GPR132 - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.0 Å

REFERENCE

PUBLICATION DATE

Oct. 11, 2023

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

NOX-6-7 - Agonist pubchem gtoplig

PHYSIOLOGICAL LIGANDS

9-hydroxyoctadecadienoic acid



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic TM6 K 239 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 239 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM2 L 77 2x39 G.H5 D 350 G.H5.22
Van-der-waals TM2 L 77 2x39 G.H5 D 350 G.H5.22
Hydrophobic TM6 Q 236 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 Q 236 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM6 V 240 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 V 240 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 S 243 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 S 243 6x36 G.H5 L 353 G.H5.25
Polar ICL3 G 231 - G.H5 K 345 G.H5.17
Polar TM3 A 143 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 143 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM6 V 240 6x33 G.H5 F 354 G.H5.26
Polar TM2 N 75 2x37 G.H5 D 350 G.H5.22
Van-der-waals TM2 N 75 2x37 G.H5 D 350 G.H5.22
Hydrophobic ICL2 A 147 - G.H5 I 344 G.H5.16
Polar TM3 R 140 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 140 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 140 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM2 L 77 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 L 77 2x39 G.H5 C 351 G.H5.23
Polar TM6 K 239 6x32 G.H5 L 353 G.H5.25