GPR132 - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.0 Å

REFERENCE

PUBLICATION DATE

Oct. 11, 2023

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

9-hydroxyoctadecadienoic acid - Agonist pubchem gtoplig chembl_ligand drugbank

PHYSIOLOGICAL LIGANDS

9-hydroxyoctadecadienoic acid



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic TM6 V 240 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 V 240 6x33 G.H5 L 353 G.H5.25
Ionic TM4 R 155 4x38 G.HN E 28 G.HN.52
Polar ICL1 N 75 - G.H5 D 350 G.H5.22
Hydrophobic ICL1 N 75 - G.H5 D 350 G.H5.22
Hydrophobic H8 H 314 8x49 G.H5 K 349 G.H5.21
Van-der-waals ICL2 R 153 34x56 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 A 147 34x50 G.H5 I 344 G.H5.16
Hydrophobic ICL3 L 232 - G.H5 I 344 G.H5.16
Hydrophobic TM3 R 140 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 140 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM6 Q 236 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 Q 236 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM2 L 77 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 L 77 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM3 V 144 3x54 G.H5 L 348 G.H5.20
Hydrophobic ICL3 L 232 - G.H5 L 348 G.H5.20
Polar TM3 A 143 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 143 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 143 3x53 G.H5 N 347 G.H5.19
Hydrophobic ICL3 L 232 - G.H5 K 345 G.H5.17
Hydrophobic TM3 V 144 3x54 G.H5 I 344 G.H5.16
Van-der-waals TM3 V 144 3x54 G.H5 I 344 G.H5.16
Polar ICL4 T 312 - G.H5 G 352 G.H5.24
Van-der-waals ICL4 T 312 - G.H5 G 352 G.H5.24
Hydrophobic ICL2 A 147 34x50 G.H5 I 343 G.H5.15
Hydrophobic ICL3 L 232 - G.H5 F 354 G.H5.26
Polar ICL2 R 154 34x57 G.H5 D 350 G.H5.22