PTH1 receptor - Gs

GPCR CLASS (FAMILY)

Class B1 (Secretin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Bos taurus

PDB CODE

6NBH

RESOLUTION

3.5 Å

REFERENCE

10.1126/SCIENCE.AAV7942

PUBLICATION DATE

April 17, 2019

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

122 interactions (Click to see)

LIGANDS

Long-acting parathyroid hormone analog - Agonist

PHYSIOLOGICAL LIGANDS

TIP39, PTHrP-(1-36), PTH, PTHrP



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 L 306 3x54 G.H5 Y 391 G.H5.23
Van-der-waals TM3 L 306 3x54 G.H5 Y 391 G.H5.23
Hydrophobic TM3 L 309 3x57 G.H5 Y 391 G.H5.23
Hydrophobic TM5 L 385 5x61 G.H5 L 393 G.H5.25
Hydrophobic TM3 L 309 3x57 G.H5 H 387 G.H5.19
Hydrophobic TM5 K 388 5x64 G.H5 L 388 G.H5.20
Hydrophobic TM5 T 392 5x68 G.h4s6 Y 358 G.h4s6.20
Polar TM5 K 388 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM5 K 388 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 K 388 5x64 G.H5 Q 384 G.H5.16
Polar ICL3 N 393 - G.S6 C 359 G.S6.01
Hydrophobic ICL3 N 393 - G.S6 C 359 G.S6.01
Van-der-waals ICL3 N 393 - G.S6 C 359 G.S6.01
Polar TM6 S 409 6x41 G.H5 L 393 G.H5.25
Hydrophobic TM6 S 409 6x41 G.H5 L 393 G.H5.25
Van-der-waals TM6 S 409 6x41 G.H5 L 393 G.H5.25
Hydrophobic ICL2 F 314 - G.S3 V 217 G.S3.01
Polar TM4 S 316 4x38 G.HN Q 35 G.HN.52
Aromatic TM2 R 219 2x46 G.H5 Y 391 G.H5.23
Hydrophobic TM2 R 219 2x46 G.H5 Y 391 G.H5.23
Van-der-waals TM2 R 219 2x46 G.H5 Y 391 G.H5.23
Hydrophobic TM5 L 385 5x61 G.H5 L 388 G.H5.20
Polar H8 G 464 8x48 G.H5 E 392 G.H5.24
Hydrophobic TM5 L 385 5x61 G.H5 L 394 G.H5.26
Polar TM3 I 310 3x58 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 310 3x58 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 310 3x58 G.H5 Q 384 G.H5.16
Ionic TM5 K 388 5x64 G.H5 D 381 G.H5.13
Polar TM5 K 388 5x64 G.H5 D 381 G.H5.13
Hydrophobic TM5 K 388 5x64 G.H5 D 381 G.H5.13
Van-der-waals TM5 K 388 5x64 G.H5 D 381 G.H5.13
Hydrophobic TM5 K 388 5x64 G.H5 L 394 G.H5.26
Polar TM2 R 219 2x46 G.H5 Q 390 G.H5.22
Hydrophobic TM2 R 219 2x46 G.H5 Q 390 G.H5.22
Van-der-waals TM2 R 219 2x46 G.H5 Q 390 G.H5.22
Hydrophobic TM3 I 310 3x58 G.H5 L 388 G.H5.20
Polar TM5 K 388 5x64 G.H5 R 385 G.H5.17
Hydrophobic TM5 K 388 5x64 G.H5 R 385 G.H5.17
Van-der-waals TM5 K 388 5x64 G.H5 R 385 G.H5.17
Hydrophobic TM5 L 389 5x65 G.H5 L 394 G.H5.26
Van-der-waals TM5 L 389 5x65 G.H5 L 394 G.H5.26
Hydrophobic TM6 V 412 6x44 G.H5 L 393 G.H5.25
Van-der-waals TM3 Y 305 3x53 G.H5 Y 391 G.H5.23
Ionic TM4 E 317 4x39 G.hns1 R 38 G.hns1.02
Polar TM4 E 317 4x39 G.hns1 R 38 G.hns1.02
Hydrophobic TM4 E 317 4x39 G.hns1 R 38 G.hns1.02
Van-der-waals TM4 E 317 4x39 G.hns1 R 38 G.hns1.02
Ionic TM5 E 391 5x67 G.H5 R 385 G.H5.17
Hydrophobic ICL3 N 393 - G.H4 L 346 G.H4.16