CRF2 receptor - G11

GPCR CLASS (FAMILY)

Class B1 (Secretin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

P

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.7 Å

REFERENCE

PUBLICATION DATE

Nov. 9, 2022

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

Urocortin - Agonist pubchem

PHYSIOLOGICAL LIGANDS

corticotrophin-releasing hormone, urocortin 2, urocortin 3, urocortin 1



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic TM6 A 311 6x41 G.H5 L 358 G.H5.25
Hydrophobic ICL2 T 216 - G.H5 I 348 G.H5.15
Hydrophobic TM5 K 293 5x64 G.H5 L 353 G.H5.20
Hydrophobic TM3 A 212 3x57 G.H5 Y 356 G.H5.23
Van-der-waals TM3 A 212 3x57 G.H5 Y 356 G.H5.23
Hydrophobic TM3 I 213 3x58 G.H5 L 353 G.H5.20
Hydrophobic TM3 I 213 3x58 G.H5 Y 356 G.H5.23
Hydrophobic TM3 A 212 3x57 G.H5 L 349 G.H5.16
Van-der-waals TM3 A 212 3x57 G.H5 L 349 G.H5.16
Hydrophobic TM3 I 213 3x58 G.H5 L 349 G.H5.16
Van-der-waals TM3 I 213 3x58 G.H5 L 349 G.H5.16
Hydrophobic TM3 L 209 3x54 G.H5 Y 356 G.H5.23
Van-der-waals TM3 L 209 3x54 G.H5 Y 356 G.H5.23
Van-der-waals TM3 Y 208 3x53 G.H5 Y 356 G.H5.23
Hydrophobic TM2 R 148 2x46 G.H5 Y 356 G.H5.23
Van-der-waals TM2 R 148 2x46 G.H5 Y 356 G.H5.23
Polar TM7 F 362 7x60 G.H5 N 357 G.H5.24
Polar TM3 A 212 3x57 G.H5 N 352 G.H5.19