HCA2 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

2.9 Å

REFERENCE

PUBLICATION DATE

April 3, 2024

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

MK 6892 - Agonist pubchem gtoplig chembl_ligand pubchem

PHYSIOLOGICAL LIGANDS

butyric acid, β-D-hydroxybutyric acid



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic ICL2 H 133 - G.S3 L 194 G.S3.01
Polar ICL2 H 133 - G.H5 T 340 G.H5.12
Hydrophobic ICL2 H 133 - G.H5 T 340 G.H5.12
Van-der-waals ICL2 H 133 - G.H5 T 340 G.H5.12
Polar TM2 S 62 2x39 G.H5 D 350 G.H5.22
Hydrophobic TM2 S 62 2x39 G.H5 D 350 G.H5.22
Van-der-waals TM2 S 62 2x39 G.H5 D 350 G.H5.22
Aromatic ICL3 H 223 - G.H5 F 354 G.H5.26
Hydrophobic ICL3 H 223 - G.H5 F 354 G.H5.26
Van-der-waals ICL3 H 223 - G.H5 F 354 G.H5.26
Hydrophobic ICL2 P 132 - G.H5 T 340 G.H5.12
Hydrophobic TM5 L 215 5x65 G.H5 I 344 G.H5.16
Hydrophobic ICL2 K 138 - G.hns1 R 32 G.hns1.03
Hydrophobic TM6 A 229 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 A 229 6x33 G.H5 L 353 G.H5.25
Hydrophobic ICL2 H 133 - G.H5 F 336 G.H5.08
Hydrophobic TM6 I 226 6x30 G.H5 K 345 G.H5.17
Van-der-waals TM6 I 226 6x30 G.H5 K 345 G.H5.17
Polar ICL3 H 223 - G.h4s6 D 315 G.h4s6.09
Hydrophobic ICL3 H 223 - G.h4s6 D 315 G.h4s6.09
Van-der-waals ICL3 H 223 - G.h4s6 D 315 G.h4s6.09
Hydrophobic TM5 R 218 5x68 G.H5 T 340 G.H5.12
Van-der-waals TM5 R 218 5x68 G.H5 T 340 G.H5.12
Hydrophobic TM6 I 233 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 I 233 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM2 S 62 2x39 G.H5 C 351 G.H5.23
Hydrophobic ICL2 H 133 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 H 133 - G.H5 I 343 G.H5.15
Hydrophobic C-term S 298 - G.H5 G 352 G.H5.24
Van-der-waals C-term S 298 - G.H5 G 352 G.H5.24
Hydrophobic TM3 R 125 3x50 G.H5 L 353 G.H5.25
Ionic TM5 R 218 5x68 G.H5 D 341 G.H5.13
Polar TM5 R 218 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 R 218 5x68 G.H5 D 341 G.H5.13
Polar TM3 R 125 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 125 3x50 G.H5 C 351 G.H5.23
Aromatic ICL3 K 225 - G.H5 F 354 G.H5.26
Hydrophobic ICL3 K 225 - G.H5 F 354 G.H5.26
Van-der-waals ICL3 K 225 - G.H5 F 354 G.H5.26
Ionic TM5 R 218 5x68 G.H5 D 337 G.H5.09
Polar TM5 R 218 5x68 G.H5 D 337 G.H5.09
Hydrophobic TM3 R 128 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM6 I 226 6x30 G.H5 F 354 G.H5.26
Hydrophobic ICL2 K 138 - G.hns1 A 31 G.hns1.02
Ionic ICL1 K 60 - G.H5 D 350 G.H5.22
Polar ICL1 K 60 - G.H5 D 350 G.H5.22
Hydrophobic ICL1 K 60 - G.H5 D 350 G.H5.22
Van-der-waals ICL1 K 60 - G.H5 D 350 G.H5.22
Hydrophobic TM3 R 128 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM3 V 129 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 129 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM5 Q 219 5x69 G.H5 K 345 G.H5.17
Polar TM5 Q 219 5x69 G.H5 D 341 G.H5.13
Hydrophobic TM5 Q 219 5x69 G.H5 D 341 G.H5.13
Van-der-waals TM5 Q 219 5x69 G.H5 D 341 G.H5.13
Polar ICL2 N 137 - G.H5 N 347 G.H5.19
Van-der-waals ICL2 N 137 - G.H5 N 347 G.H5.19
Hydrophobic ICL2 P 132 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 132 - G.H5 I 343 G.H5.15
Van-der-waals C-term P 299 - G.H5 G 352 G.H5.24
Hydrophobic ICL2 P 132 - G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 132 - G.H5 I 344 G.H5.16