FFA3 receptor (ffar3_human)
FAMILY
Class A (Rhodopsin) Lipid receptors Free fatty acid receptors FFA3 receptor
GENE
FFAR3 (GPR41)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Free fatty acid receptor 3, G-protein coupled receptor 41
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
D
|
T
|
G
|
P
|
D
|
Q
|
S
|
Y
|
F
|
10 |
TM1 | |||||||||
S
|
G
|
N
|
H
|
W
|
F
|
V
|
F
|
S
|
V
|
20 |
Y
|
L
|
L
|
T
|
F
|
L
|
V
|
G
|
L
|
P
|
30 |
L
|
N
|
L
|
L
|
A
|
L
|
V
|
V
|
F
|
V
|
40 |
ICL1 | TM2 | |||||||||||
G
|
K
|
L
|
Q
|
R
|
R
|
P
|
V
|
A
|
V
|
|||
50 |
D
|
V
|
L
|
L
|
L
|
N
|
L
|
T
|
A
|
S
|
60 |
D
|
L
|
L
|
L
|
L
|
L
|
F
|
L
|
P
|
F
|
70 |
ECL1 | |||||||||
R
|
M
|
V
|
E
|
A
|
A
|
N
|
G
|
M
|
H
|
80 |
TM3 | |||||||||
W
|
P
|
L
|
P
|
F
|
I
|
L
|
C
|
P
|
L
|
90 |
S
|
G
|
F
|
I
|
F
|
F
|
T
|
T
|
I
|
Y
|
100 |
L
|
T
|
A
|
L
|
F
|
L
|
A
|
A
|
V
|
S
|
110 |
I
|
E
|
R
|
F
|
L
|
S
|
V
|
A
|
H
|
P
|
120 |
ICL2 | TM4 | ||||||||
L
|
W
|
Y
|
K
|
T
|
R
|
P
|
R
|
L
|
G
|
130 |
Q
|
A
|
G
|
L
|
V
|
S
|
V
|
A
|
C
|
W
|
140 |
L
|
L
|
A
|
S
|
A
|
H
|
C
|
S
|
V
|
V
|
150 |
ECL2 | |||||||||
Y
|
V
|
I
|
E
|
F
|
S
|
G
|
D
|
I
|
S
|
160 |
H
|
S
|
Q
|
G
|
T
|
N
|
G
|
T
|
C
|
Y
|
170 |
TM5 | |||||||||
L
|
E
|
F
|
R
|
K
|
D
|
Q
|
L
|
A
|
I
|
180 |
L
|
L
|
P
|
V
|
R
|
L
|
E
|
M
|
A
|
V
|
190 |
V
|
L
|
F
|
V
|
V
|
P
|
L
|
I
|
I
|
T
|
200 |
S
|
Y
|
C
|
Y
|
S
|
R
|
L
|
V
|
W
|
I
|
210 |
ICL3 | TM6 | ||||||||
L
|
G
|
R
|
G
|
G
|
S
|
H
|
R
|
R
|
Q
|
220 |
R
|
R
|
V
|
A
|
G
|
L
|
L
|
A
|
A
|
T
|
230 |
L
|
L
|
N
|
F
|
L
|
V
|
C
|
F
|
G
|
P
|
240 |
Y
|
N
|
V
|
S
|
H
|
V
|
V
|
G
|
Y
|
I
|
250 |
ECL3 | TM7 | ||||||||
C
|
G
|
E
|
S
|
P
|
A
|
W
|
R
|
I
|
Y
|
260 |
V
|
T
|
L
|
L
|
S
|
T
|
L
|
N
|
S
|
C
|
270 |
V
|
D
|
P
|
F
|
V
|
Y
|
Y
|
F
|
S
|
S
|
280 |
H8 | |||||||||
S
|
G
|
F
|
Q
|
A
|
D
|
F
|
H
|
E
|
L
|
290 |
C-term | |||||||||
L
|
R
|
R
|
L
|
C
|
G
|
L
|
W
|
G
|
Q
|
300 |
W
|
Q
|
Q
|
E
|
S
|
S
|
M
|
E
|
L
|
K
|
310 |
E
|
Q
|
K
|
G
|
G
|
E
|
E
|
Q
|
R
|
A
|
320 |
D
|
R
|
P
|
A
|
E
|
R
|
K
|
T
|
S
|
E
|
330 |
H
|
S
|
Q
|
G
|
C
|
G
|
T
|
G
|
G
|
Q
|
340 |
V
|
A
|
C
|
A
|
E
|
S
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
butyric acid, propanoic acid
STRUCTURE MODELS
STRUCTURES
Found 2 structure(s) - view all details on the Structures page