ADGRE5 - Gs

GPCR CLASS (FAMILY)

Class B2 (Adhesion)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.1 Å

REFERENCE

PUBLICATION DATE

July 12, 2023

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

Apo (no ligand) - Apo (no ligand)

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic ICL2 V 644 - G.H5 H 387 G.H5.19
Aromatic ICL2 F 645 - G.H5 F 376 G.H5.08
Hydrophobic ICL2 F 645 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 F 645 - G.H5 F 376 G.H5.08
Ionic TM5 K 721 5x64 G.H5 D 381 G.H5.13
Polar TM5 K 721 5x64 G.H5 D 381 G.H5.13
Van-der-waals TM5 K 721 5x64 G.H5 D 381 G.H5.13
Hydrophobic TM3 L 640 3x57 G.H5 H 387 G.H5.19
Van-der-waals TM3 L 640 3x57 G.H5 H 387 G.H5.19
Hydrophobic ICL2 F 645 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 F 645 - G.H5 I 383 G.H5.15
Hydrophobic ICL2 V 644 - G.H5 Q 384 G.H5.16
Van-der-waals ICL2 V 644 - G.H5 Q 384 G.H5.16
Hydrophobic TM3 L 640 3x57 G.H5 Y 391 G.H5.23
Van-der-waals TM3 L 640 3x57 G.H5 Y 391 G.H5.23
Hydrophobic TM2 R 579 2x46 G.H5 Y 391 G.H5.23
Van-der-waals TM2 R 579 2x46 G.H5 Y 391 G.H5.23
Polar TM3 V 641 3x58 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 V 644 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 V 644 - G.H5 R 380 G.H5.12
Hydrophobic TM3 V 641 3x58 G.H5 L 388 G.H5.20
Hydrophobic ICL2 F 645 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 F 645 - G.H5 R 380 G.H5.12
Polar TM5 K 721 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM5 K 721 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 K 721 5x64 G.H5 Q 384 G.H5.16
Polar TM3 V 642 3x59 G.H5 R 380 G.H5.12
Hydrophobic ICL2 V 644 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 V 644 - G.H5 I 383 G.H5.15
Hydrophobic ICL2 F 645 - G.S3 V 217 G.S3.01