5-HT6 receptor - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8JLZ

RESOLUTION

3.1 Å

REFERENCE

10.1016/J.BBRC.2023.05.126

PUBLICATION DATE

June 28, 2023

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

23 interactions (Click to see)

LIGANDS

CHEMBL365751 - Agonist chembl_ligand pubchem

PHYSIOLOGICAL LIGANDS

5-hydroxytryptamine



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 A 215 5x65 G.H5 L 388 G.H5.20
Hydrophobic TM7 F 323 7x56 G.H5 E 392 G.H5.24
Van-der-waals TM7 F 323 7x56 G.H5 E 392 G.H5.24
Polar TM6 A 266 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM6 A 266 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 A 266 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM3 I 128 3x54 G.H5 L 393 G.H5.25
Hydrophobic TM5 Q 218 5x68 G.H5 L 388 G.H5.20
Hydrophobic TM5 L 225 5x75 G.S6 P 361 G.S6.03
Van-der-waals TM5 L 225 5x75 G.S6 P 361 G.S6.03
Hydrophobic ICL2 K 135 - G.hns1 A 39 G.hns1.03
Polar TM5 Q 218 5x68 G.H5 Q 384 G.H5.16
Hydrophobic TM5 Q 218 5x68 G.H5 Q 384 G.H5.16
Van-der-waals TM5 Q 218 5x68 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 128 3x54 G.H5 H 387 G.H5.19
Hydrophobic ICL2 L 132 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 L 132 - G.H5 F 376 G.H5.08
Polar TM2 S 61 2x39 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 P 131 - G.H5 R 380 G.H5.12
Hydrophobic TM3 I 128 3x54 G.H5 Y 391 G.H5.23
Polar ICL2 R 133 - G.s2s3 D 215 G.s2s3.01
Van-der-waals TM7 F 323 7x56 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 P 131 - G.H5 Q 384 G.H5.16
Hydrophobic ICL2 L 132 - G.H5 R 380 G.H5.12
Hydrophobic ICL2 K 135 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 K 135 - G.hns1 R 38 G.hns1.02
Hydrophobic TM5 Q 218 5x68 G.H5 L 394 G.H5.26
Hydrophobic H8 M 324 8x47 G.H5 Y 391 G.H5.23
Hydrophobic TM5 I 211 5x61 G.H5 L 393 G.H5.25
Van-der-waals TM5 I 211 5x61 G.H5 L 393 G.H5.25
Hydrophobic TM5 V 222 5x72 G.H5 R 385 G.H5.17
Van-der-waals TM5 V 222 5x72 G.H5 R 385 G.H5.17
Hydrophobic TM6 T 269 6x36 G.H5 L 393 G.H5.25
Ionic H8 R 325 8x48 G.H5 E 392 G.H5.24
Polar H8 R 325 8x48 G.H5 E 392 G.H5.24
Hydrophobic H8 R 325 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 R 325 8x48 G.H5 E 392 G.H5.24
Polar TM5 Q 218 5x68 G.H5 D 381 G.H5.13
Hydrophobic TM6 L 270 6x37 G.H5 L 393 G.H5.25
Hydrophobic ICL2 L 132 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 132 - G.S1 H 41 G.S1.02
Hydrophobic TM3 L 127 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 L 127 3x53 G.H5 H 387 G.H5.19
Hydrophobic ICL2 L 132 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 L 132 - G.H5 I 383 G.H5.15
Ionic TM6 K 265 6x32 G.H5 E 392 G.H5.24
Polar TM6 K 265 6x32 G.H5 L 394 G.H5.26
Hydrophobic TM6 K 265 6x32 G.H5 L 394 G.H5.26
Van-der-waals TM6 K 265 6x32 G.H5 L 394 G.H5.26
Polar TM5 Q 218 5x68 G.H5 R 385 G.H5.17
Polar TM3 I 128 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 128 3x54 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 P 131 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 131 - G.H5 I 383 G.H5.15
Hydrophobic TM5 L 225 5x75 G.H4 L 346 G.H4.16
Van-der-waals TM5 L 225 5x75 G.H4 L 346 G.H4.16
Polar H8 R 325 8x48 G.H5 Q 390 G.H5.22
Hydrophobic H8 R 325 8x48 G.H5 Q 390 G.H5.22
Van-der-waals H8 R 325 8x48 G.H5 Q 390 G.H5.22
Hydrophobic ICL2 L 132 - G.H5 C 379 G.H5.11
Aromatic TM3 R 124 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 124 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 I 128 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 I 128 3x54 G.H5 L 388 G.H5.20
Polar H8 R 325 8x48 G.H5 R 389 G.H5.21
Hydrophobic H8 R 325 8x48 G.H5 R 389 G.H5.21
Van-der-waals H8 R 325 8x48 G.H5 R 389 G.H5.21