apelin receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.7 Å

REFERENCE

PUBLICATION DATE

July 27, 2022

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

(1R,2S)-N-[4-(2,6-dimethoxyphenyl)-5-(6-methylpyridin-2-yl)-1,2,4-triazol-3-yl]-1-(5-methylpyrimidin-2-yl)-1-oxidanyl-propane-2-sulfonamide - Agonist pubchem

PHYSIOLOGICAL LIGANDS

apelin-17, Elabela/Toddler-11, Elabela/Toddler-32, [Pyr1]apelin-13, apelin-13, apelin-36, Elabela/Toddler-21, apelin receptor early endogenous ligand



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic C-term R 315 - G.H5 F 354 G.H5.26
Van-der-waals C-term R 315 - G.H5 F 354 G.H5.26
Ionic ICL1 R 62 - G.H5 D 350 G.H5.22
Polar ICL1 R 62 - G.H5 D 350 G.H5.22
Hydrophobic ICL1 R 62 - G.H5 D 350 G.H5.22
Van-der-waals ICL1 R 62 - G.H5 D 350 G.H5.22
Hydrophobic TM3 I 131 3x54 G.H5 C 351 G.H5.23
Van-der-waals TM3 I 131 3x54 G.H5 C 351 G.H5.23
Hydrophobic TM5 H 231 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 H 231 5x68 G.H5 I 344 G.H5.16
Hydrophobic ICL2 V 135 - G.S3 L 194 G.S3.01
Hydrophobic TM5 H 231 5x68 G.H5 D 341 G.H5.13
Polar TM5 H 231 5x68 G.H5 T 340 G.H5.12
Hydrophobic TM5 H 231 5x68 G.H5 T 340 G.H5.12
Van-der-waals TM5 H 231 5x68 G.H5 T 340 G.H5.12
Hydrophobic C-term D 313 - G.H5 F 354 G.H5.26
Hydrophobic C-term P 314 - G.H5 F 354 G.H5.26
Van-der-waals C-term P 314 - G.H5 F 354 G.H5.26
Hydrophobic TM6 I 249 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 I 249 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM6 I 250 6x37 G.H5 L 353 G.H5.25
Hydrophobic ICL3 F 232 - G.H5 I 344 G.H5.16
Hydrophobic TM6 L 246 6x33 G.H5 L 348 G.H5.20
Van-der-waals TM6 L 246 6x33 G.H5 L 348 G.H5.20
Hydrophobic TM3 A 130 3x53 G.H5 C 351 G.H5.23
Hydrophobic C-term F 312 - G.H5 F 354 G.H5.26
Van-der-waals C-term F 312 - G.H5 F 354 G.H5.26
Polar TM3 A 130 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM6 L 246 6x33 G.H5 F 354 G.H5.26
Hydrophobic TM6 L 246 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 246 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM3 I 131 3x54 G.H5 G 352 G.H5.24
Ionic ICL2 R 141 - G.HN E 28 G.HN.52
Polar ICL2 R 141 - G.HN E 28 G.HN.52
Hydrophobic ICL2 R 141 - G.HN E 28 G.HN.52
Van-der-waals ICL2 R 141 - G.HN E 28 G.HN.52
Hydrophobic ICL2 R 139 - G.hns1 R 32 G.hns1.03
Ionic ICL3 R 236 - G.H5 D 341 G.H5.13
Ionic ICL2 R 139 - G.HN E 28 G.HN.52