secretin receptor - Gs

GPCR CLASS (FAMILY)

Class B1 (Secretin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

6WI9

RESOLUTION

4.3 Å

REFERENCE

10.1038/S41467-020-17791-4

PUBLICATION DATE

Aug. 12, 2020

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

74 interactions (Click to see)

LIGANDS

SECRETIN - Agonist chembl_ligand pubchem

ENDOGENOUS LIGANDS

secretin, VIP



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM2 R 174 2x46 G.H5 Q 390 G.H5.22
Hydrophobic TM2 R 174 2x46 G.H5 Q 390 G.H5.22
Van-der-waals TM2 R 174 2x46 G.H5 Q 390 G.H5.22
Polar ICL3 R 330 - G.h4s6 D 354 G.h4s6.10
Hydrophobic ICL3 R 330 - G.h4s6 D 354 G.h4s6.10
Van-der-waals ICL3 R 330 - G.h4s6 D 354 G.h4s6.10
Van-der-waals TM6 S 343 6x41 G.H5 L 394 G.H5.26
Polar TM3 L 244 3x58 G.H5 Q 384 G.H5.16
Van-der-waals TM3 L 244 3x58 G.H5 Q 384 G.H5.16
Polar TM5 T 326 5x67 G.H5 R 385 G.H5.17
Hydrophobic ICL2 F 248 - G.H5 R 380 G.H5.12
Hydrophobic TM3 L 243 3x57 G.H5 H 387 G.H5.19
Van-der-waals TM3 L 243 3x57 G.H5 H 387 G.H5.19
Hydrophobic ICL2 S 247 - G.H5 I 383 G.H5.15
Hydrophobic TM3 L 244 3x58 G.H5 L 388 G.H5.20
Hydrophobic ICL3 R 330 - G.h4s6 G 355 G.h4s6.11
Polar ICL3 R 330 - G.h4s6 G 353 G.h4s6.09
Hydrophobic ICL3 R 330 - G.h4s6 G 353 G.h4s6.09
Van-der-waals ICL3 R 330 - G.h4s6 G 353 G.h4s6.09
Hydrophobic ICL2 F 248 - G.S3 V 217 G.S3.01
Van-der-waals ICL2 F 248 - G.S3 V 217 G.S3.01
Hydrophobic TM6 R 342 6x40 G.H5 L 394 G.H5.26
Hydrophobic ICL2 E 251 - G.HN Q 35 G.HN.52
Aromatic ICL2 F 248 - G.H5 F 376 G.H5.08
Hydrophobic ICL2 F 248 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 F 248 - G.H5 F 376 G.H5.08
Hydrophobic ICL2 R 252 - G.HN Q 35 G.HN.52
Van-der-waals ICL2 R 252 - G.HN Q 35 G.HN.52
Hydrophobic TM5 K 323 5x64 G.H5 R 385 G.H5.17
Polar ICL2 S 247 - G.H5 Q 384 G.H5.16
Hydrophobic ICL2 S 247 - G.H5 Q 384 G.H5.16
Van-der-waals ICL2 S 247 - G.H5 Q 384 G.H5.16
Van-der-waals ICL3 E 328 - G.S6 C 359 G.S6.01
Ionic ICL3 E 328 - G.H5 R 385 G.H5.17
Aromatic TM2 R 174 2x46 G.H5 Y 391 G.H5.23
Hydrophobic TM2 R 174 2x46 G.H5 Y 391 G.H5.23
Van-der-waals TM2 R 174 2x46 G.H5 Y 391 G.H5.23
Hydrophobic TM5 L 320 5x61 G.H5 L 394 G.H5.26
Hydrophobic ICL3 E 328 - G.h4s6 Y 358 G.h4s6.20
Van-der-waals ICL3 E 328 - G.h4s6 Y 358 G.h4s6.20
Polar TM3 A 245 3x59 G.H5 R 380 G.H5.12
Hydrophobic ICL3 E 328 - G.H4 L 346 G.H4.16
Ionic TM5 K 323 5x64 G.H5 D 381 G.H5.13
Hydrophobic TM5 K 323 5x64 G.H5 D 381 G.H5.13
Van-der-waals TM5 K 323 5x64 G.H5 D 381 G.H5.13
Hydrophobic TM2 H 178 2x50 G.H5 Y 391 G.H5.23
Van-der-waals TM2 H 178 2x50 G.H5 Y 391 G.H5.23
Hydrophobic TM6 L 346 6x44 G.H5 E 392 G.H5.24
Hydrophobic ICL2 S 247 - G.H5 R 380 G.H5.12
Hydrophobic TM3 L 240 3x54 G.H5 Y 391 G.H5.23
Van-der-waals TM3 L 240 3x54 G.H5 Y 391 G.H5.23
Polar H8 N 392 8x47 G.H5 E 392 G.H5.24
Hydrophobic H8 N 392 8x47 G.H5 E 392 G.H5.24
Van-der-waals H8 N 392 8x47 G.H5 E 392 G.H5.24
Polar TM2 C 172 2x44 G.H5 Q 390 G.H5.22
Hydrophobic TM2 C 172 2x44 G.H5 Q 390 G.H5.22
Aromatic ICL2 F 248 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 F 248 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 F 248 - G.S1 H 41 G.S1.02
Hydrophobic TM5 L 320 5x61 G.H5 L 388 G.H5.20
Hydrophobic TM3 Y 239 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 Y 239 3x53 G.H5 Y 391 G.H5.23
Polar TM5 K 323 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM5 K 323 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 K 323 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM6 R 339 6x37 G.H5 L 394 G.H5.26
Van-der-waals TM6 R 339 6x37 G.H5 L 394 G.H5.26