Structure information

MC5 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8INR

SPECIES

Homo sapiens

RESOLUTION

2.730

PREFERRED CHAIN

R

REFERENCE

10.1107/S0907444909042073

PUBLICATION DATE

Sept. 20, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
INTERMEDINE E92 2.60x60 TM2 polar (charge-assisted hydrogen bond)
INTERMEDINE T93 2.61x61 TM2 Van der Waals
INTERMEDINE I96 2.64x64 TM2 Van der Waals
INTERMEDINE I96 2.64x64 TM2 hydrophobic
INTERMEDINE N100 2.68x68 TM2 Van der Waals
INTERMEDINE N100 2.68x68 TM2 polar (hydrogen bond)
INTERMEDINE D108 3.18x18 TM3 Van der Waals
INTERMEDINE V111 3.21x21 TM3 Van der Waals
INTERMEDINE R112 3.22x22 TM3 Van der Waals
INTERMEDINE D115 3.25x25 TM3 polar (charge-assisted hydrogen bond)
INTERMEDINE N116 3.26x26 TM3 Van der Waals
INTERMEDINE N116 3.26x26 TM3 polar (hydrogen bond)
INTERMEDINE D119 3.29x29 TM3 polar (charge-assisted hydrogen bond)
INTERMEDINE I122 3.32x32 TM3 hydrophobic
INTERMEDINE I122 3.32x32 TM3 Van der Waals
INTERMEDINE C123 3.33x33 TM3 hydrophobic
INTERMEDINE C123 3.33x33 TM3 Van der Waals
INTERMEDINE F177 4.60x60 TM4 hydrophobic
INTERMEDINE F177 4.60x60 TM4 Van der Waals
INTERMEDINE I178 4.61x61 TM4 polar (hydrogen bond with backbone)
INTERMEDINE I178 4.61x61 TM4 Van der Waals
INTERMEDINE S181 ECL2 Van der Waals
INTERMEDINE I187 5.40x40 TM5 Van der Waals
INTERMEDINE I187 5.40x40 TM5 hydrophobic
INTERMEDINE L190 5.43x43 TM5 hydrophobic
INTERMEDINE L190 5.43x43 TM5 Van der Waals
INTERMEDINE H257 6.54x54 TM6 Van der Waals
INTERMEDINE L258 6.55x55 TM6 Van der Waals
INTERMEDINE M261 6.58x58 TM6 Van der Waals
INTERMEDINE M261 6.58x58 TM6 hydrophobic
INTERMEDINE F277 7.35x34 TM7 hydrophobic
INTERMEDINE F277 7.35x34 TM7 Van der Waals
INTERMEDINE N278 7.36x35 TM7 Van der Waals
INTERMEDINE N278 7.36x35 TM7 polar (hydrogen bond)
INTERMEDINE L281 7.39x38 TM7 hydrophobic

Ligands

INTERMEDINE

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Residue Diagrams

I N E L L S I V G L T L F V E V A 1 C S L A V A D M L V S M S S A W E T I T 2 A L L S C M S A V V S I C I M S D F V N 3 S G A I I A G I W A F C T G C G I V F I 4 Y L S V L L F L M A F F M S I L C L I V 5 T M L L G V F T V C W A P F F L H L T L 6 L P D M V S N C M I L I L Y M N F H 7
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ICL1 K N L H ICL1ECL1 K H L V I ECL1ICL2 A L R Y H H I M ICL2ECL2 E ECL2ICL3 L P G A S S A R ICL3ECL3 P Q N L Y C S R F M S ECL3N-term M N S S F H L H F L D L N L N A T E G N L S G P N V K N K S S P C E D M G I N-termC-term G F R I A C S F P R R D C-term A V E V F L T L G V I S L L E N I L V I G A I V K N S P M Y F F V C S L A V A D M L V S M S S A W E T I T I Y L L N N A D A F V R H I D N V F D S M I C I S V V A S M C S L L A I A V D R Y V T I F Y T A R R S G A I I A G I W A F C T G C G I V F I L Y S S T Y V I L C L I S M F F A M L F L L V S L Y I H M F L L A R T H V K R I A A Q R T S M Q G A V T V T M L L G V F T V C W A P F F L H L T L M L S C H F N M Y L I L I M C N S V M D P L I Y A F R S Q E F K E R M R K T I I C C
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Residue Table


GPCRdb(A)
GPCRdb(A)
MC5 receptor
TM2
2x60 2.60x60 E92
2x61 2.61x61 T93
2x64 2.64x64 I96
2x68 2.68x68 N100
TM3
3x18 3.18x18 D108
3x21 3.21x21 V111
3x22 3.22x22 R112
3x25 3.25x25 D115
3x26 3.26x26 N116
3x29 3.29x29 D119
3x32 3.32x32 I122
3x33 3.33x33 C123
TM4
4x60 4.60x60 F177
4x61 4.61x61 I178
TM5
5x40 5.40x40 I187
5x43 5.43x43 L190
TM6
6x54 6.54x54 H257
6x55 6.55x55 L258
6x58 6.58x58 M261
TM7
7x34 7.35x34 F277
7x35 7.36x35 N278
7x38 7.39x38 L281