A1 receptor - Gi2

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.3 Å

REFERENCE

PUBLICATION DATE

Sept. 8, 2021

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

PHYSIOLOGICAL LIGANDS

adenosine



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Polar TM6 Y 225 6x26 G.h4s6 E 319 G.h4s6.12
Hydrophobic TM3 R 108 3x53 G.H5 C 352 G.H5.23
Van-der-waals TM3 R 108 3x53 G.H5 C 352 G.H5.23
Hydrophobic TM3 V 109 3x54 G.H5 L 349 G.H5.20
Van-der-waals TM3 V 109 3x54 G.H5 L 349 G.H5.20
Hydrophobic TM5 L 211 5x69 G.H5 F 355 G.H5.26
Hydrophobic TM6 I 232 6x33 G.H5 F 355 G.H5.26
Hydrophobic H8 I 292 8x47 G.H5 G 353 G.H5.24
Hydrophobic H8 I 292 8x47 G.H5 D 351 G.H5.22
Van-der-waals H8 I 292 8x47 G.H5 D 351 G.H5.22
Hydrophobic TM6 L 236 6x37 G.H5 L 354 G.H5.25
Hydrophobic TM5 Q 210 5x68 G.H5 I 345 G.H5.16
Van-der-waals TM5 Q 210 5x68 G.H5 I 345 G.H5.16
Aromatic TM6 K 228 6x29 G.H5 F 355 G.H5.26
Hydrophobic TM6 K 228 6x29 G.H5 F 355 G.H5.26
Van-der-waals TM6 K 228 6x29 G.H5 F 355 G.H5.26
Polar TM3 R 108 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM3 R 108 3x53 G.H5 N 348 G.H5.19
Van-der-waals TM3 R 108 3x53 G.H5 N 348 G.H5.19
Hydrophobic ICL2 P 112 34x50 G.H5 I 344 G.H5.15
Hydrophobic TM7 R 291 7x56 G.H5 G 353 G.H5.24
Hydrophobic ICL2 P 112 34x50 G.H5 I 345 G.H5.16
Van-der-waals ICL2 P 112 34x50 G.H5 I 345 G.H5.16
Hydrophobic ICL2 L 113 34x51 G.S3 L 195 G.S3.01
Polar TM3 R 105 3x50 G.H5 C 352 G.H5.23
Hydrophobic TM3 R 105 3x50 G.H5 C 352 G.H5.23
Van-der-waals TM3 R 105 3x50 G.H5 C 352 G.H5.23
Ionic TM3 R 108 3x53 G.H5 D 351 G.H5.22
Polar TM3 R 108 3x53 G.H5 D 351 G.H5.22
Hydrophobic TM3 R 108 3x53 G.H5 D 351 G.H5.22
Hydrophobic ICL2 L 113 34x51 G.H5 I 344 G.H5.15
Polar TM6 K 231 6x32 G.H5 L 354 G.H5.25
Van-der-waals TM6 K 231 6x32 G.H5 L 354 G.H5.25
Hydrophobic H8 I 292 8x47 G.H5 C 352 G.H5.23
Van-der-waals H8 I 292 8x47 G.H5 C 352 G.H5.23
Hydrophobic H8 K 294 8x49 G.H5 D 351 G.H5.22
Hydrophobic TM5 I 207 5x65 G.H5 L 349 G.H5.20
Hydrophobic ICL2 L 113 34x51 G.H5 T 341 G.H5.12
Hydrophobic TM5 L 211 5x69 G.H5 K 346 G.H5.17
Polar ICL2 P 112 34x50 G.H5 N 348 G.H5.19
Van-der-waals ICL2 P 112 34x50 G.H5 N 348 G.H5.19
Ionic TM5 K 213 5x71 G.H5 D 342 G.H5.13
Polar TM5 K 213 5x71 G.H5 D 342 G.H5.13
Van-der-waals TM5 K 213 5x71 G.H5 D 342 G.H5.13
Hydrophobic TM6 I 232 6x33 G.H5 L 354 G.H5.25
Van-der-waals TM6 I 232 6x33 G.H5 L 354 G.H5.25
Hydrophobic TM5 I 207 5x65 G.H5 L 354 G.H5.25
Polar TM5 Q 210 5x68 G.H5 D 342 G.H5.13
Hydrophobic TM5 Q 210 5x68 G.H5 D 342 G.H5.13
Van-der-waals TM5 Q 210 5x68 G.H5 D 342 G.H5.13