GIP receptor - Gs

GPCR CLASS (FAMILY)

Class B1 (Secretin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.1 Å

REFERENCE

PUBLICATION DATE

April 13, 2022

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

tirzepatide - Agonist pubchem gtoplig ,

2-fluoro-4-[(1R)-6-methoxy-1-methyl-2-{(1S)-1-[4-(propan-2-yl)phenyl]ethyl}-1,2,3,4-tetrahydroisoquinolin-5-yl]-6-[(2-methylpropyl)amino]phenol - PAM pubchem

PHYSIOLOGICAL LIGANDS

gastric inhibitory polypeptide



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic TM6 S 342 6x41 G.H5 L 393 G.H5.25
Hydrophobic TM5 L 321 5x61 G.H5 L 394 G.H5.26
Van-der-waals TM5 L 321 5x61 G.H5 L 394 G.H5.26
Hydrophobic TM5 K 324 5x64 G.H5 D 381 G.H5.13
Hydrophobic TM5 K 324 5x64 G.H5 L 394 G.H5.26
Hydrophobic TM6 R 338 6x37 G.H5 L 394 G.H5.26
Van-der-waals TM6 R 338 6x37 G.H5 L 394 G.H5.26
Hydrophobic TM2 H 173 2x50 G.H5 Y 391 G.H5.23
Van-der-waals TM2 H 173 2x50 G.H5 Y 391 G.H5.23
Polar TM5 K 324 5x64 G.H5 R 385 G.H5.17
Hydrophobic TM5 K 324 5x64 G.H5 R 385 G.H5.17
Van-der-waals TM5 K 324 5x64 G.H5 R 385 G.H5.17
Hydrophobic TM5 L 325 5x65 G.H5 L 394 G.H5.26
Van-der-waals TM5 L 325 5x65 G.H5 L 394 G.H5.26
Hydrophobic TM3 L 241 3x54 G.H5 Y 391 G.H5.23
Van-der-waals TM3 L 241 3x54 G.H5 Y 391 G.H5.23
Aromatic TM2 R 169 2x46 G.H5 Y 391 G.H5.23
Hydrophobic TM2 R 169 2x46 G.H5 Y 391 G.H5.23
Van-der-waals TM2 R 169 2x46 G.H5 Y 391 G.H5.23
Hydrophobic H8 N 396 8x47 G.H5 E 392 G.H5.24
Van-der-waals H8 N 396 8x47 G.H5 E 392 G.H5.24
Polar TM3 L 244 3x57 G.H5 H 387 G.H5.19
Hydrophobic TM3 L 244 3x57 G.H5 H 387 G.H5.19
Van-der-waals TM3 L 244 3x57 G.H5 H 387 G.H5.19
Hydrophobic TM3 L 245 3x58 G.H5 L 388 G.H5.20
Van-der-waals TM3 L 245 3x58 G.H5 L 388 G.H5.20
Polar TM6 R 338 6x37 G.H5 E 392 G.H5.24
Van-der-waals TM6 R 338 6x37 G.H5 E 392 G.H5.24
Hydrophobic TM5 L 321 5x61 G.H5 L 393 G.H5.25
Polar TM3 L 245 3x58 G.H5 Q 384 G.H5.16
Hydrophobic TM3 L 245 3x58 G.H5 Q 384 G.H5.16
Van-der-waals TM3 L 245 3x58 G.H5 Q 384 G.H5.16
Polar TM6 R 338 6x37 G.H5 L 393 G.H5.25
Hydrophobic TM6 R 338 6x37 G.H5 L 393 G.H5.25
Van-der-waals TM6 R 338 6x37 G.H5 L 393 G.H5.25
Polar H8 K 397 8x48 G.H5 E 392 G.H5.24
Hydrophobic H8 K 397 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 K 397 8x48 G.H5 E 392 G.H5.24
Hydrophobic TM3 L 245 3x58 G.H5 H 387 G.H5.19
Van-der-waals TM3 L 245 3x58 G.H5 H 387 G.H5.19
Hydrophobic TM3 Y 240 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 Y 240 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM5 K 324 5x64 G.H5 L 388 G.H5.20
Van-der-waals TM5 K 324 5x64 G.H5 L 388 G.H5.20
Hydrophobic TM5 I 317 5x57 G.H5 L 393 G.H5.25
Van-der-waals TM5 I 317 5x57 G.H5 L 393 G.H5.25
Hydrophobic ICL2 V 248 - G.H5 F 376 G.H5.08
Aromatic ICL3 R 328 - G.h4s6 Y 358 G.h4s6.20
Hydrophobic ICL3 R 328 - G.h4s6 Y 358 G.h4s6.20
Van-der-waals ICL3 R 328 - G.h4s6 Y 358 G.h4s6.20
Polar TM5 K 324 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM5 K 324 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 K 324 5x64 G.H5 Q 384 G.H5.16
Hydrophobic ICL3 R 328 - G.H5 R 385 G.H5.17
Van-der-waals ICL3 R 328 - G.H5 R 385 G.H5.17
Hydrophobic ICL2 V 248 - G.S3 V 217 G.S3.01
Van-der-waals ICL2 V 248 - G.S3 V 217 G.S3.01
Hydrophobic TM5 L 321 5x61 G.H5 L 388 G.H5.20