GLP-2 receptor - Gs

GPCR CLASS (FAMILY)

Class B1 (Secretin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Bos taurus

PDB CODE

7D68

RESOLUTION

3.0 Å

REFERENCE

10.1038/S41422-020-00442-0

PUBLICATION DATE

Dec. 16, 2020

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

87 interactions (Click to see)

LIGANDS

glucagon - Agonist pubchem gtoplig chembl_ligand drugbank drug_central gtoplig pubchem pubchem pubchem pubchem

PHYSIOLOGICAL LIGANDS

glucagon-like peptide 2, glucagon-like peptide 2-(3-33)



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 V 293 - G.H5 H 387 G.H5.19
Van-der-waals ICL2 V 293 - G.H5 H 387 G.H5.19
Hydrophobic TM3 L 288 3x57 G.H5 Y 391 G.H5.23
Van-der-waals TM3 L 288 3x57 G.H5 Y 391 G.H5.23
Hydrophobic TM5 L 369 5x65 G.H5 L 394 G.H5.26
Van-der-waals TM5 L 369 5x65 G.H5 L 394 G.H5.26
Hydrophobic TM5 I 361 5x57 G.H5 L 393 G.H5.25
Hydrophobic TM6 S 386 6x41 G.H5 L 393 G.H5.25
Polar TM5 K 368 5x64 G.H5 R 385 G.H5.17
Hydrophobic TM5 K 368 5x64 G.H5 R 385 G.H5.17
Van-der-waals TM5 K 368 5x64 G.H5 R 385 G.H5.17
Aromatic ICL3 H 372 - G.h4s6 Y 358 G.h4s6.20
Hydrophobic ICL3 H 372 - G.h4s6 Y 358 G.h4s6.20
Van-der-waals ICL3 H 372 - G.h4s6 Y 358 G.h4s6.20
Polar TM6 R 382 6x37 G.H5 L 394 G.H5.26
Hydrophobic TM5 L 365 5x61 G.H5 L 393 G.H5.25
Van-der-waals TM5 L 365 5x61 G.H5 L 393 G.H5.25
Polar TM6 R 382 6x37 G.H5 L 393 G.H5.25
Hydrophobic TM6 R 382 6x37 G.H5 L 393 G.H5.25
Hydrophobic TM2 H 214 2x50 G.H5 Y 391 G.H5.23
Hydrophobic TM5 L 365 5x61 G.H5 L 388 G.H5.20
Hydrophobic TM3 L 285 3x54 G.H5 Y 391 G.H5.23
Van-der-waals TM3 L 285 3x54 G.H5 Y 391 G.H5.23
Hydrophobic TM3 L 289 3x58 G.H5 H 387 G.H5.19
Van-der-waals TM3 L 289 3x58 G.H5 H 387 G.H5.19
Hydrophobic ICL2 V 293 - G.H5 I 383 G.H5.15
Polar TM5 K 368 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 K 368 5x64 G.H5 Q 384 G.H5.16
Polar TM2 R 210 2x46 G.H5 Q 390 G.H5.22
Aromatic ICL3 H 372 - G.H5 R 385 G.H5.17
Hydrophobic ICL3 H 372 - G.H5 R 385 G.H5.17
Polar TM3 L 289 3x58 G.H5 Q 384 G.H5.16
Hydrophobic TM3 L 289 3x58 G.H5 Q 384 G.H5.16
Van-der-waals TM3 L 289 3x58 G.H5 Q 384 G.H5.16
Hydrophobic TM5 K 368 5x64 G.H5 L 388 G.H5.20
Polar H8 G 441 8x48 G.H5 E 392 G.H5.24
Hydrophobic H8 G 441 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 G 441 8x48 G.H5 E 392 G.H5.24
Hydrophobic ICL2 T 292 - G.S3 V 217 G.S3.01
Hydrophobic TM6 L 390 6x45 G.H5 L 393 G.H5.25
Polar TM7 Q 435 7x56 G.H5 E 392 G.H5.24
Hydrophobic TM3 L 289 3x58 G.H5 L 388 G.H5.20
Van-der-waals TM3 L 289 3x58 G.H5 L 388 G.H5.20
Hydrophobic TM3 Y 284 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 Y 284 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM5 L 365 5x61 G.H5 L 394 G.H5.26
Van-der-waals TM5 L 365 5x61 G.H5 L 394 G.H5.26
Hydrophobic TM6 V 389 6x44 G.H5 L 393 G.H5.25
Hydrophobic TM7 Y 436 7x57 G.H5 Y 391 G.H5.23
Aromatic TM2 R 210 2x46 G.H5 Y 391 G.H5.23
Hydrophobic TM2 R 210 2x46 G.H5 Y 391 G.H5.23
Van-der-waals TM2 R 210 2x46 G.H5 Y 391 G.H5.23
Hydrophobic TM5 K 368 5x64 G.H5 L 394 G.H5.26
Hydrophobic TM5 L 364 5x60 G.H5 Q 384 G.H5.16
Polar H8 N 440 8x47 G.H5 E 392 G.H5.24
Van-der-waals H8 N 440 8x47 G.H5 E 392 G.H5.24
Polar TM6 R 382 6x37 G.H5 E 392 G.H5.24
Van-der-waals TM6 R 382 6x37 G.H5 E 392 G.H5.24
Ionic TM5 K 368 5x64 G.H5 D 381 G.H5.13
Hydrophobic TM5 K 368 5x64 G.H5 D 381 G.H5.13
Polar TM3 L 288 3x57 G.H5 H 387 G.H5.19
Hydrophobic TM3 L 288 3x57 G.H5 H 387 G.H5.19