FFA4 receptor - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8IYS

RESOLUTION

3.0 Å

REFERENCE

10.1038/S41422-023-00835-X

PUBLICATION DATE

June 21, 2023

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

56 interactions (Click to see)

LIGANDS

TUG-891 - Agonist pubchem gtoplig chembl_ligand

PHYSIOLOGICAL LIGANDS

myristic acid, α-linolenic acid, linoleic acid, oleic acid



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM3 R 136 3x50 G.H5 Y 354 G.H5.21
Hydrophobic TM3 R 136 3x50 G.H5 Y 354 G.H5.21
Van-der-waals TM3 R 136 3x50 G.H5 Y 354 G.H5.21
Hydrophobic ICL3 E 249 - G.H4 K 305 G.H4.07
Hydrophobic TM6 L 262 6x34 G.H5 V 357 G.H5.24
Polar TM5 R 238 5x69 G.h4s6 Y 319 G.h4s6.10
Hydrophobic TM3 I 140 3x54 G.H5 L 351 G.H5.18
Van-der-waals TM3 I 140 3x54 G.H5 L 351 G.H5.18
Hydrophobic ICL2 R 148 - G.HN R 32 G.HN.50
Van-der-waals ICL2 R 148 - G.HN R 32 G.HN.50
Hydrophobic C-term M 323 - G.H5 N 355 G.H5.22
Van-der-waals C-term M 323 - G.H5 N 355 G.H5.22
Hydrophobic TM3 I 140 3x54 G.H5 L 347 G.H5.14
Van-der-waals TM3 I 140 3x54 G.H5 L 347 G.H5.14
Hydrophobic TM3 Q 144 3x58 G.H5 L 347 G.H5.14
Van-der-waals TM3 Q 144 3x58 G.H5 L 347 G.H5.14
Hydrophobic TM5 L 241 5x72 G.h4s6 Y 319 G.h4s6.10
Hydrophobic TM5 S 244 5x75 G.H5 F 337 G.H5.04
Van-der-waals TM5 S 244 5x75 G.H5 F 337 G.H5.04
Hydrophobic TM5 L 241 5x72 G.H5 F 337 G.H5.04
Van-der-waals TM5 L 241 5x72 G.H5 F 337 G.H5.04
Hydrophobic TM5 I 233 5x64 G.H5 L 347 G.H5.14
Van-der-waals TM5 I 233 5x64 G.H5 L 347 G.H5.14
Hydrophobic ICL3 L 245 - G.H4 E 301 G.H4.03
Hydrophobic TM6 L 262 6x34 G.H5 L 351 G.H5.18
Van-der-waals TM6 L 262 6x34 G.H5 L 351 G.H5.18
Hydrophobic ICL3 L 245 - G.h4s6 S 320 G.h4s6.11
Van-der-waals ICL3 L 245 - G.h4s6 S 320 G.h4s6.11
Polar C-term T 324 - G.H5 N 355 G.H5.22
Van-der-waals C-term T 324 - G.H5 N 355 G.H5.22
Polar TM5 R 238 5x69 G.H5 Q 348 G.H5.15
Hydrophobic TM5 R 238 5x69 G.H5 Q 348 G.H5.15
Van-der-waals TM5 R 238 5x69 G.H5 Q 348 G.H5.15
Hydrophobic TM6 L 262 6x34 G.H5 L 356 G.H5.23
Van-der-waals TM6 L 262 6x34 G.H5 L 356 G.H5.23
Hydrophobic TM6 R 254 6x26 G.h4s6 I 317 G.h4s6.08
Hydrophobic TM5 S 237 5x68 G.H5 L 347 G.H5.14
Van-der-waals TM5 S 237 5x68 G.H5 L 347 G.H5.14
Van-der-waals ICL3 Y 247 - G.h4s6 I 318 G.h4s6.09
Hydrophobic ICL2 V 147 - G.HN R 32 G.HN.50
Polar TM6 T 265 6x37 G.H5 L 356 G.H5.23
Hydrophobic TM6 T 265 6x37 G.H5 L 356 G.H5.23
Van-der-waals TM6 T 265 6x37 G.H5 L 356 G.H5.23
Hydrophobic ICL3 S 248 - G.H4 V 308 G.H4.10
Van-der-waals ICL3 S 248 - G.H4 V 308 G.H4.10
Hydrophobic TM5 L 241 5x72 G.H5 D 344 G.H5.11
Polar ICL3 Y 247 - G.h4s6 S 320 G.h4s6.11
Ionic TM5 R 238 5x69 G.H5 D 344 G.H5.11
Polar TM5 R 238 5x69 G.H5 D 344 G.H5.11
Hydrophobic TM5 R 238 5x69 G.H5 D 344 G.H5.11
Van-der-waals TM5 R 238 5x69 G.H5 D 344 G.H5.11
Van-der-waals TM6 R 254 6x26 G.H4 S 314 G.H4.16
Hydrophobic TM6 H 251 6x23 G.h4s6 I 317 G.h4s6.08
Van-der-waals TM6 H 251 6x23 G.h4s6 I 317 G.h4s6.08
Hydrophobic TM5 T 234 5x65 G.H5 L 351 G.H5.18
Van-der-waals TM5 T 234 5x65 G.H5 L 351 G.H5.18
Polar TM6 H 251 6x23 G.h4s6 I 318 G.h4s6.09
Hydrophobic TM5 I 230 5x61 G.H5 L 351 G.H5.18
Van-der-waals TM5 I 230 5x61 G.H5 L 351 G.H5.18
Polar TM5 S 237 5x68 G.H5 A 340 G.H5.07
Hydrophobic TM5 T 234 5x65 G.H5 L 347 G.H5.14
Hydrophobic ICL3 S 248 - G.H4 L 304 G.H4.06
Hydrophobic TM5 R 240 5x71 G.H5 A 340 G.H5.07
Hydrophobic TM6 L 266 6x38 G.H5 L 356 G.H5.23
Van-der-waals TM6 L 266 6x38 G.H5 L 356 G.H5.23
Hydrophobic TM6 V 255 6x27 G.h4s6 I 317 G.h4s6.08
Van-der-waals TM6 V 255 6x27 G.h4s6 I 317 G.h4s6.08
Hydrophobic TM6 H 251 6x23 G.H4 V 308 G.H4.10
Van-der-waals TM6 H 251 6x23 G.H4 V 308 G.H4.10
Hydrophobic TM5 I 230 5x61 G.H5 L 356 G.H5.23
Hydrophobic TM3 G 146 3x60 G.HN R 32 G.HN.50
Van-der-waals TM3 G 146 3x60 G.HN R 32 G.HN.50
Polar TM6 R 261 6x33 G.H5 V 357 G.H5.24
Hydrophobic TM6 R 261 6x33 G.H5 V 357 G.H5.24
Van-der-waals TM6 R 261 6x33 G.H5 V 357 G.H5.24
Hydrophobic ICL3 L 245 - G.H4 L 304 G.H4.06
Van-der-waals ICL3 L 245 - G.H4 L 304 G.H4.06
Hydrophobic TM5 L 241 5x72 G.H5 A 340 G.H5.07
Van-der-waals TM5 L 241 5x72 G.H5 A 340 G.H5.07
Hydrophobic TM3 L 143 3x57 G.H5 I 346 G.H5.13
Van-der-waals TM3 L 143 3x57 G.H5 I 346 G.H5.13
Polar TM5 S 244 5x75 G.h4s6 H 321 G.h4s6.12
Van-der-waals TM5 S 244 5x75 G.h4s6 H 321 G.h4s6.12
Hydrophobic TM6 H 251 6x23 G.h4s6 K 316 G.h4s6.01
Van-der-waals TM6 H 251 6x23 G.h4s6 K 316 G.h4s6.01
Hydrophobic TM3 I 140 3x54 G.H5 N 350 G.H5.17
Van-der-waals TM3 I 140 3x54 G.H5 N 350 G.H5.17
Hydrophobic TM5 R 238 5x69 G.h4s6 I 317 G.h4s6.08
Van-der-waals TM5 R 238 5x69 G.h4s6 I 317 G.h4s6.08
Polar TM3 L 143 3x57 G.H5 K 343 G.H5.10
Polar TM5 S 237 5x68 G.H5 D 344 G.H5.11
Hydrophobic TM5 S 237 5x68 G.H5 D 344 G.H5.11
Van-der-waals TM5 S 237 5x68 G.H5 D 344 G.H5.11
Hydrophobic ICL3 Y 247 - G.h4s6 Y 319 G.h4s6.10
Van-der-waals ICL3 Y 247 - G.h4s6 Y 319 G.h4s6.10
Hydrophobic TM3 R 136 3x50 G.H5 L 356 G.H5.23
Hydrophobic ICL3 L 245 - G.h4s6 F 322 G.h4s6.13
Van-der-waals ICL3 L 245 - G.h4s6 F 322 G.h4s6.13
Polar TM5 S 244 5x75 G.h4s6 S 320 G.h4s6.11
Hydrophobic TM2 T 74 2x39 G.H5 Y 354 G.H5.21
Van-der-waals TM2 T 74 2x39 G.H5 Y 354 G.H5.21
Polar TM6 Q 258 6x30 G.H5 Q 348 G.H5.15
Polar TM2 T 74 2x39 G.H5 E 353 G.H5.20
Hydrophobic TM3 C 139 3x53 G.H5 Y 354 G.H5.21
Van-der-waals TM3 C 139 3x53 G.H5 Y 354 G.H5.21
Hydrophobic TM3 R 145 3x59 G.S2 V 193 G.S2.05
Van-der-waals TM3 R 145 3x59 G.S2 V 193 G.S2.05
Hydrophobic TM3 I 140 3x54 G.H5 Y 354 G.H5.21
Van-der-waals TM3 I 140 3x54 G.H5 Y 354 G.H5.21
Polar TM3 Q 144 3x58 G.H5 K 343 G.H5.10
Hydrophobic TM3 Q 144 3x58 G.H5 K 343 G.H5.10
Van-der-waals TM3 Q 144 3x58 G.H5 K 343 G.H5.10
Hydrophobic TM5 L 241 5x72 G.H5 A 341 G.H5.08
Van-der-waals TM5 L 241 5x72 G.H5 A 341 G.H5.08
Hydrophobic TM6 L 269 6x41 G.H5 L 356 G.H5.23
Van-der-waals TM6 L 269 6x41 G.H5 L 356 G.H5.23