glucagon receptor - Gs

GPCR CLASS (FAMILY)

Class B1 (Secretin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8YW5

RESOLUTION

2.8 Å

REFERENCE

10.1038/S41421-024-00700-0

PUBLICATION DATE

Aug. 7, 2024

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

115 interactions (Click to see)

LIGANDS

Retatrutide - Agonist

PHYSIOLOGICAL LIGANDS

glucagon



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL3 H 339 - G.h4s6 T 350 G.h4s6.03
Hydrophobic TM6 L 354 6x45 G.H5 L 393 G.H5.25
Hydrophobic TM5 L 333 5x65 G.H5 L 394 G.H5.26
Hydrophobic ICL2 L 258 - G.H5 M 386 G.H5.18
Polar TM3 L 252 3x57 G.H5 H 387 G.H5.19
Hydrophobic TM3 L 252 3x57 G.H5 H 387 G.H5.19
Van-der-waals TM3 L 252 3x57 G.H5 H 387 G.H5.19
Polar H8 K 405 8x48 G.H5 E 392 G.H5.24
Hydrophobic H8 K 405 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 K 405 8x48 G.H5 E 392 G.H5.24
Hydrophobic TM6 L 347 6x38 G.H5 L 394 G.H5.26
Polar ICL2 T 257 - G.hns1 A 39 G.hns1.03
Hydrophobic ICL2 T 257 - G.hns1 A 39 G.hns1.03
Van-der-waals ICL2 T 257 - G.hns1 A 39 G.hns1.03
Aromatic TM2 R 173 2x46 G.H5 Y 391 G.H5.23
Hydrophobic TM2 R 173 2x46 G.H5 Y 391 G.H5.23
Van-der-waals TM2 R 173 2x46 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 E 260 - G.hns1 A 39 G.hns1.03
Hydrophobic ICL2 L 255 - G.H5 R 380 G.H5.12
Hydrophobic ICL3 M 338 - G.H5 R 385 G.H5.17
Van-der-waals ICL3 M 338 - G.H5 R 385 G.H5.17
Polar ICL2 L 258 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 L 258 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 L 258 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 A 256 - G.S3 V 217 G.S3.01
Hydrophobic ICL2 T 257 - G.S3 V 217 G.S3.01
Hydrophobic ICL2 E 260 - G.HN Q 35 G.HN.52
Van-der-waals ICL2 E 260 - G.HN Q 35 G.HN.52
Hydrophobic TM5 L 329 5x61 G.H5 L 388 G.H5.20
Hydrophobic ICL2 L 258 - G.H5 H 387 G.H5.19
Hydrophobic TM5 I 325 5x57 G.H5 L 393 G.H5.25
Van-der-waals H8 N 404 8x47 G.H5 E 392 G.H5.24
Polar ICL2 T 257 - G.hns1 R 38 G.hns1.02
Hydrophobic TM3 L 253 3x58 G.H5 L 388 G.H5.20
Polar TM2 R 173 2x46 G.H5 Q 390 G.H5.22
Hydrophobic TM2 R 173 2x46 G.H5 Q 390 G.H5.22
Polar ICL2 A 256 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 A 256 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 T 257 - G.S1 H 41 G.S1.02
Hydrophobic TM5 L 329 5x61 G.H5 L 394 G.H5.26
Polar TM5 K 332 5x64 G.H5 R 385 G.H5.17
Hydrophobic TM5 K 332 5x64 G.H5 R 385 G.H5.17
Hydrophobic TM5 L 329 5x61 G.H5 L 393 G.H5.25
Van-der-waals TM5 L 329 5x61 G.H5 L 393 G.H5.25
Polar TM3 L 253 3x58 G.H5 Q 384 G.H5.16
Hydrophobic TM3 L 253 3x58 G.H5 Q 384 G.H5.16
Van-der-waals TM3 L 253 3x58 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 A 256 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 A 256 - G.H5 F 376 G.H5.08
Hydrophobic TM5 L 328 5x60 G.H5 Q 384 G.H5.16
Hydrophobic TM6 L 357 6x48 G.H5 Y 391 G.H5.23
Hydrophobic TM5 K 332 5x64 G.H5 L 388 G.H5.20
Hydrophobic TM5 L 328 5x60 G.H5 L 388 G.H5.20
Polar TM5 K 332 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM5 K 332 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 K 332 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM3 Y 248 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 Y 248 3x53 G.H5 Y 391 G.H5.23
Polar ICL3 Q 337 - G.H5 R 385 G.H5.17
Hydrophobic ICL3 Q 337 - G.H5 R 385 G.H5.17
Hydrophobic TM2 H 177 2x50 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 L 258 - G.H5 I 383 G.H5.15
Polar ICL3 Q 337 - G.S6 C 359 G.S6.01
Hydrophobic ICL2 A 256 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 A 256 - G.H5 R 380 G.H5.12
Hydrophobic ICL2 T 257 - G.H5 I 383 G.H5.15
Polar ICL3 Q 337 - G.S6 Y 360 G.S6.02
Hydrophobic ICL3 Q 337 - G.S6 Y 360 G.S6.02
Van-der-waals ICL3 Q 337 - G.S6 Y 360 G.S6.02
Hydrophobic ICL2 P 259 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 P 259 - G.hns1 R 38 G.hns1.02
Hydrophobic TM3 L 253 3x58 G.H5 H 387 G.H5.19
Van-der-waals TM3 L 253 3x58 G.H5 H 387 G.H5.19
Ionic TM5 K 332 5x64 G.H5 D 381 G.H5.13
Polar TM5 K 332 5x64 G.H5 D 381 G.H5.13
Hydrophobic TM5 K 332 5x64 G.H5 L 394 G.H5.26
Hydrophobic TM3 L 249 3x54 G.H5 Y 391 G.H5.23
Van-der-waals TM3 L 249 3x54 G.H5 Y 391 G.H5.23
Polar ICL2 E 260 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 E 260 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 E 260 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL3 Q 337 - G.h4s6 Y 358 G.h4s6.20
Van-der-waals ICL3 Q 337 - G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM3 L 252 3x57 G.H5 Y 391 G.H5.23
Hydrophobic TM6 T 351 6x42 G.H5 L 393 G.H5.25
Van-der-waals TM6 T 351 6x42 G.H5 L 393 G.H5.25