GPBA receptor - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7CFN

RESOLUTION

3.0 Å

REFERENCE

10.1038/S41586-020-2569-1

PUBLICATION DATE

Sept. 9, 2020

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

0 interactions (Click to see)

LIGANDS

INT-777 - Agonist pubchem ,

INT-777 - PAM pubchem

PHYSIOLOGICAL LIGANDS

cholic acid, lithocholic acid, chenodeoxycholic acid, deoxycholic acid



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM5 Q 195 5x68 G.H5 R 385 G.H5.17
Hydrophobic TM5 Q 195 5x68 G.H5 R 385 G.H5.17
Van-der-waals TM5 Q 195 5x68 G.H5 R 385 G.H5.17
Hydrophobic TM3 V 114 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 V 114 3x54 G.H5 L 388 G.H5.20
Hydrophobic TM5 Q 195 5x68 G.H5 L 388 G.H5.20
Van-der-waals TM5 Q 195 5x68 G.H5 L 388 G.H5.20
Polar H8 Q 285 8x48 G.H5 E 392 G.H5.24
Hydrophobic H8 Q 285 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 Q 285 8x48 G.H5 E 392 G.H5.24
Hydrophobic TM6 A 225 6x36 G.H5 L 393 G.H5.25
Van-der-waals TM6 A 225 6x36 G.H5 L 393 G.H5.25
Hydrophobic TM5 T 191 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 T 191 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM5 V 206 5x79 G.h4s6 T 350 G.h4s6.03
Van-der-waals TM5 V 206 5x79 G.h4s6 T 350 G.h4s6.03
Hydrophobic TM6 L 218 6x29 G.H5 L 394 G.H5.26
Polar TM6 R 221 6x32 G.H5 L 394 G.H5.26
Van-der-waals TM6 R 221 6x32 G.H5 L 394 G.H5.26
Hydrophobic TM5 L 202 5x75 G.S6 P 361 G.S6.03
Polar ICL3 R 208 - G.hgh4 T 319 G.hgh4.09
Van-der-waals ICL3 R 208 - G.hgh4 T 319 G.hgh4.09
Hydrophobic TM5 V 206 5x79 G.H4 D 343 G.H4.13
Hydrophobic TM2 A 50 2x39 G.H5 Y 391 G.H5.23
Hydrophobic TM5 V 206 5x79 G.H4 L 346 G.H4.16
Van-der-waals TM5 V 206 5x79 G.H4 L 346 G.H4.16
Hydrophobic TM6 Q 222 6x33 G.H5 L 394 G.H5.26
Van-der-waals TM6 Q 222 6x33 G.H5 L 394 G.H5.26
Hydrophobic TM5 A 192 5x65 G.H5 L 388 G.H5.20
Polar TM3 V 114 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 V 114 3x54 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 L 118 - G.H5 R 380 G.H5.12
Hydrophobic TM5 I 199 5x72 G.H5 L 394 G.H5.26
Hydrophobic TM5 I 199 5x72 G.H5 R 385 G.H5.17
Van-der-waals TM5 I 199 5x72 G.H5 R 385 G.H5.17
Van-der-waals TM5 L 202 5x75 G.H4 R 342 G.H4.12
Hydrophobic TM5 A 205 5x78 G.hgh4 D 323 G.hgh4.13
Hydrophobic ICL2 L 118 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 L 118 - G.H5 F 376 G.H5.08
Hydrophobic TM5 L 196 5x69 G.H5 L 394 G.H5.26
Polar TM3 A 113 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 A 113 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 A 113 3x53 G.H5 H 387 G.H5.19
Ionic H8 R 286 8x49 G.H5 E 392 G.H5.24
Polar H8 R 286 8x49 G.H5 E 392 G.H5.24
Hydrophobic H8 R 286 8x49 G.H5 E 392 G.H5.24
Van-der-waals H8 R 286 8x49 G.H5 E 392 G.H5.24
Hydrophobic TM6 L 214 6x25 G.h4s6 G 355 G.h4s6.11
Hydrophobic TM6 L 214 6x25 G.h4s6 Y 358 G.h4s6.20
Hydrophobic ICL2 P 117 - G.H5 Q 384 G.H5.16
Polar TM6 R 221 6x32 G.H5 E 392 G.H5.24
Hydrophobic TM6 R 221 6x32 G.H5 E 392 G.H5.24
Van-der-waals TM6 R 221 6x32 G.H5 E 392 G.H5.24
Hydrophobic H8 D 284 8x47 G.H5 E 392 G.H5.24
Van-der-waals H8 D 284 8x47 G.H5 E 392 G.H5.24
Hydrophobic ICL2 P 117 - G.H5 H 387 G.H5.19
Hydrophobic ICL2 P 117 - G.H5 R 380 G.H5.12
Aromatic TM3 R 110 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 110 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 110 3x50 G.H5 Y 391 G.H5.23
Polar TM3 E 109 3x49 G.H5 Y 391 G.H5.23
Hydrophobic TM3 E 109 3x49 G.H5 Y 391 G.H5.23
Van-der-waals TM3 E 109 3x49 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 L 118 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 L 118 - G.H5 I 383 G.H5.15
Hydrophobic TM5 A 192 5x65 G.H5 L 393 G.H5.25
Ionic TM5 D 198 5x71 G.H5 R 385 G.H5.17
Van-der-waals TM5 D 198 5x71 G.H5 R 385 G.H5.17
Hydrophobic TM5 Q 195 5x68 G.H5 L 394 G.H5.26
Van-der-waals TM5 Q 195 5x68 G.H5 L 394 G.H5.26
Hydrophobic TM5 L 202 5x75 G.H4 L 346 G.H4.16
Hydrophobic TM3 V 114 3x54 G.H5 Y 391 G.H5.23
Hydrophobic TM3 A 113 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM5 I 199 5x72 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM5 I 199 5x72 G.h4s6 Y 358 G.h4s6.20
Polar TM5 Q 195 5x68 G.H5 Q 384 G.H5.16
Van-der-waals ICL3 R 208 - G.hgh4 Y 318 G.hgh4.08
Hydrophobic ICL2 L 118 - G.S3 V 217 G.S3.01
Ionic ICL3 R 208 - G.H4 D 343 G.H4.13
Hydrophobic TM5 E 203 5x76 G.h4s6 T 350 G.h4s6.03
Hydrophobic ICL2 P 117 - G.H5 I 383 G.H5.15
Hydrophobic ICL2 L 118 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 118 - G.S1 H 41 G.S1.02
Hydrophobic TM5 L 189 5x62 G.H5 L 393 G.H5.25
Van-der-waals TM5 L 189 5x62 G.H5 L 393 G.H5.25
Hydrophobic TM6 L 214 6x25 G.h4s6 D 354 G.h4s6.10