FFA3 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

D

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8J20

RESOLUTION

3.2 Å

REFERENCE

10.1038/S41422-023-00914-Z

PUBLICATION DATE

Jan. 24, 2024

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

40 interactions (Click to see)

LIGANDS

pentanoic acid - Agonist pubchem gtoplig chembl_ligand drugbank ,

(4R)-N-[2,5-bis(chloranyl)phenyl]-4-(furan-2-yl)-2-methyl-5-oxidanylidene-4,6,7,8-tetrahydro-1H-quinoline-3-carboxamide - PAM pubchem

PHYSIOLOGICAL LIGANDS

butyric acid, propanoic acid



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM3 S 116 3x53 G.H5 N 347 G.H5.19
Polar TM6 R 218 6x29 G.h4s6 T 316 G.h4s6.10
Polar TM7 S 279 7x56 G.H5 F 354 G.H5.26
Hydrophobic TM6 R 219 6x30 G.H5 K 345 G.H5.17
Van-der-waals TM6 R 219 6x30 G.H5 K 345 G.H5.17
Polar ICL2 Y 123 34x53 G.H5 C 351 G.H5.23
Hydrophobic ICL2 Y 123 34x53 G.H5 C 351 G.H5.23
Van-der-waals ICL2 Y 123 34x53 G.H5 C 351 G.H5.23
Hydrophobic TM2 V 50 2x39 G.H5 D 350 G.H5.22
Van-der-waals TM2 V 50 2x39 G.H5 D 350 G.H5.22
Hydrophobic TM6 V 223 6x34 G.H5 F 354 G.H5.26
Hydrophobic ICL2 Y 123 34x53 G.H5 N 347 G.H5.19
Polar ICL2 P 120 34x50 G.H5 N 347 G.H5.19
Hydrophobic TM6 R 219 6x30 G.H5 I 344 G.H5.16
Van-der-waals TM6 R 219 6x30 G.H5 I 344 G.H5.16
Hydrophobic ICL2 P 120 34x50 G.H5 T 340 G.H5.12
Hydrophobic TM3 V 117 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 117 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM6 R 219 6x30 G.H5 F 354 G.H5.26
Hydrophobic TM5 L 207 5x61 G.H5 L 348 G.H5.20
Ionic TM6 R 218 6x29 G.h4s6 E 318 G.h4s6.12
Polar TM6 R 218 6x29 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 V 227 6x38 G.H5 L 353 G.H5.25
Van-der-waals TM6 V 227 6x38 G.H5 L 353 G.H5.25
Hydrophobic ICL2 T 125 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 T 125 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 P 127 34x57 G.HN E 28 G.HN.52
Hydrophobic ICL2 K 124 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic TM5 L 211 5x65 G.H5 I 344 G.H5.16
Hydrophobic ICL2 P 120 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 120 34x50 G.H5 I 344 G.H5.16
Hydrophobic ICL2 K 124 34x54 G.H5 I 343 G.H5.15
Hydrophobic TM3 R 113 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 113 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM6 V 223 6x34 G.H5 L 353 G.H5.25
Hydrophobic TM3 V 117 3x54 G.H5 I 344 G.H5.16
Van-der-waals TM3 V 117 3x54 G.H5 I 344 G.H5.16
Polar ICL2 K 124 34x54 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 K 124 34x54 G.hns1 A 31 G.hns1.02
Hydrophobic TM3 R 113 3x50 G.H5 G 352 G.H5.24
Van-der-waals TM3 R 113 3x50 G.H5 G 352 G.H5.24
Polar TM6 R 218 6x29 G.h4s6 D 315 G.h4s6.09
Hydrophobic TM6 R 218 6x29 G.h4s6 D 315 G.h4s6.09
Van-der-waals TM6 R 218 6x29 G.h4s6 D 315 G.h4s6.09
Polar TM6 R 218 6x29 G.h4s6 K 317 G.h4s6.11
Ionic TM1 R 46 1x64 G.H5 D 350 G.H5.22
Polar TM1 R 46 1x64 G.H5 D 350 G.H5.22
Hydrophobic TM1 R 46 1x64 G.H5 D 350 G.H5.22
Van-der-waals TM1 R 46 1x64 G.H5 D 350 G.H5.22
Van-der-waals TM6 R 218 6x29 G.H5 K 345 G.H5.17
Ionic TM6 R 219 6x30 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM5 L 207 5x61 G.H5 L 353 G.H5.25
Hydrophobic ICL2 L 121 34x51 G.H5 F 336 G.H5.08
Hydrophobic H8 S 280 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 S 280 8x47 G.H5 G 352 G.H5.24
Aromatic TM6 R 222 6x33 G.H5 F 354 G.H5.26
Hydrophobic TM6 R 222 6x33 G.H5 F 354 G.H5.26
Hydrophobic TM2 V 50 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 V 50 2x39 G.H5 C 351 G.H5.23
Polar TM3 S 116 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM3 S 116 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 S 116 3x53 G.H5 C 351 G.H5.23
Hydrophobic ICL2 L 121 34x51 G.S3 L 194 G.S3.01
Hydrophobic TM5 L 211 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 L 211 5x65 G.H5 L 348 G.H5.20
Polar TM6 R 218 6x29 G.h4s6 K 314 G.h4s6.08
Ionic TM6 R 219 6x30 G.H5 D 341 G.H5.13
Polar TM6 R 219 6x30 G.H5 D 341 G.H5.13
Van-der-waals TM6 R 219 6x30 G.H5 D 341 G.H5.13
Hydrophobic ICL2 P 120 34x50 G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 120 34x50 G.H5 I 343 G.H5.15
Polar TM3 R 113 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 113 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 113 3x50 G.H5 C 351 G.H5.23