Refined structure (8FU6) of Gs - glucagon receptor

GPCR CLASS (FAMILY)

B1 (Secretin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2024-02-01

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 212 from structure (53.8%), 182 from model (46.2%)
Residue sidechains - 209 from structure (53.0%), 185 from model (47.0%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 AF2 AF2
G.HN 4 L G.HN.10 AF2 AF2
G.HN 5 G G.HN.11 AF2 AF2
G.HN 6 N G.HN.22 AF2 AF2
G.HN 7 S G.HN.23 AF2 AF2
G.HN 8 K G.HN.24 AF2 AF2
G.HN 9 T G.HN.26 Structure Structure
G.HN 10 E G.HN.27 Structure Structure
G.HN 11 D G.HN.28 Structure Structure
G.HN 12 Q G.HN.29 Structure Structure
G.HN 13 R G.HN.30 Structure Structure
G.HN 14 N G.HN.31 Structure Structure
G.HN 15 E G.HN.32 Structure Structure
G.HN 16 E G.HN.33 Structure Structure
G.HN 17 K G.HN.34 Structure Structure
G.HN 18 A G.HN.35 Structure Structure
G.HN 19 Q G.HN.36 Structure Structure
G.HN 20 R G.HN.37 Structure Structure
G.HN 21 E G.HN.38 Structure Structure
G.HN 22 A G.HN.39 Structure Structure
G.HN 23 N G.HN.40 Structure Structure
G.HN 24 K G.HN.41 Structure AF2
G.HN 25 K G.HN.42 Structure Structure
G.HN 26 I G.HN.43 Structure Structure
G.HN 27 E G.HN.44 Structure Structure
G.HN 28 K G.HN.45 Structure Structure
G.HN 29 Q G.HN.46 Structure Structure
G.HN 30 L G.HN.47 Structure Structure
G.HN 31 Q G.HN.48 Structure Structure
G.HN 32 K G.HN.49 Structure Structure
G.HN 33 D G.HN.50 Structure Structure
G.HN 34 K G.HN.51 Structure Structure
G.HN 35 Q G.HN.52 Structure Structure
G.HN 36 V G.HN.53 Structure Structure
G.hns1 37 Y G.hns1.01 Structure Structure
G.hns1 38 R G.hns1.02 Structure Structure
G.hns1 39 A G.hns1.03 Structure Structure
G.S1 40 T G.S1.01 Structure Structure
G.S1 41 H G.S1.02 Structure Structure
G.S1 42 R G.S1.03 Structure Structure
G.S1 43 L G.S1.04 Structure Structure
G.S1 44 L G.S1.05 Structure Structure
G.S1 45 L G.S1.06 Structure Structure
G.S1 46 L G.S1.07 Structure Structure
G.s1h1 47 G G.s1h1.01 Structure Structure
G.s1h1 48 A G.s1h1.02 Structure Structure
G.s1h1 49 G G.s1h1.03 AF2 AF2
G.s1h1 50 E G.s1h1.04 AF2 AF2
G.s1h1 51 S G.s1h1.05 AF2 AF2
G.s1h1 52 G G.s1h1.06 AF2 AF2
G.H1 53 K G.H1.01 AF2 AF2
G.H1 54 S G.H1.02 AF2 AF2
G.H1 55 T G.H1.03 AF2 AF2
G.H1 56 I G.H1.04 AF2 AF2
G.H1 57 V G.H1.05 AF2 AF2
G.H1 58 K G.H1.06 AF2 AF2
G.H1 59 Q G.H1.07 AF2 AF2
G.H1 60 M G.H1.08 AF2 AF2
G.H1 61 R G.H1.09 AF2 AF2
G.H1 62 I G.H1.10 AF2 AF2
G.H1 63 L G.H1.11 AF2 AF2
G.H1 64 H G.H1.12 AF2 AF2
G.h1ha 65 V G.h1ha.01 AF2 AF2
G.h1ha 66 N G.h1ha.02 AF2 AF2
G.h1ha 67 G G.h1ha.03 AF2 AF2
G.h1ha 68 F G.h1ha.04 AF2 AF2
G.h1ha 69 N G.h1ha.05 AF2 AF2
G.h1ha 70 G G.h1ha.06 AF2 AF2
G.h1ha 71 E G.h1ha.07 AF2 AF2
G.h1ha 72 G G.h1ha.08 AF2 AF2
G.h1ha 73 G G.h1ha.09 AF2 AF2
G.h1ha 74 E G.h1ha.10 AF2 AF2
G.h1ha 75 E G.h1ha.11 AF2 AF2
G.h1ha 76 D G.h1ha.12 AF2 AF2
G.h1ha 77 P G.h1ha.13 AF2 AF2
G.h1ha 78 Q G.h1ha.14 AF2 AF2
G.h1ha 79 A G.h1ha.15 AF2 AF2
G.h1ha 80 A G.h1ha.16 AF2 AF2
G.h1ha 81 R G.h1ha.17 AF2 AF2
G.h1ha 82 S G.h1ha.18 AF2 AF2
G.h1ha 83 N G.h1ha.19 AF2 AF2
G.h1ha 84 S G.h1ha.20 AF2 AF2
H.HA 85 D H.HA.01 AF2 AF2
H.HA 86 G H.HA.02 AF2 AF2
H.HA 87 E H.HA.03 AF2 AF2
H.HA 88 K H.HA.04 AF2 AF2
H.HA 89 A H.HA.05 AF2 AF2
H.HA 90 T H.HA.06 AF2 AF2
H.HA 91 K H.HA.07 AF2 AF2
H.HA 92 V H.HA.08 AF2 AF2
H.HA 93 Q H.HA.09 AF2 AF2
H.HA 94 D H.HA.10 AF2 AF2
H.HA 95 I H.HA.11 AF2 AF2
H.HA 96 K H.HA.12 AF2 AF2
H.HA 97 N H.HA.13 AF2 AF2
H.HA 98 N H.HA.14 AF2 AF2
H.HA 99 L H.HA.15 AF2 AF2
H.HA 100 K H.HA.16 AF2 AF2
H.HA 101 E H.HA.17 AF2 AF2
H.HA 102 A H.HA.18 AF2 AF2
H.HA 103 I H.HA.19 AF2 AF2
H.HA 104 E H.HA.20 AF2 AF2
H.HA 105 T H.HA.21 AF2 AF2
H.HA 106 I H.HA.22 AF2 AF2
H.HA 107 V H.HA.23 AF2 AF2
H.HA 108 A H.HA.24 AF2 AF2
H.HA 109 A H.HA.25 AF2 AF2
H.HA 110 M H.HA.26 AF2 AF2
H.HA 111 S H.HA.27 AF2 AF2
H.HA 112 N H.HA.28 AF2 AF2
H.HA 113 L H.HA.29 AF2 AF2
H.hahb 114 V H.hahb.01 AF2 AF2
H.hahb 115 P H.hahb.02 AF2 AF2
H.hahb 116 P H.hahb.03 AF2 AF2
H.hahb 117 V H.hahb.04 AF2 AF2
H.hahb 118 E H.hahb.05 AF2 AF2
H.hahb 119 L H.hahb.06 AF2 AF2
H.hahb 120 A H.hahb.07 AF2 AF2
H.hahb 121 N H.hahb.08 AF2 AF2
H.hahb 122 P H.hahb.09 AF2 AF2
H.HB 123 E H.HB.01 AF2 AF2
H.HB 124 N H.HB.02 AF2 AF2
H.HB 125 Q H.HB.03 AF2 AF2
H.HB 126 F H.HB.04 AF2 AF2
H.HB 127 R H.HB.05 AF2 AF2
H.HB 128 V H.HB.06 AF2 AF2
H.HB 129 D H.HB.07 AF2 AF2
H.HB 130 Y H.HB.08 AF2 AF2
H.HB 131 I H.HB.09 AF2 AF2
H.HB 132 L H.HB.10 AF2 AF2
H.HB 133 S H.HB.11 AF2 AF2
H.HB 134 V H.HB.12 AF2 AF2
H.HB 135 M H.HB.13 AF2 AF2
H.HB 136 N H.HB.14 AF2 AF2
H.hbhc 137 V H.hbhc.01 AF2 AF2
H.hbhc 138 P H.hbhc.02 AF2 AF2
H.hbhc 139 D H.hbhc.03 AF2 AF2
H.hbhc 140 F H.hbhc.04 AF2 AF2
H.hbhc 141 D H.hbhc.13 AF2 AF2
H.hbhc 142 F H.hbhc.14 AF2 AF2
H.hbhc 143 P H.hbhc.15 AF2 AF2
H.HC 144 P H.HC.01 AF2 AF2
H.HC 145 E H.HC.02 AF2 AF2
H.HC 146 F H.HC.03 AF2 AF2
H.HC 147 Y H.HC.04 AF2 AF2
H.HC 148 E H.HC.05 AF2 AF2
H.HC 149 H H.HC.06 AF2 AF2
H.HC 150 A H.HC.07 AF2 AF2
H.HC 151 K H.HC.08 AF2 AF2
H.HC 152 A H.HC.09 AF2 AF2
H.HC 153 L H.HC.10 AF2 AF2
H.HC 154 W H.HC.11 AF2 AF2
H.HC 155 E H.HC.12 AF2 AF2
H.hchd 156 D H.hchd.01 AF2 AF2
H.HD 157 E H.HD.01 AF2 AF2
H.HD 158 G H.HD.02 AF2 AF2
H.HD 159 V H.HD.03 AF2 AF2
H.HD 160 R H.HD.04 AF2 AF2
H.HD 161 A H.HD.05 AF2 AF2
H.HD 162 C H.HD.06 AF2 AF2
H.HD 163 Y H.HD.07 AF2 AF2
H.HD 164 E H.HD.08 AF2 AF2
H.HD 165 R H.HD.09 AF2 AF2
H.HD 166 S H.HD.10 AF2 AF2
H.HD 167 N H.HD.11 AF2 AF2
H.HD 168 E H.HD.12 AF2 AF2
H.hdhe 169 Y H.hdhe.01 AF2 AF2
H.hdhe 170 Q H.hdhe.02 AF2 AF2
H.hdhe 171 L H.hdhe.03 AF2 AF2
H.hdhe 172 I H.hdhe.04 AF2 AF2
H.hdhe 173 D H.hdhe.05 AF2 AF2
H.HE 174 C H.HE.01 AF2 AF2
H.HE 175 A H.HE.02 AF2 AF2
H.HE 176 Q H.HE.03 AF2 AF2
H.HE 177 Y H.HE.04 AF2 AF2
H.HE 178 F H.HE.05 AF2 AF2
H.HE 179 L H.HE.06 AF2 AF2
H.HE 180 D H.HE.07 AF2 AF2
H.HE 181 K H.HE.08 AF2 AF2
H.HE 182 I H.HE.09 AF2 AF2
H.HE 183 D H.HE.10 AF2 AF2
H.HE 184 V H.HE.11 AF2 AF2
H.HE 185 I H.HE.12 AF2 AF2
H.HE 186 K H.HE.13 AF2 AF2
H.hehf 187 Q H.hehf.01 AF2 AF2
H.hehf 188 A H.hehf.02 AF2 AF2
H.hehf 189 D H.hehf.03 AF2 AF2
H.hehf 190 Y H.hehf.04 AF2 AF2
H.hehf 191 V H.hehf.05 AF2 AF2
H.hehf 192 P H.hehf.06 AF2 AF2
H.hehf 193 S H.hehf.07 AF2 AF2
H.HF 194 D H.HF.01 AF2 AF2
H.HF 195 Q H.HF.02 AF2 AF2
H.HF 196 D H.HF.03 AF2 AF2
H.HF 197 L H.HF.04 AF2 AF2
H.HF 198 L H.HF.05 AF2 AF2
H.HF 199 R H.HF.06 AF2 AF2
G.hfs2 200 C G.hfs2.01 AF2 AF2
G.hfs2 201 R G.hfs2.02 AF2 AF2
G.hfs2 202 V G.hfs2.03 AF2 AF2
G.hfs2 203 L G.hfs2.04 AF2 AF2
G.hfs2 204 T G.hfs2.05 Structure Structure
G.hfs2 205 S G.hfs2.06 Structure Structure
G.hfs2 206 G G.hfs2.07 Structure Structure
G.S2 207 I G.S2.01 Structure Structure
G.S2 208 F G.S2.02 Structure Structure
G.S2 209 E G.S2.03 Structure Structure
G.S2 210 T G.S2.04 Structure Structure
G.S2 211 K G.S2.05 Structure Structure
G.S2 212 F G.S2.06 Structure Structure
G.S2 213 Q G.S2.07 Structure Structure
G.S2 214 V G.S2.08 Structure Structure
G.s2s3 215 D G.s2s3.01 Structure Structure
G.s2s3 216 K G.s2s3.02 Structure Structure
G.S3 217 V G.S3.01 Structure Structure
G.S3 218 N G.S3.02 Structure Structure
G.S3 219 F G.S3.03 Structure Structure
G.S3 220 H G.S3.04 Structure Structure
G.S3 221 M G.S3.05 Structure Structure
G.S3 222 F G.S3.06 Structure Structure
G.S3 223 D G.S3.07 Structure Structure
G.S3 224 V G.S3.08 Structure Structure
G.s3h2 225 G G.s3h2.01 Structure Structure
G.s3h2 226 G G.s3h2.02 Structure Structure
G.s3h2 227 Q G.s3h2.03 Structure Structure
G.H2 228 R G.H2.01 Structure Structure
G.H2 229 D G.H2.02 Structure Structure
G.H2 230 E G.H2.03 Structure Structure
G.H2 231 R G.H2.04 Structure Structure
G.H2 232 R G.H2.05 Structure Structure
G.H2 233 K G.H2.06 Structure Structure
G.H2 234 W G.H2.07 Structure Structure
G.H2 235 I G.H2.08 Structure Structure
G.H2 236 Q G.H2.09 Structure Structure
G.H2 237 C G.H2.10 Structure Structure
G.h2s4 238 F G.h2s4.01 Structure Structure
G.h2s4 239 N G.h2s4.02 Structure Structure
G.h2s4 240 D G.h2s4.03 Structure AF2
G.h2s4 241 V G.h2s4.04 Structure Structure
G.h2s4 242 T G.h2s4.05 Structure Structure
G.S4 243 A G.S4.01 Structure Structure
G.S4 244 I G.S4.02 Structure Structure
G.S4 245 I G.S4.03 Structure Structure
G.S4 246 F G.S4.04 Structure Structure
G.S4 247 V G.S4.05 Structure Structure
G.S4 248 V G.S4.06 Structure Structure
G.S4 249 A G.S4.07 Structure Structure
G.s4h3 250 S G.s4h3.01 Structure Structure
G.s4h3 251 S G.s4h3.02 Structure Structure
G.s4h3 252 S G.s4h3.03 AF2 AF2
G.s4h3 253 Y G.s4h3.04 AF2 AF2
G.s4h3 254 N G.s4h3.05 AF2 AF2
G.s4h3 255 M G.s4h3.06 AF2 AF2
G.s4h3 256 V G.s4h3.07 AF2 AF2
G.s4h3 257 I G.s4h3.08 AF2 AF2
G.s4h3 258 R G.s4h3.09 AF2 AF2
G.s4h3 259 E G.s4h3.10 AF2 AF2
G.s4h3 260 D G.s4h3.11 AF2 AF2
G.s4h3 261 N G.s4h3.12 Structure Structure
G.s4h3 262 Q G.s4h3.13 Structure Structure
G.s4h3 263 T G.s4h3.14 Structure Structure
G.s4h3 264 N G.s4h3.15 Structure Structure
G.H3 265 R G.H3.01 Structure Structure
G.H3 266 L G.H3.02 Structure Structure
G.H3 267 Q G.H3.03 Structure Structure
G.H3 268 E G.H3.04 Structure Structure
G.H3 269 A G.H3.05 Structure Structure
G.H3 270 L G.H3.06 Structure Structure
G.H3 271 N G.H3.07 Structure Structure
G.H3 272 L G.H3.08 Structure Structure
G.H3 273 F G.H3.09 Structure Structure
G.H3 274 K G.H3.10 Structure Structure
G.H3 275 S G.H3.11 Structure Structure
G.H3 276 I G.H3.12 Structure Structure
G.H3 277 W G.H3.13 Structure Structure
G.H3 278 N G.H3.14 Structure Structure
G.H3 279 N G.H3.15 Structure Structure
G.H3 280 R G.H3.16 Structure Structure
G.H3 281 W G.H3.17 Structure Structure
G.H3 282 L G.H3.18 Structure Structure
G.h3s5 283 R G.h3s5.01 Structure Structure
G.h3s5 284 T G.h3s5.02 Structure Structure
G.h3s5 285 I G.h3s5.03 Structure Structure
G.S5 286 S G.S5.01 Structure Structure
G.S5 287 V G.S5.02 Structure Structure
G.S5 288 I G.S5.03 Structure Structure
G.S5 289 L G.S5.04 Structure Structure
G.S5 290 F G.S5.05 Structure Structure
G.S5 291 L G.S5.06 Structure Structure
G.S5 292 N G.S5.07 Structure Structure
G.s5hg 293 K G.s5hg.01 Structure Structure
G.HG 294 Q G.HG.01 Structure Structure
G.HG 295 D G.HG.02 Structure Structure
G.HG 296 L G.HG.03 Structure Structure
G.HG 297 L G.HG.04 Structure Structure
G.HG 298 A G.HG.05 AF2 AF2
G.HG 299 E G.HG.06 AF2 AF2
G.HG 300 K G.HG.07 AF2 AF2
G.HG 301 V G.HG.08 AF2 AF2
G.HG 302 L G.HG.09 AF2 AF2
G.HG 303 A G.HG.10 AF2 AF2
G.HG 304 G G.HG.11 AF2 AF2
G.HG 305 K G.HG.12 AF2 AF2
G.HG 306 S G.HG.13 AF2 AF2
G.HG 307 K G.HG.14 AF2 AF2
G.HG 308 I G.HG.15 Structure Structure
G.HG 309 E G.HG.16 Structure Structure
G.HG 310 D G.HG.17 Structure Structure
G.hgh4 311 Y G.hgh4.01 Structure Structure
G.hgh4 312 F G.hgh4.02 Structure Structure
G.hgh4 313 P G.hgh4.03 Structure Structure
G.hgh4 314 E G.hgh4.04 Structure Structure
G.hgh4 315 F G.hgh4.05 Structure Structure
G.hgh4 316 A G.hgh4.06 Structure Structure
G.hgh4 317 R G.hgh4.07 Structure Structure
G.hgh4 318 Y G.hgh4.08 Structure Structure
G.hgh4 319 T G.hgh4.09 Structure Structure
G.hgh4 320 T G.hgh4.10 Structure Structure
G.hgh4 321 P G.hgh4.11 Structure Structure
G.hgh4 322 E G.hgh4.12 Structure Structure
G.hgh4 323 D G.hgh4.13 Structure Structure
G.hgh4 324 A G.hgh4.14 Structure Structure
G.hgh4 325 T G.hgh4.15 Structure Structure
G.hgh4 326 P G.hgh4.16 Structure Structure
G.hgh4 327 E G.hgh4.17 Structure Structure
G.hgh4 328 P G.hgh4.18 Structure Structure
G.hgh4 329 G G.hgh4.19 Structure Structure
G.hgh4 330 E G.hgh4.20 Structure Structure
G.hgh4 331 D G.hgh4.21 Structure Structure
G.H4 332 P G.H4.01 Structure Structure
G.H4 333 R G.H4.02 Structure Structure
G.H4 334 V G.H4.03 Structure Structure
G.H4 335 T G.H4.04 Structure Structure
G.H4 336 R G.H4.05 Structure Structure
G.H4 337 A G.H4.06 Structure Structure
G.H4 338 K G.H4.07 Structure Structure
G.H4 339 Y G.H4.08 Structure Structure
G.H4 340 F G.H4.10 Structure Structure
G.H4 341 I G.H4.11 Structure Structure
G.H4 342 R G.H4.12 Structure Structure
G.H4 343 D G.H4.13 Structure Structure
G.H4 344 E G.H4.14 Structure Structure
G.H4 345 F G.H4.15 Structure Structure
G.H4 346 L G.H4.16 Structure Structure
G.H4 347 R G.H4.17 Structure Structure
G.h4s6 348 I G.h4s6.01 Structure Structure
G.h4s6 349 S G.h4s6.02 Structure Structure
G.h4s6 350 T G.h4s6.03 Structure Structure
G.h4s6 351 A G.h4s6.04 Structure Structure
G.h4s6 352 S G.h4s6.08 Structure Structure
G.h4s6 353 G G.h4s6.09 Structure Structure
G.h4s6 354 D G.h4s6.10 Structure Structure
G.h4s6 355 G G.h4s6.11 Structure Structure
G.h4s6 356 R G.h4s6.12 Structure Structure
G.h4s6 357 H G.h4s6.13 Structure Structure
G.h4s6 358 Y G.h4s6.20 Structure Structure
G.S6 359 C G.S6.01 Structure Structure
G.S6 360 Y G.S6.02 Structure Structure
G.S6 361 P G.S6.03 Structure Structure
G.S6 362 H G.S6.04 Structure Structure
G.S6 363 F G.S6.05 Structure Structure
G.s6h5 364 T G.s6h5.01 Structure Structure
G.s6h5 365 C G.s6h5.02 Structure Structure
G.s6h5 366 A G.s6h5.03 Structure Structure
G.s6h5 367 V G.s6h5.04 Structure Structure
G.s6h5 368 D G.s6h5.05 Structure Structure
G.H5 369 T G.H5.01 Structure AF2
G.H5 370 E G.H5.02 Structure Structure
G.H5 371 N G.H5.03 Structure Structure
G.H5 372 I G.H5.04 Structure Structure
G.H5 373 R G.H5.05 Structure Structure
G.H5 374 R G.H5.06 Structure Structure
G.H5 375 V G.H5.07 Structure Structure
G.H5 376 F G.H5.08 Structure Structure
G.H5 377 N G.H5.09 Structure Structure
G.H5 378 D G.H5.10 Structure Structure
G.H5 379 C G.H5.11 Structure Structure
G.H5 380 R G.H5.12 Structure Structure
G.H5 381 D G.H5.13 Structure Structure
G.H5 382 I G.H5.14 Structure Structure
G.H5 383 I G.H5.15 Structure Structure
G.H5 384 Q G.H5.16 Structure Structure
G.H5 385 R G.H5.17 Structure Structure
G.H5 386 M G.H5.18 Structure Structure
G.H5 387 H G.H5.19 Structure Structure
G.H5 388 L G.H5.20 Structure Structure
G.H5 389 R G.H5.21 Structure Structure
G.H5 390 Q G.H5.22 Structure Structure
G.H5 391 Y G.H5.23 Structure Structure
G.H5 392 E G.H5.24 Structure Structure
G.H5 393 L G.H5.25 Structure Structure
G.H5 394 L G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 343 from structure (78.1%), 96 from model (21.9%)
Residue sidechains - 340 from structure (77.4%), 99 from model (22.6%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 P - AF2 AF2
N-term 3 P - AF2 AF2
N-term 4 C - AF2 AF2
N-term 5 Q - AF2 AF2
N-term 6 P - AF2 AF2
N-term 7 Q - AF2 AF2
N-term 8 R - AF2 AF2
N-term 9 P - AF2 AF2
N-term 10 L - AF2 AF2
N-term 11 L - AF2 AF2
N-term 12 L - AF2 AF2
N-term 13 L - AF2 AF2
N-term 14 L - AF2 AF2
N-term 15 L - AF2 AF2
N-term 16 L - AF2 AF2
N-term 17 L - AF2 AF2
N-term 18 A - AF2 AF2
N-term 19 C - AF2 AF2
N-term 20 Q - AF2 AF2
N-term 21 P - AF2 AF2
N-term 22 Q - AF2 AF2
N-term 23 V - AF2 AF2
N-term 24 P - AF2 AF2
N-term 25 S - AF2 AF2
N-term 26 A - AF2 AF2
N-term 27 Q - Structure Structure
N-term 28 V - Structure Structure
N-term 29 M - Structure Structure
N-term 30 D - Structure Structure
N-term 31 F - Structure Structure
N-term 32 L - Structure Structure
N-term 33 F - Structure Structure
N-term 34 E - Structure Structure
N-term 35 K - Structure Structure
N-term 36 W - Structure Structure
N-term 37 K - Structure Structure
N-term 38 L - Structure Structure
N-term 39 Y - Structure Structure
N-term 40 G - Structure Structure
N-term 41 D - Structure Structure
N-term 42 Q - Structure Structure
N-term 43 C - Structure Structure
N-term 44 H - Structure Structure
N-term 45 H - Structure Structure
N-term 46 N - AF2 AF2
N-term 47 L - AF2 AF2
N-term 48 S - AF2 AF2
N-term 49 L - AF2 AF2
N-term 50 L - AF2 AF2
N-term 51 P - AF2 AF2
N-term 52 P - AF2 AF2
N-term 53 P - AF2 AF2
N-term 54 T - AF2 AF2
N-term 55 E - AF2 AF2
N-term 56 L - AF2 AF2
N-term 57 V - AF2 AF2
N-term 58 C - AF2 AF2
N-term 59 N - AF2 AF2
N-term 60 R - AF2 AF2
N-term 61 T - AF2 AF2
N-term 62 F - AF2 AF2
N-term 63 D - AF2 AF2
N-term 64 K - AF2 AF2
N-term 65 Y - AF2 AF2
N-term 66 S - AF2 AF2
N-term 67 C - AF2 AF2
N-term 68 W - AF2 AF2
N-term 69 P - AF2 AF2
N-term 70 D - AF2 AF2
N-term 71 T - AF2 AF2
N-term 72 P - AF2 AF2
N-term 73 A - AF2 AF2
N-term 74 N - AF2 AF2
N-term 75 T - AF2 AF2
N-term 76 T - AF2 AF2
N-term 77 A - AF2 AF2
N-term 78 N - AF2 AF2
N-term 79 I - AF2 AF2
N-term 80 S - AF2 AF2
N-term 81 C - Structure Structure
N-term 82 P - Structure Structure
N-term 83 W - Structure Structure
N-term 84 Y - Structure Structure
N-term 85 L - Structure Structure
N-term 86 P - Structure Structure
N-term 87 W - Structure Structure
N-term 88 H - Structure Structure
N-term 89 H - Structure Structure
N-term 90 K - Structure Structure
N-term 91 V - Structure Structure
N-term 92 Q - Structure Structure
N-term 93 H - Structure Structure
N-term 94 R - Structure Structure
N-term 95 F - Structure Structure
N-term 96 V - Structure Structure
N-term 97 F - Structure Structure
N-term 98 K - Structure Structure
N-term 99 R - Structure AF2
N-term 100 C - Structure Structure
N-term 101 G - AF2 AF2
N-term 102 P - AF2 AF2
N-term 103 D - AF2 AF2
N-term 104 G - AF2 AF2
N-term 105 Q - AF2 AF2
N-term 106 W - AF2 AF2
N-term 107 V - AF2 AF2
N-term 108 R - AF2 AF2
N-term 109 G - AF2 AF2
N-term 110 P - AF2 AF2
N-term 111 R - AF2 AF2
N-term 112 G - AF2 AF2
N-term 113 Q - AF2 AF2
N-term 114 P - Structure Structure
N-term 115 W - Structure Structure
N-term 116 R - Structure Structure
N-term 117 D - Structure Structure
N-term 118 A - Structure Structure
N-term 119 S - Structure Structure
N-term 120 Q - Structure Structure
N-term 121 C - Structure Structure
N-term 122 Q - Structure Structure
N-term 123 M - Structure Structure
N-term 124 D - Structure Structure
N-term 125 G - Structure Structure
N-term 126 E - Structure Structure
N-term 127 E - Structure Structure
N-term 128 I - Structure Structure
N-term 129 E - Structure Structure
N-term 130 V - Structure Structure
TM1 131 Q 1.29x29 Structure Structure
TM1 132 K 1.30x30 Structure Structure
TM1 133 E 1.31x31 Structure Structure
TM1 134 V 1.32x32 Structure Structure
TM1 135 A 1.33x33 Structure Structure
TM1 136 K 1.34x34 Structure Structure
TM1 137 M 1.35x35 Structure Structure
TM1 138 Y 1.36x36 Structure Structure
TM1 139 S 1.37x37 Structure Structure
TM1 140 S 1.38x38 Structure Structure
TM1 141 F 1.39x39 Structure Structure
TM1 142 Q 1.40x40 Structure Structure
TM1 143 V 1.41x41 Structure Structure
TM1 144 M 1.42x42 Structure Structure
TM1 145 Y 1.43x43 Structure Structure
TM1 146 T 1.44x44 Structure Structure
TM1 147 V 1.45x45 Structure Structure
TM1 148 G 1.46x46 Structure Structure
TM1 149 Y 1.47x47 Structure Structure
TM1 150 S 1.48x48 Structure Structure
TM1 151 L 1.49x49 Structure Structure
TM1 152 S 1.50x50 Structure Structure
TM1 153 L 1.51x51 Structure Structure
TM1 154 G 1.52x52 Structure Structure
TM1 155 A 1.53x53 Structure Structure
TM1 156 L 1.54x54 Structure Structure
TM1 157 L 1.55x55 Structure Structure
TM1 158 L 1.56x56 Structure Structure
TM1 159 A 1.57x57 Structure Structure
TM1 160 L 1.58x58 Structure Structure
TM1 161 A 1.59x59 Structure Structure
TM1 162 I 1.60x60 Structure Structure
TM1 163 L 1.61x61 Structure Structure
TM1 164 G 1.62x62 Structure Structure
TM1 165 G 1.63x63 Structure Structure
TM1 166 L 1.64x64 Structure Structure
ICL1 167 S 12.48x48 Structure Structure
ICL1 168 K 12.49x49 Structure Structure
ICL1 169 L 12.50x50 Structure Structure
ICL1 170 H 12.51x51 Structure Structure
TM2 171 C 2.44x44 Structure Structure
TM2 172 T 2.45x45 Structure Structure
TM2 173 R 2.46x46 Structure Structure
TM2 174 N 2.47x47 Structure Structure
TM2 175 A 2.48x48 Structure Structure
TM2 176 I 2.49x49 Structure Structure
TM2 177 H 2.50x50 Structure Structure
TM2 178 A 2.51x51 Structure Structure
TM2 179 N 2.52x52 Structure Structure
TM2 180 L 2.53x53 Structure Structure
TM2 181 F 2.54x54 Structure Structure
TM2 182 A 2.55x55 Structure Structure
TM2 183 S 2.56x56 Structure Structure
TM2 184 F 2.57x57 Structure Structure
TM2 185 V 2.58x58 Structure Structure
TM2 186 L 2.59x59 Structure Structure
TM2 187 K 2.60x60 Structure Structure
TM2 188 A 2.61x61 Structure Structure
TM2 189 S 2.62x62 Structure Structure
TM2 190 S 2.63x63 Structure Structure
TM2 191 V 2.64x64 Structure Structure
TM2 192 L 2.65x65 Structure Structure
TM2 193 V 2.66x66 Structure Structure
TM2 194 I 2.67x67 Structure Structure
TM2 195 D 2.68x68 Structure Structure
TM2 196 G 2.69x69 Structure Structure
TM2 197 L 2.70x70 Structure Structure
TM2 198 L 2.71x71 Structure Structure
TM2 199 R 2.72x72 Structure Structure
TM2 200 T 2.73x73 Structure Structure
TM2 201 R 2.74x74 Structure Structure
TM2 202 Y 2.75x75 Structure Structure
TM2 203 S 2.76x76 Structure Structure
ECL1 204 Q - Structure Structure
ECL1 205 K - Structure AF2
ECL1 206 I - Structure Structure
ECL1 207 G - Structure Structure
ECL1 208 D - Structure Structure
ECL1 209 D - Structure Structure
ECL1 210 L - Structure Structure
ECL1 211 S - Structure Structure
ECL1 212 V - Structure Structure
ECL1 213 S - Structure Structure
ECL1 214 T - Structure Structure
ECL1 215 W - Structure Structure
ECL1 216 L - Structure Structure
ECL1 217 S - Structure Structure
ECL1 218 D - Structure Structure
ECL1 219 G - Structure Structure
TM3 220 A 3.25x25 Structure Structure
TM3 221 V 3.26x26 Structure Structure
TM3 222 A 3.27x27 Structure Structure
TM3 223 G 3.28x28 Structure Structure
TM3 224 C 3.29x29 Structure Structure
TM3 225 R 3.30x30 Structure Structure
TM3 226 V 3.31x31 Structure Structure
TM3 227 A 3.32x32 Structure Structure
TM3 228 A 3.33x33 Structure Structure
TM3 229 V 3.34x34 Structure Structure
TM3 230 F 3.35x35 Structure Structure
TM3 231 M 3.36x36 Structure Structure
TM3 232 Q 3.37x37 Structure Structure
TM3 233 Y 3.38x38 Structure Structure
TM3 234 G 3.39x39 Structure Structure
TM3 235 I 3.40x40 Structure Structure
TM3 236 V 3.41x41 Structure Structure
TM3 237 A 3.42x42 Structure Structure
TM3 238 N 3.43x43 Structure Structure
TM3 239 Y 3.44x44 Structure Structure
TM3 240 C 3.45x45 Structure Structure
TM3 241 W 3.46x46 Structure Structure
TM3 242 L 3.47x47 Structure Structure
TM3 243 L 3.48x48 Structure Structure
TM3 244 V 3.49x49 Structure Structure
TM3 245 E 3.50x50 Structure Structure
TM3 246 G 3.51x51 Structure Structure
TM3 247 L 3.52x52 Structure Structure
TM3 248 Y 3.53x53 Structure Structure
TM3 249 L 3.54x54 Structure Structure
TM3 250 H 3.55x55 Structure Structure
TM3 251 N 3.56x56 Structure Structure
TM3 252 L 3.57x57 Structure Structure
TM3 253 L 3.58x58 Structure Structure
TM3 254 G 3.59x59 Structure Structure
TM3 255 L 3.60x60 Structure Structure
ICL2 256 A - Structure Structure
ICL2 257 T - Structure Structure
ICL2 258 L - Structure Structure
ICL2 259 P - Structure Structure
ICL2 260 E - Structure Structure
ICL2 261 R - Structure Structure
TM4 262 S 4.40x41 Structure Structure
TM4 263 F 4.41x42 Structure Structure
TM4 264 F 4.42x43 Structure Structure
TM4 265 S 4.43x44 Structure Structure
TM4 266 L 4.44x45 Structure Structure
TM4 267 Y 4.45x46 Structure Structure
TM4 268 L 4.46x47 Structure Structure
TM4 269 G 4.47x48 Structure Structure
TM4 270 I 4.48x49 Structure Structure
TM4 271 G 4.49x491 Structure Structure
TM4 272 W 4.50x50 Structure Structure
TM4 273 G 4.51x51 Structure Structure
TM4 274 A 4.52x52 Structure Structure
TM4 275 P 4.53x53 Structure Structure
TM4 276 M 4.54x54 Structure Structure
TM4 277 L 4.55x55 Structure Structure
TM4 278 F 4.56x56 Structure Structure
TM4 279 V 4.57x57 Structure Structure
TM4 280 V 4.58x58 Structure Structure
TM4 281 P 4.59x59 Structure Structure
TM4 282 W 4.60x60 Structure Structure
TM4 283 A 4.61x61 Structure Structure
TM4 284 V 4.62x62 Structure Structure
TM4 285 V 4.63x63 Structure Structure
TM4 286 K 4.64x64 Structure Structure
TM4 287 C 4.65x65 Structure Structure
TM4 288 L 4.66x66 Structure Structure
TM4 289 F 4.67x67 Structure Structure
TM4 290 E 4.68x68 Structure Structure
ECL2 291 N - Structure Structure
ECL2 292 V - Structure Structure
ECL2 293 Q - Structure Structure
ECL2 294 C 45.50x50 Structure Structure
ECL2 295 W 45.51x51 Structure Structure
ECL2 296 T 45.52x52 Structure Structure
ECL2 297 S - Structure Structure
ECL2 298 N - Structure Structure
ECL2 299 D - Structure Structure
ECL2 300 N - Structure Structure
ECL2 301 M - Structure Structure
ECL2 302 G - Structure Structure
ECL2 303 F - Structure Structure
TM5 304 W 5.36x37 Structure Structure
TM5 305 W 5.37x38 Structure Structure
TM5 306 I 5.38x381 Structure Structure
TM5 307 L 5.39x39 Structure Structure
TM5 308 R 5.40x40 Structure Structure
TM5 309 F 5.41x41 Structure Structure
TM5 310 P 5.42x42 Structure Structure
TM5 311 V 5.43x43 Structure Structure
TM5 312 F 5.44x44 Structure Structure
TM5 313 L 5.45x45 Structure Structure
TM5 314 A 5.46x46 Structure Structure
TM5 315 I 5.47x47 Structure Structure
TM5 316 L 5.48x48 Structure Structure
TM5 317 I 5.49x49 Structure Structure
TM5 318 N 5.50x50 Structure Structure
TM5 319 F 5.51x51 Structure Structure
TM5 320 F 5.52x52 Structure Structure
TM5 321 I 5.53x53 Structure Structure
TM5 322 F 5.54x54 Structure Structure
TM5 323 V 5.55x55 Structure Structure
TM5 324 R 5.56x56 Structure Structure
TM5 325 I 5.57x57 Structure Structure
TM5 326 V 5.58x58 Structure Structure
TM5 327 Q 5.59x59 Structure Structure
TM5 328 L 5.60x60 Structure Structure
TM5 329 L 5.61x61 Structure Structure
TM5 330 V 5.62x62 Structure Structure
TM5 331 A 5.63x63 Structure Structure
TM5 332 K 5.64x64 Structure Structure
TM5 333 L 5.65x65 Structure Structure
TM5 334 R 5.66x66 Structure Structure
TM5 335 A 5.67x67 Structure Structure
ICL3 336 R - Structure Structure
ICL3 337 Q - AF2 AF2
ICL3 338 M - AF2 AF2
ICL3 339 H - AF2 AF2
ICL3 340 H - AF2 AF2
ICL3 341 T - AF2 AF2
TM6 342 D 6.33x33 AF2 AF2
TM6 343 Y 6.34x34 Structure Structure
TM6 344 K 6.35x35 Structure Structure
TM6 345 F 6.36x36 Structure Structure
TM6 346 R 6.37x37 Structure Structure
TM6 347 L 6.38x38 Structure Structure
TM6 348 A 6.39x39 Structure Structure
TM6 349 K 6.40x40 Structure Structure
TM6 350 S 6.41x41 Structure Structure
TM6 351 T 6.42x42 Structure Structure
TM6 352 L 6.43x43 Structure Structure
TM6 353 T 6.44x44 Structure Structure
TM6 354 L 6.45x45 Structure Structure
TM6 355 I 6.46x46 Structure Structure
TM6 356 P 6.47x47 Structure Structure
TM6 357 L 6.48x48 Structure Structure
TM6 358 L 6.49x49 Structure Structure
TM6 359 G 6.50x50 Structure Structure
TM6 360 V 6.51x51 Structure Structure
TM6 361 H 6.52x52 Structure Structure
TM6 362 E 6.53x53 Structure Structure
TM6 363 V 6.54x54 Structure Structure
TM6 364 V 6.55x55 Structure Structure
TM6 365 F 6.56x56 Structure Structure
TM6 366 A 6.57x57 Structure Structure
TM6 367 F 6.58x58 Structure Structure
TM6 368 V 6.59x59 Structure Structure
TM6 369 T 6.60x60 Structure Structure
TM6 370 D 6.61x61 Structure Structure
ECL3 371 E - Structure Structure
ECL3 372 H - Structure Structure
ECL3 373 A - Structure Structure
ECL3 374 Q - Structure Structure
TM7 375 G 7.32x31 Structure Structure
TM7 376 T 7.33x32 Structure Structure
TM7 377 L 7.34x33 Structure Structure
TM7 378 R 7.35x34 Structure Structure
TM7 379 S 7.36x35 Structure Structure
TM7 380 A 7.37x36 Structure Structure
TM7 381 K 7.38x37 Structure Structure
TM7 382 L 7.39x38 Structure Structure
TM7 383 F 7.40x39 Structure Structure
TM7 384 F 7.41x40 Structure Structure
TM7 385 D 7.42x41 Structure Structure
TM7 386 L 7.43x42 Structure Structure
TM7 387 F 7.44x43 Structure Structure
TM7 388 L 7.45x44 Structure Structure
TM7 389 S 7.46x45 Structure Structure
TM7 390 S 7.47x46 Structure Structure
TM7 391 F 7.48x47 Structure Structure
TM7 392 Q 7.49x49 Structure Structure
TM7 393 G 7.50x50 Structure Structure
TM7 394 L 7.51x51 Structure Structure
TM7 395 L 7.52x52 Structure Structure
TM7 396 V 7.53x53 Structure Structure
TM7 397 A 7.54x54 Structure Structure
TM7 398 V 7.55x55 Structure Structure
TM7 399 L 7.56x56 Structure Structure
TM7 400 Y 7.57x57 Structure Structure
TM7 401 C 7.58x58 Structure Structure
TM7 402 F 7.59x59 Structure Structure
TM7 403 L 7.60x60 Structure Structure
H8 404 N 8.47x47 Structure Structure
H8 405 K 8.48x48 Structure Structure
H8 406 E 8.49x49 Structure Structure
H8 407 V 8.50x50 Structure Structure
H8 408 Q 8.51x51 Structure Structure
H8 409 S 8.52x52 Structure Structure
H8 410 E 8.53x53 Structure Structure
H8 411 L 8.54x54 Structure Structure
H8 412 R 8.55x55 Structure Structure
H8 413 R 8.56x56 Structure Structure
H8 414 R 8.57x57 Structure Structure
H8 415 W 8.58x58 Structure Structure
H8 416 H 8.59x59 Structure Structure
H8 417 R 8.60x60 Structure Structure
H8 418 W 8.61x61 Structure Structure
H8 419 R 8.62x62 Structure Structure
H8 420 L 8.63x63 Structure Structure
H8 421 G 8.64x64 Structure Structure
H8 422 K 8.65x65 Structure AF2
H8 423 V 8.66x66 Structure Structure
H8 424 L 8.67x67 AF2 AF2
H8 425 W 8.68x68 AF2 AF2
H8 426 E 8.69x69 AF2 AF2
H8 427 E 8.70x70 AF2 AF2
H8 428 R 8.71x71 AF2 AF2
H8 429 N 8.72x72 AF2 AF2
C-term 430 T - AF2 AF2
C-term 431 S - AF2 AF2
C-term 432 N - AF2 AF2
C-term 433 H - AF2 AF2
C-term 434 R - AF2 AF2
C-term 435 A - AF2 AF2
C-term 436 S - AF2 AF2
C-term 437 S - AF2 AF2
C-term 438 S - AF2 AF2
C-term 439 P - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 L 329 5x61 G.H5 L 388 G.H5.20
Polar ICL2 E 260 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 E 260 - G.hns1 R 38 G.hns1.02
Polar TM6 R 346 6x37 G.H5 L 394 G.H5.26
Hydrophobic TM6 R 346 6x37 G.H5 L 394 G.H5.26
Van-der-waals TM6 R 346 6x37 G.H5 L 394 G.H5.26
Polar TM5 K 332 5x64 G.H5 R 385 G.H5.17
Hydrophobic TM5 K 332 5x64 G.H5 R 385 G.H5.17
Hydrophobic TM5 K 332 5x64 G.H5 L 394 G.H5.26
Hydrophobic TM2 H 177 2x50 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 T 257 - G.S3 V 217 G.S3.01
Van-der-waals ICL2 T 257 - G.S3 V 217 G.S3.01
Polar TM3 L 253 3x58 G.H5 Q 384 G.H5.16
Van-der-waals TM3 L 253 3x58 G.H5 Q 384 G.H5.16
Hydrophobic TM3 L 253 3x58 G.H5 H 387 G.H5.19
Hydrophobic TM5 L 328 5x60 G.H5 L 388 G.H5.20
Ionic TM5 K 332 5x64 G.H5 D 381 G.H5.13
Polar TM5 K 332 5x64 G.H5 D 381 G.H5.13
Van-der-waals TM5 K 332 5x64 G.H5 D 381 G.H5.13
Hydrophobic TM3 L 252 3x57 G.H5 H 387 G.H5.19
Polar TM6 S 350 6x41 G.H5 L 393 G.H5.25
Van-der-waals TM6 S 350 6x41 G.H5 L 393 G.H5.25
Hydrophobic TM5 L 329 5x61 G.H5 L 393 G.H5.25
Van-der-waals TM5 L 329 5x61 G.H5 L 393 G.H5.25
Ionic ICL3 R 336 - G.hgh4 D 323 G.hgh4.13
Polar ICL3 R 336 - G.hgh4 D 323 G.hgh4.13
Hydrophobic ICL3 R 336 - G.hgh4 D 323 G.hgh4.13
Van-der-waals ICL3 R 336 - G.hgh4 D 323 G.hgh4.13
Polar ICL3 Q 337 - G.H5 R 385 G.H5.17
Van-der-waals ICL3 Q 337 - G.H5 R 385 G.H5.17
Hydrophobic TM6 L 354 6x45 G.H5 L 393 G.H5.25
Hydrophobic ICL2 L 258 - G.H5 H 387 G.H5.19
Polar TM6 R 346 6x37 G.H5 E 392 G.H5.24
Hydrophobic ICL3 Q 337 - G.S6 Y 360 G.S6.02
Van-der-waals ICL3 Q 337 - G.S6 Y 360 G.S6.02
Hydrophobic ICL2 A 256 - G.H5 R 380 G.H5.12
Hydrophobic TM5 K 332 5x64 G.H5 L 388 G.H5.20
Hydrophobic TM5 L 329 5x61 G.H5 L 394 G.H5.26
Polar TM5 K 332 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM5 K 332 5x64 G.H5 Q 384 G.H5.16
Polar TM3 G 254 3x59 G.H5 R 380 G.H5.12
Polar H8 K 405 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 N 404 8x47 G.H5 E 392 G.H5.24
Aromatic TM2 R 173 2x46 G.H5 Y 391 G.H5.23
Hydrophobic TM2 R 173 2x46 G.H5 Y 391 G.H5.23
Van-der-waals TM2 R 173 2x46 G.H5 Y 391 G.H5.23
Hydrophobic ICL3 M 338 - G.h4s6 Y 358 G.h4s6.20
Van-der-waals ICL3 M 338 - G.h4s6 Y 358 G.h4s6.20
Hydrophobic ICL2 T 257 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 E 260 - G.hns1 A 39 G.hns1.03
Hydrophobic TM3 L 249 3x54 G.H5 Y 391 G.H5.23
Van-der-waals TM3 L 249 3x54 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 L 258 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 L 258 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 R 261 - G.HN Q 35 G.HN.52
Hydrophobic TM3 L 253 3x58 G.H5 L 388 G.H5.20
Hydrophobic ICL2 A 256 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 A 256 - G.H5 I 383 G.H5.15