H4 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.0 Å

REFERENCE

PUBLICATION DATE

March 20, 2024

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

CHEMBL213912 - Agonist chembl_ligand pubchem

PHYSIOLOGICAL LIGANDS

CCL16, histamine



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic ICL2 R 123 34x54 G.H5 I 343 G.H5.15
Hydrophobic TM3 R 112 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM6 L 305 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 305 6x37 G.H5 L 353 G.H5.25
Ionic TM6 R 297 6x29 G.h4s6 E 318 G.h4s6.12
Polar TM6 R 297 6x29 G.h4s6 E 318 G.h4s6.12
Hydrophobic H8 H 362 8x47 G.H5 C 351 G.H5.23
Polar ICL2 R 123 34x54 G.S1 E 33 G.S1.01
Van-der-waals ICL2 R 123 34x54 G.S1 E 33 G.S1.01
Hydrophobic TM5 I 197 5x61 G.H5 L 353 G.H5.25
Polar ICL2 T 124 34x55 G.s2s3 D 193 G.s2s3.02
Hydrophobic TM6 L 308 6x40 G.H5 L 353 G.H5.25
Hydrophobic TM5 L 201 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 L 201 5x65 G.H5 L 348 G.H5.20
Hydrophobic ICL2 V 120 34x51 G.H5 F 336 G.H5.08
Hydrophobic TM6 L 301 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 301 6x33 G.H5 L 353 G.H5.25
Hydrophobic ICL2 A 119 34x50 G.H5 I 344 G.H5.16
Hydrophobic TM3 V 116 3x54 G.H5 I 344 G.H5.16
Hydrophobic TM6 S 304 6x36 G.H5 L 353 G.H5.25
Polar TM5 R 204 5x68 G.H5 K 345 G.H5.17
Polar H8 K 363 8x48 G.H5 D 350 G.H5.22
Hydrophobic H8 K 363 8x48 G.H5 D 350 G.H5.22
Van-der-waals H8 K 363 8x48 G.H5 D 350 G.H5.22
Hydrophobic TM5 I 197 5x61 G.H5 L 348 G.H5.20
Aromatic ICL2 H 126 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 H 126 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 H 126 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 A 119 34x50 G.H5 I 343 G.H5.15
Van-der-waals ICL2 A 119 34x50 G.H5 I 343 G.H5.15
Hydrophobic TM6 R 297 6x29 G.H5 K 345 G.H5.17
Van-der-waals TM6 R 297 6x29 G.H5 K 345 G.H5.17
Hydrophobic TM5 R 204 5x68 G.H5 I 344 G.H5.16
Hydrophobic TM3 V 116 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 116 3x54 G.H5 L 348 G.H5.20
Ionic TM5 R 204 5x68 G.H5 D 341 G.H5.13
Polar TM5 R 204 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM5 R 204 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 R 204 5x68 G.H5 D 341 G.H5.13
Polar TM3 S 115 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 S 115 3x53 G.H5 N 347 G.H5.19