CT receptor - Gs

GPCR CLASS (FAMILY)

Class B1 (Secretin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

9AUC

RESOLUTION

2.4 Å

REFERENCE

10.1021/ACS.BIOCHEM.4C00114

PUBLICATION DATE

April 24, 2024

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

131 interactions (Click to see)

LIGANDS

Calcitonin gene-related peptide 1 - Agonist pubchem

PHYSIOLOGICAL LIGANDS

adrenomedullin, calcitonin, adrenomedullin 2/intermedin, α-CGRP, amylin, β-CGRP



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar H8 N 395 8x47 G.H5 Q 390 G.H5.22
Hydrophobic TM5 K 326 5x64 G.H5 L 388 G.H5.20
Hydrophobic ICL2 V 252 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 V 252 - G.H5 I 383 G.H5.15
Hydrophobic TM5 M 327 5x65 G.H5 L 394 G.H5.26
Hydrophobic TM2 H 184 2x50 G.H5 Y 391 G.H5.23
Hydrophobic TM5 K 326 5x64 G.H5 L 394 G.H5.26
Hydrophobic TM6 L 348 6x45 G.H5 L 393 G.H5.25
Hydrophobic TM3 Y 243 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 Y 243 3x53 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 V 252 - G.H5 Q 384 G.H5.16
Van-der-waals ICL2 V 252 - G.H5 Q 384 G.H5.16
Hydrophobic TM3 L 244 3x54 G.H5 Y 391 G.H5.23
Van-der-waals TM3 L 244 3x54 G.H5 Y 391 G.H5.23
Polar H8 N 396 8x48 G.H5 E 392 G.H5.24
Hydrophobic ICL2 F 253 - G.S3 V 217 G.S3.01
Van-der-waals ICL2 F 253 - G.S3 V 217 G.S3.01
Hydrophobic TM5 T 330 5x68 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM7 Y 391 7x57 G.H5 Y 391 G.H5.23
Aromatic ICL2 F 253 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 F 253 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 F 253 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 K 256 - G.HN Q 35 G.HN.52
Hydrophobic TM3 I 248 3x58 G.H5 H 387 G.H5.19
Van-der-waals TM3 I 248 3x58 G.H5 H 387 G.H5.19
Hydrophobic ICL2 F 253 - G.S3 F 219 G.S3.03
Hydrophobic TM6 A 344 6x41 G.H5 L 393 G.H5.25
Hydrophobic TM2 R 180 2x46 G.H5 Q 390 G.H5.22
Polar TM3 I 248 3x58 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 248 3x58 G.H5 Q 384 G.H5.16
Aromatic ICL2 F 253 - G.H5 F 376 G.H5.08
Hydrophobic ICL2 F 253 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 F 253 - G.H5 F 376 G.H5.08
Hydrophobic TM5 L 323 5x61 G.H5 L 393 G.H5.25
Ionic TM5 K 326 5x64 G.H5 D 381 G.H5.13
Polar TM5 K 326 5x64 G.H5 D 381 G.H5.13
Hydrophobic TM5 K 326 5x64 G.H5 D 381 G.H5.13
Van-der-waals TM5 K 326 5x64 G.H5 D 381 G.H5.13
Van-der-waals H8 E 397 8x49 G.H5 E 392 G.H5.24
Hydrophobic TM5 L 323 5x61 G.H5 L 394 G.H5.26
Hydrophobic TM3 I 248 3x58 G.H5 L 388 G.H5.20
Ionic TM5 H 331 5x69 G.hgh4 D 323 G.hgh4.13
Hydrophobic ICL2 F 253 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 F 253 - G.H5 I 383 G.H5.15
Hydrophobic ICL2 E 255 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 E 255 - G.hns1 R 38 G.hns1.02
Hydrophobic TM5 I 319 5x57 G.H5 L 393 G.H5.25
Hydrophobic TM5 T 330 5x68 G.H5 R 385 G.H5.17
Van-der-waals TM5 T 330 5x68 G.H5 R 385 G.H5.17
Aromatic TM2 R 180 2x46 G.H5 Y 391 G.H5.23
Hydrophobic TM2 R 180 2x46 G.H5 Y 391 G.H5.23
Van-der-waals TM2 R 180 2x46 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 F 253 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 F 253 - G.H5 R 380 G.H5.12
Hydrophobic ICL2 F 253 - G.H5 C 379 G.H5.11
Hydrophobic TM3 L 247 3x57 G.H5 H 387 G.H5.19
Van-der-waals TM3 L 247 3x57 G.H5 H 387 G.H5.19
Polar TM6 K 343 6x40 G.H5 E 392 G.H5.24
Polar TM5 K 326 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM5 K 326 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 K 326 5x64 G.H5 Q 384 G.H5.16
Polar TM3 V 249 3x59 G.H5 R 380 G.H5.12
Van-der-waals TM3 V 249 3x59 G.H5 R 380 G.H5.12
Hydrophobic ICL2 V 252 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 V 252 - G.H5 R 380 G.H5.12
Hydrophobic TM5 L 323 5x61 G.H5 L 388 G.H5.20
Polar TM5 K 326 5x64 G.H5 R 385 G.H5.17
Hydrophobic TM5 K 326 5x64 G.H5 R 385 G.H5.17
Van-der-waals TM5 K 326 5x64 G.H5 R 385 G.H5.17