ADGRG5 - Gs

GPCR CLASS (FAMILY)

Class B2 (Adhesion)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Bos taurus

PDB CODE

7EQ1

RESOLUTION

3.3 Å

REFERENCE

10.1038/S41586-022-04619-Y

PUBLICATION DATE

May 11, 2022

3D VIEW

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LIGAND INTERACTIONS

0 interactions (Click to see)

LIGANDS

Apo (no ligand) - Apo (no ligand)

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 L 343 3x58 G.H5 L 388 G.H5.20
Van-der-waals TM3 L 343 3x58 G.H5 L 388 G.H5.20
Polar TM5 T 437 5x60 G.H5 Q 384 G.H5.16
Van-der-waals TM5 T 437 5x60 G.H5 Q 384 G.H5.16
Polar TM6 T 458 6x41 G.H5 Y 391 G.H5.23
Van-der-waals TM6 T 458 6x41 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 V 346 - G.H5 Q 384 G.H5.16
Van-der-waals ICL2 V 346 - G.H5 Q 384 G.H5.16
Polar ICL2 N 348 - G.s2s3 K 216 G.s2s3.02
Hydrophobic TM5 R 442 5x65 G.H5 L 388 G.H5.20
Van-der-waals TM5 R 442 5x65 G.H5 L 388 G.H5.20
Hydrophobic ICL2 Y 350 - G.HN K 34 G.HN.51
Van-der-waals ICL2 Y 350 - G.HN K 34 G.HN.51
Hydrophobic TM5 L 441 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 L 441 5x64 G.H5 Q 384 G.H5.16
Polar ICL2 Y 347 - G.H5 C 379 G.H5.11
Hydrophobic ICL2 Y 347 - G.H5 C 379 G.H5.11
Van-der-waals ICL2 Y 347 - G.H5 C 379 G.H5.11
Polar TM3 L 342 3x57 G.H5 H 387 G.H5.19
Hydrophobic TM3 L 342 3x57 G.H5 H 387 G.H5.19
Van-der-waals TM3 L 342 3x57 G.H5 H 387 G.H5.19
Hydrophobic TM3 L 342 3x57 G.H5 Q 390 G.H5.22
Van-der-waals TM3 L 342 3x57 G.H5 Q 390 G.H5.22
Polar TM3 L 343 3x58 G.H5 Q 384 G.H5.16
Hydrophobic TM3 L 343 3x58 G.H5 Q 384 G.H5.16
Van-der-waals TM3 L 343 3x58 G.H5 Q 384 G.H5.16
Hydrophobic TM7 Q 506 7x60 G.H5 L 393 G.H5.25
Van-der-waals TM7 Q 506 7x60 G.H5 L 393 G.H5.25
Hydrophobic TM6 L 462 6x45 G.H5 Y 391 G.H5.23
Van-der-waals TM6 L 462 6x45 G.H5 Y 391 G.H5.23
Aromatic ICL2 Y 350 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 Y 350 - G.hns1 R 38 G.hns1.02
Hydrophobic H8 Q 517 8x57 G.h3s5 R 283 G.h3s5.01
Van-der-waals H8 Q 517 8x57 G.h3s5 R 283 G.h3s5.01
Hydrophobic ICL2 Y 347 - G.S3 V 217 G.S3.01
Van-der-waals ICL2 Y 347 - G.S3 V 217 G.S3.01
Polar ICL2 Y 347 - G.H5 R 380 G.H5.12
Aromatic ICL2 Y 347 - G.H5 R 380 G.H5.12
Hydrophobic ICL2 Y 347 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 Y 347 - G.H5 R 380 G.H5.12
Polar TM5 L 441 5x64 G.H5 R 385 G.H5.17
Hydrophobic TM5 L 441 5x64 G.H5 R 385 G.H5.17
Van-der-waals TM5 L 441 5x64 G.H5 R 385 G.H5.17
Hydrophobic TM5 L 441 5x64 G.H5 L 388 G.H5.20
Hydrophobic ICL2 Y 347 - G.H5 I 383 G.H5.15
Hydrophobic ICL2 Y 347 - G.S3 F 219 G.S3.03
Hydrophobic TM6 L 465 6x48 G.H5 Y 391 G.H5.23
Van-der-waals TM6 L 465 6x48 G.H5 Y 391 G.H5.23
Hydrophobic TM5 L 438 5x61 G.H5 L 388 G.H5.20
Van-der-waals TM5 L 438 5x61 G.H5 L 388 G.H5.20
Hydrophobic TM3 L 342 3x57 G.H5 Y 391 G.H5.23
Hydrophobic H8 R 509 8x49 G.H5 L 393 G.H5.25
Van-der-waals H8 R 509 8x49 G.H5 L 393 G.H5.25
Hydrophobic TM6 G 461 6x44 G.H5 L 393 G.H5.25
Hydrophobic ICL2 V 346 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 V 346 - G.H5 I 383 G.H5.15
Polar TM3 G 344 3x59 G.H5 R 380 G.H5.12
Van-der-waals TM3 G 344 3x59 G.H5 R 380 G.H5.12
Hydrophobic ICL2 Y 350 - G.HN Q 35 G.HN.52
Hydrophobic TM5 L 441 5x64 G.H5 D 381 G.H5.13
Van-der-waals TM5 L 441 5x64 G.H5 D 381 G.H5.13
Hydrophobic TM2 L 280 2x46 G.H5 Y 391 G.H5.23
Van-der-waals TM2 L 280 2x46 G.H5 Y 391 G.H5.23
Hydrophobic TM7 W 502 7x56 G.H5 L 393 G.H5.25
Hydrophobic TM7 S 505 7x59 G.H5 L 393 G.H5.25
Van-der-waals TM7 S 505 7x59 G.H5 L 393 G.H5.25
Polar ICL2 Y 347 - G.H5 F 376 G.H5.08
Aromatic ICL2 Y 347 - G.H5 F 376 G.H5.08
Hydrophobic ICL2 Y 347 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 Y 347 - G.H5 F 376 G.H5.08
Polar TM2 D 278 2x44 G.H5 Q 390 G.H5.22
Aromatic ICL2 Y 347 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 Y 347 - G.S1 H 41 G.S1.02
Hydrophobic TM7 W 502 7x56 G.H5 Y 391 G.H5.23
Ionic H8 R 509 8x49 G.H5 E 392 G.H5.24
Polar H8 R 509 8x49 G.H5 E 392 G.H5.24
Hydrophobic H8 R 509 8x49 G.H5 E 392 G.H5.24
Van-der-waals H8 R 509 8x49 G.H5 E 392 G.H5.24
Hydrophobic TM6 T 458 6x41 G.H5 E 392 G.H5.24
Hydrophobic ICL2 V 346 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 V 346 - G.H5 R 380 G.H5.12
Hydrophobic TM2 L 280 2x46 G.H5 Q 390 G.H5.22
Van-der-waals TM2 L 280 2x46 G.H5 Q 390 G.H5.22
Hydrophobic TM3 L 339 3x54 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 I 349 - G.H5 H 387 G.H5.19
Van-der-waals ICL2 I 349 - G.H5 H 387 G.H5.19