Y2 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.4 Å

REFERENCE

PUBLICATION DATE

May 18, 2022

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

PHYSIOLOGICAL LIGANDS

neuropeptide Y, PYY-(3-36), peptide YY, neuropeptide Y-(3-36), pancreatic polypeptide



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic ICL2 H 155 - G.H5 I 344 G.H5.16
Van-der-waals ICL2 H 155 - G.H5 I 344 G.H5.16
Polar H8 S 330 8x48 G.H5 F 354 G.H5.26
Van-der-waals H8 S 330 8x48 G.H5 F 354 G.H5.26
Hydrophobic TM5 L 246 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM5 H 249 5x68 G.H5 T 340 G.H5.12
Polar TM6 R 262 6x29 G.H5 F 354 G.H5.26
Aromatic TM6 R 262 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM6 R 262 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 262 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM5 L 246 5x65 G.H5 I 344 G.H5.16
Hydrophobic TM6 M 269 6x36 G.H5 L 353 G.H5.25
Hydrophobic ICL3 P 252 - G.H5 D 337 G.H5.09
Van-der-waals ICL3 P 252 - G.H5 D 337 G.H5.09
Hydrophobic TM3 I 152 3x54 G.H5 N 347 G.H5.19
Van-der-waals TM3 I 152 3x54 G.H5 N 347 G.H5.19
Hydrophobic TM3 I 152 3x54 G.H5 I 344 G.H5.16
Van-der-waals TM3 I 152 3x54 G.H5 I 344 G.H5.16
Van-der-waals TM7 M 328 7x56 G.H5 G 352 G.H5.24
Ionic TM5 H 249 5x68 G.H5 D 341 G.H5.13
Polar TM5 H 249 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM5 H 249 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 H 249 5x68 G.H5 D 341 G.H5.13
Polar ICL2 S 158 - G.hns1 A 31 G.hns1.02
Polar ICL2 S 158 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 H 155 - G.H5 N 347 G.H5.19
Polar H8 N 329 8x47 G.H5 C 351 G.H5.23
Hydrophobic H8 N 329 8x47 G.H5 C 351 G.H5.23
Van-der-waals H8 N 329 8x47 G.H5 C 351 G.H5.23
Van-der-waals TM6 T 266 6x33 G.H5 F 354 G.H5.26
Polar H8 N 331 8x49 G.H5 K 349 G.H5.21
Van-der-waals H8 N 331 8x49 G.H5 K 349 G.H5.21
Polar H8 N 329 8x47 G.H5 G 352 G.H5.24
Hydrophobic H8 N 329 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 N 329 8x47 G.H5 G 352 G.H5.24
Polar TM3 C 151 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM3 C 151 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 C 151 3x53 G.H5 C 351 G.H5.23
Ionic ICL2 E 157 - G.hns1 R 32 G.hns1.03
Polar ICL2 E 157 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 E 157 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 E 157 - G.hns1 R 32 G.hns1.03
Polar TM3 C 151 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 C 151 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 C 151 3x53 G.H5 N 347 G.H5.19
Hydrophobic ICL3 P 252 - G.H5 F 334 G.H5.06
Van-der-waals ICL3 P 252 - G.H5 F 334 G.H5.06
Hydrophobic TM3 R 148 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 148 3x50 G.H5 L 353 G.H5.25
Polar ICL3 N 256 - G.H5 D 341 G.H5.13
Hydrophobic ICL2 H 155 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 H 155 - G.H5 I 343 G.H5.15
Van-der-waals ICL3 G 253 - G.S6 T 321 G.S6.03
Hydrophobic ICL3 A 255 - G.H4 E 308 G.H4.16
Van-der-waals ICL3 A 255 - G.H4 E 308 G.H4.16
Polar TM6 T 266 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 T 266 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 T 266 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM3 I 152 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 152 3x54 G.H5 L 348 G.H5.20
Polar H8 N 331 8x49 G.H5 D 350 G.H5.22
Hydrophobic H8 N 331 8x49 G.H5 D 350 G.H5.22
Van-der-waals H8 N 331 8x49 G.H5 D 350 G.H5.22
Hydrophobic ICL3 A 254 - G.S6 Y 320 G.S6.02
Hydrophobic TM2 T 85 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 T 85 2x39 G.H5 C 351 G.H5.23
Polar TM3 R 148 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 148 3x50 G.H5 C 351 G.H5.23
Polar ICL3 N 256 - G.H5 K 345 G.H5.17