GPR3 - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8WW2

RESOLUTION

2.8 Å

REFERENCE

10.1038/S41422-024-00932-5

PUBLICATION DATE

Feb. 14, 2024

3D VIEW

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LIGAND INTERACTIONS

0 interactions (Click to see)

LIGANDS

oleic acid - Agonist pubchem gtoplig chembl_ligand drug_central

PHYSIOLOGICAL LIGANDS

sphingosine 1-phosphate



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 Q 230 5x75 G.H4 L 346 G.H4.16
Hydrophobic ICL2 L 142 34x51 G.H5 C 379 G.H5.11
Hydrophobic TM6 L 249 6x37 G.H5 L 393 G.H5.25
Ionic TM5 R 222 5x67 G.H5 D 381 G.H5.13
Polar TM5 R 222 5x67 G.H5 D 381 G.H5.13
Hydrophobic TM5 I 227 5x72 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM4 E 147 4x36 G.HN E 35 G.HN.52
Van-der-waals TM4 E 147 4x36 G.HN E 35 G.HN.52
Hydrophobic TM5 H 223 5x68 G.H5 L 388 G.H5.20
Van-der-waals TM5 H 223 5x68 G.H5 L 388 G.H5.20
Hydrophobic ICL2 L 142 34x51 G.H5 I 383 G.H5.15
Van-der-waals ICL2 L 142 34x51 G.H5 I 383 G.H5.15
Hydrophobic TM5 V 220 5x65 G.H5 L 393 G.H5.25
Polar TM5 H 223 5x68 G.H5 Q 384 G.H5.16
Hydrophobic TM5 H 223 5x68 G.H5 Q 384 G.H5.16
Van-der-waals TM5 H 223 5x68 G.H5 Q 384 G.H5.16
Hydrophobic TM5 H 223 5x68 G.H5 D 381 G.H5.13
Hydrophobic ICL2 Y 144 34x53 G.H5 H 387 G.H5.19
Polar TM6 T 248 6x36 G.H5 E 392 G.H5.24
Van-der-waals TM6 T 248 6x36 G.H5 E 392 G.H5.24
Hydrophobic TM6 G 245 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM5 I 227 5x72 G.H5 L 394 G.H5.26
Hydrophobic TM5 A 224 5x69 G.H5 L 394 G.H5.26
Hydrophobic TM3 S 137 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 L 138 3x54 G.H5 H 387 G.H5.19
Polar ICL2 L 142 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 L 142 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 T 143 34x52 G.S3 V 217 G.S3.01
Polar TM3 S 137 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 S 137 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM5 I 216 5x61 G.H5 L 393 G.H5.25
Ionic TM7 R 300 7x56 G.H5 E 392 G.H5.24
Polar TM7 R 300 7x56 G.H5 E 392 G.H5.24
Hydrophobic TM7 R 300 7x56 G.H5 E 392 G.H5.24
Hydrophobic ICL2 L 142 34x51 G.S3 V 217 G.S3.01
Hydrophobic TM5 I 227 5x72 G.H5 R 385 G.H5.17
Van-der-waals TM5 I 227 5x72 G.H5 R 385 G.H5.17
Hydrophobic TM6 K 244 6x32 G.H5 L 394 G.H5.26
Ionic TM6 K 244 6x32 G.H5 E 392 G.H5.24
Polar TM6 K 244 6x32 G.H5 E 392 G.H5.24
Van-der-waals TM6 K 244 6x32 G.H5 E 392 G.H5.24
Hydrophobic TM3 L 138 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 L 138 3x54 G.H5 L 388 G.H5.20
Aromatic TM3 R 134 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 134 3x50 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 L 142 34x51 G.H5 R 380 G.H5.12
Polar TM5 H 223 5x68 G.H5 R 385 G.H5.17
Hydrophobic TM5 H 223 5x68 G.H5 R 385 G.H5.17
Van-der-waals TM5 H 223 5x68 G.H5 R 385 G.H5.17
Hydrophobic ICL2 A 141 34x50 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 A 141 34x50 G.H5 I 383 G.H5.15
Polar TM5 Q 226 5x71 G.H5 R 385 G.H5.17
Polar TM3 L 138 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 L 138 3x54 G.H5 Q 384 G.H5.16
Polar TM5 R 222 5x67 G.H5 Q 384 G.H5.16
Van-der-waals TM5 R 222 5x67 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 Y 145 34x54 G.H5 H 387 G.H5.19
Hydrophobic TM5 I 219 5x64 G.H5 L 388 G.H5.20
Hydrophobic TM5 V 220 5x65 G.H5 L 388 G.H5.20
Van-der-waals TM5 V 220 5x65 G.H5 L 388 G.H5.20
Hydrophobic ICL2 L 142 34x51 G.H5 F 376 G.H5.08
Van-der-waals ICL2 L 142 34x51 G.H5 F 376 G.H5.08
Hydrophobic ICL2 Y 145 34x54 G.hns1 A 38 G.hns1.02
Van-der-waals ICL2 Y 145 34x54 G.hns1 A 38 G.hns1.02