CT receptor - Gs

GPCR CLASS (FAMILY)

Class B1 (Secretin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

5UZ7

RESOLUTION

4.1 Å

REFERENCE

10.1038/NATURE22327

PUBLICATION DATE

May 3, 2017

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

0 interactions (Click to see)

LIGANDS

calcitonin (salmon synthetic) - Agonist pubchem

PHYSIOLOGICAL LIGANDS

adrenomedullin 2/intermedin, amylin, β-CGRP, α-CGRP, calcitonin, adrenomedullin



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL3 T 345 - G.H5 L 393 G.H5.25
Van-der-waals ICL3 T 345 - G.H5 L 393 G.H5.25
Hydrophobic ICL3 L 348 - G.H5 E 392 G.H5.24
Hydrophobic ICL2 V 252 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 V 252 - G.H5 I 383 G.H5.15
Hydrophobic TM5 L 323 5x61 G.H5 L 388 G.H5.20
Van-der-waals TM5 L 323 5x61 G.H5 L 388 G.H5.20
Polar ICL3 H 331 - G.h4s6 Y 358 G.h4s6.20
Hydrophobic ICL3 H 331 - G.h4s6 Y 358 G.h4s6.20
Van-der-waals ICL3 H 331 - G.h4s6 Y 358 G.h4s6.20
Hydrophobic ICL3 L 348 - G.H5 L 393 G.H5.25
Hydrophobic TM3 L 244 3x54 G.H5 Y 391 G.H5.23
Polar TM2 R 180 2x46 G.H5 Q 390 G.H5.22
Hydrophobic TM2 R 180 2x46 G.H5 Q 390 G.H5.22
Van-der-waals TM2 R 180 2x46 G.H5 Q 390 G.H5.22
Van-der-waals TM3 Y 243 3x53 G.H5 Y 391 G.H5.23
Polar TM5 K 326 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM5 K 326 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 K 326 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM5 M 327 5x65 G.H5 L 394 G.H5.26
Van-der-waals TM5 M 327 5x65 G.H5 L 394 G.H5.26
Hydrophobic ICL2 F 253 - G.S3 V 217 G.S3.01
Hydrophobic TM3 I 248 3x58 G.H5 H 387 G.H5.19
Hydrophobic ICL2 V 252 - G.H5 Q 384 G.H5.16
Van-der-waals ICL2 V 252 - G.H5 Q 384 G.H5.16
Hydrophobic ICL2 V 252 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 V 252 - G.H5 R 380 G.H5.12
Polar ICL3 T 330 - G.h4s6 Y 358 G.h4s6.20
Hydrophobic ICL3 T 330 - G.h4s6 Y 358 G.h4s6.20
Van-der-waals ICL3 T 330 - G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM3 L 247 3x57 G.H5 Y 391 G.H5.23
Aromatic TM2 R 180 2x46 G.H5 Y 391 G.H5.23
Hydrophobic TM2 R 180 2x46 G.H5 Y 391 G.H5.23
Van-der-waals TM2 R 180 2x46 G.H5 Y 391 G.H5.23
Polar TM5 K 326 5x64 G.H5 R 385 G.H5.17
Polar ICL2 T 254 - G.H5 H 387 G.H5.19
Polar ICL2 F 253 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 F 253 - G.S1 H 41 G.S1.02
Hydrophobic TM3 L 247 3x57 G.H5 H 387 G.H5.19
Van-der-waals TM3 L 247 3x57 G.H5 H 387 G.H5.19
Hydrophobic TM3 I 248 3x58 G.H5 L 388 G.H5.20
Polar TM3 I 248 3x58 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 248 3x58 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 248 3x58 G.H5 Q 384 G.H5.16
Hydrophobic TM2 H 184 2x50 G.H5 Y 391 G.H5.23