Structure information

CRF2 receptor

PROTEIN CLASS

Class B1 (Secretin)

PDB CODE

7TRY

SPECIES

Homo sapiens

RESOLUTION

3.700

PREFERRED CHAIN

P

REFERENCE

10.1038/S41467-022-33851-3

PUBLICATION DATE

Nov. 9, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Urocortin F68 N-term hydrophobic
Urocortin F256 45.52x52 ECL2 Van der Waals
Urocortin F256 45.52x52 ECL2 polar (hydrogen bond with backbone)
Urocortin G257 ECL2 Van der Waals
Urocortin K258 ECL2 Van der Waals
Urocortin Y323 6.53x53 TM6 hydrophobic
Urocortin Y323 6.53x53 TM6 Van der Waals
Urocortin V328 ECL3 Van der Waals
Urocortin F340 7.38x37 TM7 Van der Waals

Ligands

Urocortin

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Residue Diagrams

V L A A V S V C H G L Y N V V L A I R Y 1 W N L I T T F I L R N V M W F L L Q L V 2 V F M W F F N T V V F Y N F I T T I C R 3 R K C L F L F G I W C I P F P I I V A W A 4 L F V F N I L L V L I I P G Q Y I Y D V 5 L V L L P L L G I T Y M L F F V 6 V S V F F G Q F S Q L F S N F Y I F M 7
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ICL1 R S I R ICL1ECL1 D H E V H E S N ECL1ICL2 T Y S T E R L ICL2ECL2 N E Q C W F G K E P G D L ECL2ICL3 S T T ICL3ECL3 N P G E D ECL3N-term M D A A L L H S L L E A N C S L A L A E E L L L D G W G P P L D P E G P Y S Y C N T T L D Q I G T C W P R S A A G A L V E R P C P E Y F N G V K Y N T T R N A Y R E C L E N G T W A S K I N Y S Q C E N-termC-term R A M S I P T S P T R I S F H S I K Q T A A V C-term P I L D D K Q R K Y D L H Y R I A L V V N Y L G H C V S V A A L V A A F L L F L A L C L R N V I H W N L I T T F I L R N V M W F L L Q L V E V W C R C I T T I F N Y F V V T N F F W M F V E G C Y L H T A I V M R K C L F L F I G W C I P F P I I V A W A I G K L Y Y E V D Y I Y Q G P I I L V L L I N F V F L F N I V R I L M T K L R A S E T I Q Y R K A V K A T L V L L P L L G I T Y M L F F V D L S Q I M F I Y F N S F L Q S F Q G F F V S V F Y C F F N G E V R K W Q D R V P V R S A R W H R H H S L M A
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Residue Table


GPCRdb(A)
GPCRdb(B)
CRF2 receptor
ECL2
45x52 45.52x52 F256
TM6
6x48 6.53x53 Y323
TM7
7x33 7.38x37 F340