EP2 receptor - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7CX4

RESOLUTION

2.9 Å

REFERENCE

10.1126/SCIADV.ABF1268

PUBLICATION DATE

May 5, 2021

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

46 interactions (Click to see)

LIGANDS

evatanepag - Agonist pubchem gtoplig chembl_ligand drugbank

PHYSIOLOGICAL LIGANDS

PGE1, PGI2, thromboxane A2, PGF2α, PGD2, PGE2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 Y 142 34x51 G.H5 C 379 G.H5.11
Van-der-waals ICL2 Y 142 34x51 G.H5 C 379 G.H5.11
Hydrophobic ICL2 R 146 34x55 G.hns1 A 39 G.hns1.03
Hydrophobic TM5 M 225 5x66 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 Y 142 34x51 G.H5 I 383 G.H5.15
Van-der-waals ICL2 Y 142 34x51 G.H5 I 383 G.H5.15
Polar ICL2 R 146 34x55 G.HN Q 35 G.HN.52
Polar H8 R 319 8x47 G.H5 E 392 G.H5.24
Hydrophobic H8 R 319 8x47 G.H5 E 392 G.H5.24
Van-der-waals H8 R 319 8x47 G.H5 E 392 G.H5.24
Hydrophobic TM5 M 225 5x66 G.H5 L 388 G.H5.20
Polar TM3 E 133 3x49 G.H5 Y 391 G.H5.23
Hydrophobic TM3 E 133 3x49 G.H5 Y 391 G.H5.23
Van-der-waals TM3 E 133 3x49 G.H5 Y 391 G.H5.23
Hydrophobic TM6 E 258 6x29 G.H5 E 392 G.H5.24
Van-der-waals TM6 E 258 6x29 G.H5 E 392 G.H5.24
Hydrophobic ICL2 Y 142 34x51 G.S3 F 219 G.S3.03
Hydrophobic TM5 L 222 5x63 G.H5 L 388 G.H5.20
Van-der-waals TM5 L 222 5x63 G.H5 L 388 G.H5.20
Polar TM5 M 225 5x66 G.H5 R 385 G.H5.17
Hydrophobic TM5 M 225 5x66 G.H5 R 385 G.H5.17
Van-der-waals TM5 M 225 5x66 G.H5 R 385 G.H5.17
Aromatic TM2 F 67 2x39 G.H5 Y 391 G.H5.23
Hydrophobic TM2 F 67 2x39 G.H5 Y 391 G.H5.23
Van-der-waals TM2 F 67 2x39 G.H5 Y 391 G.H5.23
Aromatic ICL2 Y 144 34x53 G.H5 H 387 G.H5.19
Hydrophobic ICL2 Y 144 34x53 G.H5 H 387 G.H5.19
Van-der-waals ICL2 Y 144 34x53 G.H5 H 387 G.H5.19
Van-der-waals TM5 S 229 5x70 G.H5 R 385 G.H5.17
Polar TM3 S 137 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 S 137 3x53 G.H5 H 387 G.H5.19
Hydrophobic ICL2 Y 142 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 P 141 34x50 G.H5 H 387 G.H5.19
Polar TM6 H 262 6x33 G.H5 L 388 G.H5.20
Hydrophobic TM6 H 262 6x33 G.H5 L 388 G.H5.20
Polar TM3 S 137 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM3 S 137 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 S 137 3x53 G.H5 Y 391 G.H5.23
Aromatic TM3 H 140 3x56 G.H5 R 380 G.H5.12
Hydrophobic TM2 S 65 2x37 G.H5 Q 390 G.H5.22
Hydrophobic H8 P 320 8x48 G.H5 E 392 G.H5.24
Hydrophobic ICL2 Y 142 34x51 G.S3 V 217 G.S3.01
Hydrophobic TM6 H 262 6x33 G.H5 E 392 G.H5.24
Hydrophobic H8 P 321 8x49 G.H5 E 392 G.H5.24
Van-der-waals H8 P 321 8x49 G.H5 E 392 G.H5.24
Polar TM3 G 139 3x55 G.H5 R 380 G.H5.12
Van-der-waals TM3 G 139 3x55 G.H5 R 380 G.H5.12
Polar H8 R 319 8x47 G.H5 L 393 G.H5.25
Hydrophobic H8 R 319 8x47 G.H5 L 393 G.H5.25
Van-der-waals H8 R 319 8x47 G.H5 L 393 G.H5.25
Hydrophobic TM3 I 138 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 I 138 3x54 G.H5 L 388 G.H5.20
Hydrophobic ICL2 Q 145 34x54 G.S1 H 41 G.S1.02
Van-der-waals ICL2 Q 145 34x54 G.S1 H 41 G.S1.02
Polar TM3 R 134 3x50 G.H5 Y 391 G.H5.23
Aromatic TM3 R 134 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 134 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 134 3x50 G.H5 Y 391 G.H5.23
Polar ICL2 Y 142 34x51 G.H5 R 380 G.H5.12
Hydrophobic ICL2 Y 142 34x51 G.H5 R 380 G.H5.12
Van-der-waals ICL2 Y 142 34x51 G.H5 R 380 G.H5.12
Hydrophobic ICL2 P 141 34x50 G.H5 Q 384 G.H5.16
Van-der-waals ICL2 P 141 34x50 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 P 141 34x50 G.H5 I 383 G.H5.15
Hydrophobic H8 P 320 8x48 G.H5 Y 391 G.H5.23
Van-der-waals H8 P 320 8x48 G.H5 Y 391 G.H5.23
Polar TM3 I 138 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 138 3x54 G.H5 Q 384 G.H5.16
Polar ICL2 Q 145 34x54 G.H5 H 387 G.H5.19
Van-der-waals ICL2 Q 145 34x54 G.H5 H 387 G.H5.19
Hydrophobic ICL2 P 141 34x50 G.H5 R 380 G.H5.12
Van-der-waals ICL2 P 141 34x50 G.H5 R 380 G.H5.12
Polar ICL2 Y 142 34x51 G.H5 F 376 G.H5.08
Aromatic ICL2 Y 142 34x51 G.H5 F 376 G.H5.08
Hydrophobic ICL2 Y 142 34x51 G.H5 F 376 G.H5.08
Van-der-waals ICL2 Y 142 34x51 G.H5 F 376 G.H5.08
Ionic TM6 E 259 6x30 G.H5 R 385 G.H5.17
Polar TM6 E 259 6x30 G.H5 R 385 G.H5.17
Hydrophobic TM6 E 259 6x30 G.H5 R 385 G.H5.17
Van-der-waals TM6 E 259 6x30 G.H5 R 385 G.H5.17
Polar ICL2 R 146 34x55 G.s2s3 K 216 G.s2s3.02