Refined structure (8G59) of Gq - FFA4 receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2024-02-01

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 219 from structure (61.0%), 140 from model (39.0%)
Residue sidechains - 42 from structure (11.7%), 317 from model (88.3%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 T G.HN.02 Structure AF2
G.HN 3 L G.HN.03 Structure AF2
G.HN 4 E G.HN.04 Structure AF2
G.HN 5 S G.HN.05 Structure AF2
G.HN 6 I G.HN.06 Structure AF2
G.HN 7 M G.HN.07 Structure AF2
G.HN 8 A G.HN.08 Structure AF2
G.HN 9 C G.HN.09 Structure AF2
G.HN 10 C G.HN.10 Structure AF2
G.HN 11 L G.HN.11 Structure AF2
G.HN 12 S G.HN.30 Structure AF2
G.HN 13 E G.HN.31 Structure AF2
G.HN 14 E G.HN.32 Structure Structure
G.HN 15 A G.HN.33 Structure AF2
G.HN 16 K G.HN.34 Structure AF2
G.HN 17 E G.HN.35 Structure AF2
G.HN 18 A G.HN.36 Structure AF2
G.HN 19 R G.HN.37 Structure AF2
G.HN 20 R G.HN.38 Structure AF2
G.HN 21 I G.HN.39 Structure AF2
G.HN 22 N G.HN.40 Structure Structure
G.HN 23 D G.HN.41 Structure AF2
G.HN 24 E G.HN.42 Structure AF2
G.HN 25 I G.HN.43 Structure AF2
G.HN 26 E G.HN.44 Structure AF2
G.HN 27 R G.HN.45 Structure AF2
G.HN 28 Q G.HN.46 Structure AF2
G.HN 29 L G.HN.47 Structure AF2
G.HN 30 R G.HN.48 Structure AF2
G.HN 31 R G.HN.49 Structure AF2
G.HN 32 D G.HN.50 Structure AF2
G.HN 33 K G.HN.51 Structure AF2
G.HN 34 R G.HN.52 Structure AF2
G.HN 35 D G.HN.53 Structure AF2
G.hns1 36 A G.hns1.01 Structure AF2
G.hns1 37 R G.hns1.02 Structure AF2
G.hns1 38 R G.hns1.03 Structure AF2
G.S1 39 E G.S1.01 Structure AF2
G.S1 40 L G.S1.02 Structure AF2
G.S1 41 K G.S1.03 Structure AF2
G.S1 42 L G.S1.04 Structure AF2
G.S1 43 L G.S1.05 Structure AF2
G.S1 44 L G.S1.06 Structure AF2
G.S1 45 L G.S1.07 Structure AF2
G.s1h1 46 G G.s1h1.01 Structure AF2
G.s1h1 47 T G.s1h1.02 Structure AF2
G.s1h1 48 G G.s1h1.03 Structure AF2
G.s1h1 49 E G.s1h1.04 Structure AF2
G.s1h1 50 S G.s1h1.05 Structure AF2
G.s1h1 51 G G.s1h1.06 Structure AF2
G.H1 52 K G.H1.01 Structure Structure
G.H1 53 S G.H1.02 Structure Structure
G.H1 54 T G.H1.03 AF2 AF2
G.H1 55 F G.H1.04 AF2 AF2
G.H1 56 I G.H1.05 AF2 AF2
G.H1 57 K G.H1.06 AF2 AF2
G.H1 58 Q G.H1.07 AF2 AF2
G.H1 59 M G.H1.08 AF2 AF2
G.H1 60 R G.H1.09 AF2 AF2
G.H1 61 I G.H1.10 AF2 AF2
G.H1 62 I G.H1.11 AF2 AF2
G.H1 63 H G.H1.12 AF2 AF2
G.h1ha 64 G G.h1ha.01 AF2 AF2
G.h1ha 65 S G.h1ha.02 AF2 AF2
G.h1ha 66 G G.h1ha.03 AF2 AF2
G.h1ha 67 Y G.h1ha.04 AF2 AF2
G.h1ha 68 S G.h1ha.05 AF2 AF2
H.HA 69 D H.HA.01 AF2 AF2
H.HA 70 E H.HA.02 AF2 AF2
H.HA 71 D H.HA.03 AF2 AF2
H.HA 72 K H.HA.04 AF2 AF2
H.HA 73 R H.HA.05 AF2 AF2
H.HA 74 G H.HA.06 AF2 AF2
H.HA 75 F H.HA.07 AF2 AF2
H.HA 76 T H.HA.08 AF2 AF2
H.HA 77 K H.HA.09 AF2 AF2
H.HA 78 L H.HA.10 AF2 AF2
H.HA 79 V H.HA.11 AF2 AF2
H.HA 80 Y H.HA.12 AF2 AF2
H.HA 81 Q H.HA.13 AF2 AF2
H.HA 82 N H.HA.14 AF2 AF2
H.HA 83 I H.HA.15 AF2 AF2
H.HA 84 F H.HA.16 AF2 AF2
H.HA 85 T H.HA.17 AF2 AF2
H.HA 86 A H.HA.18 AF2 AF2
H.HA 87 M H.HA.19 AF2 AF2
H.HA 88 Q H.HA.20 AF2 AF2
H.HA 89 A H.HA.21 AF2 AF2
H.HA 90 M H.HA.22 AF2 AF2
H.HA 91 I H.HA.23 AF2 AF2
H.HA 92 R H.HA.24 AF2 AF2
H.HA 93 A H.HA.25 AF2 AF2
H.HA 94 M H.HA.26 AF2 AF2
H.HA 95 D H.HA.27 AF2 AF2
H.HA 96 T H.HA.28 AF2 AF2
H.HA 97 L H.HA.29 AF2 AF2
H.hahb 98 K H.hahb.01 AF2 AF2
H.hahb 99 I H.hahb.04 AF2 AF2
H.hahb 100 P H.hahb.05 AF2 AF2
H.hahb 101 Y H.hahb.06 AF2 AF2
H.hahb 102 K H.hahb.07 AF2 AF2
H.hahb 103 Y H.hahb.08 AF2 AF2
H.hahb 104 E H.hahb.09 AF2 AF2
H.HB 105 H H.HB.01 AF2 AF2
H.HB 106 N H.HB.02 AF2 AF2
H.HB 107 K H.HB.03 AF2 AF2
H.HB 108 A H.HB.04 AF2 AF2
H.HB 109 H H.HB.05 AF2 AF2
H.HB 110 A H.HB.06 AF2 AF2
H.HB 111 Q H.HB.07 AF2 AF2
H.HB 112 L H.HB.08 AF2 AF2
H.HB 113 V H.HB.09 AF2 AF2
H.HB 114 R H.HB.10 AF2 AF2
H.HB 115 E H.HB.11 AF2 AF2
H.HB 116 V H.HB.12 AF2 AF2
H.HB 117 D H.HB.13 AF2 AF2
H.HB 118 V H.HB.14 AF2 AF2
H.hbhc 119 E H.hbhc.01 AF2 AF2
H.hbhc 120 K H.hbhc.02 AF2 AF2
H.hbhc 121 V H.hbhc.03 AF2 AF2
H.hbhc 122 S H.hbhc.04 AF2 AF2
H.hbhc 123 A H.hbhc.05 AF2 AF2
H.hbhc 124 F H.hbhc.14 AF2 AF2
H.hbhc 125 E H.hbhc.15 AF2 AF2
H.HC 126 N H.HC.01 AF2 AF2
H.HC 127 P H.HC.02 AF2 AF2
H.HC 128 Y H.HC.03 AF2 AF2
H.HC 129 V H.HC.04 AF2 AF2
H.HC 130 D H.HC.05 AF2 AF2
H.HC 131 A H.HC.06 AF2 AF2
H.HC 132 I H.HC.07 AF2 AF2
H.HC 133 K H.HC.08 AF2 AF2
H.HC 134 S H.HC.09 AF2 AF2
H.HC 135 L H.HC.10 AF2 AF2
H.HC 136 W H.HC.11 AF2 AF2
H.HC 137 N H.HC.12 AF2 AF2
H.hchd 138 D H.hchd.01 AF2 AF2
H.HD 139 P H.HD.01 AF2 AF2
H.HD 140 G H.HD.02 AF2 AF2
H.HD 141 I H.HD.03 AF2 AF2
H.HD 142 Q H.HD.04 AF2 AF2
H.HD 143 E H.HD.05 AF2 AF2
H.HD 144 C H.HD.06 AF2 AF2
H.HD 145 Y H.HD.07 AF2 AF2
H.HD 146 D H.HD.08 AF2 AF2
H.HD 147 R H.HD.09 AF2 AF2
H.HD 148 R H.HD.10 AF2 AF2
H.HD 149 R H.HD.11 AF2 AF2
H.HD 150 E H.HD.12 AF2 AF2
H.hdhe 151 Y H.hdhe.01 AF2 AF2
H.hdhe 152 Q H.hdhe.02 AF2 AF2
H.hdhe 153 L H.hdhe.03 AF2 AF2
H.hdhe 154 S H.hdhe.04 AF2 AF2
H.hdhe 155 D H.hdhe.05 AF2 AF2
H.HE 156 S H.HE.01 AF2 AF2
H.HE 157 T H.HE.02 AF2 AF2
H.HE 158 K H.HE.03 AF2 AF2
H.HE 159 Y H.HE.04 AF2 AF2
H.HE 160 Y H.HE.05 AF2 AF2
H.HE 161 L H.HE.06 AF2 AF2
H.HE 162 N H.HE.07 AF2 AF2
H.HE 163 D H.HE.08 AF2 AF2
H.HE 164 L H.HE.09 AF2 AF2
H.HE 165 D H.HE.10 AF2 AF2
H.HE 166 R H.HE.11 AF2 AF2
H.HE 167 V H.HE.12 AF2 AF2
H.HE 168 A H.HE.13 AF2 AF2
H.hehf 169 D H.hehf.01 AF2 AF2
H.hehf 170 P H.hehf.02 AF2 AF2
H.hehf 171 A H.hehf.03 AF2 AF2
H.hehf 172 Y H.hehf.04 AF2 AF2
H.hehf 173 L H.hehf.05 AF2 AF2
H.hehf 174 P H.hehf.06 AF2 AF2
H.hehf 175 T H.hehf.07 AF2 AF2
H.HF 176 Q H.HF.01 AF2 AF2
H.HF 177 Q H.HF.02 AF2 AF2
H.HF 178 D H.HF.03 AF2 AF2
H.HF 179 V H.HF.04 AF2 AF2
H.HF 180 L H.HF.05 AF2 AF2
H.HF 181 R H.HF.06 AF2 AF2
G.hfs2 182 V G.hfs2.01 Structure AF2
G.hfs2 183 R G.hfs2.02 Structure AF2
G.hfs2 184 V G.hfs2.03 Structure AF2
G.hfs2 185 P G.hfs2.04 Structure AF2
G.hfs2 186 T G.hfs2.05 Structure AF2
G.hfs2 187 T G.hfs2.06 Structure Structure
G.hfs2 188 G G.hfs2.07 Structure AF2
G.S2 189 I G.S2.01 Structure AF2
G.S2 190 I G.S2.02 Structure AF2
G.S2 191 E G.S2.03 Structure AF2
G.S2 192 Y G.S2.04 Structure AF2
G.S2 193 P G.S2.05 Structure AF2
G.S2 194 F G.S2.06 Structure AF2
G.S2 195 D G.S2.07 Structure AF2
G.S2 196 L G.S2.08 Structure AF2
G.s2s3 197 Q G.s2s3.01 Structure AF2
G.s2s3 198 S G.s2s3.02 Structure AF2
G.S3 199 V G.S3.01 Structure AF2
G.S3 200 I G.S3.02 Structure AF2
G.S3 201 F G.S3.03 Structure AF2
G.S3 202 R G.S3.04 Structure AF2
G.S3 203 M G.S3.05 Structure AF2
G.S3 204 V G.S3.06 Structure AF2
G.S3 205 D G.S3.07 Structure AF2
G.S3 206 V G.S3.08 Structure AF2
G.s3h2 207 G G.s3h2.01 Structure AF2
G.s3h2 208 G G.s3h2.02 Structure AF2
G.s3h2 209 Q G.s3h2.03 Structure AF2
G.H2 210 R G.H2.01 Structure AF2
G.H2 211 S G.H2.02 Structure AF2
G.H2 212 E G.H2.03 Structure AF2
G.H2 213 R G.H2.04 Structure AF2
G.H2 214 R G.H2.05 Structure AF2
G.H2 215 K G.H2.06 Structure AF2
G.H2 216 W G.H2.07 Structure AF2
G.H2 217 I G.H2.08 Structure AF2
G.H2 218 H G.H2.09 Structure AF2
G.H2 219 C G.H2.10 Structure AF2
G.h2s4 220 F G.h2s4.01 Structure AF2
G.h2s4 221 E G.h2s4.02 Structure AF2
G.h2s4 222 N G.h2s4.03 Structure AF2
G.h2s4 223 V G.h2s4.04 Structure AF2
G.h2s4 224 T G.h2s4.05 Structure AF2
G.S4 225 S G.S4.01 Structure AF2
G.S4 226 I G.S4.02 Structure AF2
G.S4 227 M G.S4.03 Structure AF2
G.S4 228 F G.S4.04 Structure AF2
G.S4 229 L G.S4.05 Structure AF2
G.S4 230 V G.S4.06 Structure AF2
G.S4 231 A G.S4.07 Structure AF2
G.s4h3 232 L G.s4h3.01 Structure Structure
G.s4h3 233 S G.s4h3.02 Structure Structure
G.s4h3 234 E G.s4h3.03 Structure Structure
G.s4h3 235 Y G.s4h3.04 AF2 AF2
G.s4h3 236 D G.s4h3.05 AF2 AF2
G.s4h3 237 Q G.s4h3.06 AF2 AF2
G.s4h3 238 V G.s4h3.07 AF2 AF2
G.s4h3 239 L G.s4h3.08 AF2 AF2
G.s4h3 240 V G.s4h3.09 Structure AF2
G.s4h3 241 E G.s4h3.10 Structure AF2
G.s4h3 242 S G.s4h3.11 Structure AF2
G.s4h3 243 D G.s4h3.12 Structure AF2
G.s4h3 244 N G.s4h3.13 Structure AF2
G.s4h3 245 E G.s4h3.14 Structure Structure
G.s4h3 246 N G.s4h3.15 Structure AF2
G.H3 247 R G.H3.01 Structure AF2
G.H3 248 M G.H3.02 Structure AF2
G.H3 249 E G.H3.03 Structure AF2
G.H3 250 E G.H3.04 Structure AF2
G.H3 251 S G.H3.05 Structure AF2
G.H3 252 K G.H3.06 Structure AF2
G.H3 253 A G.H3.07 Structure AF2
G.H3 254 L G.H3.08 Structure AF2
G.H3 255 F G.H3.09 Structure AF2
G.H3 256 R G.H3.10 Structure AF2
G.H3 257 T G.H3.11 Structure AF2
G.H3 258 I G.H3.12 Structure AF2
G.H3 259 I G.H3.13 Structure AF2
G.H3 260 T G.H3.14 Structure Structure
G.H3 261 Y G.H3.15 Structure AF2
G.H3 262 P G.H3.16 Structure AF2
G.H3 263 W G.H3.17 Structure AF2
G.H3 264 F G.H3.18 Structure AF2
G.h3s5 265 Q G.h3s5.01 Structure AF2
G.h3s5 266 N G.h3s5.02 Structure AF2
G.h3s5 267 S G.h3s5.03 Structure AF2
G.S5 268 S G.S5.01 Structure AF2
G.S5 269 V G.S5.02 Structure AF2
G.S5 270 I G.S5.03 Structure AF2
G.S5 271 L G.S5.04 Structure AF2
G.S5 272 F G.S5.05 Structure AF2
G.S5 273 L G.S5.06 Structure Structure
G.S5 274 N G.S5.07 Structure AF2
G.s5hg 275 K G.s5hg.01 Structure AF2
G.HG 276 K G.HG.01 Structure AF2
G.HG 277 D G.HG.02 Structure AF2
G.HG 278 L G.HG.03 Structure AF2
G.HG 279 L G.HG.04 Structure AF2
G.HG 280 E G.HG.05 Structure AF2
G.HG 281 E G.HG.06 Structure AF2
G.HG 282 K G.HG.07 Structure AF2
G.HG 283 I G.HG.08 Structure AF2
G.HG 284 M G.HG.09 Structure AF2
G.HG 285 Y G.HG.12 Structure AF2
G.HG 286 S G.HG.13 Structure AF2
G.HG 287 H G.HG.14 Structure AF2
G.HG 288 L G.HG.15 Structure AF2
G.HG 289 V G.HG.16 Structure AF2
G.HG 290 D G.HG.17 Structure AF2
G.hgh4 291 Y G.hgh4.01 Structure AF2
G.hgh4 292 F G.hgh4.02 Structure AF2
G.hgh4 293 P G.hgh4.03 Structure AF2
G.hgh4 294 E G.hgh4.04 Structure AF2
G.hgh4 295 Y G.hgh4.05 Structure AF2
G.hgh4 296 D G.hgh4.06 Structure AF2
G.hgh4 297 G G.hgh4.07 Structure AF2
G.hgh4 298 P G.hgh4.08 Structure AF2
G.H4 299 Q G.H4.01 Structure AF2
G.H4 300 R G.H4.02 Structure AF2
G.H4 301 D G.H4.03 Structure AF2
G.H4 302 A G.H4.04 Structure AF2
G.H4 303 Q G.H4.05 Structure AF2
G.H4 304 A G.H4.06 Structure AF2
G.H4 305 A G.H4.07 Structure AF2
G.H4 306 R G.H4.08 Structure AF2
G.H4 307 E G.H4.09 Structure AF2
G.H4 308 F G.H4.10 Structure AF2
G.H4 309 I G.H4.11 Structure AF2
G.H4 310 L G.H4.12 Structure Structure
G.H4 311 K G.H4.13 Structure AF2
G.H4 312 M G.H4.14 Structure AF2
G.H4 313 F G.H4.15 Structure AF2
G.H4 314 V G.H4.16 Structure AF2
G.H4 315 D G.H4.17 Structure Structure
G.h4s6 316 L G.h4s6.01 Structure AF2
G.h4s6 317 N G.h4s6.08 Structure AF2
G.h4s6 318 P G.h4s6.09 Structure AF2
G.h4s6 319 D G.h4s6.10 Structure AF2
G.h4s6 320 S G.h4s6.11 Structure AF2
G.h4s6 321 D G.h4s6.12 Structure AF2
G.h4s6 322 K G.h4s6.13 Structure AF2
G.h4s6 323 I G.h4s6.20 Structure AF2
G.S6 324 I G.S6.01 Structure Structure
G.S6 325 Y G.S6.02 Structure Structure
G.S6 326 S G.S6.03 AF2 AF2
G.S6 327 H G.S6.04 AF2 AF2
G.S6 328 F G.S6.05 AF2 AF2
G.s6h5 329 T G.s6h5.01 AF2 AF2
G.s6h5 330 C G.s6h5.02 AF2 AF2
G.s6h5 331 A G.s6h5.03 AF2 AF2
G.s6h5 332 T G.s6h5.04 Structure Structure
G.s6h5 333 D G.s6h5.05 Structure Structure
G.H5 334 T G.H5.01 Structure Structure
G.H5 335 E G.H5.02 Structure Structure
G.H5 336 N G.H5.03 Structure Structure
G.H5 337 I G.H5.04 Structure Structure
G.H5 338 R G.H5.05 Structure Structure
G.H5 339 F G.H5.06 Structure Structure
G.H5 340 V G.H5.07 Structure Structure
G.H5 341 F G.H5.08 Structure Structure
G.H5 342 A G.H5.09 Structure Structure
G.H5 343 A G.H5.10 Structure Structure
G.H5 344 V G.H5.11 Structure Structure
G.H5 345 K G.H5.12 Structure Structure
G.H5 346 D G.H5.13 Structure Structure
G.H5 347 T G.H5.14 Structure Structure
G.H5 348 I G.H5.15 Structure Structure
G.H5 349 L G.H5.16 Structure Structure
G.H5 350 Q G.H5.17 Structure Structure
G.H5 351 L G.H5.18 Structure Structure
G.H5 352 N G.H5.19 Structure Structure
G.H5 353 L G.H5.20 Structure Structure
G.H5 354 K G.H5.21 Structure Structure
G.H5 355 E G.H5.22 Structure AF2
G.H5 356 Y G.H5.23 Structure Structure
G.H5 357 N G.H5.24 Structure Structure
G.H5 358 L G.H5.25 Structure Structure
G.H5 359 V G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 281 from structure (80.5%), 68 from model (19.5%)
Residue sidechains - 272 from structure (77.9%), 77 from model (22.1%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 S - AF2 AF2
N-term 3 P - AF2 AF2
N-term 4 E - AF2 AF2
N-term 5 C - AF2 AF2
N-term 6 A - AF2 AF2
N-term 7 R - AF2 AF2
N-term 8 A - AF2 AF2
N-term 9 A - AF2 AF2
N-term 10 G - AF2 AF2
N-term 11 D - AF2 AF2
N-term 12 A - AF2 AF2
N-term 13 P - AF2 AF2
N-term 14 L - AF2 AF2
N-term 15 R - AF2 AF2
N-term 16 S - AF2 AF2
N-term 17 L - AF2 AF2
N-term 18 E - AF2 AF2
N-term 19 Q - AF2 AF2
N-term 20 A - AF2 AF2
N-term 21 N - AF2 AF2
N-term 22 R - AF2 AF2
N-term 23 T - Structure Structure
N-term 24 R - Structure Structure
N-term 25 F - Structure Structure
N-term 26 P - Structure Structure
N-term 27 F - Structure Structure
N-term 28 F - Structure Structure
N-term 29 S - Structure Structure
N-term 30 D - Structure AF2
N-term 31 V - Structure Structure
N-term 32 K - Structure Structure
N-term 33 G - Structure Structure
N-term 34 D - Structure AF2
TM1 35 H 1.27x27 Structure AF2
TM1 36 R 1.28x28 Structure Structure
TM1 37 L 1.29x29 Structure AF2
TM1 38 V 1.30x30 Structure AF2
TM1 39 L 1.31x31 Structure Structure
TM1 40 A 1.32x32 Structure Structure
TM1 41 A 1.33x33 Structure Structure
TM1 42 V 1.34x34 Structure Structure
TM1 43 E 1.35x35 Structure Structure
TM1 44 T 1.36x36 Structure Structure
TM1 45 T 1.37x37 Structure Structure
TM1 46 V 1.38x38 Structure Structure
TM1 47 L 1.39x39 Structure Structure
TM1 48 V 1.40x40 Structure Structure
TM1 49 L 1.41x41 Structure Structure
TM1 50 I 1.42x42 Structure Structure
TM1 51 F 1.43x43 Structure Structure
TM1 52 A 1.44x44 Structure Structure
TM1 53 V 1.45x45 Structure Structure
TM1 54 S 1.46x46 Structure Structure
TM1 55 L 1.47x47 Structure Structure
TM1 56 L 1.48x48 Structure Structure
TM1 57 G 1.49x49 Structure Structure
TM1 58 N 1.50x50 Structure Structure
TM1 59 V 1.51x51 Structure Structure
TM1 60 C 1.52x52 Structure Structure
TM1 61 A 1.53x53 Structure Structure
TM1 62 L 1.54x54 Structure Structure
TM1 63 V 1.55x55 Structure Structure
TM1 64 L 1.56x56 Structure Structure
TM1 65 V 1.57x57 Structure Structure
TM1 66 A 1.58x58 Structure Structure
TM1 67 R 1.59x59 Structure Structure
TM1 68 R 1.60x60 Structure Structure
ICL1 69 R - Structure Structure
ICL1 70 R - Structure Structure
ICL1 71 R - AF2 AF2
ICL1 72 G - AF2 AF2
ICL1 73 A - AF2 AF2
ICL1 74 T - AF2 AF2
TM2 75 A 2.40x40 AF2 AF2
TM2 76 C 2.41x41 AF2 AF2
TM2 77 L 2.42x42 Structure Structure
TM2 78 V 2.43x43 Structure Structure
TM2 79 L 2.44x44 Structure Structure
TM2 80 N 2.45x45 Structure Structure
TM2 81 L 2.46x46 Structure Structure
TM2 82 F 2.47x47 Structure Structure
TM2 83 C 2.48x48 Structure Structure
TM2 84 A 2.49x49 Structure Structure
TM2 85 D 2.50x50 Structure Structure
TM2 86 L 2.51x51 Structure Structure
TM2 87 L 2.52x52 Structure Structure
TM2 88 F 2.53x53 Structure Structure
TM2 89 I 2.54x54 Structure Structure
TM2 90 S 2.55x55 Structure Structure
TM2 91 A 2.56x56 Structure Structure
TM2 92 I 2.57x57 Structure Structure
TM2 93 P 2.58x58 Structure Structure
TM2 94 L 2.59x59 Structure Structure
TM2 95 V 2.60x60 Structure Structure
TM2 96 L 2.61x61 Structure Structure
TM2 97 A 2.62x62 Structure Structure
TM2 98 V 2.63x63 Structure Structure
TM2 99 R 2.64x64 Structure Structure
TM2 100 W 2.65x65 Structure Structure
TM2 101 T 2.66x66 Structure Structure
ECL1 102 E - Structure Structure
ECL1 103 A 23.49x49 Structure Structure
ECL1 104 W 23.50x50 Structure Structure
ECL1 105 L 23.51x51 Structure Structure
ECL1 106 L 23.52x52 Structure Structure
TM3 107 G 3.21x21 Structure Structure
TM3 108 P 3.22x22 Structure Structure
TM3 109 V 3.23x23 Structure Structure
TM3 110 A 3.24x24 Structure Structure
TM3 111 C 3.25x25 Structure Structure
TM3 112 H 3.26x26 Structure Structure
TM3 113 L 3.27x27 Structure Structure
TM3 114 L 3.28x28 Structure Structure
TM3 115 F 3.29x29 Structure Structure
TM3 116 Y 3.30x30 Structure Structure
TM3 117 V 3.31x31 Structure Structure
TM3 118 M 3.32x32 Structure Structure
TM3 119 T 3.33x33 Structure Structure
TM3 120 L 3.34x34 Structure Structure
TM3 121 S 3.35x35 Structure Structure
TM3 122 G 3.36x36 Structure Structure
TM3 123 S 3.37x37 Structure Structure
TM3 124 V 3.38x38 Structure Structure
TM3 125 T 3.39x39 Structure Structure
TM3 126 I 3.40x40 Structure Structure
TM3 127 L 3.41x41 Structure Structure
TM3 128 T 3.42x42 Structure Structure
TM3 129 L 3.43x43 Structure Structure
TM3 130 A 3.44x44 Structure Structure
TM3 131 A 3.45x45 Structure Structure
TM3 132 V 3.46x46 Structure Structure
TM3 133 S 3.47x47 Structure Structure
TM3 134 L 3.48x48 Structure Structure
TM3 135 E 3.49x49 Structure Structure
TM3 136 R 3.50x50 Structure Structure
TM3 137 M 3.51x51 Structure Structure
TM3 138 V 3.52x52 Structure Structure
TM3 139 C 3.53x53 Structure Structure
TM3 140 I 3.54x54 Structure Structure
TM3 141 V 3.55x55 Structure Structure
TM3 142 H 3.56x56 Structure Structure
ICL2 143 L 34.50x50 Structure Structure
ICL2 144 Q 34.51x51 Structure Structure
ICL2 145 R 34.52x52 AF2 AF2
ICL2 146 G 34.53x53 AF2 AF2
ICL2 147 V 34.54x54 AF2 AF2
ICL2 148 R 34.55x55 AF2 AF2
ICL2 149 G 34.56x56 AF2 AF2
ICL2 150 P 34.57x57 AF2 AF2
TM4 151 G 4.38x38 Structure Structure
TM4 152 R 4.39x39 Structure AF2
TM4 153 R 4.40x40 Structure Structure
TM4 154 A 4.41x41 Structure Structure
TM4 155 R 4.42x42 Structure Structure
TM4 156 A 4.43x43 Structure Structure
TM4 157 V 4.44x44 Structure Structure
TM4 158 L 4.45x45 Structure Structure
TM4 159 L 4.46x46 Structure Structure
TM4 160 A 4.47x47 Structure Structure
TM4 161 L 4.48x48 Structure Structure
TM4 162 I 4.49x49 Structure Structure
TM4 163 W 4.50x50 Structure Structure
TM4 164 G 4.51x51 Structure Structure
TM4 165 Y 4.52x52 Structure Structure
TM4 166 S 4.53x53 Structure Structure
TM4 167 A 4.54x54 Structure Structure
TM4 168 V 4.55x55 Structure Structure
TM4 169 A 4.56x56 Structure Structure
TM4 170 A 4.57x57 Structure Structure
TM4 171 L 4.58x59 Structure Structure
TM4 172 P 4.59x60 Structure Structure
TM4 173 L 4.60x61 Structure Structure
TM4 174 C 4.61x62 Structure Structure
TM4 175 V 4.62x63 Structure Structure
TM4 176 F 4.63x64 Structure Structure
TM4 177 F 4.64x65 Structure Structure
ECL2 178 R - Structure Structure
ECL2 179 V - Structure Structure
ECL2 180 V - Structure Structure
ECL2 181 P - Structure Structure
ECL2 182 Q - Structure Structure
ECL2 183 R - AF2 AF2
ECL2 184 L - AF2 AF2
ECL2 185 P - AF2 AF2
ECL2 186 G - AF2 AF2
ECL2 187 A - AF2 AF2
ECL2 188 D - AF2 AF2
ECL2 189 Q - Structure Structure
ECL2 190 E - Structure AF2
ECL2 191 I - Structure Structure
ECL2 192 S - Structure Structure
ECL2 193 I - Structure Structure
ECL2 194 C 45.50x50 Structure Structure
ECL2 195 T 45.51x51 Structure Structure
ECL2 196 L 45.52x52 Structure Structure
ECL2 197 I - Structure Structure
ECL2 198 W - Structure Structure
ECL2 199 P - Structure Structure
TM5 200 T 5.31x32 Structure Structure
TM5 201 I 5.32x33 Structure Structure
TM5 202 P 5.33x34 Structure Structure
TM5 203 G 5.34x35 Structure Structure
TM5 204 E 5.35x36 Structure Structure
TM5 205 I 5.36x37 Structure Structure
TM5 206 S 5.37x38 Structure Structure
TM5 207 W 5.38x39 Structure Structure
TM5 208 D 5.39x40 Structure Structure
TM5 209 V 5.40x41 Structure Structure
TM5 210 S 5.41x42 Structure Structure
TM5 211 F 5.42x43 Structure Structure
TM5 212 V 5.43x44 Structure Structure
TM5 213 T 5.44x45 Structure Structure
TM5 214 L 5.45x46 Structure Structure
TM5 215 N 5.46x461 Structure Structure
TM5 216 F 5.47x47 Structure Structure
TM5 217 L 5.48x48 Structure Structure
TM5 218 V 5.49x49 Structure Structure
TM5 219 P 5.50x50 Structure Structure
TM5 220 G 5.51x51 Structure Structure
TM5 221 L 5.52x52 Structure Structure
TM5 222 V 5.53x53 Structure Structure
TM5 223 I 5.54x54 Structure Structure
TM5 224 V 5.55x55 Structure Structure
TM5 225 I 5.56x56 Structure Structure
TM5 226 S 5.57x57 Structure Structure
TM5 227 Y 5.58x58 Structure Structure
TM5 228 S 5.59x59 Structure Structure
TM5 229 K 5.60x60 Structure Structure
TM5 230 I 5.61x61 Structure Structure
TM5 231 L 5.62x62 Structure Structure
TM5 232 Q 5.63x63 Structure Structure
TM5 233 I 5.64x64 Structure Structure
TM5 234 T 5.65x65 Structure Structure
TM5 235 K 5.66x66 Structure Structure
TM5 236 A 5.67x67 Structure Structure
TM5 237 S 5.68x68 Structure Structure
TM5 238 R 5.69x69 Structure Structure
TM5 239 K 5.70x70 Structure Structure
TM5 240 R 5.71x71 Structure Structure
TM5 241 L 5.72x72 Structure Structure
TM5 242 T 5.73x73 Structure Structure
TM5 243 V 5.74x74 Structure Structure
TM5 244 S 5.75x75 Structure Structure
TM5 245 L 5.76x76 Structure Structure
ICL3 246 A - Structure Structure
ICL3 247 Y - Structure Structure
TM6 248 S 6.19x20 Structure Structure
TM6 249 E 6.20x21 Structure Structure
TM6 250 S 6.21x22 Structure Structure
TM6 251 H 6.22x23 Structure Structure
TM6 252 Q 6.23x24 Structure Structure
TM6 253 I 6.24x25 Structure Structure
TM6 254 R 6.25x26 Structure Structure
TM6 255 V 6.26x27 Structure Structure
TM6 256 S 6.27x28 Structure Structure
TM6 257 Q 6.28x29 Structure Structure
TM6 258 Q 6.29x30 Structure Structure
TM6 259 D 6.30x31 Structure Structure
TM6 260 F 6.31x32 Structure Structure
TM6 261 R 6.32x33 Structure Structure
TM6 262 L 6.33x34 Structure Structure
TM6 263 F 6.34x35 Structure Structure
TM6 264 R 6.35x36 Structure Structure
TM6 265 T 6.36x37 Structure Structure
TM6 266 L 6.37x38 Structure Structure
TM6 267 F 6.38x39 Structure Structure
TM6 268 L 6.39x40 Structure Structure
TM6 269 L 6.40x41 Structure Structure
TM6 270 M 6.41x42 Structure Structure
TM6 271 V 6.42x43 Structure Structure
TM6 272 S 6.43x44 Structure Structure
TM6 273 F 6.44x45 Structure Structure
TM6 274 F 6.45x46 Structure Structure
TM6 275 I 6.46x461 Structure Structure
TM6 276 M 6.47x47 Structure Structure
TM6 277 W 6.48x48 Structure Structure
TM6 278 S 6.49x49 Structure Structure
TM6 279 P 6.50x50 Structure Structure
TM6 280 I 6.51x51 Structure Structure
TM6 281 I 6.52x52 Structure Structure
TM6 282 I 6.53x53 Structure Structure
TM6 283 T 6.54x54 Structure Structure
TM6 284 I 6.55x55 Structure Structure
TM6 285 L 6.56x56 Structure AF2
TM6 286 L 6.57x57 Structure Structure
TM6 287 I 6.58x58 Structure Structure
TM6 288 L 6.59x59 Structure Structure
TM6 289 I 6.60x60 Structure AF2
TM6 290 Q 6.61x61 Structure Structure
TM6 291 N 6.62x62 Structure Structure
TM6 292 F 6.63x63 Structure Structure
TM6 293 K 6.64x64 AF2 AF2
TM6 294 Q 6.65x65 AF2 AF2
ECL3 295 D - AF2 AF2
ECL3 296 L - Structure Structure
ECL3 297 V - Structure Structure
ECL3 298 I - Structure Structure
TM7 299 W 7.31x30 Structure Structure
TM7 300 P 7.32x31 Structure Structure
TM7 301 S 7.33x32 Structure Structure
TM7 302 L 7.34x33 Structure Structure
TM7 303 F 7.35x34 Structure Structure
TM7 304 F 7.36x35 Structure Structure
TM7 305 W 7.37x36 Structure Structure
TM7 306 V 7.38x37 Structure Structure
TM7 307 V 7.39x38 Structure Structure
TM7 308 A 7.40x39 Structure Structure
TM7 309 F 7.41x40 Structure Structure
TM7 310 T 7.42x41 Structure Structure
TM7 311 F 7.43x42 Structure Structure
TM7 312 A 7.44x43 Structure Structure
TM7 313 N 7.45x45 Structure Structure
TM7 314 S 7.46x46 Structure Structure
TM7 315 A 7.47x47 Structure Structure
TM7 316 L 7.48x48 Structure Structure
TM7 317 N 7.49x49 Structure Structure
TM7 318 P 7.50x50 Structure Structure
TM7 319 I 7.51x51 Structure Structure
TM7 320 L 7.52x52 Structure Structure
TM7 321 Y 7.53x53 Structure Structure
TM7 322 N 7.54x54 Structure Structure
TM7 323 M 7.55x55 Structure Structure
TM7 324 T 7.56x56 Structure Structure
H8 325 L 8.47x47 AF2 AF2
H8 326 C 8.48x48 AF2 AF2
H8 327 R 8.49x49 AF2 AF2
H8 328 N 8.50x50 AF2 AF2
H8 329 E 8.51x51 AF2 AF2
H8 330 W 8.52x52 AF2 AF2
H8 331 K 8.53x53 AF2 AF2
H8 332 K 8.54x54 AF2 AF2
H8 333 I 8.55x55 AF2 AF2
H8 334 F 8.56x56 AF2 AF2
H8 335 C 8.57x57 AF2 AF2
H8 336 C 8.58x58 AF2 AF2
H8 337 F 8.59x59 AF2 AF2
H8 338 W 8.60x60 AF2 AF2
H8 339 F 8.61x61 AF2 AF2
C-term 340 P - AF2 AF2
C-term 341 E - AF2 AF2
C-term 342 K - AF2 AF2
C-term 343 G - AF2 AF2
C-term 344 A - AF2 AF2
C-term 345 I - AF2 AF2
C-term 346 L - AF2 AF2
C-term 347 T - AF2 AF2
C-term 348 D - AF2 AF2
C-term 349 T - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 I 230 5x61 G.H5 L 353 G.H5.20
Hydrophobic TM5 S 237 5x68 G.H5 L 349 G.H5.16
Ionic ICL2 R 148 34x55 G.HN D 32 G.HN.50
Polar ICL2 R 148 34x55 G.HN D 32 G.HN.50
Hydrophobic ICL2 R 148 34x55 G.HN D 32 G.HN.50
Van-der-waals ICL2 R 148 34x55 G.HN D 32 G.HN.50
Hydrophobic C-term T 349 - G.s3h2 Q 209 G.s3h2.03
Polar TM5 R 238 5x69 G.H5 Q 350 G.H5.17
Hydrophobic TM5 R 238 5x69 G.H5 Q 350 G.H5.17
Van-der-waals TM5 R 238 5x69 G.H5 Q 350 G.H5.17
Polar ICL2 Q 144 34x51 G.H5 N 352 G.H5.19
Hydrophobic TM6 R 261 6x33 G.H5 V 359 G.H5.26
Van-der-waals TM6 R 261 6x33 G.H5 V 359 G.H5.26
Hydrophobic TM5 R 240 5x71 G.H5 K 345 G.H5.12
Van-der-waals TM5 R 240 5x71 G.H5 K 345 G.H5.12
Hydrophobic ICL2 L 143 34x50 G.H5 I 348 G.H5.15
Van-der-waals ICL2 L 143 34x50 G.H5 I 348 G.H5.15
Hydrophobic ICL2 R 145 34x52 G.H5 I 348 G.H5.15
Ionic TM4 R 152 4x39 G.HN E 24 G.HN.42
Hydrophobic TM6 L 266 6x38 G.H5 L 358 G.H5.25
Hydrophobic TM6 L 262 6x34 G.H5 V 359 G.H5.26
Van-der-waals TM6 L 262 6x34 G.H5 V 359 G.H5.26
Hydrophobic TM5 L 241 5x72 G.H5 D 346 G.H5.13
Van-der-waals TM5 L 241 5x72 G.H5 D 346 G.H5.13
Polar C-term T 349 - G.H2 R 213 G.H2.04
Hydrophobic C-term T 349 - G.H2 R 213 G.H2.04
Van-der-waals C-term T 349 - G.H2 R 213 G.H2.04
Ionic TM5 R 238 5x69 G.H5 D 346 G.H5.13
Polar TM5 R 238 5x69 G.H5 D 346 G.H5.13
Polar ICL2 G 146 34x53 G.H5 E 355 G.H5.22
Hydrophobic ICL2 G 146 34x53 G.H5 E 355 G.H5.22
Van-der-waals ICL2 G 146 34x53 G.H5 E 355 G.H5.22
Hydrophobic TM6 L 262 6x34 G.H5 L 358 G.H5.25
Polar TM3 R 136 3x50 G.H5 Y 356 G.H5.23
Aromatic TM3 R 136 3x50 G.H5 Y 356 G.H5.23
Hydrophobic TM3 R 136 3x50 G.H5 Y 356 G.H5.23
Van-der-waals TM3 R 136 3x50 G.H5 Y 356 G.H5.23
Hydrophobic TM6 H 251 6x23 G.H4 F 308 G.H4.10
Van-der-waals TM6 H 251 6x23 G.H4 F 308 G.H4.10
Hydrophobic TM5 L 241 5x72 G.H5 A 342 G.H5.09
Van-der-waals TM5 L 241 5x72 G.H5 A 342 G.H5.09
Polar ICL3 A 246 - G.S6 Y 325 G.S6.02
Hydrophobic ICL3 A 246 - G.S6 Y 325 G.S6.02
Van-der-waals ICL3 A 246 - G.S6 Y 325 G.S6.02
Hydrophobic TM3 I 140 3x54 G.H5 N 352 G.H5.19
Hydrophobic TM5 S 244 5x75 G.h4s6 K 322 G.h4s6.13
Van-der-waals TM5 S 244 5x75 G.h4s6 K 322 G.h4s6.13
Hydrophobic TM6 R 254 6x26 G.H4 D 315 G.H4.17
Hydrophobic TM5 S 244 5x75 G.H5 F 339 G.H5.06
Van-der-waals TM5 S 244 5x75 G.H5 F 339 G.H5.06
Polar C-term T 347 - G.H3 T 257 G.H3.11
Hydrophobic C-term T 347 - G.H3 T 257 G.H3.11
Van-der-waals C-term T 347 - G.H3 T 257 G.H3.11
Hydrophobic TM5 S 244 5x75 G.S6 Y 325 G.S6.02
Van-der-waals TM5 S 244 5x75 G.S6 Y 325 G.S6.02
Polar ICL3 Y 247 - G.H5 D 346 G.H5.13
Hydrophobic TM5 I 230 5x61 G.H5 L 358 G.H5.25
Van-der-waals TM5 I 230 5x61 G.H5 L 358 G.H5.25
Polar C-term T 349 - G.H3 R 256 G.H3.10
Hydrophobic C-term T 349 - G.H3 R 256 G.H3.10
Van-der-waals C-term T 349 - G.H3 R 256 G.H3.10
Polar TM3 C 139 3x53 G.H5 Y 356 G.H5.23
Hydrophobic TM3 C 139 3x53 G.H5 Y 356 G.H5.23
Van-der-waals TM3 C 139 3x53 G.H5 Y 356 G.H5.23
Polar TM6 T 265 6x37 G.H5 L 358 G.H5.25
Hydrophobic TM6 T 265 6x37 G.H5 L 358 G.H5.25
Van-der-waals TM6 T 265 6x37 G.H5 L 358 G.H5.25
Hydrophobic ICL3 A 246 - G.h4s6 D 321 G.h4s6.12
Hydrophobic C-term T 349 - G.H3 I 258 G.H3.12
Van-der-waals C-term T 349 - G.H3 I 258 G.H3.12
Hydrophobic TM5 T 234 5x65 G.H5 L 349 G.H5.16
Van-der-waals TM5 T 234 5x65 G.H5 L 349 G.H5.16
Hydrophobic TM3 I 140 3x54 G.H5 Y 356 G.H5.23
Van-der-waals TM3 I 140 3x54 G.H5 Y 356 G.H5.23
Polar TM5 S 237 5x68 G.H5 D 346 G.H5.13
Van-der-waals TM5 S 237 5x68 G.H5 D 346 G.H5.13
Polar ICL2 R 148 34x55 G.HN Q 28 G.HN.46
Hydrophobic ICL2 R 148 34x55 G.HN Q 28 G.HN.46
Van-der-waals ICL2 R 148 34x55 G.HN Q 28 G.HN.46
Polar ICL2 R 145 34x52 G.H2 I 217 G.H2.08
Polar ICL1 T 74 - G.H5 Y 356 G.H5.23
Hydrophobic ICL1 T 74 - G.H5 Y 356 G.H5.23
Hydrophobic TM5 R 240 5x71 G.H5 F 341 G.H5.08
Hydrophobic TM5 T 234 5x65 G.H5 L 353 G.H5.20
Hydrophobic TM3 I 140 3x54 G.H5 L 349 G.H5.16
Hydrophobic ICL2 L 143 34x50 G.H5 K 345 G.H5.12
Van-der-waals ICL2 L 143 34x50 G.H5 K 345 G.H5.12
Hydrophobic ICL2 R 145 34x52 G.H5 L 351 G.H5.18
Van-der-waals ICL2 R 145 34x52 G.H5 L 351 G.H5.18
Hydrophobic TM6 Q 258 6x30 G.H5 V 359 G.H5.26
Van-der-waals TM6 Q 258 6x30 G.H5 V 359 G.H5.26
Hydrophobic TM3 R 136 3x50 G.H5 L 358 G.H5.25
Van-der-waals TM3 R 136 3x50 G.H5 L 358 G.H5.25
Polar TM7 T 324 7x56 G.H5 N 357 G.H5.24
Hydrophobic TM7 T 324 7x56 G.H5 N 357 G.H5.24
Van-der-waals TM7 T 324 7x56 G.H5 N 357 G.H5.24
Hydrophobic ICL3 A 246 - G.H5 F 339 G.H5.06
Van-der-waals ICL3 A 246 - G.H5 F 339 G.H5.06
Hydrophobic C-term L 346 - G.H3 T 257 G.H3.11
Hydrophobic TM6 L 262 6x34 G.H5 L 353 G.H5.20
Polar H8 L 325 8x47 G.H5 N 357 G.H5.24
Hydrophobic H8 L 325 8x47 G.H5 N 357 G.H5.24
Van-der-waals H8 L 325 8x47 G.H5 N 357 G.H5.24
Hydrophobic TM6 H 251 6x23 G.h4s6 P 318 G.h4s6.09
Hydrophobic TM5 L 241 5x72 G.H5 F 339 G.H5.06
Van-der-waals TM5 L 241 5x72 G.H5 F 339 G.H5.06
Hydrophobic ICL2 L 143 34x50 G.S2 F 194 G.S2.06
Van-der-waals ICL2 L 143 34x50 G.S2 F 194 G.S2.06
Hydrophobic ICL2 V 147 34x54 G.HN R 31 G.HN.49
Van-der-waals ICL2 V 147 34x54 G.HN R 31 G.HN.49
Polar TM6 H 251 6x23 G.h4s6 D 319 G.h4s6.10
Polar TM6 R 254 6x26 G.H4 V 314 G.H4.16
Hydrophobic TM6 R 254 6x26 G.H4 V 314 G.H4.16
Van-der-waals TM6 R 254 6x26 G.H4 V 314 G.H4.16
Hydrophobic TM5 L 245 5x76 G.S6 Y 325 G.S6.02
Polar TM3 E 135 3x49 G.H5 Y 356 G.H5.23
Polar ICL2 G 146 34x53 G.H5 N 352 G.H5.19
Hydrophobic TM5 I 233 5x64 G.H5 L 349 G.H5.16
Hydrophobic TM3 I 140 3x54 G.H5 L 353 G.H5.20
Polar C-term D 348 - G.H3 T 257 G.H3.11
Hydrophobic C-term D 348 - G.H3 T 257 G.H3.11
Van-der-waals C-term D 348 - G.H3 T 257 G.H3.11
Hydrophobic TM5 L 245 5x76 G.h4s6 K 322 G.h4s6.13
Van-der-waals TM5 L 245 5x76 G.h4s6 K 322 G.h4s6.13
Polar C-term T 349 - G.H3 T 257 G.H3.11
Hydrophobic C-term T 349 - G.H3 T 257 G.H3.11
Van-der-waals C-term T 349 - G.H3 T 257 G.H3.11