MC5 receptor - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8INR

RESOLUTION

2.7 Å

REFERENCE

10.1107/S0907444909042073

PUBLICATION DATE

Sept. 20, 2023

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

69 interactions (Click to see)

LIGANDS

INTERMEDINE - Agonist chembl_ligand pubchem pubchem pubchem

PHYSIOLOGICAL LIGANDS

β-MSH, α-MSH, agouti-related protein, γ-MSH, ACTH



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL3 L 222 - G.h4s6 T 350 G.h4s6.03
Hydrophobic TM6 Q 235 6x32 G.H5 E 392 G.H5.24
Van-der-waals TM6 Q 235 6x32 G.H5 E 392 G.H5.24
Hydrophobic TM5 I 219 5x72 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM5 I 219 5x72 G.h4s6 Y 358 G.h4s6.20
Polar TM3 I 144 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 144 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 144 3x54 G.H5 Q 384 G.H5.16
Ionic TM5 R 218 5x71 G.H5 D 381 G.H5.13
Polar TM5 R 218 5x71 G.H5 D 381 G.H5.13
Hydrophobic TM5 R 218 5x71 G.H5 D 381 G.H5.13
Van-der-waals TM5 R 218 5x71 G.H5 D 381 G.H5.13
Hydrophobic ICL3 P 223 - G.H4 L 346 G.H4.16
Hydrophobic ICL2 L 148 - G.S3 V 217 G.S3.01
Hydrophobic ICL2 L 148 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 L 148 - G.H5 I 383 G.H5.15
Polar ICL2 R 149 - G.s2s3 K 216 G.s2s3.02
Hydrophobic ICL2 R 149 - G.s2s3 K 216 G.s2s3.02
Hydrophobic TM5 H 215 5x68 G.H5 L 394 G.H5.26
Hydrophobic ICL3 A 225 - G.h4s6 T 350 G.h4s6.03
Hydrophobic TM3 I 144 3x54 G.H5 Y 391 G.H5.23
Ionic TM5 H 215 5x68 G.H5 D 381 G.H5.13
Polar TM5 H 215 5x68 G.H5 D 381 G.H5.13
Polar ICL2 H 151 - G.HN Q 35 G.HN.52
Van-der-waals ICL2 H 151 - G.HN Q 35 G.HN.52
Polar TM5 H 215 5x68 G.H5 Q 384 G.H5.16
Hydrophobic TM5 H 215 5x68 G.H5 Q 384 G.H5.16
Van-der-waals TM5 H 215 5x68 G.H5 Q 384 G.H5.16
Polar TM6 T 239 6x36 G.H5 E 392 G.H5.24
Hydrophobic TM6 T 239 6x36 G.H5 E 392 G.H5.24
Van-der-waals TM6 T 239 6x36 G.H5 E 392 G.H5.24
Polar TM3 T 143 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 T 143 3x53 G.H5 Y 391 G.H5.23
Polar ICL2 L 148 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 L 148 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 148 - G.S1 H 41 G.S1.02
Hydrophobic TM5 A 212 5x65 G.H5 L 394 G.H5.26
Van-der-waals TM5 A 212 5x65 G.H5 L 394 G.H5.26
Hydrophobic TM5 I 219 5x72 G.H5 R 385 G.H5.17
Hydrophobic TM3 T 143 3x53 G.H5 H 387 G.H5.19
Hydrophobic ICL3 L 222 - G.H4 L 346 G.H4.16
Van-der-waals ICL3 L 222 - G.H4 L 346 G.H4.16
Hydrophobic TM2 M 71 2x39 G.H5 Y 391 G.H5.23
Hydrophobic TM5 L 211 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 144 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 I 144 3x54 G.H5 L 388 G.H5.20
Hydrophobic ICL2 A 147 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 A 147 - G.H5 I 383 G.H5.15
Hydrophobic TM5 F 209 5x62 G.H5 L 393 G.H5.25
Van-der-waals TM5 F 209 5x62 G.H5 L 393 G.H5.25
Aromatic TM5 H 215 5x68 G.H5 R 385 G.H5.17
Hydrophobic TM5 H 215 5x68 G.H5 R 385 G.H5.17
Hydrophobic TM5 A 221 5x74 G.hgh4 D 323 G.hgh4.13
Hydrophobic ICL2 H 151 - G.hns1 A 39 G.hns1.03
Aromatic TM3 R 140 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 140 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 140 3x50 G.H5 Y 391 G.H5.23
Hydrophobic ICL3 P 223 - G.H4 D 343 G.H4.13
Van-der-waals ICL3 P 223 - G.H4 D 343 G.H4.13
Hydrophobic TM5 A 212 5x65 G.H5 L 393 G.H5.25
Ionic ICL4 R 298 - G.H5 E 392 G.H5.24
Hydrophobic ICL4 R 298 - G.H5 E 392 G.H5.24
Van-der-waals ICL4 R 298 - G.H5 E 392 G.H5.24
Hydrophobic TM5 V 216 5x69 G.H5 L 394 G.H5.26
Hydrophobic ICL2 H 151 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 H 151 - G.hns1 R 38 G.hns1.02
Hydrophobic TM4 T 155 4x38 G.HN Q 35 G.HN.52
Van-der-waals TM4 T 155 4x38 G.HN Q 35 G.HN.52
Hydrophobic ICL2 L 148 - G.H5 R 380 G.H5.12
Hydrophobic TM5 M 208 5x61 G.H5 L 393 G.H5.25
Van-der-waals TM5 M 208 5x61 G.H5 L 393 G.H5.25
Hydrophobic TM5 M 208 5x61 G.H5 Y 391 G.H5.23
Van-der-waals TM5 R 218 5x71 G.H5 R 385 G.H5.17
Hydrophobic ICL2 R 149 - G.S3 V 217 G.S3.01
Van-der-waals ICL2 R 149 - G.S3 V 217 G.S3.01
Hydrophobic TM6 G 236 6x33 G.H5 L 393 G.H5.25
Hydrophobic ICL3 P 223 - G.H4 R 342 G.H4.12
Van-der-waals ICL3 P 223 - G.H4 R 342 G.H4.12
Hydrophobic TM5 A 212 5x65 G.H5 L 388 G.H5.20
Polar ICL3 P 223 - G.h4s6 T 350 G.h4s6.03
Hydrophobic ICL2 A 147 - G.H5 Q 384 G.H5.16
Hydrophobic TM6 T 239 6x36 G.H5 L 393 G.H5.25
Hydrophobic ICL2 H 152 - G.hns1 A 39 G.hns1.03
Polar ICL3 G 224 - G.h4s6 T 350 G.h4s6.03
Hydrophobic ICL3 G 224 - G.h4s6 T 350 G.h4s6.03
Van-der-waals ICL3 G 224 - G.h4s6 T 350 G.h4s6.03
Hydrophobic ICL2 L 148 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 L 148 - G.H5 F 376 G.H5.08
Hydrophobic TM3 I 144 3x54 G.H5 H 387 G.H5.19
Van-der-waals TM3 I 144 3x54 G.H5 H 387 G.H5.19
Van-der-waals TM6 T 232 6x29 G.H5 L 394 G.H5.26
Hydrophobic ICL2 L 148 - G.H5 C 379 G.H5.11