S1P1 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

D

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.4 Å

REFERENCE

PUBLICATION DATE

Sept. 29, 2021

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

PHYSIOLOGICAL LIGANDS

sphingosine 1-phosphate, sphingosylphosphorylcholine, dihydrosphingosine 1-phosphate



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic ICL2 L 151 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL3 R 238 - G.H5 K 330 G.H5.02
Hydrophobic ICL3 K 239 - G.H5 F 334 G.H5.06
Van-der-waals ICL3 K 239 - G.H5 F 334 G.H5.06
Hydrophobic TM5 R 231 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 R 231 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM6 K 250 6x29 G.H5 K 345 G.H5.17
Hydrophobic ICL3 L 235 - G.H5 F 336 G.H5.08
Hydrophobic ICL2 L 151 - G.S1 V 34 G.S1.02
Hydrophobic H8 N 315 8x47 G.H5 G 352 G.H5.24
Ionic TM6 K 250 6x29 G.H5 D 341 G.H5.13
Polar TM6 K 250 6x29 G.H5 D 341 G.H5.13
Van-der-waals TM6 K 250 6x29 G.H5 D 341 G.H5.13
Hydrophobic TM5 I 224 5x61 G.H5 L 353 G.H5.25
Van-der-waals TM5 I 224 5x61 G.H5 L 353 G.H5.25
Hydrophobic ICL2 H 152 - G.hns1 A 31 G.hns1.02
Polar H8 K 316 8x48 G.H5 F 354 G.H5.26
Van-der-waals H8 K 316 8x48 G.H5 F 354 G.H5.26
Hydrophobic ICL2 L 151 - G.S1 E 33 G.S1.01
Hydrophobic TM2 M 80 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 M 80 2x39 G.H5 C 351 G.H5.23
Hydrophobic ICL3 R 238 - G.H5 D 337 G.H5.09
Van-der-waals ICL3 R 238 - G.H5 D 337 G.H5.09
Hydrophobic TM6 K 250 6x29 G.H5 L 348 G.H5.20
Hydrophobic TM5 S 232 5x69 G.H5 I 344 G.H5.16
Hydrophobic TM3 M 146 3x54 G.H5 C 351 G.H5.23
Van-der-waals TM3 M 146 3x54 G.H5 C 351 G.H5.23
Hydrophobic ICL2 M 149 - G.H5 N 347 G.H5.19
Van-der-waals ICL2 M 149 - G.H5 N 347 G.H5.19
Polar ICL2 N 153 - G.H5 D 350 G.H5.22
Hydrophobic ICL2 N 153 - G.H5 D 350 G.H5.22
Van-der-waals ICL2 N 153 - G.H5 D 350 G.H5.22
Ionic ICL2 K 150 - G.HN E 28 G.HN.52
Polar ICL3 T 236 - G.H5 D 337 G.H5.09
Hydrophobic ICL3 T 236 - G.H5 D 337 G.H5.09
Hydrophobic TM6 K 250 6x29 G.H5 I 344 G.H5.16
Polar TM3 R 142 3x50 G.H5 G 352 G.H5.24
Polar TM2 R 78 2x37 G.H5 D 350 G.H5.22
Hydrophobic TM7 T 314 7x56 G.H5 L 353 G.H5.25
Hydrophobic ICL3 K 239 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 K 239 - G.S6 Y 320 G.S6.02
Hydrophobic ICL3 R 238 - G.H5 Q 333 G.H5.05
Hydrophobic TM3 M 146 3x54 G.H5 L 348 G.H5.20
Van-der-waals ICL3 L 235 - G.H5 D 337 G.H5.09
Hydrophobic TM3 R 142 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM3 M 146 3x54 G.H5 L 353 G.H5.25
Hydrophobic ICL2 M 149 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 M 149 - G.H5 I 343 G.H5.15
Hydrophobic TM6 L 254 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 254 6x33 G.H5 L 353 G.H5.25
Polar TM6 T 257 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM6 T 257 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM3 M 146 3x54 G.H5 N 347 G.H5.19
Ionic ICL3 K 239 - G.H5 D 341 G.H5.13
Polar ICL3 K 239 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 K 239 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 K 239 - G.H5 D 341 G.H5.13
Hydrophobic TM3 R 142 3x50 G.H5 C 351 G.H5.23
Polar ICL3 T 236 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 T 236 - G.H5 D 341 G.H5.13
Hydrophobic ICL2 L 151 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 L 151 - G.H5 I 343 G.H5.15