CCK1 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

D

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7EZH

RESOLUTION

3.2 Å

REFERENCE

10.1038/S41589-021-00841-3

PUBLICATION DATE

Aug. 25, 2021

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

65 interactions (Click to see)

LIGANDS

CCK-8 - Agonist pubchem gtoplig chembl_ligand drug_central drugbank

ENDOGENOUS LIGANDS

desulfated cholecystokinin-8, CCK-33, CCK-8, CCK-39, gastrin-17, CCK-58, CCK-4



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL3 N 299 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 N 299 - G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 V 311 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 V 311 6x33 G.H5 L 353 G.H5.25
Polar ICL3 S 300 - G.h4s6 E 318 G.h4s6.12
Ionic H8 R 376 8x49 G.H5 D 350 G.H5.22
Polar H8 R 376 8x49 G.H5 D 350 G.H5.22
Hydrophobic H8 R 376 8x49 G.H5 D 350 G.H5.22
Van-der-waals H8 R 376 8x49 G.H5 D 350 G.H5.22
Hydrophobic TM2 T 76 2x39 G.H5 C 351 G.H5.23
Polar TM6 S 301 6x23 G.h4s6 K 314 G.h4s6.08
Polar TM3 R 139 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 139 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 139 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM6 V 311 6x33 G.H5 F 354 G.H5.26
Van-der-waals TM6 V 311 6x33 G.H5 F 354 G.H5.26
Hydrophobic TM3 I 143 3x54 G.H5 C 351 G.H5.23
Polar ICL2 R 150 34x54 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 R 150 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic TM6 A 307 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 A 307 6x29 G.H5 F 354 G.H5.26
Polar TM6 S 301 6x23 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 S 301 6x23 G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL2 P 146 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 146 34x50 G.H5 I 344 G.H5.16
Hydrophobic TM6 L 315 6x37 G.H5 L 353 G.H5.25
Polar ICL2 R 150 34x54 G.S1 E 33 G.S1.01
Van-der-waals ICL2 R 150 34x54 G.S1 E 33 G.S1.01
Polar H8 R 376 8x49 G.H5 K 349 G.H5.21
Hydrophobic H8 R 376 8x49 G.H5 K 349 G.H5.21
Van-der-waals H8 R 376 8x49 G.H5 K 349 G.H5.21
Hydrophobic TM3 R 139 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 139 3x50 G.H5 L 353 G.H5.25
Hydrophobic H8 N 374 8x47 G.H5 G 352 G.H5.24
Polar TM2 T 76 2x39 G.H5 D 350 G.H5.22
Van-der-waals TM2 T 76 2x39 G.H5 D 350 G.H5.22
Hydrophobic TM3 A 142 3x53 G.H5 C 351 G.H5.23
Polar TM3 A 142 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 142 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 142 3x53 G.H5 N 347 G.H5.19
Hydrophobic ICL2 L 147 34x51 G.H5 I 343 G.H5.15
Van-der-waals ICL2 L 147 34x51 G.H5 I 343 G.H5.15
Hydrophobic ICL2 R 150 34x54 G.H5 I 343 G.H5.15
Hydrophobic ICL2 L 147 34x51 G.H5 F 336 G.H5.08
Van-der-waals ICL2 L 147 34x51 G.H5 F 336 G.H5.08
Hydrophobic ICL2 L 147 34x51 G.S3 L 194 G.S3.01
Hydrophobic ICL2 L 147 34x51 G.H5 T 340 G.H5.12
Polar ICL2 V 151 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic TM6 K 308 6x30 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 308 6x30 G.H5 F 354 G.H5.26
Hydrophobic TM3 I 143 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 143 3x54 G.H5 L 348 G.H5.20
Hydrophobic ICL2 P 146 34x50 G.H5 I 343 G.H5.15
Polar ICL2 R 150 34x54 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 R 150 34x54 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 P 146 34x50 G.H5 T 340 G.H5.12