D5 receptor - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8IRV

RESOLUTION

3.1 Å

REFERENCE

10.1038/S41422-023-00808-0

PUBLICATION DATE

June 7, 2023

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

56 interactions (Click to see)

LIGANDS

rotigotine - Agonist pubchem gtoplig chembl_ligand drugbank drug_central

PHYSIOLOGICAL LIGANDS

L-NOREPINEPHRINE, noradrenaline, 5-hydroxytryptamine, dopamine, (-)-noradrenaline



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 A 265 5x78 G.H4 L 336 G.H4.16
Hydrophobic TM5 A 269 5x82 G.H4 D 333 G.H4.13
Van-der-waals TM5 A 269 5x82 G.H4 D 333 G.H4.13
Aromatic TM3 R 138 3x50 G.H5 Y 381 G.H5.23
Hydrophobic TM3 R 138 3x50 G.H5 Y 381 G.H5.23
Van-der-waals TM3 R 138 3x50 G.H5 Y 381 G.H5.23
Van-der-waals TM6 T 297 6x36 G.H5 Y 381 G.H5.23
Hydrophobic TM5 A 266 5x79 G.H4 L 336 G.H4.16
Van-der-waals TM5 A 266 5x79 G.H4 L 336 G.H4.16
Polar ICL2 K 149 34x54 G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 K 149 34x54 G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 R 150 34x55 G.hns1 A 39 G.hns1.03
Hydrophobic ICL2 K 149 34x54 G.S1 H 41 G.S1.02
Van-der-waals ICL2 K 149 34x54 G.S1 H 41 G.S1.02
Hydrophobic TM6 V 294 6x33 G.H5 L 383 G.H5.25
Van-der-waals TM6 V 294 6x33 G.H5 L 383 G.H5.25
Hydrophobic TM6 T 297 6x36 G.H5 L 383 G.H5.25
Van-der-waals TM6 T 297 6x36 G.H5 L 383 G.H5.25
Hydrophobic TM5 I 248 5x61 G.H5 L 383 G.H5.25
Van-der-waals TM5 I 248 5x61 G.H5 L 383 G.H5.25
Polar TM5 Q 255 5x68 G.H5 R 375 G.H5.17
Hydrophobic TM5 Q 255 5x68 G.H5 R 375 G.H5.17
Van-der-waals TM5 Q 255 5x68 G.H5 R 375 G.H5.17
Hydrophobic TM6 K 293 6x32 G.H5 E 382 G.H5.24
Van-der-waals TM6 K 293 6x32 G.H5 E 382 G.H5.24
Hydrophobic TM5 I 251 5x64 G.H5 Q 374 G.H5.16
Hydrophobic TM4 T 153 4x38 G.hns1 R 38 G.hns1.02
Van-der-waals TM4 T 153 4x38 G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 F 146 34x51 G.H5 R 370 G.H5.12
Van-der-waals ICL2 F 146 34x51 G.H5 R 370 G.H5.12
Polar TM5 Q 255 5x68 G.H5 D 371 G.H5.13
Hydrophobic TM5 Q 255 5x68 G.H5 D 371 G.H5.13
Van-der-waals TM5 Q 255 5x68 G.H5 D 371 G.H5.13
Hydrophobic ICL2 F 146 34x51 G.S3 V 217 G.S3.01
Van-der-waals ICL2 F 146 34x51 G.S3 V 217 G.S3.01
Ionic TM5 R 258 5x71 G.H5 D 371 G.H5.13
Polar TM5 R 258 5x71 G.H5 D 371 G.H5.13
Van-der-waals TM5 R 258 5x71 G.H5 D 371 G.H5.13
Ionic TM5 R 264 5x77 G.hgh4 D 313 G.hgh4.13
Polar TM5 R 264 5x77 G.hgh4 D 313 G.hgh4.13
Hydrophobic TM5 R 264 5x77 G.hgh4 D 313 G.hgh4.13
Van-der-waals TM5 R 264 5x77 G.hgh4 D 313 G.hgh4.13
Hydrophobic TM5 L 262 5x75 G.H4 L 336 G.H4.16
Van-der-waals TM5 L 262 5x75 G.H4 L 336 G.H4.16
Hydrophobic ICL2 P 145 34x50 G.H5 R 370 G.H5.12
Van-der-waals ICL2 P 145 34x50 G.H5 R 370 G.H5.12
Hydrophobic TM6 K 290 6x29 G.H5 L 384 G.H5.26
Van-der-waals TM6 K 290 6x29 G.H5 L 384 G.H5.26
Polar TM5 Q 270 5x83 G.H4 R 337 G.H4.17
Hydrophobic TM5 Q 270 5x83 G.H4 R 337 G.H4.17
Van-der-waals TM5 Q 270 5x83 G.H4 R 337 G.H4.17
Hydrophobic TM3 I 142 3x54 G.H5 H 377 G.H5.19
Polar TM5 Q 255 5x68 G.H5 Q 374 G.H5.16
Van-der-waals TM5 Q 255 5x68 G.H5 Q 374 G.H5.16
Hydrophobic TM5 A 269 5x82 G.hgh4 Y 308 G.hgh4.08
Van-der-waals TM5 A 269 5x82 G.hgh4 Y 308 G.hgh4.08
Polar TM3 I 142 3x54 G.H5 Q 374 G.H5.16
Van-der-waals TM3 I 142 3x54 G.H5 Q 374 G.H5.16
Hydrophobic ICL2 F 146 34x51 G.H5 C 369 G.H5.11
Van-der-waals ICL2 F 146 34x51 G.H5 C 369 G.H5.11
Polar TM5 H 268 5x81 G.hgh4 T 309 G.hgh4.09
Hydrophobic TM5 H 268 5x81 G.hgh4 T 309 G.hgh4.09
Van-der-waals TM5 H 268 5x81 G.hgh4 T 309 G.hgh4.09
Aromatic ICL2 F 146 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 F 146 34x51 G.S1 H 41 G.S1.02
Van-der-waals ICL2 F 146 34x51 G.S1 H 41 G.S1.02
Hydrophobic TM5 I 259 5x72 G.H5 L 384 G.H5.26
Hydrophobic ICL2 Y 148 34x53 G.H5 H 377 G.H5.19
Van-der-waals TM5 L 262 5x75 G.S6 C 349 G.S6.01
Hydrophobic TM5 A 252 5x65 G.H5 L 378 G.H5.20
Van-der-waals TM5 A 252 5x65 G.H5 L 378 G.H5.20
Hydrophobic TM5 E 263 5x76 G.h4s6 T 340 G.h4s6.03
Van-der-waals TM5 E 263 5x76 G.h4s6 T 340 G.h4s6.03
Hydrophobic ICL2 F 146 34x51 G.H5 I 373 G.H5.15
Van-der-waals ICL2 F 146 34x51 G.H5 I 373 G.H5.15
Hydrophobic ICL2 K 149 34x54 G.H5 I 373 G.H5.15
Van-der-waals ICL2 K 149 34x54 G.H5 I 373 G.H5.15
Hydrophobic ICL2 F 146 34x51 G.S3 F 219 G.S3.03
Polar TM6 T 297 6x36 G.H5 E 382 G.H5.24
Van-der-waals TM6 T 297 6x36 G.H5 E 382 G.H5.24
Hydrophobic TM5 L 262 5x75 G.S6 P 351 G.S6.03
Polar TM3 S 143 3x55 G.H5 R 370 G.H5.12
Van-der-waals TM3 S 143 3x55 G.H5 R 370 G.H5.12
Polar TM3 A 141 3x53 G.H5 H 377 G.H5.19
Hydrophobic TM3 A 141 3x53 G.H5 H 377 G.H5.19
Van-der-waals TM3 A 141 3x53 G.H5 H 377 G.H5.19
Hydrophobic TM3 I 142 3x54 G.H5 L 378 G.H5.20
Van-der-waals TM3 I 142 3x54 G.H5 L 378 G.H5.20
Hydrophobic TM3 I 142 3x54 G.H5 Y 381 G.H5.23
Van-der-waals TM3 I 142 3x54 G.H5 Y 381 G.H5.23
Polar H8 N 362 8x47 G.H5 Q 380 G.H5.22
Polar TM6 K 293 6x32 G.H5 L 384 G.H5.26
Hydrophobic TM6 K 293 6x32 G.H5 L 384 G.H5.26
Van-der-waals TM6 K 293 6x32 G.H5 L 384 G.H5.26
Hydrophobic TM5 A 266 5x79 G.h4s6 T 340 G.h4s6.03
Van-der-waals TM5 A 266 5x79 G.h4s6 T 340 G.h4s6.03
Hydrophobic ICL2 P 145 34x50 G.H5 I 373 G.H5.15
Van-der-waals ICL2 P 145 34x50 G.H5 I 373 G.H5.15
Hydrophobic TM5 I 256 5x69 G.H5 L 384 G.H5.26
Van-der-waals TM5 I 256 5x69 G.H5 L 384 G.H5.26
Hydrophobic TM3 I 142 3x54 G.H5 L 383 G.H5.25
Polar ICL2 R 150 34x55 G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 R 150 34x55 G.hns1 R 38 G.hns1.02
Van-der-waals TM2 T 76 2x39 G.H5 Y 381 G.H5.23
Hydrophobic TM5 I 259 5x72 G.h4s6 Y 348 G.h4s6.20
Van-der-waals TM5 I 259 5x72 G.h4s6 Y 348 G.h4s6.20
Hydrophobic TM5 Q 255 5x68 G.H5 L 378 G.H5.20
Van-der-waals TM5 A 265 5x78 G.H4 R 332 G.H4.12
Hydrophobic ICL2 P 145 34x50 G.H5 Q 374 G.H5.16
Van-der-waals ICL2 P 145 34x50 G.H5 Q 374 G.H5.16
Hydrophobic TM5 I 259 5x72 G.H5 R 375 G.H5.17
Van-der-waals TM5 I 259 5x72 G.H5 R 375 G.H5.17
Hydrophobic TM6 L 298 6x37 G.H5 L 383 G.H5.25
Van-der-waals TM6 L 298 6x37 G.H5 L 383 G.H5.25
Van-der-waals TM5 R 258 5x71 G.H5 R 375 G.H5.17
Aromatic ICL2 F 146 34x51 G.H5 F 366 G.H5.08
Hydrophobic ICL2 F 146 34x51 G.H5 F 366 G.H5.08
Van-der-waals ICL2 F 146 34x51 G.H5 F 366 G.H5.08