MRGPRX4 (mrgx4_human)

FAMILY

Class A (Rhodopsin) Orphan receptors Class A orphans MRGPRX4

GENE

MRGPRX4 (MRGX4, SNSR5, SNSR6)

ORGANISM

Human (Homo sapiens)

ALT. NAMES

Mas-related G-protein coupled receptor member X4, Sensory neuron-specific G-protein coupled receptor 5/6

SOURCE

SWISSPROT

SEQUENCE

N-term        
M
D
P
T
V
P
V
F
G
T
10
                   
K
L
T
P
I
N
G
R
E
E
20
          TM1    
T
P
C
Y
N
Q
T
L
S
F
30
                   
T
V
L
T
C
I
I
S
L
V
40
                   
G
L
T
G
N
A
V
V
L
W
50
            ICL1
L
L
G
Y
R
M
R
R
N
A
60
TM2              
V
S
I
Y
I
L
N
L
A
A
70
                   
A
D
F
L
F
L
S
F
Q
I
80
                   
I
R
L
P
L
R
L
I
N
I
90
TM3              
S
H
L
I
R
K
I
L
V
S
100
                   
V
M
T
F
P
Y
F
T
G
L
110
                   
S
M
L
S
A
I
S
T
E
R
120
            ICL2
C
L
S
V
L
W
P
I
W
Y
130
            TM4  
R
C
R
R
P
T
H
L
S
A
140
                   
V
V
C
V
L
L
W
G
L
S
150
                   
L
L
F
S
M
L
E
W
R
F
160
  ECL2          
C
D
F
L
F
S
G
A
D
S
170
TM5              
S
W
C
E
T
S
D
F
I
P
180
                   
V
A
W
L
I
F
L
C
V
V
190
                   
L
C
V
S
S
L
V
L
L
V
200
        ICL3    
R
I
L
C
G
S
R
K
M
P
210
TM6              
L
T
R
L
Y
V
T
I
L
L
220
                   
T
V
L
V
F
L
L
C
G
L
230
                   
P
F
G
I
L
G
A
L
I
Y
240
ECL3       TM7
R
M
H
L
N
L
E
V
L
Y
250
                   
C
H
V
Y
L
V
C
M
S
L
260
                   
S
S
L
N
S
S
A
N
P
I
270
                   
I
Y
F
F
V
G
S
F
R
Q
280
C-term        
R
Q
N
R
Q
N
L
K
L
V
290
                   
L
Q
R
A
L
Q
D
K
P
E
300
                   
V
D
K
G
E
G
Q
L
P
E
310
                   
E
S
L
E
L
S
G
S
R
L
320
   
G
P

LINKS

Guide To Pharmacology

UniProt

DIAGRAMS

ICL1 R R ICL1ECL1 I N I ECL1ICL2 P I W Y R C R R P T ICL2ECL2 D F L F S G A ECL2ICL3 G S R K M ICL3ECL3 I Y R M H L N L E ECL3N-term M D P T V P V F G T K L T P I N G R E E T P C Y N N-termC-term Q R Q N R Q N L K L V L Q R A L Q D K P E V D K G E G Q L P E E S L E L S G S R L G P C-term Q T L S F T V L T C I I S L V G L T G N A V V L W L L G Y R M N A V S I Y I L N L A A A D F L F L S F Q I I R L P L R L S H L I R K I L V S V M T F P Y F T G L S M L S A I S T E R C L S V L W H L S A V V C V L L W G L S L L F S M L E W R F C D S S W C E T S D F I P V A W L I F L C V V L C V S S L V L L V R I L C P L T R L Y V T I L L T V L V F L L C G L P F G I L G A L V L Y C H V Y L V C M S L S S L N S S A N P I I Y F F V G S F R
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

A N G T L G V L S I I C T L V T F S L T 1 L N L A A A D F L F L S F Q I I R L P L 2 A S L M S L G T F Y P F T M V S V L I K 3 S A V V C V L L W G L S L L F S M L E W 4 S S V C L V V C L F I L W A V P I F D S 5 L L T V L V F L L C G L P F G I L G A L 6 I P N A S S N L S S L S M C V L Y V H 7
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

0 mutation data points available.

PHYSIOLOGICAL LIGANDS

No physiological ligands available

STRUCTURE MODELS

mrgx4_human inactive,

mrgx4_human active

STRUCTURES

Found 1 structure(s) - view all details on the Structures page

PDBs: 7S8P