Refined structure (8J21) of Gi1 - FFA3 receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2024-11-26

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 223 from structure (63.0%), 131 from model (37.0%)
Residue sidechains - 223 from structure (63.0%), 131 from model (37.0%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 Structure Structure
G.HN 3 C G.HN.09 Structure Structure
G.HN 4 T G.HN.10 Structure Structure
G.HN 5 L G.HN.11 Structure Structure
G.HN 6 S G.HN.30 Structure Structure
G.HN 7 A G.HN.31 Structure Structure
G.HN 8 E G.HN.32 Structure Structure
G.HN 9 D G.HN.33 Structure Structure
G.HN 10 K G.HN.34 Structure Structure
G.HN 11 A G.HN.35 Structure Structure
G.HN 12 A G.HN.36 Structure Structure
G.HN 13 V G.HN.37 Structure Structure
G.HN 14 E G.HN.38 Structure Structure
G.HN 15 R G.HN.39 Structure Structure
G.HN 16 S G.HN.40 Structure Structure
G.HN 17 K G.HN.41 Structure Structure
G.HN 18 M G.HN.42 Structure Structure
G.HN 19 I G.HN.43 Structure Structure
G.HN 20 D G.HN.44 Structure Structure
G.HN 21 R G.HN.45 Structure Structure
G.HN 22 N G.HN.46 Structure Structure
G.HN 23 L G.HN.47 Structure Structure
G.HN 24 R G.HN.48 Structure Structure
G.HN 25 E G.HN.49 Structure Structure
G.HN 26 D G.HN.50 Structure Structure
G.HN 27 G G.HN.51 Structure Structure
G.HN 28 E G.HN.52 Structure Structure
G.HN 29 K G.HN.53 Structure Structure
G.hns1 30 A G.hns1.01 Structure Structure
G.hns1 31 A G.hns1.02 Structure Structure
G.hns1 32 R G.hns1.03 Structure Structure
G.S1 33 E G.S1.01 Structure Structure
G.S1 34 V G.S1.02 Structure Structure
G.S1 35 K G.S1.03 Structure Structure
G.S1 36 L G.S1.04 Structure Structure
G.S1 37 L G.S1.05 Structure Structure
G.S1 38 L G.S1.06 Structure Structure
G.S1 39 L G.S1.07 Structure Structure
G.s1h1 40 G G.s1h1.01 Structure Structure
G.s1h1 41 A G.s1h1.02 Structure Structure
G.s1h1 42 G G.s1h1.03 Structure Structure
G.s1h1 43 E G.s1h1.04 Structure Structure
G.s1h1 44 S G.s1h1.05 Structure Structure
G.s1h1 45 G G.s1h1.06 Structure Structure
G.H1 46 K G.H1.01 Structure Structure
G.H1 47 S G.H1.02 Structure Structure
G.H1 48 T G.H1.03 Structure Structure
G.H1 49 I G.H1.04 Structure Structure
G.H1 50 V G.H1.05 Structure Structure
G.H1 51 K G.H1.06 Structure Structure
G.H1 52 Q G.H1.07 Structure Structure
G.H1 53 M G.H1.08 Structure Structure
G.H1 54 K G.H1.09 Structure Structure
G.H1 55 I G.H1.10 Structure Structure
G.H1 56 I G.H1.11 Structure Structure
G.H1 57 H G.H1.12 AF2 AF2
G.h1ha 58 E G.h1ha.01 AF2 AF2
G.h1ha 59 A G.h1ha.02 AF2 AF2
G.h1ha 60 G G.h1ha.03 AF2 AF2
G.h1ha 61 Y G.h1ha.04 AF2 AF2
G.h1ha 62 S G.h1ha.05 AF2 AF2
H.HA 63 E H.HA.01 AF2 AF2
H.HA 64 E H.HA.02 AF2 AF2
H.HA 65 E H.HA.03 AF2 AF2
H.HA 66 C H.HA.04 AF2 AF2
H.HA 67 K H.HA.05 AF2 AF2
H.HA 68 Q H.HA.06 AF2 AF2
H.HA 69 Y H.HA.07 AF2 AF2
H.HA 70 K H.HA.08 AF2 AF2
H.HA 71 A H.HA.09 AF2 AF2
H.HA 72 V H.HA.10 AF2 AF2
H.HA 73 V H.HA.11 AF2 AF2
H.HA 74 Y H.HA.12 AF2 AF2
H.HA 75 S H.HA.13 AF2 AF2
H.HA 76 N H.HA.14 AF2 AF2
H.HA 77 T H.HA.15 AF2 AF2
H.HA 78 I H.HA.16 AF2 AF2
H.HA 79 Q H.HA.17 AF2 AF2
H.HA 80 S H.HA.18 AF2 AF2
H.HA 81 I H.HA.19 AF2 AF2
H.HA 82 I H.HA.20 AF2 AF2
H.HA 83 A H.HA.21 AF2 AF2
H.HA 84 I H.HA.22 AF2 AF2
H.HA 85 I H.HA.23 AF2 AF2
H.HA 86 R H.HA.24 AF2 AF2
H.HA 87 A H.HA.25 AF2 AF2
H.HA 88 M H.HA.26 AF2 AF2
H.HA 89 G H.HA.27 AF2 AF2
H.HA 90 R H.HA.28 AF2 AF2
H.HA 91 L H.HA.29 AF2 AF2
H.hahb 92 K H.hahb.01 AF2 AF2
H.hahb 93 I H.hahb.04 AF2 AF2
H.hahb 94 D H.hahb.05 AF2 AF2
H.hahb 95 F H.hahb.06 AF2 AF2
H.hahb 96 G H.hahb.07 AF2 AF2
H.hahb 97 D H.hahb.08 AF2 AF2
H.hahb 98 S H.hahb.09 AF2 AF2
H.HB 99 A H.HB.01 AF2 AF2
H.HB 100 R H.HB.02 AF2 AF2
H.HB 101 A H.HB.03 AF2 AF2
H.HB 102 D H.HB.04 AF2 AF2
H.HB 103 D H.HB.05 AF2 AF2
H.HB 104 A H.HB.06 AF2 AF2
H.HB 105 R H.HB.07 AF2 AF2
H.HB 106 Q H.HB.08 AF2 AF2
H.HB 107 L H.HB.09 AF2 AF2
H.HB 108 F H.HB.10 AF2 AF2
H.HB 109 V H.HB.11 AF2 AF2
H.HB 110 L H.HB.12 AF2 AF2
H.HB 111 A H.HB.13 AF2 AF2
H.HB 112 G H.HB.14 AF2 AF2
H.hbhc 113 A H.hbhc.01 AF2 AF2
H.hbhc 114 A H.hbhc.02 AF2 AF2
H.hbhc 115 E H.hbhc.03 AF2 AF2
H.hbhc 116 E H.hbhc.04 AF2 AF2
H.hbhc 117 G H.hbhc.12 AF2 AF2
H.hbhc 118 F H.hbhc.13 AF2 AF2
H.hbhc 119 M H.hbhc.14 AF2 AF2
H.hbhc 120 T H.hbhc.15 AF2 AF2
H.HC 121 A H.HC.01 AF2 AF2
H.HC 122 E H.HC.02 AF2 AF2
H.HC 123 L H.HC.03 AF2 AF2
H.HC 124 A H.HC.04 AF2 AF2
H.HC 125 G H.HC.05 AF2 AF2
H.HC 126 V H.HC.06 AF2 AF2
H.HC 127 I H.HC.07 AF2 AF2
H.HC 128 K H.HC.08 AF2 AF2
H.HC 129 R H.HC.09 AF2 AF2
H.HC 130 L H.HC.10 AF2 AF2
H.HC 131 W H.HC.11 AF2 AF2
H.HC 132 K H.HC.12 AF2 AF2
H.hchd 133 D H.hchd.01 AF2 AF2
H.HD 134 S H.HD.01 AF2 AF2
H.HD 135 G H.HD.02 AF2 AF2
H.HD 136 V H.HD.03 AF2 AF2
H.HD 137 Q H.HD.04 AF2 AF2
H.HD 138 A H.HD.05 AF2 AF2
H.HD 139 C H.HD.06 AF2 AF2
H.HD 140 F H.HD.07 AF2 AF2
H.HD 141 N H.HD.08 AF2 AF2
H.HD 142 R H.HD.09 AF2 AF2
H.HD 143 S H.HD.10 AF2 AF2
H.HD 144 R H.HD.11 AF2 AF2
H.HD 145 E H.HD.12 AF2 AF2
H.hdhe 146 Y H.hdhe.01 AF2 AF2
H.hdhe 147 Q H.hdhe.02 AF2 AF2
H.hdhe 148 L H.hdhe.03 AF2 AF2
H.hdhe 149 N H.hdhe.04 AF2 AF2
H.hdhe 150 D H.hdhe.05 AF2 AF2
H.HE 151 S H.HE.01 AF2 AF2
H.HE 152 A H.HE.02 AF2 AF2
H.HE 153 A H.HE.03 AF2 AF2
H.HE 154 Y H.HE.04 AF2 AF2
H.HE 155 Y H.HE.05 AF2 AF2
H.HE 156 L H.HE.06 AF2 AF2
H.HE 157 N H.HE.07 AF2 AF2
H.HE 158 D H.HE.08 AF2 AF2
H.HE 159 L H.HE.09 AF2 AF2
H.HE 160 D H.HE.10 AF2 AF2
H.HE 161 R H.HE.11 AF2 AF2
H.HE 162 I H.HE.12 AF2 AF2
H.HE 163 A H.HE.13 AF2 AF2
H.hehf 164 Q H.hehf.01 AF2 AF2
H.hehf 165 P H.hehf.02 AF2 AF2
H.hehf 166 N H.hehf.03 AF2 AF2
H.hehf 167 Y H.hehf.04 AF2 AF2
H.hehf 168 I H.hehf.05 AF2 AF2
H.hehf 169 P H.hehf.06 AF2 AF2
H.hehf 170 T H.hehf.07 AF2 AF2
H.HF 171 Q H.HF.01 AF2 AF2
H.HF 172 Q H.HF.02 AF2 AF2
H.HF 173 D H.HF.03 AF2 AF2
H.HF 174 V H.HF.04 AF2 AF2
H.HF 175 L H.HF.05 AF2 AF2
H.HF 176 R H.HF.06 AF2 AF2
G.hfs2 177 T G.hfs2.01 AF2 AF2
G.hfs2 178 R G.hfs2.02 AF2 AF2
G.hfs2 179 V G.hfs2.03 AF2 AF2
G.hfs2 180 K G.hfs2.04 AF2 AF2
G.hfs2 181 T G.hfs2.05 AF2 AF2
G.hfs2 182 T G.hfs2.06 Structure Structure
G.hfs2 183 G G.hfs2.07 Structure Structure
G.S2 184 I G.S2.01 Structure Structure
G.S2 185 V G.S2.02 Structure Structure
G.S2 186 E G.S2.03 Structure Structure
G.S2 187 T G.S2.04 Structure Structure
G.S2 188 H G.S2.05 Structure Structure
G.S2 189 F G.S2.06 Structure Structure
G.S2 190 T G.S2.07 Structure Structure
G.S2 191 F G.S2.08 Structure Structure
G.s2s3 192 K G.s2s3.01 Structure Structure
G.s2s3 193 D G.s2s3.02 Structure Structure
G.S3 194 L G.S3.01 Structure Structure
G.S3 195 H G.S3.02 Structure Structure
G.S3 196 F G.S3.03 Structure Structure
G.S3 197 K G.S3.04 Structure Structure
G.S3 198 M G.S3.05 Structure Structure
G.S3 199 F G.S3.06 Structure Structure
G.S3 200 D G.S3.07 Structure Structure
G.S3 201 V G.S3.08 Structure Structure
G.s3h2 202 G G.s3h2.01 Structure Structure
G.s3h2 203 G G.s3h2.02 Structure Structure
G.s3h2 204 Q G.s3h2.03 Structure Structure
G.H2 205 R G.H2.01 Structure Structure
G.H2 206 S G.H2.02 Structure Structure
G.H2 207 E G.H2.03 Structure Structure
G.H2 208 R G.H2.04 Structure Structure
G.H2 209 K G.H2.05 Structure Structure
G.H2 210 K G.H2.06 Structure Structure
G.H2 211 W G.H2.07 Structure Structure
G.H2 212 I G.H2.08 Structure Structure
G.H2 213 H G.H2.09 Structure Structure
G.H2 214 C G.H2.10 Structure Structure
G.h2s4 215 F G.h2s4.01 Structure Structure
G.h2s4 216 E G.h2s4.02 Structure Structure
G.h2s4 217 G G.h2s4.03 Structure Structure
G.h2s4 218 V G.h2s4.04 Structure Structure
G.h2s4 219 T G.h2s4.05 Structure Structure
G.S4 220 A G.S4.01 Structure Structure
G.S4 221 I G.S4.02 Structure Structure
G.S4 222 I G.S4.03 Structure Structure
G.S4 223 F G.S4.04 Structure Structure
G.S4 224 C G.S4.05 Structure Structure
G.S4 225 V G.S4.06 Structure Structure
G.S4 226 A G.S4.07 Structure Structure
G.s4h3 227 L G.s4h3.01 Structure Structure
G.s4h3 228 S G.s4h3.02 Structure Structure
G.s4h3 229 D G.s4h3.03 Structure Structure
G.s4h3 230 Y G.s4h3.04 Structure Structure
G.s4h3 231 D G.s4h3.05 Structure Structure
G.s4h3 232 L G.s4h3.06 Structure Structure
G.s4h3 233 V G.s4h3.07 Structure Structure
G.s4h3 234 L G.s4h3.08 Structure Structure
G.s4h3 235 A G.s4h3.09 AF2 AF2
G.s4h3 236 E G.s4h3.10 AF2 AF2
G.s4h3 237 D G.s4h3.11 AF2 AF2
G.s4h3 238 E G.s4h3.12 AF2 AF2
G.s4h3 239 E G.s4h3.13 AF2 AF2
G.s4h3 240 M G.s4h3.14 Structure Structure
G.s4h3 241 N G.s4h3.15 Structure Structure
G.H3 242 R G.H3.01 Structure Structure
G.H3 243 M G.H3.02 Structure Structure
G.H3 244 H G.H3.03 Structure Structure
G.H3 245 E G.H3.04 Structure Structure
G.H3 246 S G.H3.05 Structure Structure
G.H3 247 M G.H3.06 Structure Structure
G.H3 248 K G.H3.07 Structure Structure
G.H3 249 L G.H3.08 Structure Structure
G.H3 250 F G.H3.09 Structure Structure
G.H3 251 D G.H3.10 Structure Structure
G.H3 252 S G.H3.11 Structure Structure
G.H3 253 I G.H3.12 Structure Structure
G.H3 254 C G.H3.13 Structure Structure
G.H3 255 N G.H3.14 Structure Structure
G.H3 256 N G.H3.15 Structure Structure
G.H3 257 K G.H3.16 Structure Structure
G.H3 258 W G.H3.17 Structure Structure
G.H3 259 F G.H3.18 Structure Structure
G.h3s5 260 T G.h3s5.01 Structure Structure
G.h3s5 261 D G.h3s5.02 Structure Structure
G.h3s5 262 T G.h3s5.03 Structure Structure
G.S5 263 S G.S5.01 Structure Structure
G.S5 264 I G.S5.02 Structure Structure
G.S5 265 I G.S5.03 Structure Structure
G.S5 266 L G.S5.04 Structure Structure
G.S5 267 F G.S5.05 Structure Structure
G.S5 268 L G.S5.06 Structure Structure
G.S5 269 N G.S5.07 Structure Structure
G.s5hg 270 K G.s5hg.01 Structure Structure
G.HG 271 K G.HG.01 Structure Structure
G.HG 272 D G.HG.02 Structure Structure
G.HG 273 L G.HG.03 Structure Structure
G.HG 274 F G.HG.04 Structure Structure
G.HG 275 E G.HG.05 Structure Structure
G.HG 276 E G.HG.06 Structure Structure
G.HG 277 K G.HG.07 Structure Structure
G.HG 278 I G.HG.08 Structure Structure
G.HG 279 K G.HG.09 Structure Structure
G.HG 280 K G.HG.12 Structure Structure
G.HG 281 S G.HG.13 Structure Structure
G.HG 282 P G.HG.14 Structure Structure
G.HG 283 L G.HG.15 Structure Structure
G.HG 284 T G.HG.16 Structure Structure
G.HG 285 I G.HG.17 Structure Structure
G.hgh4 286 C G.hgh4.01 Structure Structure
G.hgh4 287 Y G.hgh4.02 Structure Structure
G.hgh4 288 P G.hgh4.03 Structure Structure
G.hgh4 289 E G.hgh4.04 Structure Structure
G.hgh4 290 Y G.hgh4.05 Structure Structure
G.hgh4 291 A G.hgh4.06 Structure Structure
G.hgh4 292 G G.hgh4.07 Structure Structure
G.hgh4 293 S G.hgh4.08 Structure Structure
G.H4 294 N G.H4.01 Structure Structure
G.H4 295 T G.H4.02 Structure Structure
G.H4 296 Y G.H4.03 Structure Structure
G.H4 297 E G.H4.04 Structure Structure
G.H4 298 E G.H4.05 Structure Structure
G.H4 299 A G.H4.06 Structure Structure
G.H4 300 A G.H4.07 Structure Structure
G.H4 301 A G.H4.08 Structure Structure
G.H4 302 Y G.H4.10 Structure Structure
G.H4 303 I G.H4.11 Structure Structure
G.H4 304 Q G.H4.12 Structure Structure
G.H4 305 C G.H4.13 Structure Structure
G.H4 306 Q G.H4.14 Structure Structure
G.H4 307 F G.H4.15 Structure Structure
G.H4 308 E G.H4.16 Structure Structure
G.H4 309 D G.H4.17 Structure Structure
G.h4s6 310 L G.h4s6.01 Structure Structure
G.h4s6 311 N G.h4s6.02 Structure Structure
G.h4s6 312 K G.h4s6.03 Structure Structure
G.h4s6 313 R G.h4s6.04 Structure Structure
G.h4s6 314 K G.h4s6.08 Structure Structure
G.h4s6 315 D G.h4s6.09 Structure Structure
G.h4s6 316 T G.h4s6.10 Structure Structure
G.h4s6 317 K G.h4s6.11 Structure Structure
G.h4s6 318 E G.h4s6.12 Structure Structure
G.S6 319 I G.S6.01 Structure Structure
G.S6 320 Y G.S6.02 Structure Structure
G.S6 321 T G.S6.03 Structure Structure
G.S6 322 H G.S6.04 Structure Structure
G.S6 323 F G.S6.05 Structure Structure
G.s6h5 324 T G.s6h5.01 Structure Structure
G.s6h5 325 C G.s6h5.02 Structure Structure
G.s6h5 326 A G.s6h5.03 Structure Structure
G.s6h5 327 T G.s6h5.04 Structure Structure
G.s6h5 328 D G.s6h5.05 Structure Structure
G.H5 329 T G.H5.01 Structure Structure
G.H5 330 K G.H5.02 Structure Structure
G.H5 331 N G.H5.03 Structure Structure
G.H5 332 V G.H5.04 Structure Structure
G.H5 333 Q G.H5.05 Structure Structure
G.H5 334 F G.H5.06 Structure Structure
G.H5 335 V G.H5.07 Structure Structure
G.H5 336 F G.H5.08 Structure Structure
G.H5 337 D G.H5.09 Structure Structure
G.H5 338 A G.H5.10 Structure Structure
G.H5 339 V G.H5.11 Structure Structure
G.H5 340 T G.H5.12 Structure Structure
G.H5 341 D G.H5.13 Structure Structure
G.H5 342 V G.H5.14 Structure Structure
G.H5 343 I G.H5.15 Structure Structure
G.H5 344 I G.H5.16 Structure Structure
G.H5 345 K G.H5.17 Structure Structure
G.H5 346 N G.H5.18 Structure Structure
G.H5 347 N G.H5.19 Structure Structure
G.H5 348 L G.H5.20 Structure Structure
G.H5 349 K G.H5.21 Structure Structure
G.H5 350 D G.H5.22 Structure Structure
G.H5 351 C G.H5.23 Structure Structure
G.H5 352 G G.H5.24 Structure Structure
G.H5 353 L G.H5.25 Structure Structure
G.H5 354 F G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 274 from structure (90.1%), 30 from model (9.9%)
Residue sidechains - 255 from structure (83.9%), 49 from model (16.1%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 D - AF2 AF2
N-term 3 T - AF2 AF2
N-term 4 G - AF2 AF2
N-term 5 P - AF2 AF2
N-term 6 D - AF2 AF2
N-term 7 Q - AF2 AF2
N-term 8 S - AF2 AF2
N-term 9 Y - AF2 AF2
N-term 10 F - AF2 AF2
TM1 11 S 1.29x29 AF2 AF2
TM1 12 G 1.30x30 AF2 AF2
TM1 13 N 1.31x31 Structure Structure
TM1 14 H 1.32x32 Structure Structure
TM1 15 W 1.33x33 Structure Structure
TM1 16 F 1.34x34 Structure AF2
TM1 17 V 1.35x35 Structure Structure
TM1 18 F 1.36x36 Structure Structure
TM1 19 S 1.37x37 Structure Structure
TM1 20 V 1.38x38 Structure Structure
TM1 21 Y 1.39x39 Structure Structure
TM1 22 L 1.40x40 Structure Structure
TM1 23 L 1.41x41 Structure AF2
TM1 24 T 1.42x42 Structure Structure
TM1 25 F 1.43x43 Structure Structure
TM1 26 L 1.44x44 Structure Structure
TM1 27 V 1.45x45 Structure Structure
TM1 28 G 1.46x46 Structure Structure
TM1 29 L 1.47x47 Structure Structure
TM1 30 P 1.48x48 Structure Structure
TM1 31 L 1.49x49 Structure Structure
TM1 32 N 1.50x50 Structure Structure
TM1 33 L 1.51x51 Structure Structure
TM1 34 L 1.52x52 Structure Structure
TM1 35 A 1.53x53 Structure Structure
TM1 36 L 1.54x54 Structure Structure
TM1 37 V 1.55x55 Structure Structure
TM1 38 V 1.56x56 Structure AF2
TM1 39 F 1.57x57 Structure Structure
TM1 40 V 1.58x58 Structure Structure
TM1 41 G 1.59x59 Structure Structure
TM1 42 K 1.60x60 Structure Structure
TM1 43 L 1.61x61 Structure Structure
TM1 44 Q 1.62x62 Structure AF2
TM1 45 R 1.63x63 Structure Structure
TM1 46 R 1.64x64 Structure Structure
ICL1 47 P - Structure Structure
TM2 48 V 2.37x37 Structure Structure
TM2 49 A 2.38x38 Structure Structure
TM2 50 V 2.39x39 Structure Structure
TM2 51 D 2.40x40 Structure Structure
TM2 52 V 2.41x41 Structure Structure
TM2 53 L 2.42x42 Structure Structure
TM2 54 L 2.43x43 Structure Structure
TM2 55 L 2.44x44 Structure Structure
TM2 56 N 2.45x45 Structure Structure
TM2 57 L 2.46x46 Structure Structure
TM2 58 T 2.47x47 Structure Structure
TM2 59 A 2.48x48 Structure AF2
TM2 60 S 2.49x49 Structure Structure
TM2 61 D 2.50x50 Structure Structure
TM2 62 L 2.51x51 Structure Structure
TM2 63 L 2.52x52 Structure Structure
TM2 64 L 2.53x53 Structure Structure
TM2 65 L 2.54x54 Structure Structure
TM2 66 L 2.55x55 Structure Structure
TM2 67 F 2.56x56 Structure Structure
TM2 68 L 2.57x57 Structure Structure
TM2 69 P 2.58x58 Structure Structure
TM2 70 F 2.59x59 Structure Structure
TM2 71 R 2.60x60 Structure Structure
TM2 72 M 2.61x61 Structure Structure
TM2 73 V 2.62x62 Structure Structure
ECL1 74 E - Structure Structure
ECL1 75 A - Structure Structure
ECL1 76 A - Structure Structure
ECL1 77 N - Structure AF2
ECL1 78 G - Structure Structure
ECL1 79 M - Structure Structure
ECL1 80 H 23.49x49 Structure Structure
ECL1 81 W 23.50x50 Structure Structure
ECL1 82 P 23.51x51 Structure Structure
ECL1 83 L 23.52x52 Structure Structure
TM3 84 P 3.21x21 Structure Structure
TM3 85 F 3.22x22 Structure Structure
TM3 86 I 3.23x23 Structure Structure
TM3 87 L 3.24x24 Structure Structure
TM3 88 C 3.25x25 Structure Structure
TM3 89 P 3.26x26 Structure Structure
TM3 90 L 3.27x27 Structure Structure
TM3 91 S 3.28x28 Structure Structure
TM3 92 G 3.29x29 Structure Structure
TM3 93 F 3.30x30 Structure Structure
TM3 94 I 3.31x31 Structure AF2
TM3 95 F 3.32x32 Structure Structure
TM3 96 F 3.33x33 Structure Structure
TM3 97 T 3.34x34 Structure Structure
TM3 98 T 3.35x35 Structure Structure
TM3 99 I 3.36x36 Structure Structure
TM3 100 Y 3.37x37 Structure Structure
TM3 101 L 3.38x38 Structure Structure
TM3 102 T 3.39x39 Structure Structure
TM3 103 A 3.40x40 Structure Structure
TM3 104 L 3.41x41 Structure Structure
TM3 105 F 3.42x42 Structure Structure
TM3 106 L 3.43x43 Structure Structure
TM3 107 A 3.44x44 Structure Structure
TM3 108 A 3.45x45 Structure Structure
TM3 109 V 3.46x46 Structure Structure
TM3 110 S 3.47x47 Structure Structure
TM3 111 I 3.48x48 Structure Structure
TM3 112 E 3.49x49 Structure Structure
TM3 113 R 3.50x50 Structure Structure
TM3 114 F 3.51x51 Structure Structure
TM3 115 L 3.52x52 Structure Structure
TM3 116 S 3.53x53 Structure Structure
TM3 117 V 3.54x54 Structure Structure
TM3 118 A 3.55x55 Structure Structure
TM3 119 H 3.56x56 Structure AF2
ICL2 120 P 34.50x50 Structure Structure
ICL2 121 L 34.51x51 Structure Structure
ICL2 122 W 34.52x52 Structure Structure
ICL2 123 Y 34.53x53 Structure Structure
ICL2 124 K 34.54x54 Structure Structure
ICL2 125 T 34.55x55 Structure Structure
ICL2 126 R 34.56x56 Structure Structure
ICL2 127 P 34.57x57 Structure Structure
TM4 128 R 4.38x38 Structure Structure
TM4 129 L 4.39x39 Structure Structure
TM4 130 G 4.40x40 Structure Structure
TM4 131 Q 4.41x41 Structure Structure
TM4 132 A 4.42x42 Structure Structure
TM4 133 G 4.43x43 Structure Structure
TM4 134 L 4.44x44 Structure Structure
TM4 135 V 4.45x45 Structure Structure
TM4 136 S 4.46x46 Structure Structure
TM4 137 V 4.47x47 Structure Structure
TM4 138 A 4.48x48 Structure Structure
TM4 139 C 4.49x49 Structure Structure
TM4 140 W 4.50x50 Structure Structure
TM4 141 L 4.51x51 Structure Structure
TM4 142 L 4.52x52 Structure Structure
TM4 143 A 4.53x53 Structure Structure
TM4 144 S 4.54x54 Structure Structure
TM4 145 A 4.55x55 Structure Structure
TM4 146 H 4.56x56 Structure Structure
TM4 147 C 4.57x57 Structure Structure
TM4 148 S 4.58x58 Structure Structure
TM4 149 V 4.59x59 Structure Structure
TM4 150 V 4.60x60 Structure Structure
TM4 151 Y 4.61x61 Structure Structure
TM4 152 V 4.62x62 Structure Structure
TM4 153 I 4.63x63 Structure Structure
TM4 154 E 4.64x64 Structure Structure
TM4 155 F 4.65x65 Structure Structure
ECL2 156 S - Structure Structure
ECL2 157 G - Structure Structure
ECL2 158 D - Structure Structure
ECL2 159 I - AF2 AF2
ECL2 160 S - AF2 AF2
ECL2 161 H - AF2 AF2
ECL2 162 S - AF2 AF2
ECL2 163 Q - AF2 AF2
ECL2 164 G - AF2 AF2
ECL2 165 T - Structure Structure
ECL2 166 N - Structure Structure
ECL2 167 G - Structure Structure
ECL2 168 T - Structure Structure
ECL2 169 C 45.50x50 Structure Structure
ECL2 170 Y 45.51x51 Structure Structure
ECL2 171 L 45.52x52 Structure Structure
ECL2 172 E - Structure Structure
ECL2 173 F - Structure Structure
ECL2 174 R - Structure Structure
ECL2 175 K - Structure AF2
ECL2 176 D - Structure Structure
TM5 177 Q 5.31x32 Structure Structure
TM5 178 L 5.32x33 Structure Structure
TM5 179 A 5.33x34 Structure Structure
TM5 180 I 5.34x35 Structure Structure
TM5 181 L 5.35x36 Structure Structure
TM5 182 L 5.36x37 Structure Structure
TM5 183 P 5.37x38 Structure Structure
TM5 184 V 5.38x39 Structure Structure
TM5 185 R 5.39x40 Structure Structure
TM5 186 L 5.40x41 Structure Structure
TM5 187 E 5.41x42 Structure Structure
TM5 188 M 5.42x43 Structure Structure
TM5 189 A 5.43x44 Structure Structure
TM5 190 V 5.44x45 Structure Structure
TM5 191 V 5.45x46 Structure Structure
TM5 192 L 5.46x461 Structure Structure
TM5 193 F 5.47x47 Structure Structure
TM5 194 V 5.48x48 Structure AF2
TM5 195 V 5.49x49 Structure Structure
TM5 196 P 5.50x50 Structure Structure
TM5 197 L 5.51x51 Structure Structure
TM5 198 I 5.52x52 Structure AF2
TM5 199 I 5.53x53 Structure Structure
TM5 200 T 5.54x54 Structure Structure
TM5 201 S 5.55x55 Structure Structure
TM5 202 Y 5.56x56 Structure Structure
TM5 203 C 5.57x57 Structure Structure
TM5 204 Y 5.58x58 Structure Structure
TM5 205 S 5.59x59 Structure Structure
TM5 206 R 5.60x60 Structure Structure
TM5 207 L 5.61x61 Structure Structure
TM5 208 V 5.62x62 Structure Structure
TM5 209 W 5.63x63 Structure Structure
TM5 210 I 5.64x64 Structure Structure
TM5 211 L 5.65x65 Structure Structure
TM5 212 G 5.66x66 Structure Structure
TM5 213 R 5.67x67 Structure Structure
ICL3 214 G - Structure Structure
ICL3 215 G - Structure AF2
TM6 216 S 6.26x27 Structure Structure
TM6 217 H 6.27x28 Structure Structure
TM6 218 R 6.28x29 Structure Structure
TM6 219 R 6.29x30 Structure Structure
TM6 220 Q 6.30x31 Structure AF2
TM6 221 R 6.31x32 Structure Structure
TM6 222 R 6.32x33 Structure Structure
TM6 223 V 6.33x34 Structure Structure
TM6 224 A 6.34x35 Structure Structure
TM6 225 G 6.35x36 Structure Structure
TM6 226 L 6.36x37 Structure Structure
TM6 227 L 6.37x38 Structure AF2
TM6 228 A 6.38x39 Structure Structure
TM6 229 A 6.39x40 Structure Structure
TM6 230 T 6.40x41 Structure Structure
TM6 231 L 6.41x42 Structure Structure
TM6 232 L 6.42x43 Structure Structure
TM6 233 N 6.43x44 Structure Structure
TM6 234 F 6.44x45 Structure Structure
TM6 235 L 6.45x46 Structure Structure
TM6 236 V 6.46x461 Structure Structure
TM6 237 C 6.47x47 Structure Structure
TM6 238 F 6.48x48 Structure Structure
TM6 239 G 6.49x49 Structure Structure
TM6 240 P 6.50x50 Structure Structure
TM6 241 Y 6.51x51 Structure Structure
TM6 242 N 6.52x52 Structure Structure
TM6 243 V 6.53x53 Structure Structure
TM6 244 S 6.54x54 Structure Structure
TM6 245 H 6.55x55 Structure Structure
TM6 246 V 6.56x56 Structure Structure
TM6 247 V 6.57x57 Structure Structure
TM6 248 G 6.58x58 Structure Structure
TM6 249 Y 6.59x59 Structure Structure
TM6 250 I 6.60x60 Structure Structure
TM6 251 C 6.61x61 Structure AF2
TM6 252 G 6.62x62 Structure Structure
ECL3 253 E - Structure Structure
ECL3 254 S - Structure Structure
ECL3 255 P - Structure Structure
ECL3 256 A - Structure AF2
TM7 257 W 7.34x33 Structure Structure
TM7 258 R 7.35x34 Structure Structure
TM7 259 I 7.36x35 Structure AF2
TM7 260 Y 7.37x36 Structure Structure
TM7 261 V 7.38x37 Structure Structure
TM7 262 T 7.39x38 Structure AF2
TM7 263 L 7.40x39 Structure Structure
TM7 264 L 7.41x40 Structure Structure
TM7 265 S 7.42x41 Structure Structure
TM7 266 T 7.43x42 Structure Structure
TM7 267 L 7.44x43 Structure Structure
TM7 268 N 7.45x45 Structure Structure
TM7 269 S 7.46x46 Structure Structure
TM7 270 C 7.47x47 Structure Structure
TM7 271 V 7.48x48 Structure Structure
TM7 272 D 7.49x49 Structure Structure
TM7 273 P 7.50x50 Structure Structure
TM7 274 F 7.51x51 Structure AF2
TM7 275 V 7.52x52 Structure Structure
TM7 276 Y 7.53x53 Structure Structure
TM7 277 Y 7.54x54 Structure Structure
TM7 278 F 7.55x55 Structure Structure
TM7 279 S 7.56x56 Structure Structure
H8 280 S 8.47x47 Structure Structure
H8 281 S 8.48x48 Structure Structure
H8 282 G 8.49x49 Structure Structure
H8 283 F 8.50x50 Structure Structure
H8 284 Q 8.51x51 Structure Structure
H8 285 A 8.52x52 Structure Structure
H8 286 D 8.53x53 Structure Structure
H8 287 F 8.54x54 Structure Structure
H8 288 H 8.55x55 Structure Structure
H8 289 E 8.56x56 Structure Structure
H8 290 L 8.57x57 Structure Structure
H8 291 L 8.58x58 Structure Structure
H8 292 R 8.59x59 Structure Structure
H8 293 R 8.60x60 AF2 AF2
H8 294 L 8.61x61 AF2 AF2
C-term 295 C - AF2 AF2
C-term 296 G - AF2 AF2
C-term 297 L - AF2 AF2
C-term 298 W - AF2 AF2
C-term 299 G - AF2 AF2
C-term 300 Q - AF2 AF2
C-term 301 W - AF2 AF2
C-term 302 Q - AF2 AF2
C-term 303 Q - AF2 AF2
C-term 304 E - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 S 116 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM2 V 50 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 V 50 2x39 G.H5 C 351 G.H5.23
Hydrophobic ICL2 T 125 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 T 125 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic TM3 V 117 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 117 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM6 L 226 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 226 6x37 G.H5 L 353 G.H5.25
Polar ICL2 Y 123 34x53 G.H5 C 351 G.H5.23
Hydrophobic ICL2 Y 123 34x53 G.H5 C 351 G.H5.23
Van-der-waals ICL2 Y 123 34x53 G.H5 C 351 G.H5.23
Polar TM6 R 218 6x29 G.h4s6 K 314 G.h4s6.08
Hydrophobic ICL2 L 121 34x51 G.S3 L 194 G.S3.01
Hydrophobic TM3 R 113 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 113 3x50 G.H5 L 353 G.H5.25
Polar H8 S 280 8x47 G.H5 K 349 G.H5.21
Hydrophobic TM6 R 219 6x30 G.H5 K 345 G.H5.17
Van-der-waals TM6 R 219 6x30 G.H5 K 345 G.H5.17
Polar TM3 R 113 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 113 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 113 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM6 R 222 6x33 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 222 6x33 G.H5 F 354 G.H5.26
Polar TM7 S 279 7x56 G.H5 L 353 G.H5.25
Polar TM6 R 218 6x29 G.h4s6 D 315 G.h4s6.09
Hydrophobic TM6 R 218 6x29 G.h4s6 D 315 G.h4s6.09
Van-der-waals TM6 R 218 6x29 G.h4s6 D 315 G.h4s6.09
Hydrophobic ICL2 P 120 34x50 G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 120 34x50 G.H5 I 343 G.H5.15
Hydrophobic ICL2 P 120 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 120 34x50 G.H5 I 344 G.H5.16
Hydrophobic ICL2 L 121 34x51 G.H5 F 336 G.H5.08
Hydrophobic TM5 L 211 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM6 R 218 6x29 G.H5 K 345 G.H5.17
Hydrophobic TM6 V 223 6x34 G.H5 F 354 G.H5.26
Hydrophobic TM2 V 50 2x39 G.H5 D 350 G.H5.22
Ionic TM6 R 219 6x30 G.h4s6 E 318 G.h4s6.12
Polar TM6 R 219 6x30 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 R 219 6x30 G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL2 K 124 34x54 G.H5 I 343 G.H5.15
Van-der-waals ICL2 K 124 34x54 G.H5 I 343 G.H5.15
Hydrophobic TM6 R 218 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 218 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM5 Y 204 5x58 G.H5 L 353 G.H5.25
Van-der-waals TM5 Y 204 5x58 G.H5 L 353 G.H5.25
Hydrophobic ICL2 L 121 34x51 G.H5 I 343 G.H5.15
Polar TM6 R 218 6x29 G.h4s6 T 316 G.h4s6.10
Hydrophobic TM6 R 218 6x29 G.h4s6 T 316 G.h4s6.10
Van-der-waals TM6 R 218 6x29 G.h4s6 T 316 G.h4s6.10
Hydrophobic ICL2 L 121 34x51 G.H5 T 340 G.H5.12
Hydrophobic TM5 L 211 5x65 G.H5 I 344 G.H5.16
Hydrophobic ICL2 Y 123 34x53 G.H5 N 347 G.H5.19
Van-der-waals ICL2 Y 123 34x53 G.H5 N 347 G.H5.19
Hydrophobic TM6 R 219 6x30 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 219 6x30 G.H5 F 354 G.H5.26
Hydrophobic TM6 V 223 6x34 G.H5 L 348 G.H5.20
Hydrophobic TM6 L 227 6x38 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 227 6x38 G.H5 L 353 G.H5.25
Polar H8 S 280 8x47 G.H5 G 352 G.H5.24
Hydrophobic H8 S 280 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 S 280 8x47 G.H5 G 352 G.H5.24
Polar ICL2 K 124 34x54 G.hns1 A 31 G.hns1.02
Ionic TM1 R 46 1x64 G.H5 D 350 G.H5.22
Polar TM1 R 46 1x64 G.H5 D 350 G.H5.22
Hydrophobic TM1 R 46 1x64 G.H5 D 350 G.H5.22
Van-der-waals TM1 R 46 1x64 G.H5 D 350 G.H5.22
Hydrophobic TM2 V 48 2x37 G.H5 D 350 G.H5.22
Hydrophobic ICL2 K 124 34x54 G.H5 N 347 G.H5.19
Van-der-waals ICL2 K 124 34x54 G.H5 N 347 G.H5.19
Hydrophobic TM5 L 207 5x61 G.H5 L 353 G.H5.25
Polar TM6 R 219 6x30 G.H5 D 341 G.H5.13
Hydrophobic TM7 S 279 7x56 G.H5 G 352 G.H5.24
Van-der-waals TM7 S 279 7x56 G.H5 G 352 G.H5.24
Hydrophobic TM3 S 116 3x53 G.H5 C 351 G.H5.23
Polar TM7 S 279 7x56 G.H5 F 354 G.H5.26
Polar ICL2 P 120 34x50 G.H5 N 347 G.H5.19