Van-der-waals ICL2 N 153 34x54 G.H5 D 350 G.H5.22
Hydrophobic TM3 R 142 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM3 M 146 3x54 G.H5 L 348 G.H5.20
Polar TM3 T 145 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM6 T 257 6x36 G.H5 L 353 G.H5.25
Hydrophobic ICL2 L 151 34x52 G.S1 V 34 G.S1.02
Van-der-waals ICL2 L 151 34x52 G.S1 V 34 G.S1.02
Hydrophobic TM5 L 235 5x72 G.H5 I 344 G.H5.16
Hydrophobic TM6 L 254 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 254 6x33 G.H5 L 353 G.H5.25
Hydrophobic ICL2 L 151 34x52 G.S1 E 33 G.S1.01
Polar TM2 R 78 2x37 G.H5 K 349 G.H5.21
Van-der-waals TM2 R 78 2x37 G.H5 K 349 G.H5.21
Ionic ICL3 K 239 - G.H5 D 341 G.H5.13
Polar ICL3 K 239 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 K 239 - G.H5 D 341 G.H5.13
Polar TM3 R 142 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 142 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 142 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM5 R 231 5x68 G.H5 I 344 G.H5.16
Ionic ICL3 K 243 - G.H4 E 308 G.H4.16
Polar ICL3 K 243 - G.H4 E 308 G.H4.16
Hydrophobic ICL3 K 243 - G.H4 E 308 G.H4.16
Van-der-waals ICL3 K 243 - G.H4 E 308 G.H4.16
Hydrophobic TM3 T 145 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 T 145 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM3 M 146 3x54 G.H5 N 347 G.H5.19
Van-der-waals TM3 M 146 3x54 G.H5 N 347 G.H5.19
Hydrophobic TM6 K 250 6x29 G.H5 L 348 G.H5.20
Hydrophobic ICL3 K 239 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 K 239 - G.S6 Y 320 G.S6.02
Hydrophobic H8 K 316 8x48 G.H5 F 354 G.H5.26
Van-der-waals H8 K 316 8x48 G.H5 F 354 G.H5.26
Hydrophobic H8 N 315 8x47 G.H5 G 352 G.H5.24
Hydrophobic TM5 V 228 5x65 G.H5 L 348 G.H5.20
Polar ICL2 H 152 34x53 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 H 152 34x53 G.hns1 A 31 G.hns1.02
Hydrophobic TM6 K 250 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM6 K 250 6x29 G.H5 K 345 G.H5.17
Hydrophobic TM5 L 235 5x72 G.H5 D 341 G.H5.13
Van-der-waals TM5 L 235 5x72 G.H5 D 341 G.H5.13
Polar ICL3 R 238 - G.H5 Q 333 G.H5.05
Hydrophobic ICL3 R 238 - G.H5 Q 333 G.H5.05
Van-der-waals ICL3 R 238 - G.H5 Q 333 G.H5.05
Hydrophobic ICL2 M 149 34x50 G.H5 I 343 G.H5.15
Van-der-waals ICL2 M 149 34x50 G.H5 I 343 G.H5.15
Hydrophobic TM5 I 224 5x61 G.H5 L 353 G.H5.25
Hydrophobic TM5 L 235 5x72 G.H5 T 340 G.H5.12
Van-der-waals TM5 L 235 5x72 G.H5 T 340 G.H5.12
Ionic TM6 K 250 6x29 G.H5 D 341 G.H5.13
Polar TM6 K 250 6x29 G.H5 D 341 G.H5.13
Hydrophobic TM6 K 250 6x29 G.H5 D 341 G.H5.13
Van-der-waals TM6 K 250 6x29 G.H5 D 341 G.H5.13
Polar ICL3 K 243 - G.S6 I 319 G.S6.01
Van-der-waals ICL3 K 243 - G.S6 I 319 G.S6.01
Hydrophobic TM3 M 146 3x54 G.H5 C 351 G.H5.23
Van-der-waals TM3 M 146 3x54 G.H5 C 351 G.H5.23
Polar ICL2 M 149 34x50 G.H5 N 347 G.H5.19
Hydrophobic ICL2 M 149 34x50 G.H5 N 347 G.H5.19
Van-der-waals ICL2 M 149 34x50 G.H5 N 347 G.H5.19
Polar ICL3 K 243 - G.S6 T 321 G.S6.03
Hydrophobic TM6 K 250 6x29 G.H5 I 344 G.H5.16
Van-der-waals TM6 K 250 6x29 G.H5 I 344 G.H5.16