Structure information

secretin receptor

PROTEIN CLASS

Class B1 (Secretin)

PDB CODE

6WI9

SPECIES

Homo sapiens

RESOLUTION

4.300

PREFERRED CHAIN

R

REFERENCE

10.1038/S41467-020-17791-4

PUBLICATION DATE

Aug. 12, 2020

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
SECRETIN R30 N-term polar (hydrogen bond with backbone)
SECRETIN R30 N-term Van der Waals
SECRETIN L31 N-term polar (hydrogen bond with backbone)
SECRETIN L31 N-term Van der Waals
SECRETIN N72 N-term Van der Waals
SECRETIN I73 N-term Van der Waals
SECRETIN I73 N-term hydrophobic
SECRETIN A122 N-term Van der Waals
SECRETIN A122 N-term hydrophobic
SECRETIN N126 N-term Van der Waals
SECRETIN V127 N-term Van der Waals
SECRETIN V127 N-term polar (hydrogen bond with backbone)
SECRETIN R135 1.32x32 TM1 Van der Waals
SECRETIN H136 1.33x33 TM1 Van der Waals
SECRETIN L139 1.36x36 TM1 Van der Waals
SECRETIN L139 1.36x36 TM1 hydrophobic
SECRETIN L142 1.39x39 TM1 Van der Waals
SECRETIN L142 1.39x39 TM1 hydrophobic
SECRETIN Y146 1.43x43 TM1 hydrophobic
SECRETIN Y146 1.43x43 TM1 Van der Waals
SECRETIN N192 2.64x64 TM2 Van der Waals
SECRETIN N192 2.64x64 TM2 polar (hydrogen bond)
SECRETIN F200 2.72x72 TM2 hydrophobic
SECRETIN F200 2.72x72 TM2 Van der Waals
SECRETIN F222 3.36x36 TM3 hydrophobic
SECRETIN F222 3.36x36 TM3 Van der Waals
SECRETIN Q223 3.37x37 TM3 Van der Waals
SECRETIN I226 3.40x40 TM3 hydrophobic
SECRETIN I226 3.40x40 TM3 Van der Waals
SECRETIN D287 45.52x52 ECL2 Van der Waals
SECRETIN N289 ECL2 polar (hydrogen bond)
SECRETIN N289 ECL2 Van der Waals
SECRETIN N289 ECL2 polar (hydrogen bond with backbone)
SECRETIN W295 5.36x37 TM5 Van der Waals
SECRETIN W295 5.36x37 TM5 hydrophobic
SECRETIN I298 5.39x39 TM5 Van der Waals
SECRETIN L370 7.39x38 TM7 Van der Waals
SECRETIN L370 7.39x38 TM7 hydrophobic
SECRETIN E373 7.42x41 TM7 Van der Waals
SECRETIN L374 7.43x42 TM7 Van der Waals
SECRETIN L374 7.43x42 TM7 hydrophobic

Ligands

SECRETIN

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Residue Diagrams

L L M V L S S S Y G V T Y M V K L K L L 1 M H L F V S F I L R A L S N F I K D A V 2 V L L W S Y N A M I C Y Q F L V M V L K 3 Y L Q G F V A G F W G S P A I F V A L W A 4 F L I F N I L I S L I V P G R I I W W I S 5 L L L I P L F G I H Y I V F A F S 6 V A V V L G Q F S G L A L E F F L Q I 7
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ICL1 R R L H ICL1ECL1 F S S D D V T Y C D A H ECL1ICL2 S F F ICL2ECL2 D V G C W D I N A ECL2ICL3 Q E T R G ICL3ECL3 P E D ECL3N-term M R P H L S P P L Q Q L L L P V L L A C A A H S T G A L P R L C D V L Q V L W E E Q D Q C L Q E L S R E Q T G D L G T E Q P V P G C E G M W D N I S C W P S S V P G R M V E V E C P R F L R M L T S R N G S L F R N C T Q D G W S E T F P R P N L A C G V N V N D S N-termC-term S F S N S T K A S H L E Q S Q G T C R T S I I C-term S N E K R H S Y L L K L K V M Y T V G Y S S S L V M L L V A L G I L C A F C T R N Y I H M H L F V S F I L R A L S N F I K D A V L R A G C K L V M V L F Q Y C I M A N Y S W L L V E G L Y L H T L L A I S E R K Y L Q G F V A F G W G S P A I F V A L W A I A R H F L E N A S I W W I I R G P V I L S I L I N F I L F I N I L R I L M R K L R T N E V S H Y K R L A R S T L L L I P L F G I H Y I V F A F S A M E I Q L F F E L A L G S F Q G L V V A V L Y C F L N G E V Q K W H L L H P V Q L E K W Q Q R E F P V A
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Residue Table


GPCRdb(A)
GPCRdb(B)
secretin receptor
TM1
1x28 1.32x32 R135
1x29 1.33x33 H136
1x32 1.36x36 L139
1x35 1.39x39 L142
1x39 1.43x43 Y146
TM2
2x57 2.64x64 N192
TM3
3x32 3.36x36 F222
3x33 3.37x37 Q223
3x36 3.40x40 I226
ECL2
45x52 45.52x52 D287
TM5
5x41 5.36x37 W295
5x43 5.39x39 I298
TM7
7x34 7.39x38 L370
7x37 7.42x41 E373
7x38 7.43x42 L374