5-HT1E receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

2.9 Å

REFERENCE

PUBLICATION DATE

April 14, 2021

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

BRL-54443 - Agonist pubchem gtoplig chembl_ligand

PHYSIOLOGICAL LIGANDS

5-hydroxytryptamine, tryptamine



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic TM5 L 212 5x68 G.H5 K 345 G.H5.17
Hydrophobic TM6 A 289 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 A 289 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 R 285 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 285 6x29 G.H5 F 354 G.H5.26
Hydrophobic ICL2 I 128 34x51 G.H5 T 340 G.H5.12
Van-der-waals ICL2 I 128 34x51 G.H5 T 340 G.H5.12
Hydrophobic TM3 I 124 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 124 3x54 G.H5 L 348 G.H5.20
Polar ICL2 R 132 34x55 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 R 132 34x55 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 R 132 34x55 G.s2s3 D 193 G.s2s3.02
Hydrophobic TM6 I 292 6x36 G.H5 L 353 G.H5.25
Hydrophobic ICL2 R 132 34x55 G.S3 L 194 G.S3.01
Van-der-waals ICL2 R 132 34x55 G.S3 L 194 G.S3.01
Hydrophobic TM3 I 124 3x54 G.H5 C 351 G.H5.23
Polar H8 N 348 8x47 G.H5 D 350 G.H5.22
Hydrophobic H8 N 348 8x47 G.H5 D 350 G.H5.22
Van-der-waals H8 N 348 8x47 G.H5 D 350 G.H5.22
Polar TM3 R 120 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 120 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 120 3x50 G.H5 C 351 G.H5.23
Hydrophobic ICL2 I 128 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 I 128 34x51 G.S3 L 194 G.S3.01
Hydrophobic TM5 I 205 5x61 G.H5 L 353 G.H5.25
Van-der-waals TM5 I 205 5x61 G.H5 L 353 G.H5.25
Hydrophobic TM3 I 124 3x54 G.H5 I 344 G.H5.16
Van-der-waals TM3 I 124 3x54 G.H5 I 344 G.H5.16
Hydrophobic ICL2 R 132 34x55 G.hns1 R 32 G.hns1.03
Polar TM7 F 347 7x56 G.H5 G 352 G.H5.24
Hydrophobic TM7 F 347 7x56 G.H5 G 352 G.H5.24
Van-der-waals TM7 F 347 7x56 G.H5 G 352 G.H5.24
Hydrophobic TM6 L 293 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM5 L 212 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 L 212 5x68 G.H5 I 344 G.H5.16
Polar TM3 A 123 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 123 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 123 3x53 G.H5 N 347 G.H5.19
Hydrophobic ICL2 A 127 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 A 127 34x50 G.H5 I 344 G.H5.16
Hydrophobic TM6 I 292 6x36 G.H5 G 352 G.H5.24
Van-der-waals TM6 I 292 6x36 G.H5 G 352 G.H5.24
Hydrophobic TM5 L 212 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 L 212 5x68 G.H5 D 341 G.H5.13
Hydrophobic ICL2 A 127 34x50 G.H5 I 343 G.H5.15
Hydrophobic ICL2 I 128 34x51 G.H5 I 343 G.H5.15
Van-der-waals H8 E 349 8x48 G.H5 K 349 G.H5.21