CCR5 - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.0 Å

REFERENCE

PUBLICATION DATE

July 14, 2021

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

CCL5 - Agonist gtoplig

PHYSIOLOGICAL LIGANDS

CCL7, CCL11, CCL4, CCL14, CCL3, CCL5, CCL16, CCL13, CCL8, CCL2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic TM6 K 324 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 324 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM3 V 225 3x54 G.H5 I 344 G.H5.16
Van-der-waals TM3 V 225 3x54 G.H5 I 344 G.H5.16
Hydrophobic TM6 A 328 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 I 332 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM7 V 395 7x56 G.H5 G 352 G.H5.24
Van-der-waals TM7 V 395 7x56 G.H5 G 352 G.H5.24
Hydrophobic ICL2 V 229 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 V 229 34x51 G.S3 L 194 G.S3.01
Hydrophobic ICL2 L 232 34x54 G.H5 I 343 G.H5.15
Van-der-waals ICL2 L 232 34x54 G.H5 I 343 G.H5.15
Hydrophobic TM5 I 312 5x61 G.H5 L 353 G.H5.25
Hydrophobic TM5 T 315 5x64 G.H5 I 344 G.H5.16
Van-der-waals TM5 T 315 5x64 G.H5 I 344 G.H5.16
Hydrophobic ICL2 A 228 34x50 G.H5 I 343 G.H5.15
Van-der-waals ICL2 A 228 34x50 G.H5 I 343 G.H5.15
Hydrophobic TM5 L 316 5x65 G.H5 F 354 G.H5.26
Hydrophobic TM4 T 236 4x38 G.hns1 R 32 G.hns1.03
Van-der-waals TM4 T 236 4x38 G.hns1 R 32 G.hns1.03
Polar ICL2 R 235 34x57 G.H5 N 347 G.H5.19
Polar ICL2 L 232 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 L 232 34x54 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 L 232 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic TM6 L 331 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM3 R 221 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 221 3x50 G.H5 L 353 G.H5.25
Ionic ICL3 R 320 - G.h4s6 E 318 G.h4s6.12
Polar ICL3 R 320 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 R 320 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 R 320 - G.h4s6 E 318 G.h4s6.12
Van-der-waals TM7 V 395 7x56 G.H5 F 354 G.H5.26
Hydrophobic ICL2 L 232 34x54 G.S3 L 194 G.S3.01
Polar TM3 R 221 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 221 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 221 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM5 L 316 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 L 316 5x65 G.H5 L 348 G.H5.20
Polar TM6 N 321 6x26 G.h4s6 D 315 G.h4s6.09
Hydrophobic ICL2 A 228 34x50 G.H5 I 344 G.H5.16
Hydrophobic TM6 A 328 6x33 G.H5 F 354 G.H5.26
Hydrophobic H8 G 396 8x47 G.H5 F 354 G.H5.26
Van-der-waals H8 G 396 8x47 G.H5 F 354 G.H5.26
Polar TM3 A 224 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 224 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 224 3x53 G.H5 N 347 G.H5.19
Hydrophobic ICL2 V 229 34x51 G.H5 T 340 G.H5.12
Hydrophobic TM6 K 323 6x28 G.h4s6 D 315 G.h4s6.09
Hydrophobic TM5 C 319 5x68 G.H5 F 354 G.H5.26
Hydrophobic TM5 C 319 5x68 G.H5 K 345 G.H5.17
Van-der-waals TM5 C 319 5x68 G.H5 K 345 G.H5.17
Polar H8 G 396 8x47 G.H5 G 352 G.H5.24
Hydrophobic H8 G 396 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 G 396 8x47 G.H5 G 352 G.H5.24
Hydrophobic TM3 V 225 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 225 3x54 G.H5 L 348 G.H5.20
Hydrophobic ICL2 V 229 34x51 G.H5 F 336 G.H5.08
Polar ICL3 R 320 - G.S6 I 319 G.S6.01
Van-der-waals ICL3 R 320 - G.S6 Y 320 G.S6.02
Polar H8 E 397 8x48 G.H5 F 354 G.H5.26
Hydrophobic H8 E 397 8x48 G.H5 F 354 G.H5.26
Hydrophobic TM6 A 328 6x33 G.H5 L 348 G.H5.20